Calzad Tablet 10'S
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Introduction About CALZAD TABLET
CALZAD TABLET contains Calcium dobesilate which belongs to the group of medicines called Vasoprotective agents. It is used to manage microangiopathies such as diabetic retinopathy, hemorrhoidal syndrome (condition of inflamed and swollen blood vessels in rectum or around anus), chronic venous insufficiency/vascular dysfunction (condition of leg veins in which blood gets pooled in the legs due to failure of valves present in leg veins presenting with pain, cramps, and inactivity of legs).
Microangiopathy or microcirculation disorder is a disease of small blood vessels in which walls of those vessels become weak and bleed, resulting in reduced blood flow. In diabetic retinopathy, microangiopathy reduces the blood flow to retina, causing floaters (dark spots in the vision), blurred vision or even blindness. CALZAD TABLET is not recommended for use in patients who are allergic to Calcium dobesilate. It should be used with caution in patients with liver diseases such as obstructive jaundice, diabetic retinopathy (eye disorder that occurs due to diabetes), venous disorder such as varicose veins (enlarged veins in legs and feet), and dialysis patients with serious renal failure.
CALZAD TABLET is not recommended for use in pregnant and breastfeeding women, also it should be used with caution in children and adolescents (below 18 years of age). Consult your doctor before taking it. The most common side effects associated with the use of CALZAD TABLET are fever, bloating, constipation, diarrhoea, pain, nausea, vomiting and arthralgia (joint pain). Consult your doctor if any of the symptom worsens.
Uses Of CALZAD TABLET
It is used:
- To manage microangiopathies especially in diabetic retinopathy
- To manage hemorrhoidal syndrome and chronic venous insufficiency
- To manage piles and varicose veins
- To manages other microcirculation disorders
How CALZAD TABLET Works
CALZAD TABLET works by reducing the permeability or leakage in the blood vessels by acting on collagen chains, resulting in strengthening of the vessel walls which also reduces the action of the chemical messengers that increase the permeability of vessel walls, thereby resulting in reduced bleeding in small vessels.
How to use CALZAD TABLET
Take CALZAD TABLET as advised by your physician. Swallow the medicine with a glass of water and take this medicine along with food. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of CALZAD TABLET
Common
- fever
- signs of gastrointestinal disorders such as bloating, constipation, diarrhea, heartburn, pain, nausea and vomiting.
- skin reactions
- arthralgia (joint pain)
Uncommon
- fast heartbeat
Rare
- itching, rash
- chills
Stop taking CALZAD TABLET and contact your doctor if you experience any of the following side effects:
- signs of agranulocytosis (deficiency of white blood cells causing increased vulnerability to infection) such as high fever, oral cavity infections (tonsillitis), sore throat, and or anogenital inflammation
- signs of infection such as cough, fever, chills and sweat
- severe skin rash
- high fever
- bone pain
How To Manage Side Effects
Constipation
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptoms get worse.
Diarrhea
Drink lot of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.
Nausea And Vomiting
Try to take CALZAD TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if the symptom gets worse.
Skin rash Or Itching
Tap or pat your skin upon itching. Try not to scratch the itchy skin. Take cool or warm bath and place cool damp towel on the skin. Wear loose cotton clothes. Avoid using perfumed moisturizers, deodorants or soaps.
Warning & Precautions
Pregnancy
Monitoring requiredCALZAD TABLET is not recommended for use in pregnant women unless it is considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
ContraindicatedCALZAD TABLET is not recommended for use if you are breastfeeding since it may pass into the breast milk. Consult your doctor before taking CALZAD TABLET.
Driving and Using Machines
Use with CautionCALZAD TABLET is unlikely to affect your ability to drive and use of machines. Consult your doctor before taking it.
Kidney
Use with CautionCALZAD TABLET should be used with caution in patients undergoing dialysis with serious renal failure. Consult your doctor for advice before taking CALZAD TABLET.
Liver
Use with CautionCALZAD TABLET should be used with caution in patients with liver diseases such as obstructive jaundice. Consult your doctor before taking it.
Allergy
ContraindicatedCALZAD TABLET is not recommended for use if you are allergic to Calcium dobesilate, or any other ingredients of this medicine.
Use In Pediatrics
Use with CautionCALZAD TABLET should be used with caution in children and adolescents (below 18 years of age). Consult child’s doctor for advice.
Use In Geriatrics
Use with CautionCALZAD TABLET should be used with caution in elderly patients (aged 65 and above). Consult your doctor before taking it.
Others
Before taking CALZAD TABLET, inform your doctor if you have:
- diabetic retinopathy (eye disorder that occurs due to diabetes)
- venous disorder such as varicose veins (enlarged veins in legs and feet)
Interactions
A. Drug-Drug Interactions:
Before taking CALZAD TABLET, inform your doctor if you are taking any medicines including prescription or non-prescription medicines, herbals or vitamin supplements.
Overdosage:
If you or anyone else accidentally takes too much of CALZAD TABLET, consult your doctor immediately or visit the nearby hospital if you experience any unusual symptoms.
Synopsis
| Drug | : | Calcium dobesilate |
| Pharmacological Category | : | Vasoprotective agent |
| Therapeutic Indication | : | Microangiopathy or microcirculation disorder |
| Dosage Forms | : | Capsule |
More Information
Storage
- Keep the medicine out of reach in children
- Store CALZAD TABLET at room temperature
FAQs About CALZAD TABLET
Q: What is CALZAD TABLET used for?
A: CALZAD TABLET is used to manage microangiopathies such as diabetic retinopathy, hemorrhoidal syndrome (condition of inflamed and swollen blood vessels in rectum or around anus), chronic venous insufficiency/vascular dysfunction (condition of leg veins in which blood gets pooled in the legs due to failure of valves present in leg veins presenting with pain, cramps, and inactivity of legs).
Q: Is CALZAD TABLET safe to use in children and elderly?
A: CALZAD TABLET should be used with caution in children and adolescents (below 18 years of age) and in elderly patients (above 65 years of age). Consult your doctor for advice before taking CALZAD TABLET.
Q: Is CALZAD TABLET safe to use in patients undergoing dialysis?
A: CALZAD TABLET should be used with caution in dialysis patients with serious renal failure. In such cases the dose can be reduced accordingly. Consult your doctor for advice before taking CALZAD TABLET.
Q: How does CALZAD TABLET work?
A: CALZAD TABLET works on the walls of the small vessel and decreases their leakage and fragility. It also improves blood flow by decreasing viscosity/thickness of blood.
Q: Can CALZAD TABLET be taken during pregnancy or breast feeding?
A: CALZAD TABLET is not recommended for use in pregnant women unless it is clearly advised by your doctor. It is also not recommended for use in breastfeeding mothers as it may pass into breast milk. Consult your doctor before taking it.
Q: When should I stop taking CALZAD TABLET?
A: Stop taking CALZAD TABLET and contact your doctor immediately, if you experience any signs of agranulocytosis (high fever, oral cavity infections, sore throat, and/or anogenital inflammation) and signs of infection (fever, chills, sweats and cough), skin rash, fever and bone pain.
References
1. Laurence L Brunton, Bruce A Chubner, Bjorn C knollmann. Goodman & Gillman’s. The Pharmaceutical Basis of Therapeutics. Twelth edition. 2011. Page-1247.
2. Yilmaz Unal, Salih Tuncal, Koray Kosmaz, Berkay Kucuk, Kemal Kismet, Turgut Cavusoglu, Pinar Celepli, Mehmet Senes, Selin Yildiz, Sema Hucumenoglu. The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. April 2019. [Accessed on 8th July 2022] https://pubmed.ncbi.nlm.nih.gov/29589984/
3. E Rabe, K A Jaeger, M Bulitta, F Pannier. Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2011. [Accessed on 8th July 2022] https://pubmed.ncbi.nlm.nih.gov/21478142/
4. Berko Ilac ve Kimya Sanayi A.S. X-ven 500 mg Capsules. [Revised in November 2017] [Accessed on 8th July 2022] https://berkoilac.com.tr/wp-content/uploads/2019/05/x-ven-PIL-revD.pdf
5. OM Pharma. Doxium 500. [Accessed on 8th July 2022] https://www.e-lactancia.org/media/papers/Dobesilate-DS-OMPharma2018.pdf
6. Ikonremedies. [Accessed on 8th July 2022] https://www.ikonremedies.com/product/maycal-d-tablets/
Useful Diagnostic Tests
- Complete blood count
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