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BZON 25mg(L) - Bladder And Prostate Disorders-Dru

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Introduction About BZON 25MG(L)

BZON 25MG(L) contains Bethanechol which belongs to the group of medicines called Cholinergic agents. It is used in the management of urinary retention (inability to empty the bladder) following an operation or after giving birth or other health problems (such as brain, spinal or nerve problems) and also used to manage reflux esophagitis (inflammation of the esophagus due to back flow of stomach contents into the esophagus).

BZON 25MG(L) is not recommended for use in patients with gut or heart problems, asthma, fits, parkinsonism or if you had recent surgery on your stomach. BZON 25MG(L) should be used with caution in patients taking certain medicines for heart problems, as a critical fall in blood pressure may occur.

BZON 25MG(L) should be used with caution in pregnant and breastfeeding women only if clearly advised by the doctor. It is not recommended for use in elderly patients (above 70 years of age).

The most common side effects of taking BZON 25MG(L) are diarrhea, skin flushing, increased salivation and sweating, decreased body temperature (hypothermia), etc. Consult your doctor if any of the side effect worsens.

Uses Of BZON 25MG(L)

Indicated to manage,

urinary retention
reflux esophagitis

How BZON 25MG(L) Works

BZON 25MG(L) works by making the contraction of urinary bladder muscles adequately strong to initiate urination and empty the bladder. It also stimulates motility and increases tone of the stomach and often restores impaired rhythmic peristalsis (wave-like muscle contractions that move food through the digestive tract).

How to use BZON 25MG(L)

Take BZON 25MG(L) as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

Side Effects Of BZON 25MG(L)

Common

diarrhea
skin flushing
increased salivation and sweating
hypothermia (decreased body temperature)
urinary urgency
bradycardia (slow pulse rate)
drop in blood pressure

Uncommon

nausea, vomiting
gastrointestinal disturbances

Rare

orthostatic hypotension (sudden changes of posture leads to feeling of dizziness or giddiness due to low blood pressure)

How To Manage Side Effects

Diarrhea

Drink lot of fluids, like water or fruit juice to keep yourself hydrated. Avoid taking high fat or spicy foods. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Take BZON 25MG(L) on an empty stomach (one hour before meals or two hours after meals). Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Use with Caution

BZON 25MG(L) should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking it.

Breastfeeding

Use with Caution

BZON 25MG(L) should be used with caution in breastfeeding women only if considered clearly necessary. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Consult your doctor if you feel any side effect during management with BZON 25MG(L) that may stop you from driving or using machines.

Allergy

Consult your doctor

Do not take BZON 25MG(L) if you are allergic to Bethanechol or any other ingredients of this medicine.

Lungs

Contraindicated

BZON 25MG(L) is not recommended for use in patients with latent or active bronchial asthma. Consult your doctor before taking BZON 25MG(L).

Heart Disease

Contraindicated

BZON 25MG(L) is not recommended for use in patients who have pronounced bradycardia (slow heartbeat) or low blood pressure, coronary artery disease (narrowing or blockage of the coronary arteries, usually due to plaque buildup) or who had heart attack recently. Consult your doctor before taking BZON 25MG(L).

Use In Pediatrics

Consult your doctor

Safety and effectiveness of BZON 25MG(L) in children have not been established. Consult your child’s doctor for advice.

Use In Geriatrics

Contraindicated

BZON 25MG(L) is not recommended for use in elderly patients (above 70 years of age). Consult your doctor before taking it.

Others

BZON 25MG(L) is not recommended for use if you:

have blockage of the gut
have problems passing urine due to a blockage
had recent surgery on the stomach
have hypothyroidism
have peptic ulcer
have vasomotor instability (hot flushing)
have epilepsy (fits)
have parkinsonism
have weak strength or integrity of your gastrointestinal or bladder wall
have mechanical obstruction (partial or complete blockage of the intestine)
have increased muscular activity of the gastrointestinal tract or urinary bladder that might prove harmful (Ex. following recent urinary bladder surgery, gastrointestinal resection and anastomosis (surgical connection between two structures) or when there is possible digestive tract obstruction)
have bladder neck obstruction
have spastic gastrointestinal disturbances
have acute inflammatory lesions of the digestive tract
have peritonitis (inflamed membrane lining the abdominal wall)
have marked vagotonia (too much excitability of the vagus nerve)

Before taking BZON 25MG(L), inform your doctor if you:

urinary retention problem
have bacteriuria (presence of bacteria in the urine)

Interactions

A. Drug-Drug interactions:

Before taking BZON 25MG(L), inform your doctor if you are taking any of the following medicines:

medicines used to manage abnormal heart rhythms (Ex. quinidine, procainamide)
other medicines used to manage urinary retention (Ex. distigmine and carbachol)
medicines used to reduce high blood pressure in emergency situations (Ex. trimethaphan, hexamethonium)

Overdosage:

If you or anyone else accidentally take too much of BZON 25MG(L), consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of BZON 25MG(L) are abdominal discomfort, salivation, hot feeling, sweating, nausea, and vomiting.

Synopsis

Drug	:	Bethanechol chloride
Pharmacological Category	:	Cholinergic agents
Therapeutic Indication	:	Urinary retention, Reflux esophagitis
Dosage Forms	:	Tablet

More Information

Keep BZON 25MG(L) out of reach of children
Store at room temperature

FAQs About BZON 25MG(L)

Q. How does BZON 25MG(L) act?

A. BZON 25MG(L) works by making the contraction of urinary bladder muscles adequately strong to initiate urination and empty the bladder. It also stimulates motility and increases tone of the stomach and often restores impaired rhythmic peristalsis (wave-like muscle contractions that move food through the digestive tract).

Q. What is BZON 25MG(L) used for?

A. It is used in the management of urinary retention (inability to empty the bladder) following an operation or after giving birth or other health problems (such as brain, spinal or nerve problems) and also used to manage reflux esophagitis (inflammation of the esophagus due to back flow of stomach contents into the esophagus).

Q. What are the common side effects of BZON 25MG(L)?

A. The common side effects of taking BZON 25MG(L) are diarrhea, skin flushing, increased salivation and sweating, decreased body temperature (hypothermia), urinary urgency, and bradycardia (slow pulse rate below 60 beats per minute) and drop in blood pressure. Consult your doctor immediately if any of the side effect worsens.

Q. What to do If I forget to take a dose of BZON 25MG(L)?

A. You should take BZON 25MG(L) immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose of BZON 25MG(L) to match up your missed dose.

Q. Does BZON 25MG(L) cause diarrhea?

A. BZON 25MG(L) may cause diarrhea in some individuals. To manage this effect, drink lot of fluids, like water or fruit juice to keep yourself hydrated. Avoid eating high fat or spicy foods. Avoid taking any medicine on your own to manage diarrhea. Consult your doctor if the symptom does not improve.

References

1. Joan Heller Brown, Katharina Brandl, and Jurgen Wess. Muscarinic Receptor Agonists and Antagonists. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page –152.

2. Inderbir S. Padda; Armen Derian. Bethanechol. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. May 2022. [Accessed on 21st November 2023] https://www.ncbi.nlm.nih.gov/books/NBK560587/

3. Columbia University. Bethanechol Prior to Pancreatic Surgery. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2022] [Accessed on 21st November 2023] https://clinicaltrials.gov/ct2/show/NCT03572283

4. Shivani Gaitonde, Rena D. Malik, Alana L. Christie, Philippe E. Zimmern. Bethanechol: Is it still being prescribed for bladder dysfunction in women. The International Journal of Clinical Practice. August 2018. [Accessed on 21st November 2023] https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13248

5. BDR Pharmaceuticals International Pvt. Ltd. Urivoid Tablets (Bethanechol chloride). Ciplamed [Revised in September 2020] [Accessed on 21st November 2023] https://www.ciplamed.com/content/urivoid-tablets-0

6. Taj Pharmaceuticals Ltd. Tefecholine (Bethanechol chloride Tablets 25 mg USP). [Revised in August 2015] [Accessed on 21st November 2023] https://tajpharmaindia.com/wp-content/uploads/2015/09/PIL-TEFECHOLINE-BETHANECHOL-CHLORIDE-TAB.pdf

Useful Diagnostic Tests

Urodynamic testing

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Pushpraj Singh - MBBS

Last updated on 21 Nov 2023 | 05:56 PM(IST)

Lab updated