Brufen 400mg Tablet 15'S

Introduction About BRUFEN 400MG TABLET

Brufen 400mg Tablet is an oral medication commonly included in care plans designed to support relief from pain, inflammation, and discomfort associated with various conditions. It is widely used in individuals experiencing muscle pain, joint discomfort, dental pain, or fever-related symptoms where reducing inflammation and improving comfort is important. The tablet works by influencing certain chemical messengers in the body that are responsible for pain and swelling, thereby supporting overall relief and improved daily functioning.

This tablet is generally considered suitable for adults and adolescents when used under medical guidance. It is typically taken after food to help minimize stomach discomfort. The dosage and duration depend on the condition being managed and individual response. It should be swallowed whole with water and taken exactly as advised by a healthcare professional.

While using Brufen 400mg Tablet, certain precautions should be followed. Avoid taking it on an empty stomach unless directed otherwise. Prolonged or excessive use may affect the stomach, kidneys, or heart in some individuals. Inform your doctor about any existing medical conditions or medications you are taking to reduce the risk of interactions.

Brufen 400mg Tablet should be used cautiously in individuals with a history of stomach ulcers, kidney or liver conditions, or heart-related concerns. Use during pregnancy and breastfeeding should be based on medical advice. Common side effects may include stomach discomfort, nausea, or dizziness. Seek medical attention if severe reactions occur.

Uses Of BRUFEN 400MG TABLET

• Helps relieve mild to moderate pain
• Aids in reducing inflammation
• Effective in lowering fever and easing body aches
• Provides relief from joint and muscle discomfort

Benefits of BRUFEN 400MG TABLET

Brufen 400mg Tablet for Pain Relief

Brufen 400mg Tablet helps reduce discomfort by acting on pain signals in the body. It is commonly used for headaches, dental pain, and muscle aches, supporting improved comfort in daily activities.

Brufen 400mg Tablet for Inflammation Support

The tablet helps reduce inflammation associated with conditions like arthritis or injuries. This may help improve movement and reduce swelling when used appropriately.

Brufen 400mg Tablet for Fever Management

It supports the reduction of elevated body temperature by acting on temperature-regulating centres, helping individuals feel more comfortable during fever episodes.

Brufen 400mg Tablet for Musculoskeletal Comfort

Brufen may be included in care plans for joint or muscle discomfort, helping support better mobility and ease of movement when taken as directed.

How BRUFEN 400MG TABLET Works

How Brufen 400mg Tablet Works in the Body

Brufen 400mg Tablet contains Ibuprofen, which belongs to a group of medicines that act on pain and inflammation pathways.

Action of Ibuprofen on Pain and Inflammation

Ibuprofen works by blocking the production of certain natural substances (prostaglandins) in the body that are responsible for pain, swelling, and fever.

How the Tablet Supports Comfort and Relief

By reducing these chemical signals, Brufen helps decrease pain intensity, swelling, and fever, supporting overall comfort and improved daily functioning.

How to use BRUFEN 400MG TABLET

• Take the tablet exactly as prescribed by your healthcare professional
• Swallow it whole with water; do not crush or chew
•  Preferably take it after food to reduce stomach discomfort
•  Follow the prescribed dosage and duration
•  Do not exceed the recommended dose
•  Avoid long-term use without medical advice

What if I forgot to take BRUFEN 400MG TABLET

•  Take the missed dose as soon as you remember
•  Skip it if it is close to the next scheduled dose
•  Do not double the dose
•  Continue with your regular schedule
•  Consult your doctor if multiple doses are missed

Overdose

Taking more than the prescribed amount may increase the risk of side effects such as stomach irritation, dizziness, or kidney issues. Seek immediate medical attention in case of overdose.

Side Effects Of BRUFEN 400MG TABLET

How To Manage Side Effects

Dizziness Or Drowsiness

• Stay well-hydrated: Drink enough water throughout the day. Dehydration is one of the most common causes of dizziness.
• Eat regular meals: Low blood sugar can trigger dizziness, so avoid skipping meals and include healthy snacks like fruits or nuts.
• Sit or lie down immediately: If you feel dizzy, rest in a comfortable position to prevent falls or injuries.
• Take slow, deep breaths: This helps improve oxygen flow and reduces dizziness caused by anxiety or stress.
• Have an electrolyte-rich drink: Coconut water or oral rehydration solutions can help restore salt and mineral balance.
• Use a cool compress: Applying a damp, cool cloth to your forehead may help calm dizziness.
• Practice balance exercises: Gentle movements like yoga or tai chi can help improve body coordination over time.
• Avoid sudden movements: Stand up slowly from sitting or lying positions to prevent a sudden drop in blood pressure.

Nausea And Vomiting

• Ginger: Ginger tea, ginger water, or a small piece of fresh ginger can help calm the stomach and reduce the urge to vomit.
• Lemon: Sipping warm lemon water or smelling fresh lemon may help ease nausea and freshen the stomach.
• Mint (Pudina): Mint tea or chewing fresh mint leaves may help soothe the stomach and reduce queasiness.
• Cold Water or Ice Chips: Taking small sips of cold water or sucking on ice chips can help reduce nausea.
• Fennel Seeds (Saunf): Chewing fennel seeds or drinking fennel seed water may help relieve nausea and bloating.
• Clove: Sucking on a clove or drinking clove tea can help reduce the uneasy feeling in the stomach.

Warning & Precautions

Pregnancy

Consult your doctor

Brufen 400mg Tablet should be used during pregnancy only if advised by a healthcare professional, especially in later stages.  

Breastfeeding

Consult your doctor

Brufen 400mg Tablet may pass into breast milk in small amounts. Consult your doctor before taking it.  

Driving and Using Machines

Use with Caution

Brufen 400mg Tablet may cause dizziness in some individuals; avoid driving or operating machinery if you feel affected.

Kidney

Use with Caution

Brufen 400mg Tablet should be used cautiously in patients with kidney conditions; monitoring may be required. Consult your doctor for advice.

Liver

Use with Caution

Brufen 400mg Tablet should be used with caution in liver disorders; follow medical guidance.

Allergy

Contraindicated

Brufen 400mg Tablet is not recommended if you are allergic to ibuprofen or similar medicines.

Heart Disease

Use with Caution

Brufen 400mg Tablet should be used carefully in individuals with heart-related conditions. Consult your doctor for advice

Use In Pediatrics

Consult your doctor

Brufen 400mg Tablet should be used in children only under medical supervision. Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

Brufen 400mg Tablet should be used with caution in elderly patients. Consult your doctor before taking it.

Other Warnings for BRUFEN 400MG TABLET

Before using Brufen 400mg Tablet, inform your doctor if you

• Have a history of stomach ulcers
•  Have asthma

Who should not take BRUFEN 400MG TABLET

Brufen 400mg Tablet is not recommended for use if you have

•  Active stomach ulcers or bleeding
•  History of NSAID-related reactions

Safety Advice

• Use Exactly as Prescribed: Take Brufen 400mg Tablet only as directed by your healthcare professional. Do not exceed the recommended dose or duration, as improper use may increase the risk of side effects.
•  Take After Food: Always take the tablet after meals or with food to help reduce the risk of stomach irritation or discomfort.
•  Be Alert for Stomach Symptoms: Watch for signs like severe stomach pain, heartburn, vomiting, or blood in stools. Seek medical attention if any unusual symptoms occur.
•  Avoid Long-Term Self-Use: Do not use Brufen 400mg Tablet for extended periods without medical advice, as prolonged use may affect the stomach, kidneys, or heart.
• Avoid Combining with Other Painkillers: Do not take other NSAIDs or pain-relief medicines along with Brufen unless advised, as this may increase the risk of side effects.
•  Stay Hydrated: Drink adequate water during use, as proper hydration supports kidney function and overall well-being.
•  Inform Healthcare Providers: Always inform your doctor, dentist, or pharmacist that you are taking Brufen before any treatment or when starting new medications.
•  Use Caution in Certain Conditions: Inform your doctor if you have a history of stomach ulcers, kidney, liver, or heart conditions before using this medicine.
• • Take at the Same Time if Prescribed Regularly: If advised for regular use, take it at consistent times each day to maintain steady effect.

Diet and Lifestyle Advice

• Take with food or milk: Always take Brufen after meals or with milk to reduce the risk of stomach irritation. Avoid taking it on an empty stomach.
• Stay well hydrated: Drink plenty of water throughout the day. Proper hydration supports kidney function and helps your body handle the medication better.
• Limit spicy and oily foods: Such foods may worsen acidity or gastric discomfort, especially when taking pain-relief medicines.
•  Include gut-friendly foods: Add foods like curd, bananas, oats, and boiled vegetables to support digestion and reduce stomach sensitivity.
• Avoid overexertion: If you are taking Brufen for pain or inflammation, give your body enough rest to recover properly.
•  Maintain proper posture: For muscle or joint pain, correct posture (while sitting, standing, or lifting) helps reduce strain and improves recovery.
•  Use hot or cold therapy: Applying a warm compress for stiffness or a cold pack for swelling can complement the effect of the medicine.
• Monitor for stomach discomfort: If you notice symptoms like burning sensation, nausea, or stomach pain, consult a doctor promptly.
•  Avoid long-term self-use: Use Brufen only for the duration advised by your doctor. Long-term or frequent use may affect the stomach, kidneys, or heart.
• Stay active but gentle: Light stretching or low-impact activities (like walking) can help improve circulation and reduce stiffness without worsening pain

1. Brufen 400mg Tablet vs Paracetamol

Drug - Drug interaction

1. Other NSAIDs (e.g., diclofenac, naproxen)

• Interaction: Taking Brufen with other NSAIDs may increase the risk of stomach irritation, ulcers, and bleeding.
• Management: Avoid combining multiple NSAIDs unless specifically advised. Use a single pain reliever as recommended by your doctor.

2. Anticoagulants (e.g., warfarin, heparin)

• Interaction: This combination may increase the risk of bleeding due to additive blood-thinning effects.
• Management: Use only under strict medical supervision. Regular monitoring and dose adjustments may be required.

3. Antiplatelet Medicines (e.g., aspirin, clopidogrel)

• Interaction: May enhance the risk of bleeding, especially gastrointestinal bleeding.
• Management: Use cautiously and only if prescribed. Watch for signs of unusual bleeding.

4. Corticosteroids (e.g., prednisolone)

• Interaction: Increased risk of stomach ulcers, irritation, and bleeding.
• Management: Combination should be used carefully with medical advice. Protective medications may be recommended.

5. Antihypertensive Medicines (e.g., ACE inhibitors, beta-blockers)

• Interaction: Brufen may reduce the effectiveness of blood pressure-lowering medicines.
• Management: Monitor blood pressure regularly. Dose adjustments may be needed.

6. Diuretics (e.g., furosemide, hydrochlorothiazide)

• Interaction: May reduce the effectiveness of diuretics and increase the risk of kidney-related side effects.
• Management: Ensure proper hydration and monitor kidney function as advised by your doctor.

7. Lithium

• Interaction: Brufen may increase lithium levels in the blood, raising the risk of toxicity.
• Management: Regular monitoring of lithium levels is required. Dose adjustments may be necessary.

8. Methotrexate

• Interaction: May increase methotrexate levels, leading to a higher risk of toxicity.
• Management: Avoid concurrent use or use with caution under strict medical supervision.

9. Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g., sertraline, fluoxetine)

• Interaction: Increased risk of bleeding, especially from the stomach.
• Management: Use cautiously and report any signs of bleeding to your doctor.

10. Cyclosporine and Tacrolimus

• Interaction: Increased risk of kidney damage when used together.
• Management: Kidney function should be monitored closely. Use only if clearly advised.

11. Antidiabetic Medicines (e.g., insulin, metformin)

• Interaction: May affect blood sugar levels in some individuals.
• Management: Monitor blood glucose levels regularly and adjust treatment if required.

12. Zidovudine

• Interaction: May increase the risk of blood-related side effects such as bleeding or bruising.
• Management: Use under medical supervision with regular monitoring.

Drug - Food interaction

1. Spicy and Oily Foods

• Interaction: These foods may aggravate stomach irritation and worsen symptoms like acidity or discomfort when taking Brufen.
• Management: Limit intake of spicy and oily foods, especially if you experience stomach sensitivity.

2. Caffeine-Containing Foods and Beverages (e.g., tea, coffee, energy drinks)

• Interaction: Excess caffeine may increase the chances of gastric irritation or restlessness in some individuals.
• Management: Consume caffeine in moderation and avoid excessive intake while taking the medicine.

3. High-Fat Meals

• Interaction: Very high-fat meals may delay the absorption of ibuprofen, slightly slowing its onset of action.
• Management: Maintain a balanced diet and take the tablet consistently with or after normal meals.

4. Acidic Foods and Beverages (e.g., citrus fruits, carbonated drinks)

• Interaction: May increase stomach acidity and irritation when combined with Brufen.
• Management: Limit excessive intake, especially if you are prone to acidity or gastric discomfort.

5. Herbal Products (e.g., garlic, ginger, ginkgo biloba)

• Interaction: Some herbal products may increase the risk of bleeding when taken along with Brufen.
• Management: Avoid excessive use and consult your doctor before using herbal supplements regularly.

Synopsis

More Information

FAQs About BRUFEN 400MG TABLET

References

1.Flamingo Pharma (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in December 2023]. [Accessed on 13th April 2026]

2. Vincent Trung H. Ngo; Tushar Bajaj. Ibuprofen. NIH National Library of Medicine, National centre for biotechnology information. StatPearls. [Revised in 11th August 2024]. [Accessed on 13th April 2026] 

3. Rabia Bushra, Nousheen Aslam. An Overview of Clinical Pharmacology of Ibuprofen. NIH National Library of Medicine, National centre for biotechnology information. PubMed Central. [Revised in July 2010]. [Accessed on 13th April 2026]

Useful Diagnostic Tests

• Kidney function test

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 16 Apr 2026 | 03:40 PM(IST)