Brinzotim Eye Drops 5ml
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Introduction About BRINZOTIM EYE DROPS
BRINZOTIM EYE DROPS is a combination of Brinzolamide and Timolol which belongs to the group of medicines called Ophthamic anti-glaucoma agents. It is used in adults to manage increased pressure in the eye caused due to glaucoma or ocular hypertension. It is typically used in patients who have not responded adequately to therapy with beta-blockers (Ex. timolol) alone.
BRINZOTIM EYE DROPS is for ophthalmic use only. Instil few drops of the medicine into the affected eye(s). Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. If you wear soft contact lenses, remove the lens before applying BRINZOTIM EYE DROPS and wait for at least 15 minutes before reinsertion.
Before using BRINZOTIM EYE DROPS inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have or previously had any breathing problems, asthma, COPD, diabetes, thyroid problems, low blood pressure or problems in blood circulation as a precaution.
Do not use BRINZOTIM EYE DROPS without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of using BRINZOTIM EYE DROPS are burning or stinging of eyes, eye redness and itching, blurred vision and bitter taste. Consult your doctor if any of these side effect bothers you.
Uses Of BRINZOTIM EYE DROPS
- Manage glaucoma/ocular hypertension in adults
How BRINZOTIM EYE DROPS Works
BRINZOTIM EYE DROPS reduces intraocular pressure by decreasing the production of aqueous humour (a type of lubricating eye fluid) in the eye. As a result, it reduces strain on the eyes which therefore reduces elevated intraocular pressure.
How to use BRINZOTIM EYE DROPS
Use BRINZOTIM EYE DROPS as advised by your physician. It is for ophthalmic use only. Wash your hands before and after application. Tilt your head slightly and gently pull the lower eyelid downwards.
Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination.
Apply applying BRINZOTIM EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying BRINZOTIM EYE DROPS and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon the severity of the disease condition. Do not stop using BRINZOTIM EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again.
Side Effects Of BRINZOTIM EYE DROPS
Common
- burning and stinging of the eyes
- metallic taste or bitter taste
- eye redness, itching or watering
- eye discomfort
- eye pain
- blurred vision
Uncommon
- inflammation in and around the eyes
- corneal staining
- sensation of foreign body in the eye
- dry eyes, eye discharge
- low blood pressure
- low WBC count
- cough
- bloody urine, body weakness
Rare
- increased eye sensitivity towards light
- eyelid crusting
- problems in sleeping
- throat pain, running nose
Stop using BRINZOTIM EYE DROPS and contact your immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, swelling of the eye, eyelids, face, lips, tongue, hands or throat leading to difficulty in breathing)
How To Manage Side Effects
Eye irritation Or Itching
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops or television. Wear protective eyeglasses while going outdoors.
Eye pain Or Sensitivity
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Warning & Precautions
Pregnancy
ContraindicatedBRINZOTIM EYE DROPS is generally not recommended for use in pregnant women. Therefore, consult your doctor for advice before using it.
Breastfeeding
ContraindicatedBRINZOTIM EYE DROPS is generally not recommended for use in breastfeeding women. Therefore, consult your doctor for advice before using it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you experience dizziness or blurred vision after using BRINZOTIM EYE DROPS.
Kidney
Consult your doctorBRINZOTIM EYE DROPS is not recommended for use in patients with severe kidney diseases. It should be used with caution in patients with other minor kidney problems. Therefore, consult your doctor before using it.
Liver
Use with CautionBRINZOTIM EYE DROPS should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.
Allergy
ContraindicatedDo not use BRINZOTIM EYE DROPS if you are allergic to Brinzolamide, Timolol, sulphonamides (such as glipizide, gliclazide), diuretics (such as furosemide) or to any other beta-blockers (Ex. labetalol).
Lungs
Consult your doctorBRINZOTIM EYE DROPS is not recommended for use in patients who currently have or previously had any lung problems such as asthma or COPD. It should be used with caution in patients with breathing difficulties. Therefore, consult your doctor before using it.
Heart Disease
Consult your doctorBRINZOTIM EYE DROPS is not recommended for use in patients with heart problems (such as slow or irregular heartbeat or heart failure). It should be used with caution in patients with coronary artery disease. Therefore, consult your doctor before using it.
Use In Pediatrics
Use with CautionBRINZOTIM EYE DROPS should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before using it.
Use In Geriatrics
Use with CautionBRINZOTIM EYE DROPS should be used with caution in elderly patients. Therefore, consult your doctor before using it.
Others
BRINZOTIM EYE DROPS is not recommended for use if you:
- have severe allergic rhinitis (hay fever causing nasal block, repeated sneezing, red, watery itching eyes)
- have hyperchloremic acidosis (a condition where there is too much of acidity in blood)
Before using BRINZOTIM EYE DROPS, inform your doctor if you:
- have low blood pressure
- have Raynaud’s disease (poor blood circulation to hands and feet)
- have diabetes
- have an overactivity of thyroid gland
- have muscle weakness
- have dry eyes or problems in your cornea
- wear soft contact lenses
- have any surgery in the upcoming days
- have atopy (a tendency to develop allergic reaction very easily)
Interactions
A. Drug-Drug interactions:
Before using BRINZOTIM EYE DROPS, inform your doctor if you are taking any of the following medicines such as:
- other carbonic anhydrase inhibitors (used to manage glaucoma) Ex. acetazolamide and brinzolamide
- medicines used to manage hypertension and other heart problems (such as clonidine, guanetidine, nifedipine, verapamil or diltiazem)
- amiodarone, digoxin, quinidine (medicines used to manage irregular heartbeat)
- medicines used to manage stomach ulcers (such as ranitidine, pantoprazole)
- adrenaline (a medicines used to manage hypersensitivity reactions)
- other beta-blockers (used to manage hypertension or glaucoma) such as pindolol, labetalol, propranolol, atenolol etc.
- medicines used for depression (such as fluoxetine and paroxetine)
- medicines used to manage diabetes (such as metformin, insulin)
- medicines used to manage viral infections (such as ritonavir, nelfinavir, atazanavir)
- medicines used to manage fungal infections (such as ketoconazole, fluconazole, itraconazole)
- medicines used to manage bacterial infections (such as amoxicillin, cefixime, azithromycin, clarithromycin)
Overdosage:
If you or anyone else accidentally used more BRINZOTIM EYE DROPS, rinse your eye with warm water. If still irritation persists, consult your doctor. If you or anyone else accidentally swallowed this medicine, contact your doctor or visit the nearby hospital. Symptoms of overdosage might include headache, dizziness, difficulty in breathing, slow heart rate and chest pain.
Synopsis
| Drug | : | Brinzolamide, Timolol |
| Pharmacological Category | : | Carbonic anhydrase inhibitors, Beta-blockers |
| Therapeutic Indication | : | Glaucoma, Ocular hypertension |
| Dosage Forms | : | Eye drops |
More Information
- Keep BRINZOTIM EYE DROPS out of reach of children
- Store BRINZOTIM EYE DROPS at room temperature
FAQs About BRINZOTIM EYE DROPS
Q: Can the use of BRINZOTIM EYE DROPS cause blurred vision?
A: Yes. BRINZOTIM EYE DROPS may cause blurred vision after application. If your vision becomes blur, close your eyes for some time and rest. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Q: Can I use other eye medicines while using BRINZOTIM EYE DROPS?
A: Yes. You can use other eye medicines while undergoing therapy with BRINZOTIM EYE DROPS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.
Q: Who should avoid using BRINZOTIM EYE DROPS?
A: BRINZOTIM EYE DROPS should be avoided in patients with severe kidney or heart problems. It should be used with caution in patients with liver problems, low blood pressure, diabetes, thyroid problems and problems in blood circulation. It is also not suitable for use in pregnant or breastfeeding women. Patients aged below 18 years must consult your doctor before using BRINZOTIM EYE DROPS.
Q: How to use BRINZOTIM EYE DROPS?
A: Use BRINZOTIM EYE DROPS as advised by your physician. It is for ophthalmic use only. Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. If you wear soft contact lenses, remove the lens before applying BRINZOTIM EYE DROPS and wait for at least 15 minutes before reinsertion.
Q: What is the use of BRINZOTIM EYE DROPS?
A: BRINZOTIM EYE DROPS is a prescription medicine used to manage increased pressure within the eyes. It is typically used in patients who have not responded adequately to therapy with beta-blockers (Ex. timolol) alone.
Q: How long does it take for [GBNKRYWORD] to work?
A: It may take about 1 to 4 weeks for BRINZOTIM EYE DROPS to show the results. Therefore, continue to use BRINZOTIM EYE DROPS as prescribed by your physician.
Q: What are the side effects of BRINZOTIM EYE DROPS?
A: The most common side effects of using BRINZOTIM EYE DROPS are burning or stinging of eyes, eye redness and itching, blurred vision and bitter taste. Consult your doctor if any of these side effect bothers you.
Q: Can I use BRINZOTIM EYE DROPS while wearing contact lenses?
A: If you wear soft contact lenses, remove the lens before applying BRINZOTIM EYE DROPS and wait for at least 15 minutes before reinsertion. This is because BRINZOTIM EYE DROPS contains preservatives which may interact with your contact lens and make your lens to discolour.
Q: Can I stop using BRINZOTIM EYE DROPS without consulting my doctor?
A: Do not stop using BRINZOTIM EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again. If you think that you are feeling better or if you wish to stop using BRINZOTIM EYE DROPS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the dose.
Q: Is BRINZOTIM EYE DROPS safe for pregnant and breastfeeding women?
A: BRINZOTIM EYE DROPS is generally not recommended for use in pregnant women or breastfeeding women. Therefore, consult your doctor before using it.
Q: Can I drive or ride a bike after using BRINZOTIM EYE DROPS?
A: Do not drive if you feel dizzy or experience blurred vision after using BRINZOTIM EYE DROPS. It also effects the ability to perform tasks that need alertness or coordination, and so be cautious while driving.
Q: What if I miss a dose of BRINZOTIM EYE DROPS?
A: If you missed a dose of BRINZOTIM EYE DROPS, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and apply the regular dose. Do not apply a double dose to compensate the missed dose.
References
1. KD. Tripathi. Antiadrenergic drugs and Drugs for Glaucoma. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 148 & 153.
2. Robert F. Reilly and Edwin K. Jackson. Regulation of Renal volume and vascular volume. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. Page – 680.
3. Keiji Yoshikawa, Jun Kozaki, and Hidetaka Maeda. Efficacy and safety of brinzolamide/timolol fixed combination compared with timolol in Japanese patients with open-angle glaucoma or ocular hypertension. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. February 2014. [Accessed on 12th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926459/
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in December 2019]. [Accessed on 12th December 2022] https://www.medicines.org.uk/emc/files/pil.11573.pdf
5. Brio-T Eye drops. Sunways Private Ltd. [Accessed on 12th December 2022] http://www.sunways.com/Products/SunwaysProducts/Brio-T.html
6. Central Drugs Standard Control Organization (CDSCO). Brinzolamide USP…………1.0% w/v Timolol Maleate IP……......0.683%w/v eq. to Timolol………………0.5%w/v Benzalkonium Chloride IP (As preservative) ………………0.01% w/v Ophthalmic Suspension. February 2016. [Accessed on 12th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
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