BREVIPIL 100 Tablet 10's

Introduction About BREVIPIL 100 TABLET

BREVIPIL 100 TABLET contains Brivaracetam, which belongs to the class of medicines known as anti-epileptics. It is indicated for the management of seizures associated with epilepsy in adults and adolescents, as prescribed by a healthcare professional, and acts by selectively binding to Synaptic Vesicle Protein 2A (SV2A) on nerve cells in the brain. This action helps to reduce abnormal electrical activity and limits the spread of seizure signals, thereby aiding in seizure control. BREVIPIL 100 TABLET may be used as monotherapy or as an add-on therapy with other anti-epileptic medicines. It helps in the control of seizures when taken regularly, as directed by a physician.

You can take this medicine regularly with or without food, preferably at the same time each day, as advised by your healthcare professional, to help achieve optimal therapeutic benefit. The dosage and frequency will be determined by your doctor based on your medical condition and response to management to ensure effective seizure control. If required, the dose may be adjusted gradually under medical supervision.

This medicine is generally prescribed for long-term use as advised by a healthcare professional. It is important to continue taking it for the duration recommended by your doctor, even if you feel well, as missing doses or discontinuing management may lead to worsening of seizures. Do not stop taking this medicine without consulting your doctor, as sudden discontinuation may increase the risk of seizure recurrence or severity.

Common side effects associated with this medicine includes dizziness, headache, nausea, vomiting, and fatigue. Some individuals may also experience behavioral changes such as irritability, agitation, or aggressive behavior. These effects are more commonly observed during the initial weeks of management and often reduce as the body adjusts to the medicine. Most side effects are mild and do not require medical attention, however, some may be serious. In rare cases, patients receiving this medicine have reported thoughts of self-harm or suicide. Seek immediate medical advice if you notice worsening mood changes or unusual behavior.

Before starting this medicine, inform your healthcare professional if you have a history of liver or kidney disorders, depression, or suicidal thoughts. You should also consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as medical advice is required to assess the potential risks and benefits before use.

Uses Of BREVIPIL 100 TABLET

• Management of seizures associated with epilepsy in adults and adolescents, as prescribed by a healthcare professional

Benefits of BREVIPIL 100 TABLET

1. Helps Control Seizures: Assists in the management of seizures associated with epilepsy when taken as prescribed by a healthcare professional.
2. Reduces Abnormal Brain Activity: Works by targeting Synaptic Vesicle Protein 2A (SV2A) to suppress excessive electrical activity in the brain.
3. Supports Long-Term Seizure Management: Helps maintain seizure control with regular and continued use under medical supervision.
4. Can Be Used Alone or with Other Medicines: Suitable for use as monotherapy or as an add-on therapy with other anti-epileptic drugs.
5. Aids in controlling Seizure Spread: Limits the transmission of abnormal electrical signals that can trigger seizures.
6. Supports Overall Epilepsy Management Plan: Forms part of a comprehensive epilepsy management approach as advised by a healthcare professional.

How BREVIPIL 100 TABLET Works

BREVIPIL 100 Tablet contains Brivaracetam, an anti-epileptic medicine that helps in managing seizures associated with epilepsy. It works by interacting with specific proteins in the brain to regulate electrical activity, helping the brain function more steadily.

Understanding the Mechanism of Action of Brivaracetam

Brivaracetam acts by selectively binding to Synaptic Vesicle Protein 2A (SV2A), a protein found on nerve cells. This binding helps modulate the release of neurotransmitters and reduces excessive electrical activity in the brain, which is associated with seizures.

Role of SV2A Protein in Brain Signal Regulation

The SV2A protein plays a crucial role in controlling the release of chemical messengers between nerve cells. By interacting with SV2A, Brivaracetam supports the regulation of nerve signals, helping maintain a balanced neurological environment.

How Brivaracetam Interacts with Brain Nerve Cells

Brivaracetam binds to SV2A on the surface of nerve cells (neurons), which helps stabilize their activity. This interaction limits abnormal electrical signals in the brain, helping to maintain consistent neurological function and seizure control.

Why SV2A Binding Is Important in Neurological Care

Binding to SV2A is essential because it modulates the communication between nerve cells. Proper SV2A function helps reduce the spread of abnormal electrical activity, making it a key target in epilepsy management and neurological health.

How to use BREVIPIL 100 TABLET

How to Take BREVIPIL 100 Tablet

BREVIPIL 100 Tablet should be taken exactly as prescribed by your healthcare professional. Regular intake at the same time each day helps maintain consistent blood levels and supports seizure management.

Directions for Use of Brivaracetam Tablet

Take the tablet with or without food and swallow it whole with a glass of water. Follow the instructions provided by your doctor regarding the timing and frequency of doses.

Administration Guidelines for BREVIPIL 100 Tablet

Always follow your doctor’s instructions regarding dosage schedule, frequency, and duration. Avoid altering the dose on your own and report any unusual side effects promptly.

Dosage Information for BREVIPIL 100 Tablet

The exact dose of BREVIPIL 100 Tablet is determined based on the patient’s age, medical condition, and response to therapy. Your doctor may adjust the dose gradually to achieve optimal seizure control.

How the Dosage of Brivaracetam Is Decided

Dosage decisions are made by your healthcare professional, considering factors such as seizure type, other medications, liver or kidney function, and individual response. Regular follow-ups ensure safe and effective use.

Why Following the Prescribed Dosage Matters

Adhering to the prescribed dosage ensures consistent seizure control and reduces the risk of increased seizure activity. Sudden changes or stopping the medicine without medical advice can worsen symptoms.

Can BREVIPIL 100 Tablet Be Taken with Food?

BREVIPIL 100 Tablet can be taken with or without food, allowing flexibility in your daily routine. Taking it at the same time each day is recommended for maximum benefit.

Things to Know Before Changing the Dosage

Do not adjust or stop your dosage without consulting your doctor. Any change in dose should be guided by a healthcare professional, as sudden changes can increase seizure frequency or severity.

What if I forgot to take BREVIPIL 100 TABLET

If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Side Effects Of BREVIPIL 100 TABLET

Common:

• Dizziness
• Headache
• Nausea
• Vomiting
• Fatigue
• Behavioral changes such as irritability, agitation, or aggressive behavior

When to consult your doctor?

• Severe Allergic Reactions symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.
• Suicidal Thoughts or Behavior symptoms such as thoughts of self-harm, suicide, or unusual changes in mood or behavior.
• Severe Dizziness or Loss of Coordination symptoms such as intense unsteadiness, fainting, or difficulty walking.
• Intense Fatigue or Weakness symptoms such as sudden or extreme tiredness
• Severe Nausea or Vomiting
• Severe Irritation, Agitation, or Aggressive Behavior
• Unusual Seizure Activity

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to reduce falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Stay Hydrated: Drink plenty of water throughout the day to help ease headache symptoms.
• Rest in a Quiet Environment: Minimize noise and bright lights by resting in a calm, dark room.
• Use Over-the-Counter Pain Relief: Consult your doctor about using mild pain relievers like acetaminophen to alleviate headaches.
• Avoid Stressful Activities: Limit activities that increase stress or physical exertion when experiencing headaches.
• Seek Medical Advice: Contact your healthcare provider if headaches become severe, persistent, or are accompanied by other symptoms.

Nausea And Vomiting

• Stay Hydrated: Sip fluids slowly, such as water, ginger tea, or clear soups to support hydration and reduce discomfort.
• Eat Small, Bland Meals: Choose light foods like crackers, toast, or plain rice to minimize stomach irritation.
• Avoid Strong Odors and Spicy Foods: These can worsen feelings of nausea and should be limited during symptoms.
• Rest and Relaxation: Rest in a comfortable position and avoid sudden movements to calm the digestive system.
• Seek Medical Advice: Consult a healthcare provider promptly if nausea is severe, persistent, or accompanied by vomiting.

Warning & Precautions

Pregnancy

Monitoring required

BREVIPIL 100 TABLET is not recommended for use in pregnant women unless considered necessary. Consult your doctor before use if you are pregnant or planning pregnancy.

Breastfeeding

Contraindicated

BREVIPIL 100 TABLET is not recommended for use in breastfeeding women as it may pass through breast milk. Medical advice is required for mothers who are breastfeeding.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel sleepy, dizzy, or tired while taking medicine. Be aware of your response to the medicine before performing tasks that require alertness.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking the medicine. Alcohol may increase side effects such as dizziness, drowsiness, or impaired coordination.

Kidney

Contraindicated

BREVIPIL 100 TABLET is not recommended for use in patients with impaired renal function. Kidney function should be assessed by a healthcare professional before use. Consult your doctor before taking it.

Liver

Use with Caution

BREVIPIL 100 TABLET should be taken with caution in patients with hepatic impairment. Liver function monitoring may be required during prolonged use. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take BREVIPIL 100 TABLET if you are allergic to Brivaracetam or any other ingredients of this medicine. Seek immediate medical attention in case of allergic reactions.

Use In Pediatrics

Contraindicated

BREVIPIL 100 TABLET is not recommended for use in children under 4 years of age. Pediatric dosing and safety have not been established for this age group. Consult your doctor before giving it.

Use In Geriatrics

Use with Caution

BREVIPIL 100 TABLET should be used with caution in elderly patients (aged 65 years and above). Elderly patients may be more sensitive to side effects such as dizziness, drowsiness, or fatigue. Consult your doctor before taking it.

Other Warnings for BREVIPIL 100 TABLET

Before taking medicine, inform your doctor if you have:

• Depression, suicidal ideations, or any unusual changes in mood and behaviour
• Mention history of seizures or other neurological conditions

Diet and Lifestyle Advice

Drug - Drug interaction

1. Other Anti-Epileptic Medicines (e.g., Levetiracetam, Lamotrigine, Valproate)
   • Interaction: Using BREVIPIL 100 Tablet with other anti-epileptic drugs may alter the blood levels of Brivaracetam or the co-administered medicine.
   • Effects: May increase drowsiness, dizziness, or coordination problems; may also affect seizure control.
   • Management: Inform your doctor if you notice increased side effects or changes in seizure patterns. Dose adjustments may be required.
2. CYP2C19 Inhibitors (e.g., Omeprazole, Fluoxetine)
   • Interaction: Medicines that inhibit the CYP2C19 enzyme can increase Brivaracetam levels in the blood.
   • Effects: Higher risk of side effects such as fatigue, dizziness, or sedation.
   • Management: Your doctor may monitor for side effects and adjust the dose if necessary.
3. CYP2C19 Inducers (e.g., Rifampicin, Carbamazepine)
   • Interaction: Enzyme-inducing medicines may reduce Brivaracetam levels in the blood.
   • Effects: Potential reduction in seizure control effectiveness.
   • Management: Inform your doctor; dosage modification or additional monitoring may be needed.
4. Benzodiazepines (e.g., Lorazepam, Clobazam)
   • Interaction: Combining with Brivaracetam may enhance sedative effects.
   • Effects: Increased drowsiness, fatigue, or impaired coordination.
   • Management: Avoid activities requiring alertness, and report excessive sedation to your doctor.
5. Opioids (e.g., Morphine, Tramadol)
   • Interaction: May increase central nervous system depression when taken with Brivaracetam.
   • Effects: Drowsiness, slowed breathing, or confusion.
   • Management: Monitor closely; dosage adjustment may be necessary under medical supervision.

Drug - Food interaction

1. Regular Meals
   • Interaction: Irregular meals do not significantly affect Brivaracetam absorption but maintaining a consistent routine helps manage overall health.
   • Effects: Fatigue or dizziness may be more noticeable if meals are skipped.
   • Management: Take BREVIPIL 100 Tablet at the same time daily, with or without food.
2. Alcohol
   • Interaction: Alcohol may increase drowsiness or dizziness while taking Brivaracetam.
   • Effects: Impaired alertness, increased risk of accidents, and reduced coordination.
   • Management: Avoid alcohol or consult your doctor regarding safe limits.
3. Caffeine or Energy Drinks
   • Interaction: High caffeine intake may worsen nervousness, irritability, or sleep disturbances while on Brivaracetam.
   • Effects: Increased agitation or insomnia.
   • Management: Limit caffeine-containing beverages while taking this medicine.
4. High-Fat Meals
   • Interaction: Large, fatty meals may slightly delay absorption, though overall effect is minor.
   • Effects: Mild digestive discomfort may occur.
   • Management: Take with smaller, balanced meals if you notice stomach upset.

Synopsis

More Information

FAQs About BREVIPIL 100 TABLET

References

1. Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 303-326.

2. Felix Zahnert, Kristina Krause, Ilka Immisch, Lena Habermehl, Iris Gorny, Izabella Chmielewska, Leona Möller, Anna M. Weyand, Peter M. Mross, Jan Wagner, Katja Menzler and Susanne Knake. Brivaracetam in the Treatment of Patients with Epilepsy - First Clinical Experiences. Journal of Frontiers in neurology. February 2018. [Accessed on 16th Jan 2026] 

3. Farbod Khaleghi, and Eric C. Nemec. A Novel Adjunctive Therapy for Partial-Onset Seizures. February 2017. [Accessed on 16th Jan 2026]  

4. UCB Pharma limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 16th Jan 2026]  

Useful Diagnostic Tests

• Complete Blood Count (CBC) with ESR
• Complete Blood Count (CBC)
• ECG at Home

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 18 Nov 2024 | 03:55 PM(IST)