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Introduction About BON K2 TABLET
BON K2 TABLET is a combination of Calcitriol, Calcium Citrate Malate, and Menaquinone, which belongs to the group of medicines called Vitamin D analogs, Calcium compounds, and Vitamin K derivatives. It is used in the management of bone disorders like osteopenia, osteoporosis, and post-menopausal women with osteoporosis.
Thinning and weakening of bones occur due to excessive absorption of calcium from the bones, generally because of nutritional deficiencies, underlying conditions, or increasing age. It is characterized by symptoms such as bleeding gums, weak grip strength, brittle fingernails, loss of height, frequent fractures, and neck and back pain.
BON K2 TABLET is not recommended for use in patients allergic to calcitriol, other vitamin D metabolites (such as alfacalcidol and cholecalciferol), and/or any other ingredients of this medicine.
BON K2 TABLET is also not recommended for use in patients with hypercalcemia (high calcium levels in the blood) and/or metastatic calcification (extra deposits of calcium in your body).
Before taking BON K2 TABLET, inform your doctor if you are immobilized (due to an operation or any other reason) and/or have liver problems (such as non-alcoholic fatty liver disease).
BON K2 TABLET should be used with caution by pregnant and breastfeeding women only if it is clearly necessary. BON K2 TABLET should be used with caution in children and adolescents (aged below 18 years).
The most common side effects associated with the use of BON K2 TABLET are hypercalcemia (high calcium levels in the blood), headache, skin rash, excess thirst, and nausea. abdominal pain and/or urinary tract infection. Consult your doctor if any of these symptoms worsen.
Uses Of BON K2 TABLET
To manage:
- Osteoporosis (including post-menopausal osteoporosis)
- Osteopenia
How BON K2 TABLET Works
BON K2 TABLET helps in promoting bone health, whereas calcitriol works by aiding the body to absorb more calcium from food or supplements, which also regulates the production of parathyroid hormone (the chemical responsible for maintaining calcium and phosphorus balance in the body).
Calcium Citrate Malate works by facilitating calcium retention and bone accrual, which leads to the consolidation and maintenance of bone mass, thus reducing the risk of bone fracture and osteoporosis.
Menaquinone works by increasing collagen production through osteoblastic cells and inhibiting calcium deposits in the arteries, thus increasing healthy bone deposits and thereby managing osteoporosis in affected individuals.
How to use BON K2 TABLET
Take BON K2 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of BON K2 TABLET
Common
- signs of hypercalcemia (increased calcium levels in the blood) such as tiredness, weakness, vomiting, excessive urination, and high blood pressure
- headache
- skin rash
- excess thirst
- nausea
- abdominal pain
- urinary tract infection
Uncommon
- high blood pressure
- drowsiness
- high fever
- anorexia (eating disorder)
- ophthalmic conditions such as conjunctivitis and photophobia
Rare
- signs of hypercalcemia (increased calcium levels in the blood) such as loss of appetite, weight loss, nausea, vomiting, headache, sluggishness, drowsiness, and weakness
- signs of extreme hypercalcemia (very high calcium levels in the blood) such as high fever, thirst, dehydration, passing more urine, wetting the bed, constipation, stomach pain, blockage of the bowel, irregular heartbeat, urinary bladder infection, restricted growth, and/or mental problems
- signs of allergic reactions such as itchy skin, skin rashes, and/or reddening of the skin
Stop taking BON K2 TABLET and contact your doctor if you experience any of the following side effects:
- signs of severe allergic reactions such as itchy skin, skin rashes, and reddening of the skin
How To Manage Side Effects
Headache
If BON K2 TABLET causes a headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking BON K2 TABLET. If it lasts more than a week or is severe, inform your doctor.
Nausea And Vomiting
Try to take BON K2 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Thirst
Try to drink plenty of cold water and sip on cold, unsweetened drinks, and use lip balm if your lips are dry. Brush your teeth two times a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
Monitoring requiredBON K2 TABLET should be used with caution during pregnancy and by women planning for pregnancy only if it is necessary. Consult your doctor before taking it.
Breastfeeding
Monitoring requiredBON K2 TABLET should be used with caution in breastfeeding women only if it is necessary. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionBON K2 TABLET is unlikely to affect your ability to drive or operate machines. Consult your doctor before taking it
Kidney
Use with CautionBON K2 TABLET should be used with caution in patients with kidney problems such as renal osteodystrophy. Consult your doctor before taking it.
Liver
Use with CautionBON K2 TABLET should be used with caution in patients with liver problems such as non-alcoholic fatty liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take BON K2 TABLET if you are allergic to calcitriol, other vitamin D metabolites (such as alfacalcidol and cholecalciferol), and/or any other ingredients of this medicine. Consult your doctor before taking BON K2 TABLET.
Use In Pediatrics
Use with CautionBON K2 TABLET should be used with caution in children and adolescents (below 18 years). Consult your doctor before taking it.
Use In Geriatrics
Use with CautionBON K2 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.
Others
BON K2 TABLET is not recommended for use if you:
- have hypercalcemia (high calcium levels in the blood)
- have metastatic calcification (extra deposits of calcium in your body)
- are unwell due to high levels of vitamin D in your body
Before taking BON K2 TABLET, inform your doctor if you:
- are immobilized due to an operation or any other reason
Interactions
A. Drug-Drug Interactions:
Before taking BON K2 TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines containing vitamin D
- diuretics (a medicine used to manage high blood pressure) Ex. bendroflumethiazide, chlortalidone, and indapamide
- digoxin and digitoxin (medicines used to manage heart diseases)
- medicines containing magnesium, such as antacids (medicines used to manage indigestion), Ex. magnesium hydroxide
- medicines used to manage pain and inflammation, such as corticosteroids (Ex. hydrocortisone, prednisolone, and dexamethasone)
- medicines used to manage high levels of blood cholesterol, such as ion-exchange resins Ex. cholestyramine
- phosphate (a medicine used to manage certain urinary tract infections)
B. Drug-Food Interactions:
Avoid having vitamin D-rich foods (such as dairy products like milk and cheese) or fortified foods (eatables to which vitamin D is added) while taking BON K2 TABLET since it may increase the risk of side effects. Consult your doctor before taking it.
Overdosage:
If you or anyone else accidentally takes too much of BON K2 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include signs of hypercalcemia such as loss of appetite, weight loss, nausea, vomiting, constipation, headache, sluggishness, drowsiness, and/or weakness.
Synopsis
| Drug | : | Calcitriol, Calcium Citrate Malate, and Menaquinone |
| Pharmacological Category | : | Vitamin D analogs, Calcium compounds and Vitamin K derivatives |
| Therapeutic Indication | : | Osteoporosis, Osteopenia |
| Dosage Forms | : | Tablet |
More Information
- Keep the medicine out of the reach of children
- Store below 25°C away from light and moisture
FAQs About BON K2 TABLET
Q: What is BON K2 TABLET used for?
A: BON K2 TABLET is used to manage bone disorders like osteopenia, osteoporosis, and post-menopausal women with osteoporosis. Thinning and weakening of bones occur due to excessive absorption of calcium from the bones, generally because of nutritional deficiencies, underlying conditions, or increasing age. Consult your doctor before taking it.
Q: What happens if you take more BON K2 TABLET than your required dose?
A: If you or anyone else accidentally takes too much BON K2 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include signs of hypercalcemia such as loss of appetite, weight loss, nausea, vomiting, constipation, headache, sluggishness, drowsiness, and/or weakness.
Q: What side effects are seen with BON K2 TABLET?
A: The most common side effects associated with the use of BON K2 TABLET are hypercalcemia (high calcium levels in the blood), headache, skin rash, excess thirst, and nausea. abdominal pain and/or urinary tract infection. Consult your doctor if any of these symptoms worsen.
Q: Who should avoid taking BON K2 TABLET?
A: BON K2 TABLET is not recommended for use in patients allergic to calcitriol, other vitamin D metabolites (such as alfacalcidol and cholecalciferol), and/or any other ingredients of this medicine. BON K2 TABLET is also not recommended for use in patients with hypercalcemia (high calcium levels in the blood) and/or metastatic calcification (extra deposits of calcium in your body). Consult your doctor before taking it.
Q: Is BON K2 TABLET safe to use in children or elderly patients?
A: Yes, BON K2 TABLET can be used, but with caution in children and adolescents (below 18 years) and in elders (aged above 65 years). Consult your doctor before taking it.
Q: How does BON K2 TABLET work?
A: BON K2 TABLET helps in promoting bone health, where calcitriol works by aiding the body to absorb more calcium from food and supplements, which also regulates the production of parathyroid hormone (the chemical responsible for maintaining calcium and phosphorus balance in the body). Calcium citrate malate works by facilitating calcium retention and bone accrual, which leads to the consolidation and maintenance of bone mass, thus reducing the risk of bone fractures and osteoporosis. Menaquinone works by increasing collagen production through osteoblastic cells and inhibiting calcium deposits in the arteries, thus increasing healthy bone deposits and thereby managing osteoporosis in affected individuals.
Q: Is BON K2 TABLET safe for use by pregnant and breastfeeding women?
A: Yes, BON K2 TABLET can be used, but with caution during pregnancy and in women planning for pregnancy only if it is necessary. It is also used with caution in breastfeeding women if deemed necessary by the consulting doctor. Consult your doctor before taking it.
Q: What if I forget to take my BON K2 TABLET dose?
A: If you forgot to take your BON K2 TABLET dose, take it as soon as possible when you remember. Do not double the dose to make up for the missed dosage. Consult your doctor if you have doubts about a missed dosage.
Q: How much BON K2 TABLET can be taken in a day?
A: Take BON K2 TABLET as advised by your physician, who shall decide the correct dose and duration for you depending on your age, body weight, and disease condition.
References
1. Edward Giovannucci, Martin Hewison, Roger Bouillon, David Goltzman, David Feldman. The Vitamin D analogs, Eldecalcitol. Vitamin D: Volume 2: Health, Disease and Therapeutics. Fourth edition. 2018. Page 215.
2. Paul Insel, Elaine Turner, Don Ross. Calcium Supplements: Are they right for you? Discovering Nutrition. Third edition. 2010. Page 417.
3. Jan Gordeladze. Vitamin K2 and Bone Heath. Vitamin K2 is Vital for Health and well-being. Edition. 2017. Page 110.
4. Brandon E. Lung; Myles L. Mowery; David E E. Komatsu. Calcitriol. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. July 2022. [Accessed on 8th February 2024] https://www.ncbi.nlm.nih.gov/books/NBK526025/
5. Hamid Lorvand Amiri, Shahram Agah, Javad Tolouei Azar, Sharieh Hosseini , Farzad Shidfar , Seyedeh Neda Mousavi. Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. September 2016. [Accessed on 8th February 2024] https://pubmed.ncbi.nlm.nih.gov/27720403/
6. Ji Yeon Lee, Tsz-Yin So, and Jennifer Thackray. A Review on Vitamin D Deficiency Treatment in Pediatric Patients. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2013. [Accessed on 8th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979050/
7. Meghan Meehan, Sue Penckofer. The Role of Vitamin D in the Aging Adult. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2014. [Accessed on 8th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399494/
8. Atnahs Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 8th February 2024] https://www.medicines.org.uk/emc/files/pil.11802.pdf
9. INTEGRACE PVT LTD. BON K2. [Accessed on 8th February 2024] https://integracehealth.com/product/bonk2/
Useful Diagnostic Tests
- Calcium
- Vitamin D 1,25 Dihydroxy
- Extended Arthritis Care
- Comprehensive Arthritis Care
- Basic Bone Care
- Advance Bone Care
- Comprehensive Bone Care
- Esr Automated
- Phosphorus-Inorganic, Serum
- Basic Arthritis Care Plan
- Bone Strength Package
- Arthritis Profile-Basic
- Arthritis Profile-Advanced
- Pth-Intact Molecule Parathyroid Hormone
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