BIXIBAT Tablet 10's

Introduction About BIXIBAT TABLET

BIXIBAT Tablet contains Elobixibat 5 mg and belongs to a group of medicines that act on bile acid transport in the intestine. It may be prescribed for adult patients with chronic constipation under the supervision of a doctor. BIXIBAT Tablet is intended to support bowel regularity and improve bowel movement in individuals for whom this medicine has been considered appropriate based on medical evaluation.

The active ingredient in BIXIBAT Tablet works mainly within the intestine by influencing the movement and reabsorption of bile acids. This action increases the availability of bile acids in the colon, which can influence intestinal water content and bowel movement. The medicine therefore works through a bile-acid-related pathway that is different from many commonly used constipation medicines.

BIXIBAT Tablet may be recommended by a doctor after considering factors such as age, bowel symptoms, medical history, existing health conditions, and other medicines being taken. Individuals with relevant medical conditions or those taking prescription medicines, over-the-counter medicines, or supplements should inform their doctor before using BIXIBAT Tablet. The suitability of the medicine may vary according to individual health needs.

BIXIBAT Tablet should be taken exactly as directed by the doctor. It is intended for oral administration and should be taken according to the prescribed schedule and meal-related instructions. The recommended dose and duration of use may vary according to individual requirements and medical assessment. Do not change the prescribed dose or schedule without consulting your doctor.

Some individuals may experience gastrointestinal effects while using BIXIBAT Tablet. The occurrence and intensity of these effects may vary among individuals. If any unwanted symptom persists, becomes severe, or causes concern, consult your doctor promptly.

Uses Of BIXIBAT TABLET

It is used in the management of:

• Chronic idiopathic constipation (CIC) in adults
• Chronic constipation not associated with organic disease
• Constipation associated with straining and hard stools

Benefits of BIXIBAT TABLET

Supports Bowel Regularity in Chronic Constipation

BIXIBAT Tablet is prescribed for adults with chronic constipation to support more regular bowel movements and a consistent bowel pattern. It helps maintain a more predictable bowel routine when used according to the doctor's advice.

Helps Ease Difficulty in Passing Stools

BIXIBAT Tablet supports individuals experiencing difficulty passing stools associated with persistent constipation, helping address this aspect of altered bowel habits.

Supports Improvement in Stool Consistency

BIXIBAT Tablet supports changes in stool consistency in appropriate patients, which is relevant for individuals experiencing hard or difficult-to-pass stools.

Helps Address Persistent Changes in Bowel Habits

BIXIBAT Tablet is recommended when constipation involves ongoing changes in normal bowel habits. The response can vary depending on individual symptoms and medical assessment.

How BIXIBAT TABLET Works

How BIXIBAT Tablet Works

BIXIBAT Tablet contains Elobixibat, which acts on bile acid transport in the intestine. It influences the reabsorption of bile acids in the terminal part of the small intestine, resulting in greater availability of bile acids within the colon.

Elobixibat and the Ileal Bile Acid Transporter

Elobixibat acts on the ileal bile acid transporter, a protein responsible for transporting bile acids back into the body from the terminal ileum. By inhibiting this transporter, Elobixibat reduces the reabsorption of bile acids in this part of the intestine.

Effect of Elobixibat on Bile Acid Reabsorption

Elobixibat reduces the reabsorption of bile acids in the terminal ileum. As a result, a greater amount of bile acids remains within the intestinal contents and passes towards the colon.

Effect of BIXIBAT on Bile Acids in the Colon

The increased amount of bile acids reaching the colon influences the local intestinal environment. This contributes to changes in water movement and bowel activity within the colon.

How to use BIXIBAT TABLET

How to Take BIXIBAT Tablet

• Take BIXIBAT Tablet orally with water.
• Swallow the tablet whole without crushing or chewing it.
• Take it according to the schedule prescribed by your doctor.

BIXIBAT Tablet Recommended Dosage

• The usual adult starting dose is 5 mg once daily.
• Depending on individual response, the doctor may adjust the dose to 10 mg once daily.
• The maximum recommended daily dose is 15 mg.

When to Take BIXIBAT Tablet

• Take BIXIBAT Tablet on an empty stomach before breakfast.
• If prescribed more than once daily, the additional dose should be taken before dinner.
• Maintain the recommended interval between doses.

Duration of BIXIBAT Tablet Use

• Continue BIXIBAT Tablet for the duration prescribed by your doctor.
• The duration may vary according to your bowel symptoms and medical assessment.

What if I forgot to take BIXIBAT TABLET

• If you miss a dose, take the next dose at the usual scheduled time.
• Do not take an extra dose to compensate for the missed tablet.

Side Effects Of BIXIBAT TABLET

Common Side Effects:

• Abdominal discomfort or bloating
• Diarrhoea or loose stools
• Nausea
• Mild headache

How To Manage Side Effects

Warning & Precautions

Other Warnings for BIXIBAT TABLET

Before taking BIXIBAT Tablet, inform your doctor if you have:

• A current or previous condition associated with drug-induced or disease-induced constipation
• A history of persistent abdominal pain
• A history of recurrent diarrhoea
• Previous difficulty tolerating medicines that affect bowel function

Who should not take BIXIBAT TABLET

It Is Not Recommended in Individuals With:

• Known hypersensitivity to Elobixibat or any of the ecipients in BIXIBAT Tablet
• Documented intestinal obstruction associated with a tumour or hernia
• Suspected intestinal obstruction associated with a tumour or hernia, as the condition may be aggravated

Diet and Lifestyle Advice

• Include Fibre-Rich Foods: Add fruits, vegetables, whole grains, oats, pulses, and legumes to your daily diet to support healthy bowel habits.
• Drink Adequate Water: Maintain sufficient fluid intake throughout the day to support normal stool consistency.
• Stay Physically Active: Include suitable activities such as walking or regular exercise to support normal bowel activity.
• Follow a Regular Toilet Routine: Respond to the natural urge to pass stools and avoid regularly delaying bowel movements.
• Choose Balanced Meals: Include a variety of fibre-containing foods as part of balanced daily meals.
• Limit Low-Fibre Processed Foods: Reduce frequent consumption of highly processed foods that provide little dietary fibre.
• Increase Fibre Gradually: If your usual diet is low in fibre, increase fibre intake gradually to allow your digestive system to adjust.

Drug - Drug interaction

1. Bile Acid Preparations (e.g., Ursodeoxycholic Acid, Chenodeoxycholic Acid)

Interaction: Elobixibat may interfere with the intestinal reabsorption of bile acid preparations through its inhibitory effect on the ileal bile acid transporter.

Effects: The effects of these bile acid preparations may be reduced.

Management: Inform your doctor if you are taking ursodeoxycholic acid, chenodeoxycholic acid, or other bile acid preparations before using BIXIBAT Tablet.

2. Aluminium-Containing Antacids (e.g., Sucralfate Hydrate, Aldioxa)

Interaction: Aluminium-containing medicines may bind or absorb bile acids in the gastrointestinal tract and may interfere with the action of Elobixibat.

Effects: The effect of BIXIBAT Tablet may be reduced.

Management: Inform your doctor if you are taking aluminium-containing antacids or other medicines containing these ingredients.

3. Bile Acid-Sequestering Medicines (e.g., Cholestyramine, Colestimide)

Interaction: These medicines absorb bile acids in the gastrointestinal tract and may interfere with the action of Elobixibat.

Effects: The effect of BIXIBAT Tablet may be reduced.

Management: Tell your doctor if you are taking cholestyramine, colestimide, or other medicines that bind bile acids.

4. Digoxin and Dabigatran Etexilate

Interaction: Elobixibat inhibits P-glycoprotein, which may affect the transport of medicines such as digoxin and dabigatran etexilate.

Effects: Blood levels of these medicines may increase and potentially enhance their effects.

Management: Inform your doctor if you are taking digoxin or dabigatran etexilate before starting BIXIBAT Tablet. Medical monitoring may be required.

5. Midazolam

Interaction: Elobixibat may affect the blood level of midazolam.

Effects: Blood levels of midazolam may decrease, potentially reducing its effect.

Management: Inform your doctor if you are taking midazolam before using BIXIBAT Tablet.

Synopsis

Drug	Elobixibat 5 mg
Pharmacological Category	Ileal bile acid transporter inhibitor
Therapeutic Indication	Used in the management of chronic idiopathic constipation (CIC) in adults, except constipation associated with organic disease.
Dosage Forms	Tablet

More Information

1. How BIXIBAT Tablet Fits Into Understanding Chronic Constipation and Bowel Habits

Understanding Changes in Bowel Frequency

Chronic constipation can involve infrequent bowel movements, difficulty passing stools, or changes in usual bowel habits. BIXIBAT Tablet may be prescribed as part of medically guided care when persistent constipation requires further management.

Bowel Habits and Daily Routine

Irregular bowel patterns can affect everyday comfort and routine. Maintaining adequate fluid intake, consuming appropriate dietary fibre, staying physically active, and following a consistent toileting routine can support healthy bowel habits.

Recognising Persistent Constipation

Constipation that continues for a prolonged period or repeatedly affects normal bowel habits should be discussed with a doctor. Medical evaluation can help identify contributing factors and determine an appropriate approach.

Importance of Individual Medical Assessment

The suitability of BIXIBAT Tablet depends on individual symptoms, medical history, age, and other medicines being used. A doctor can assess these factors before recommending the medicine.

Supporting Informed Use of BIXIBAT Tablet

Understanding the prescribed medicine, following its administration instructions, and discussing relevant health conditions with a doctor can help patients use BIXIBAT Tablet appropriately.

2. Why Understanding Bowel Habits Is Important When Using BIXIBAT Tablet

What Can Influence Normal Bowel Patterns?

Dietary habits, fluid intake, physical activity, changes in routine, and certain medicines can influence bowel patterns. Identifying changes in these factors can help provide useful information during a medical consultation.

Why Keeping Track of Bowel Changes Can Be Useful

Noting changes in bowel frequency, stool consistency, and difficulty passing stools can help patients describe their symptoms more clearly when discussing chronic constipation with their doctor.

When Changes in Bowel Habits Need Medical Advice

Persistent or unusual changes in bowel habits should not be ignored. A doctor can assess ongoing symptoms and determine whether further evaluation or medical management is appropriate.

Role of Doctor-Guided Medicine Use

BIXIBAT Tablet should be used according to the doctor's prescription. The recommended approach may differ between individuals depending on their symptoms, medical history, and other relevant factors.

Making Informed Decisions About BIXIBAT Tablet

Patients can make better-informed decisions by understanding the medicine's active ingredient, prescribed purpose, administration instructions, and relevant safety information before using BIXIBAT Tablet.

FAQs About BIXIBAT TABLET

References

1. Anna Ozaki 1,†, Takaomi Kessoku 1,2,†,?, Yuki Kasai 1, Yuma Takeda 3, Naoki Okubo 3, Michihiro Iwaki 1, Takashi Kobayashi 1, Tsutomu Yoshihara 1,2, Yasushi Honda 1,2, Akiko Fuyuki 1,2, Takuma Higurashi 1, Hiroto Ishiki 4, Masataka Taguri 5, Shunsuke Oyamada 6, Noritoshi Kobayashi 3, Atsushi Nakajima 1, Yasushi Ichikawa 3. Elobixibat Effectively Relieves Chronic Constipation in Patients with Cancer Regardless of the Amount of Food Intake. National Library of Medicine, National Center for Biotechnology Information. PubMed central. [Accessed date 23/09/2026]

2. Torrent Pharmaceuticals Ltd. ELOBETRA 5 mg.[Accessed date 23/09/2026]

3. steris healthcare ltd. ELOXICLEAR 5.[Accessed date 23/09/2026]