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Introduction About BISOT 2.5 TABLET
BISOT 2.5 TABLET is used to manage hypertension, angina (chest pain) and heart failure in adults. It is a combination of Bisoprolol and Telmisartan which works by relaxing your blood vessels supplying the heart which in turn reduces strain on the heart. It is also used to reduce the risk of cardiovascular events such as heart attack or stroke in adults who are known to have a reduced or blocked blood supply to the heart or legs and had a stroke or with a high risk of diabetes.
Your doctor may check your kidney function test, blood pressure and the amount of electrolytes (Ex. potassium) in your body prior to the management or at regular intervals during management with this medicine. BISOT 2.5 TABLET is not recommended for use in patients having severe liver problems such as cholestasis or biliary obstruction (flow of bile from liver stops or slows). BISOT 2.5 TABLET should be used with caution in patients having diabetes, kidney disease, heart problems and raised aldosterone levels.
BISOT 2.5 TABLET is not recommended for use in early pregnancy and must not be taken by women who are pregnant for more than 3 months and it is not recommended for use in breastfeeding women. BISOT 2.5 TABLET is not recommended for use in children and adolescents (up to the age of 18 years) and it should be used with caution in elderly patients (aged 65 years and above). The most common side effect of taking BISOT 2.5 TABLET is low blood pressure. Consult your doctor if the symptom worsens.
Uses Of BISOT 2.5 TABLET
- Management of hypertension (high blood pressure), angina and heart failure
How BISOT 2.5 TABLET Works
BISOT 2.5 TABLET contains two medicines namely, bisoprolol and telmisartan. Bisoprolol works by blocking beta-1 receptors in the heart, which slows the heart rate, reduces the force of the heart's contractions, and lowers blood pressure. This helps the heart work more efficiently and reduces its workload, making bisoprolol effective for high blood pressure, chest pain (angina), and heart failure.
Telmisartan is an Angiotensin Receptor Blocker. It works by blocking the angiotensin receptor in the body which helps in keeping the blood vessels relaxed, thus lowering the strain on heart and enables heart to pump blood more easily.
How to use BISOT 2.5 TABLET
Take BISOT 2.5 TABLET as advised by your physician. Swallow this medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of BISOT 2.5 TABLET for you depending upon your age, body weight and disease condition.
Side Effects Of BISOT 2.5 TABLET
Common
- low blood pressure
Uncommon
- Urinary tract infection
- Signs of upper respiratory tract infection (sore throat, inflamed sinuses, common cold)
- Anemia, feeling of weakness
- Insomnia, fainting
- Feeling of spinning (vertigo)
- Slow heart rate, chest pain
- Dizziness on standing up (orthostatic hypotension)
- Cough
- Shortness of breath
- Abdominal pain, abdominal discomfort, bloating
- Diarrhea
- Vomiting
- Increased sweating
- Drug rash, itching
- Muscle cramps, muscle or back pain
Rare
- Signs of low platelet count (easy bleeding or bruising)
- Severe allergic reaction (anaphylactic reaction)
- Allergic reaction (Ex. rash, itching, wheezing)
- Low sugar level in blood (in diabetic patients)
- Feeling anxious, sleepiness
- Impaired vision
- Fast heartbeat
- Dry mouth, dysgeusia (impaired sense of taste)
- Eczema (a skin condition with red, itchy, irritated skin)
- Flu-like-illness
- Severe drug rash, pain in joints, joint stiffness
Stop taking BISOT 2.5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Sepsis (body's life-threatening response to infection which can lead to death, organ failure)
- Angioedema (rapid swelling of the skin and mucosa)
How To Manage Side Effects
Diarrhea
Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own to manage without consulting your doctor.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Take BISOT 2.5 TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals. Consult your doctor if your symptom does not improve.
Stomach Pain
Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedBISOT 2.5 TABLET is not recommended in early pregnancy and must not be taken when more than 3 months pregnant, as it may cause serious harm to the baby if used after 3 months of pregnancy. Consult your doctor before taking BISOT 2.5 TABLET.
Breastfeeding
ContraindicatedBISOT 2.5 TABLET is not recommended for use in breastfeeding women. Your doctor may choose another management especially if you want to breast-feed when your baby is new-born or born prematurely. Consult your doctor for advice before taking BISOT 2.5 TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or tired after taking BISOT 2.5 TABLET. Consult your doctor before taking BISOT 2.5 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol as it may increase the risk of low blood pressure.
Kidney
Use with CautionBISOT 2.5 TABLET should be taken with caution in patients with kidney disease, kidney artery stenosis (narrowing of blood vessels to one or both the kidneys) and with a history of kidney transplant. Consult your doctor before taking BISOT 2.5 TABLET.
Liver
Consult your doctorBISOT 2.5 TABLET is not recommended for use in patients with severe liver problems such as cholestasis or biliary obstruction (flow of bile from liver stops or slows). BISOT 2.5 TABLET should be used with caution in patients with liver diseases. Consult your doctor before taking BISOT 2.5 TABLET.
Allergy
ContraindicatedBISOT 2.5 TABLET is not recommended for use if you are allergic to Telmisartan or Bisoprolol.
Lungs
ContraindicatedBISOT 2.5 TABLET is not recommended for use if you have severe asthma. Therefore, consult your doctor for advice.
Use In Pediatrics
ContraindicatedBISOT 2.5 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionBISOT 2.5 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking this medicine.
Others
Before taking BISOT 2.5 TABLET, inform your doctor if you have:
- High potassium levels in the body
- Raised aldosterone levels (water and salt retention in the body along with imbalance of various blood minerals)
- Diabetes
Interactions
A. Drug-Drug interactions:
Before taking BISOT 2.5 TABLET, inform your doctor if you are taking any of the following medicines:
- Angiotensin converting enzyme inhibitors (Ex. enalapril, lisinopril, ramipril), angiotensin II receptor antagonists (Ex. candesartan, irbesartan) and aliskiren (medicines used to manage high blood pressure)
- Digoxin (used to manage heart failure and abnormal heart rhythm)
- Medicines containing lithium (used to manage some types of depression)
- Medicines that may increase blood potassium levels such as salt substitutes containing potassium
- Non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen (medicines used to manage pain and inflammation
- Heparin (used to manage or manage blood clot)
- Immunosuppressive agents such as ciclosporin or tacrolimus (used to manage organ rejection after transplant)
- Antibiotic trimethoprim (medicine used to manage urinary tract infections)
- Diuretics such as furosemide, hydrochlorothiazide and potassium-sparing diuretics (Ex. amiloride, spironolactone) (used to manage oedema or high blood pressure)
- Corticosteroids such as dexamethasone, hydrocortisone (used to manage inflammatory conditions)
- Baclofen (used for muscle spasm)
- Amifostine (medicine used in cancer chemotherapy)
- Barbiturates such as phenobarbital, pentobarbital (used to manage seizures)
- Antidepressants such as citalopram, fluoxetine, paroxetine (used to manage depression)
- Narcotics such as morphine and codeine (used to manage moderate to severe pain)
Overdosage:
If you or anyone else accidentally take too much of BISOT 2.5 TABLET, consult your doctor immediately or visit the nearby hospital. The most common symptoms of overdose are low blood pressure, fast or slow heartbeat, dizziness, elevated levels of creatinine and sudden kidney failure.
Synopsis
| Drug | : | Telmisartan, Bisoprolol |
| Pharmacological Category | : | Angiotensin receptor blockers, Beta-blockers |
| Therapeutic Indication | : | Essential hypertension, management of heart attack and stroke |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep BISOT 2.5 TABLET out of reach of children
- Store at room temperature
FAQs About BISOT 2.5 TABLET
Q: Can BISOT 2.5 TABLET be used to manage high blood pressure?
A: BISOT 2.5 TABLET can be considered as a drug of choice for high blood pressure. It contains bisoprolol and telmisartan which helps to relax the blood vessels and then normalize the blood pressure. Although, BISOT 2.5 TABLET can manage high blood pressure, you doctor might manage you with other drugs depending upon your condition.
Q: Can BISOT 2.5 TABLET cause slow heart rate?
A: Yes, BISOT 2.5 TABLET can make your heart to beat slow. If you experience any abnormally slow heart rate with shortness of breath, feeling of fainting and spinning sensation (vertigo) consult your doctor immediately.
Q: What precautions do I need to follow while taking BISOT 2.5 TABLET?
A: Patients taking BISOT 2.5 TABLET must inform their doctor about their pre-existing disease conditions like kidney, heart or liver problems. Consult your doctor immediately if you experience any unusual symptoms after taking BISOT 2.5 TABLET.
Q: What happens if I stop taking BISOT 2.5 TABLET?
A: Do not stop taking BISOT 2.5 TABLET without talking to your doctor first. Stopping this medicine suddenly can cause your blood pressure to spike and may increase the risk for heart attack or stroke.
Q: Is BISOT 2.5 TABLET safe to use in patients with kidney problems?
A: BISOT 2.5 TABLET should be taken with caution in patients with kidney disease, kidney artery stenosis (narrowing of blood vessels to one or both the kidneys) and with a history of kidney transplant. Your doctor may assess your kidney functioning during management with this medicine to manage the risk of kidney damage or any unusual effects. Consult your doctor before taking BISOT 2.5 TABLET.
Q: How long should BISOT 2.5 TABLET be taken?
A: BISOT 2.5 TABLET does not manage high blood pressure but controls it. Your blood pressure may decrease during the first 2 weeks of management, but it may take 4 weeks for you to notice the full benefit of this medicine. Consult your doctor for the exact duration of recommendation for you.
References
1. KD. Tripathi. Drugs Affecting Renin Angiotensin System. Essentials of medical pharmacology. Eighth edition. 2019. Page-535-538.
2. Philippe Gosse. A Review of Telmisartan in the Treatment of Hypertension: Blood Pressure Control in the Early Morning Hours. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. September 2006. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993985/
3. Manjula S*and Krishna Kumar M. Expert Opinion on the use of Bisoprolol+Telmisartan Combination in Indian Patients with Hypertension. Cardio-Biology and Clinical Sciences. Open Science Publications. [Published in January 2024]. [Accessed on 10th July 2024] https://www.opensciencepublications.com/wp-content/uploads/IJCBCS-2454-5945-7-113.pdf
4. Bisoprolol fumarate 1.25 mg, 2.5 mg, 3.75 mg, 5 mg, 7.5 mg or 10 mg film-coated tablets bisoprolol fumarate. EMC. UK. [Revised in December 2021]. [Accessed on 10th July 2024] https://www.medicines.org.uk/emc/files/pil.13703.pdf
5. Telmisartan. EMC. UK. [Revised in November 2023]. [Accessed on 10th July 2024] https://www.medicines.org.uk/emc/files/pil.9981.pdf
Useful Diagnostic Tests
- Cardiac Risk Profile
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