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Introduction About BETNOVATE GM CREAM
BETNOVATE GM CREAM is a combination of Betamethasone, Gentamicin and Miconazole which belongs to the group of medicines called Corticosteroids, Antibiotics and Antifungals respectively. It is used to manage skin infections which are sensitive to steroids (steroid responsive dermatosis) associated with mixed infections.
BETNOVATE GM CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, pruritus without inflammation, perianal and genital pruritus, primary cutaneous viral infections, primary infected skin lesions caused by bacterial, fungal, or yeast infections and perforated eardrum. BETNOVATE GM CREAM should be used with caution in patients with liver or kidney disease. Contact your doctor before applying.
BETNOVATE GM CREAM is generally not recommended for use in pregnancy. BETNOVATE GM CREAM is generally not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.
BETNOVATE GM CREAM is not recommended for use in children under 2 years of age. Contact your doctor before applying. BETNOVATE GM CREAM should be used with caution in elderly patients who have history of renal or hepatic impairment. Contact your doctor before applying. The most common side effects of this medicine are pruritis, skin burning sensation or pain in the skin. Contact your physician if any of the above symptoms worsen.
Uses Of BETNOVATE GM CREAM
- Used for steroid responsive dermatosis associated with mixed infection
How BETNOVATE GM CREAM Works
BETNOVATE GM CREAM helps to manage infection, where Betamethasone belongs to corticosteroid which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Gentamicin is an antibiotic which stops the growth of bacteria in the skin. Miconazole is an antifungal which inhibits the fungal growth. Together, manages skin infection effectively.
How to use BETNOVATE GM CREAM
Apply BETNOVATE GM CREAM as directed by your physician. It is for external use only. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. It should not be used continuously for more than one week without re-evaluation by the physician. Avoid applying to open wounds.
Side Effects Of BETNOVATE GM CREAM
Common
- pruritus
- skin burning sensation or pain in the skin
Rare
- blister, dermatitis, skin irritation (including dry skin and erythema)
- rash and skin discoloration
- application site hypersensitivity reactions
Stop applying BETNOVATE GM CREAM and contact your physician immediately if you experience any of the following side effects:
- prolonged or significant diarrhoea with abdominal pain
How To Manage Side Effects
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if itching worsens.
Warning & Precautions
Pregnancy
BETNOVATE GM CREAM is generally not recommended for use in pregnancy. Contact your doctor before applying.
Breastfeeding
BETNOVATE GM CREAM is generally not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.
Kidney
BETNOVATE GM CREAM should be used with caution in patients with kidney disease. Dosage will be adjusted in patients with reduced renal function. Contact your doctor before applying.
Liver
BETNOVATE GM CREAM should be used with caution in patients with liver disease. Contact your doctor before applying.
Allergy
BETNOVATE GM CREAM should be used with caution in patients with allergic (hypersensitive) history to Betamethasone, Gentamicin, Miconazole, or to other ingredients of this medicine.
Others
BETNOVATE GM CREAM is not recommended for use if you have:
- rosacea
- acne vulgaris
- perioral dermatitis
- pruritus without inflammation
- perianal and genital pruritus
- primary cutaneous viral infections
- primary infected skin lesions caused by bacterial, fungal, or yeast infections
- perforated eardrum
Before applying BETNOVATE GM CREAM inform your doctor if you have:
- psoriasis
- infection
- chronic leg ulcers
Use in pediatrics:
BETNOVATE GM CREAM is not recommended for use in children under 2 years of age. Contact your doctor before applying.
Use in geriatrics:
BETNOVATE GM CREAM should be used with caution in elderly patients who have history of renal or hepatic impairment. Contact your doctor before applying.
Interactions
A. Drug-Drug interactions:
Tell your doctor if you are taking,
- ritonavir (medicines used for HIV infections)
- itraconazole (medicines used for fungal infections)
- neuromuscular blocking agents like atracurium, doxacurium, pancuronium (medicines used in anaesthesia)
- aminoglycosides Ex. amikacin (medicines used to manage bacterial infections)
- warfarin, acenocoumarol (medicines used to manage or manage blood clots)
Overdosage:
If you or anyone else accidentally use too much of BETNOVATE GM CREAM, consult your doctor immediately or visit the nearby hospital. Acute overdosage is very unlikely, however, in the case of chronic overdosage or misuse, hypercortisolism-like (rare hormonal disorder caused by over exposure to the hormone, cortisol) symptoms may occur.
Synopsis
| Drug | : |
Betamethasone, Gentamicin, Miconazole |
| Pharmacological Category | : |
Corticosteroids, Antibiotics, Antifungals |
| Therapeutic Indication | : |
Skin infections |
| Dosage Forms | : |
Cream |
More Information
- Keep out of reach of children
- Store BETNOVATE GM CREAM below 25°C
FAQs About BETNOVATE GM CREAM
What are the possible side effects of applying BETNOVATE GM CREAM?
The most common side effects of this medicine are pruritis, skin burning sensation or skin pain. Contact your physician if any of the symptoms worsen.
How BETNOVATE GM CREAM works?
BETNOVATE GM CREAM helps to manage infection, where Betamethasone belongs to corticosteroid which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Gentamicin is an antibiotic which stops the growth of bacteria in the skin. Miconazole is an antifungal which inhibits the fungal growth.
How long does BETNOVATE GM CREAM to work?
Usually, BETNOVATE GM CREAM starts working soon after applying it. However, it may take some days to work against all the harmful bacteria and make you feel better.
Can I stop applying BETNOVATE GM CREAM?
Do not stop applying BETNOVATE GM CREAM suddenly without consulting your doctor, as it leads to adrenal insufficiency. Therefore, it is important to apply BETNOVATE GM CREAM until your doctor advice you to stop using the medicine.
Can I use BETNOVATE GM CREAM for long time?
No. Do not apply BETNOVATE GM CREAM for more than seven days without medical supervision. If the condition worsens or does not improve within seven days, contact your doctor.
References
1. K.D. Tripathi. Corticosteroids, Aminoglycoside Antibiotics & Antifungal drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 289,747, 792.
2. Bethesda (MD). Betamethasone. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/9782
3. Bethesda (MD). Gentamicin. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/3467
4. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4189
5. GlaxoSmithKline Pharmaceuticals Limited. Betamethasone + Gentamicin + Miconazole. [Revised in September 2020] [Accessed on 22nd June 2022] https://india-pharma.gsk.com/media/6347/betnovate-gm.pdf
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