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Introduction About BETHERAN 25MG TABLET
BETHERAN 25MG TABLET is used in the management of urinary retention (inability to empty the bladder) following an operation or after giving birth or other health problems (such as brain, spinal, or nerve problems) and is also used to manage reflux esophagitis (inflammation of the esophagus due to backflow of stomach contents into the esophagus).
BETHERAN 25MG TABLET contains bethanechol, which belongs to the group of medicines called Cholinergic agents. It works by making the contraction of urinary bladder muscles sufficiently strong to initiate urination and empty the bladder. It also stimulates motility, increases the tone of the stomach, and often restores impaired rhythmic peristalsis (wave-like muscle contractions that move food through the digestive tract).
BETHERAN 25MG TABLET is not recommended for use in patients with gut or heart problems, asthma, fits, parkinsonism, or if you have had recent surgery on your stomach. BETHERAN 25MG TABLET should be used with caution in patients taking certain medicines for heart problems, as a critical fall in blood pressure may occur.
BETHERAN 25MG TABLET should be used with caution by pregnant and breastfeeding women only if clearly advised by the doctor. It is not recommended for use in elderly patients (above 70 years of age).
The most common side effects of taking BETHERAN 25MG TABLET are diarrhea, skin flushing, increased salivation and sweating, decreased body temperature (hypothermia), etc. Consult your doctor if any of the side effects worsen.
Uses Of BETHERAN 25MG TABLET
Indicated to manage,
- Urinary retention
- Reflux esophagitis
How BETHERAN 25MG TABLET Works
BETHERAN 25MG TABLET works by making the contraction of urinary bladder muscles sufficiently strong to initiate urination and empty the bladder. It also stimulates motility, increases the tone of the stomach, and often restores impaired rhythmic peristalsis (wave-like muscle contractions that move food through the digestive tract).
How to use BETHERAN 25MG TABLET
Take BETHERAN 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Side Effects Of BETHERAN 25MG TABLET
Common
- Diarrhea
- Skin flushing
- Increased salivation and sweating
- Hypothermia (decreased body temperature)
- Urinary urgency
- Bradycardia (slow pulse rate)
- Drop in blood pressure
Uncommon
- Nausea, vomiting
- Gastrointestinal disturbances
Rare
- Orthostatic hypotension (sudden changes of posture leading to a feeling of dizziness or giddiness due to low blood pressure)
How To Manage Side Effects
Diarrhea
Drink plenty of clear fluids, like water, diluted fruit juices, or oral rehydration solutions, to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.
Warning & Precautions
Pregnancy
Use with CautionBETHERAN 25MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
Use with CautionBETHERAN 25MG TABLET should be used with caution in breastfeeding women only if considered clearly necessary. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionConsult your doctor if you feel any side effects during management with BETHERAN 25MG TABLET that may stop you from driving or using machines.
Allergy
ContraindicatedDo not take BETHERAN 25MG TABLET if you are allergic to Bethanechol or any other ingredients of this medicine.
Lungs
ContraindicatedBETHERAN 25MG TABLET is not recommended for use in patients with latent or active bronchial asthma. Consult your doctor before taking BETHERAN 25MG TABLET.
Heart Disease
ContraindicatedBETHERAN 25MG TABLET is not recommended for use in patients who have pronounced bradycardia (slow heartbeat) or low blood pressure, coronary artery disease (narrowing or blockage of the coronary arteries, usually due to plaque buildup), or who had a heart attack recently. Consult your doctor before taking BETHERAN 25MG TABLET.
Use In Pediatrics
Consult your doctorSafety and effectiveness of BETHERAN 25MG TABLET in children have not been established. Consult your child’s doctor for advice.
Use In Geriatrics
ContraindicatedBETHERAN 25MG TABLET is not recommended for use in elderly patients (above 70 years of age). Consult your doctor before taking it.
Others
BETHERAN 25MG TABLET is not recommended for use if you:
- Have blockage of the gut
- Have problems passing urine due to a blockage
- Had recent surgery on the stomach
- Have hypothyroidism
- Have a peptic ulcer
- Have vasomotor instability (hot flushing)
- Have epilepsy (fits)
- Have parkinsonism
- Have weak strength or integrity of your gastrointestinal or bladder wall
- Have mechanical obstruction (partial or complete blockage of the intestine)
- Have increased muscular activity of the gastrointestinal tract or urinary bladder that might prove harmful (Ex. following recent urinary bladder surgery, gastrointestinal resection and anastomosis (surgical connection between two structures), or when there is possible digestive tract obstruction)
- Have bladder-neck obstruction
- Have spastic gastrointestinal disturbances
- Have acute inflammatory lesions of the digestive tract
- Have peritonitis (an inflamed membrane lining the abdominal wall)
- Have marked vagotonia (too much excitability of the vagus nerve)
Before taking BETHERAN 25MG TABLET, inform your doctor if you:
- Have urinary retention problem
- Have bacteriuria (the presence of bacteria in the urine)
Interactions
A. Drug-drug interactions:
- Anti-arrhythmic (Ex. quinidine, procainamide)
- Parasympathomimetic (Ex. distigmine and carbachol)
- Ganglionic blocking agents (Ex. trimetaphan, hexamethonium)
Overdosage:
If you or anyone else accidentally takes too much of BETHERAN 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of BETHERAN 25MG TABLET are abdominal discomfort, salivation, a hot feeling, sweating, nausea, and vomiting.
Synopsis
| Drug | : | Bethanechol chloride |
| Pharmacological Category | : | Cholinergic agents |
| Therapeutic Indication | : | Urinary retention, reflux esophagitis |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep BETHERAN 25MG TABLET out of reach of children
- Store at room temperature
FAQs About BETHERAN 25MG TABLET
Q: How does BETHERAN 25MG TABLET act?
A: BETHERAN 25MG TABLET works by making the contraction of urinary bladder muscles sufficiently strong to initiate urination and empty the bladder. It also stimulates motility, increases the tone of the stomach, and often restores impaired rhythmic peristalsis (wave-like muscle contractions that move food through the digestive tract).
Q: What is BETHERAN 25MG TABLET used for?
A: BETHERAN 25MG TABLET is used in the management of urinary retention (inability to empty the bladder) following an operation or after giving birth or other health problems (such as brain, spinal, or nerve problems) and is also used to manage reflux esophagitis (inflammation of the esophagus due to backflow of stomach contents into the esophagus).
Q: What are the common side effects of BETHERAN 25MG TABLET?
A: The common side effects of taking BETHERAN 25MG TABLET are diarrhea, skin flushing, increased salivation and sweating, decreased body temperature (hypothermia), urinary urgency, bradycardia (a slow pulse rate below 60 beats per minute), and a drop in blood pressure. Consult your doctor immediately if any of the side effects worsen.
Q: What should I do if I forget to take a dose of BETHERAN 25MG TABLET?
A: You should take BETHERAN 25MG TABLET immediately when you remember. If it is time for your next dose, skip the missed dose and follow your regular dose schedule. Do not double the dose of BETHERAN 25MG TABLET to make up for your missed dose.
Q: Does BETHERAN 25MG TABLET cause diarrhea?
A: BETHERAN 25MG TABLET may cause diarrhea in some individuals. To manage this effect, drink a lot of fluids, like water or fruit juice, to keep yourself hydrated. Avoid eating high-fat or spicy foods. Avoid taking any medicine on your own to manage diarrhea. Consult your doctor if the symptom does not improve.
Q: Is BETHERAN 25MG TABLET safe during pregnancy?
A: BETHERAN 25MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking it.
Q: Can BETHERAN 25MG TABLET be used with children?
A: The safety and effectiveness of BETHERAN 25MG TABLET in children have not been established. Consult your child’s doctor for advice.
Q: What is the best time to take BETHERAN 25MG TABLET?
A: Take BETHERAN 25MG TABLET on an empty stomach (one hour before or 2 hours after meals) to decrease the chance of nausea and vomiting, or as directed by the doctor.
Q: What precautions must be taken while using BETHERAN 25MG TABLET?
A: Before taking BETHERAN 25MG TABLET, inform your doctor if you have urinary retention problems or bacteriuria (the presence of bacteria in the urine).
Q: What are the symptoms of BETHERAN 25MG TABLET overdosage?
A: If you or anyone else accidentally takes too much of BETHERAN 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of BETHERAN 25MG TABLET are abdominal discomfort, salivation, a hot feeling, sweating, nausea, and vomiting.
References
1. Joan Heller Brown, Katharina Brandl, and Jurgen Wess. Muscarinic Receptor Agonists and Antagonists. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page –152.
2. Inderbir S. Padda; Armen Derian. Bethanechol. NIH National Library of Medicine, National Center for Biotechnology Information. StatPearls [Internet]. May 2022. [Accessed on 14th June 2024] https://www.ncbi.nlm.nih.gov/books/NBK560587/
3. Columbia University. Bethanechol Prior to Pancreatic Surgery. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2022] [Accessed on 14th June 2024] https://clinicaltrials.gov/ct2/show/NCT03572283
4. Shivani Gaitonde, Rena D. Malik, Alana L. Christie, and Philippe E. Zimmern. Bethanechol: Is it still being prescribed for bladder dysfunction in women. The International Journal of Clinical Practice. August 2018. [Accessed on 14th June 2024] https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13248
5. Taj Pharmaceuticals Ltd. Tefecholine (Bethanechol chloride Tablets 25 mg USP). [Revised in August 2015] [Accessed on 14th June 2024] https://tajpharmaindia.com/wp-content/uploads/2015/09/PIL-TEFECHOLINE-BETHANECHOL-CHLORIDE-TAB.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Urine Routine & Microscopy
- Kidney Function Test (KFT)
- Healthy Midlife Checkup
- Men Health Checkup - Advanced
- Complete Women Checkup
- Full Body Checkup - Gold
- Elderly Checkup - Female
- Elderly Checkup - Male
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