BESVIL TRIO 100 Capsule 10's

Introduction About BESVIL TRIO 100 CAPSULE

Besvil Trio 100 is a combination inhaler used for the long-term management of Chronic Obstructive Pulmonary Disease (COPD). It contains three active ingredients such as Fluticasone furoate a corticosteroid that helps reduce inflammation in the lungs, Umeclidinium a long-acting muscarinic antagonist (LAMA) that helps relax and open the airways and Vilanterol a long-acting beta-agonist (LABA) that works by improving airflow by relaxing the airway muscles.    

This combination therapy is designed to reduce COPD symptoms, manage flare-ups, and improve lung function over time, making it ideal for individuals with moderate to severe COPD. For optimal results, patients should use the inhaler once daily, typically at the same time each day, to ensure consistent symptom control. It is important to follow the prescribed dosage and ensure proper inhaler technique to maximize the efficacy of the medication.

When using Besvil Trio 100, it is important to adhere to precautions and directions for use. The inhaler should be used as prescribed. Do not exceed the recommended dose to avoid the risk of side effects such as increased heart rate or potential lung infections. Patients should avoid using Besvil Trio 100 if they are allergic to any of its components.

Close monitoring of potassium levels and blood sugar is advised especially for those with a history of diabetes or electrolyte imbalance. Pregnant and breastfeeding women should consult their healthcare provider before starting the medication, as the effects of Besvil Trio 100 during pregnancy are not well-studied.

The common side effects of Besvil Trio 100 include upper respiratory infections, pneumonia, oral thrush, headache, back pain, and bronchitis. While these side effects are generally mild, patients should contact their healthcare provider if they experience symptoms such as wheezing, chest pain or difficulty breathing.

Besvil Trio 100 is not recommended for use in children due to insufficient safety data, and caution is advised when prescribing it to elderly patients or those with pre-existing conditions like heart disease, glaucoma or osteoporosis.

Uses Of BESVIL TRIO 100 CAPSULE

• Management of Chronic Obstructive Pulmonary Disease (COPD)
• Improves lung function and breathing capacity

Benefits of BESVIL TRIO 100 CAPSULE

Manage and controls COPD flare-ups

BESVIL TRIO 100 helps manage and control COPD flare-ups by combining anti-inflammatory and bronchodilator actions. Its triple formulation (ICS, LABA, and LAMA) reduces airway inflammation, relaxes the airway muscles and keeps the bronchial passages open. This combination significantly lowers the risk of sudden symptom worsening such as shortness of breath or coughing. Regular use helps maintain stable breathing and reduces the need for emergency treatments. By minimizing flare-ups, it supports better long-term lung health and improves daily quality of life.

Enhances lung function and oxygen flow

BESVIL TRIO 100 enhances lung function and oxygen flow by targeting airway inflammation and bronchoconstriction. The combination works together to open the airways, improve airflow and reduce breathing difficulties. This helps increase oxygen supply to the lungs, making it easier to breathe and improving overall lung capacity. Regular use contributes to better daily functioning and improved exercise tolerance for COPD patients.

How BESVIL TRIO 100 CAPSULE Works

Mechanism of Action of BESVIL TRIO 100 in COPD

BESVIL TRIO 100 combines three active ingredients - ICS (inhaled corticosteroid), LABA (long-acting beta2-agonist), and LAMA (long-acting muscarinic antagonist) to manage COPD. The ICS reduces inflammation, while the LABA and LAMA help to relax airway muscles and manage bronchoconstriction, improving airflow and breathing.

Airway Relaxation and Inflammation Control

The LABA component in BESVIL TRIO 100 relaxes the muscles around the airways, helping them stay open for better airflow. Simultaneously, the ICS controls airway inflammation, reducing swelling and mucus production, which can cause narrowing of the air passages. Together they help maintain open, clear airways and reduce COPD symptoms like wheezing and breathlessness.

How to use BESVIL TRIO 100 CAPSULE

Recommended Dosage for BESVIL TRIO 100

The usual recommended dosage of BESVIL TRIO 100 is one inhalation once daily or as directed by your healthcare provider. This fixed daily dose delivers a consistent amount of medication to manage COPD symptoms and manage flare-ups. It is important not to exceed the prescribed dose and to use the inhaler consistently every day for best results.

When and how often to take BESVIL TRIO 100

BESVIL TRIO 100 should be taken once a day at the same time each day, preferably in the morning. This helps maintain steady levels of medication in your lungs and ensures continuous symptom control. Using it at a regular time also helps build a routine, improving adherence to treatment and overall effectiveness.

Tips for Effective Inhaler Use

• Shake the inhaler gently (if required) and exhale fully before inhaling the medication
• Place the mouthpiece in your mouth, seal your lips and inhale deeply and steadily
• Hold your breath for 5–10 seconds after inhalation to allow the medication to settle in your lungs
• Rinse your mouth after use to reduce the risk of side effects like oral thrush
• Store the inhaler in a dry place and track the number of doses remaining

What if I forgot to take BESVIL TRIO 100 CAPSULE

If you forget to use a dose of BESVIL TRIO 100, use it as soon as you remember, unless it is close to the time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. Missing an occasional dose may slightly reduce the effectiveness of your COPD control, so it is important to use it consistently. If you frequently forget doses, consider setting a daily reminder or alarm.

Overdose

BESVIL TRIO 100 overdose symptoms

• Taking more than the prescribed dose of BESVIL TRIO 100 can lead to serious side effects. Overdose symptoms may include seizures, chest pain, extremely high or low blood pressure, a rapid heart rate (up to 200 beats/min), nervousness, headache, tremors, and muscle cramps
• Other signs can include dry mouth, palpitations, nausea, dizziness, fatigue, malaise, insomnia, and elevated blood sugar levels. These symptoms can vary in severity and may not appear immediately.

What to do in case of BESVIL TRIO 100 overdose

• If you suspect an overdose of BESVIL TRIO 100, seek immediate medical attention, even if you feel fine or no symptoms are present. Overdoses can cause delayed or sudden health complications
• Do not attempt to self-manage or wait for symptoms to worsen. Always follow your doctor's dosing instructions strictly and never take more than prescribed. If in doubt, contact your doctor or go to the nearest emergency facility without delay

Side Effects Of BESVIL TRIO 100 CAPSULE

Common Side Effects of BESVIL TRIO 100

BESVIL TRIO 100 like many COPD maintenance inhalers, may cause side effects in some individuals:

• upper respiratory tract infections
• pneumonia
• bronchitis
• oral candidiasis (thrush)
• headache
• back pain and joint pain (arthralgia)
• flu-like symptoms
• sinusitis
• sore throat (pharyngitis)
• nasal congestion (rhinitis)
• altered taste (dysgeusia)
• constipation
• diarrhea
• urinary tract infections

Rare

• cough, hoarseness (dysphonia)
• oropharyngeal pain and gastroenteritis

When to consult a doctor?

• skin rash or redness
• hives (urticaria)
• swelling, sometimes of the face or mouth (angioedema)
• wheezing, coughing or having difficulty in breathing
• suddenly feeling weak or light headed (may lead to collapse or loss of consciousness)

Is BESVIL TRIO 100 Safe for Long-Term Use?       

BESVIL TRIO 100 is generally considered safe for long-term use in patients with moderate to severe COPD, especially when prescribed by a healthcare provider and used as directed. The triple-combination therapy offers sustained symptom relief, improved lung function, and reduced exacerbations. However, long-term use may carry risks of oral infections, voice changes, or bone density reduction, particularly due to the corticosteroid component. Regular follow-ups and correct inhaler technique can help minimize these risks. Patients should inform their doctor about any persistent or unusual symptoms during ongoing treatment.

Warning & Precautions

Pregnancy

Monitoring required

Besvil Trio 100 should be used during pregnancy only if the potential benefits outweigh the risks. There is insufficient data on the use of its individual components. It is crucial to inform your doctor if you are pregnant, as they will assess the potential risks and benefits before prescribing this medication.

Breastfeeding

Monitoring required

If you are breastfeeding women, Besvil Trio 100 should only be used if the potential benefits outweigh the risks. It is important to discuss with your doctor before starting treatment to ensure both your health and the safety of your baby.

Kidney

Use with Caution

If you have kidney disease, inform your doctor before using Besvil Trio 100. The medication should be used with caution in patients with kidney problems. Regular monitoring may be recommended during treatment.

Liver

Consult your doctor

If you have liver disease, consult your doctor before starting Besvil Trio 100. The components of this medication may be processed in the liver, so your doctor may adjust the dose or monitor you more closely during treatment.

Allergy

Contraindicated

Besvil Trio 100 should be avoided if you are allergic to any of its components or milk proteins. If you experience any signs of an allergic reaction, such as rash, swelling, or difficulty breathing, seek medical attention immediately.

Lungs

Consult your doctor

If you have other lung infections or conditions such as tuberculosis, inform your doctor before using Besvil Trio 100. This medication may weaken your immune system, increasing the risk of serious infections. It can also worsen asthma symptoms in some patients, so if you experience severe difficulty breathing or wheezing, consult a doctor immediately.

Heart Disease

Consult your doctor

If you have heart disease, including conditions like high blood pressure or heart failure, inform your doctor before taking Besvil Trio 100. Some components of this medication may affect your heart rate or blood pressure, so close monitoring is recommended.

Use In Pediatrics

Contraindicated

Besvil Trio 100 is not recommended for use in children. There is insufficient data on its safety and effectiveness in pediatric patients, so alternative treatments should be considered for children.

Other Warnings for BESVIL TRIO 100 CAPSULE

Before taking BESVIL TRIO 100, inform your doctor if you:

• have a history of glaucoma or cataracts
• have osteoporosis (weak bones)

Who should not take [GBNKEYWORD

BESVIL TRIO 100 is not recommended for use if you:

• undergo primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required.

Safety Advice

Regular Monitoring and Check-Ups During Treatment

Routine medical monitoring is essential while using BESVIL TRIO 100 to ensure safety and effectiveness. Your doctor may recommend:

• Lung function tests to evaluate treatment progress.
• Blood tests to monitor potassium levels and blood glucose, especially in diabetic patients.
• Eye exams if you are at risk for glaucoma or cataracts.
• Bone density scans in long-term users, particularly the elderly or postmenopausal women.
• Monitoring for signs of oral infections, such as thrush, and respiratory infections, like pneumonia. 

Drug - Drug interaction

1. CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir, Clarithromycin)

• Interaction: Fluticasone furoate is metabolized by the CYP3A4 enzyme. Strong CYP3A4 inhibitors can increase fluticasone levels, leading to systemic corticosteroid effects such as adrenal suppression and Cushingoid symptoms
• Management: Avoid concurrent use when possible. If unavoidable, monitor for signs of systemic corticosteroid exposure (e.g., weight gain, fatigue, glucose imbalance)

2. Non-Selective Beta-Blockers (e.g., Propranolol)

• Interaction: May antagonize the bronchodilatory effect of vilanterol, potentially reducing its effectiveness and worsening bronchospasm
• Management: Avoid non-selective beta-blockers in COPD patients. If beta-blocker use is necessary (e.g., for cardiac conditions), use a cardio-selective beta-blocker (e.g., atenolol) with caution and under close supervision

3. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

• Interaction: Co-use may enhance hypokalemic effects of beta-agonists like vilanterol, increasing the risk of cardiac arrhythmias
• Management: Monitor serum potassium levels regularly, especially in patients on loop or thiazide diuretics. Consider potassium supplementation or adjust medication

4. Other Long-Acting Bronchodilators (e.g., Tiotropium, Salmeterol)

• Interaction: Using additional LABAs or LAMAs with Besvil Trio 100 may increase the risk of side effects such as tremors, palpitations, and hypertension
• Management: Avoid concurrent use of other long-acting bronchodilators unless clearly indicated. Use only one LABA/LAMA combination at a time

5. Anticholinergic Medications (e.g., Ipratropium)

• Interaction: Increases the risk of anticholinergic side effects, such as dry mouth, constipation, urinary retention, and glaucoma exacerbation
• Management: Use with caution. Monitor for symptoms of anticholinergic excess, especially in elderly or glaucoma patients

6. Immunosuppressants (e.g., Methotrexate, Azathioprine)

• Interaction: Combined immunosuppressive effects of fluticasone and other agents may increase susceptibility to infections
• Management: Monitor for signs of infection (fever, sore throat, cough). Avoid concurrent use unless necessary and benefit outweighs risk

7. Antidiabetic Medications (e.g., Insulin, Metformin)

• Interaction: Corticosteroids like fluticasone may cause elevated blood glucose levels, potentially reducing the effectiveness of antidiabetic medications.
• Management: Monitor blood glucose levels closely. Dosage adjustments of antidiabetic medications may be needed.

Drug - Food interaction

Grapefruit and CYP3A4 Inhibition

• Grapefruit or grapefruit juice is a known CYP3A4 inhibitor, which could theoretically affect fluticasone furoate, a component of BESVIL TRIO 100 that is metabolized via this pathway
• Risk: Regular consumption of large amounts of grapefruit may increase systemic exposure to fluticasone, leading to adverse corticosteroid effects such as adrenal suppression or immunosuppression
• Recommendation: It is best to avoid frequent or excessive grapefruit consumption while on BESVIL TRIO 100, although occasional intake is unlikely to be harmful

More Information

FAQs About BESVIL TRIO 100 CAPSULE

References

1. GlaxoSmithKline. 2017. US Food and Drug Administration (USFDA). [Revised on June 2023] [Accessed on 2nd May 2025]  

2. GlaxoSmithKline Trading Services Limited. [Accessed on 2nd May 2025]  

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 03 May 2025 | 10:21 AM(IST)