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Introduction About BEPOFLY 180 TABLET
BEPOFLY 180 TABLET contains Bempedoic Acid which belongs to the group of medicines called Lipid lowering agents. It is used alone or together with cholesterol-lowering medicine (statins) to manage primary hypercholesterolaemia (condition in which blood cholesterol level rises above the normal limits) or mixed dyslipidaemia in adults when statins become intolerable to manage the condition in affected individuals.
Mixed dyslipidaemia is a condition that occurs due to elevations in low-density lipoprotein (LDL) (known as bad cholesterol) and triglyceride levels accompanied with low levels of high-density lipoprotein (HDL) (known as good cholesterol) which is generally characterized by the symptoms such as tightness/pain in chest, dizziness, and awareness of heartbeat (palpitation).
BEPOFLY 180 TABLET is not recommended for use if you are allergic to bempedoic acid. It should be used with caution in patients with severe liver or kidney problems, and in patients with a history of gout (condition caused due to raised blood uric acid levels). It is not recommended for use in pregnant and breastfeeding women, also, not recommended for use in children and adolescents (aged below 18 years) and it should be used with caution in elderly patients (aged 75 years and above). Consult your doctor before taking BEPOFLY 180 TABLET.
Before taking BEPOFLY 180 TABLET, your doctor might advise you to take liver function test to assess your liver function. The most common side effects associated with the use of BEPOFLY 180 TABLET are anaemia (lower number of red blood cells) and pain in shoulders, legs, or arms. Consult your doctor if any of the symptom worsens.
Uses Of BEPOFLY 180 TABLET
Used alone or together with cholesterol-lowering medicine (statins) to manage:
- primary hypercholesterolaemia
- mixed dyslipidaemia
How BEPOFLY 180 TABLET Works
BEPOFLY 180 TABLET works by inhibiting ATP citrate lyase (enzyme responsible for synthesis of cholesterol especially low-density lipoprotein (LDL) / bad cholesterol) which leads to enhanced LDL uptake and clearance in the liver resulting in lowered total blood cholesterol levels.
How to use BEPOFLY 180 TABLET
Take BEPOFLY 180 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of BEPOFLY 180 TABLET
Common
- anaemia (reduced red blood cell count)
- gout (severe joint pain) due to increased blood uric acid levels
- pain in shoulders, legs, or arms
Uncommon
- signs of high creatinine levels such as nausea, vomiting, or weakness
- signs of high urea nitrogen level in blood such as urge to urinate more or less often than normal, itching, weakness, and swelling (typically in legs, feet, or ankles)
- signs of decreased glomerular filtration rate (a measure of how properly your kidneys are working) such as urinating more/less, itching, weakness, swelling (in legs, feet, or ankles), muscle cramps, nausea, and vomiting
How To Manage Side Effects
Muscle Spasms
Stay active and gently move your shoulder, legs, or arms. Try doing pain specific exercises for weeks to stop pain from recurring. Use cushion while sitting to support your lower back and rest your arms on a cushion in your lap. Use heat or cold packs on the affected areas. Do not slouch while sitting.
Warning & Precautions
Pregnancy
ContraindicatedBEPOFLY 180 TABLET is not recommended for use during pregnancy and in women planning for pregnancy. Consult your doctor before taking BEPOFLY 180 TABLET.
Breastfeeding
ContraindicatedBEPOFLY 180 TABLET is not recommended for use in breastfeeding women. Consult your doctor taking BEPOFLY 180 TABLET.
Driving and Using Machines
Use with CautionBEPOFLY 180 TABLET has no or negligible effect on your ability to drive and use machines. Consult your doctor before taking BEPOFLY 180 TABLET.
Kidney
Use with CautionBEPOFLY 180 TABLET should be used with caution in patients with severe kidney problems. Consult your doctor before taking BEPOFLY 180 TABLET.
Liver
Use with CautionBEPOFLY 180 TABLET should be used with caution in patients with severe liver problems. Consult your doctor before taking BEPOFLY 180 TABLET.
Allergy
ContraindicatedBEPOFLY 180 TABLET is not recommended for use if you are allergic to bempedoic acid, or any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedBEPOFLY 180 TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your doctor before taking BEPOFLY 180 TABLET.
Use In Geriatrics
Use with CautionBEPOFLY 180 TABLET should be used with caution in elderly patients (above 75 years of age). Consult your doctor before taking BEPOFLY 180 TABLET.
Others
Before taking BEPOFLY 180 TABLET, inform your doctor if you:
- ever had a history of gout (condition caused due to raised blood uric acid levels)
Interactions
A. Drug-Drug Interactions:
Before taking BEPOFLY 180 TABLET, inform your doctor, if you are taking any of the following medicines:
- other medicines used to lower blood cholesterol levels Ex. atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin
- medicines used to manage pulmonary artery hypertension Ex. bosentan
- medicines used to manage high blood pressure and heart failure Ex. fimasartan
- medicines used to manage hepatitis C Ex. asunaprevir, glecaprevir, grazoprevir, voxilaprevir
Overdosage:
If you or anyone else accidentally takes too much of BEPOFLY 180 TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Bempedoic Acid |
| Pharmacological Category | : | Lipid lowering agents |
| Therapeutic Indication | : | Primary hypercholesterolaemia or Mixed dyslipidaemia |
| Dosage Forms | : | Tablet |
More Information
- Keep the medicine out of reach of children
- Store BEPOFLY 180 TABLET at room temperature
FAQs About BEPOFLY 180 TABLET
Q: What is BEPOFLY 180 TABLET used for?
A: BEPOFLY 180 TABLET is used alone or together with cholesterol-lowering medicine (statins) to manage primary hypercholesterolaemia (condition that occurs due to high cholesterol levels in blood) or mixed dyslipidaemia (condition marked by elevations of bad cholesterol and triglyceride levels with low levels of good cholesterol in the blood) in adults when statins become intolerable to manage the condition in affected individuals.
Q: What common side effects are seen with BEPOFLY 180 TABLET?
A: The most common side effects associated with the use of BEPOFLY 180 TABLET are anaemia (lower number of red blood cells), gout (increased blood uric acid levels), and pain in shoulders, legs, and/or arms. Consult your doctor if any of the symptom worsens.
Q: Who should avoid taking BEPOFLY 180 TABLET?
A: BEPOFLY 180 TABLET is not recommended for use if you are allergic to bempedoic acid. It is also not recommended for use in pregnant and breastfeeding women. Also, not indicated for use in children and adolescents (below 18 years of age). Consult your doctor before taking the medicine.
Q: How BEPOFLY 180 TABLET works?
A: BEPOFLY 180 TABLET works by inhibiting ATP citrate lyase (enzyme responsible for synthesis of cholesterol especially low-density lipoprotein (LDL) / bad cholesterol) which leads to enhanced LDL uptake and clearance in the liver resulting in lowered total blood cholesterol levels.
Q: What if I forget to take a dose of BEPOFLY 180 TABLET?
A: You should take BEPOFLY 180 TABLET immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Q: Is BEPOFLY 180 TABLET safe to use in children or elderly patients?
A: BEPOFLY 180 TABLET is not recommended for use in children and adolescents (below 18 years of age) and it should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking BEPOFLY 180 TABLET.
References
1. HK Chopra, Navin C Nanda, Jagat Narula, JS Wander, CN Manjunath, Praveen Chandra, Vivek Kumar, CK Ponde, AK Pancholia. Advances in Bempedoic Acid and Inclisirin Therapy in Dyslipidaemia. Advances in Statin Therapy & Beyond in CVD (ASTC); A Textbook of Cardiology. First edition. 2022. Page 893.
2. Elani Streja, Dan A. Streja. Management of Dyslipidemia in the Elderly. NIH National Library of Medicine. National Center for Biotechnology Information. Endotext [Internet]. September 2020. [Accessed on 4th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK279133/
3. Esperion Therapeutics, Inc. Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant (CLEAR Serenity). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2020] [Accessed on 4th August 2022] https://clinicaltrials.gov/ct2/show/NCT02988115
4. Daiichi Sankyo Europe GmbH. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 4th August 2022] https://www.medicines.org.uk/emc/files/pil.11743.pdf
Useful Diagnostic Tests
- Lipid profile
- Blood Tests
- Urine Analysis
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