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Introduction About BENIDIP CH 4/12.5 TABLET
BENIDIP CH 4/12.5 TABLET is a combination of Benidipine and Chlorthalidone which belongs to the group of medicines called Antihypertensive agents. It is used in the management of hypertension.
Hypertension (high blood pressure) is a common condition in which the long-term force of the blood against artery walls is high enough that it may eventually cause heart disease. Symptoms include headaches, shortness of breath or nosebleeds (if condition is severe).
Along with this management your doctor might want you to make certain lifestyle changes such as eating a healthy diet, quitting smoking and alcohol, regular exercise and reducing your weight.
Prior to the management your doctor might take certain blood tests to understand your existing condition.
BENIDIP CH 4/12.5 TABLET is not recommended for use in patients with low blood pressure. Before taking BENIDIP CH 4/12.5 TABLET inform your doctor if you have kidney or liver disease.
Safety and effectiveness of BENIDIP CH 4/12.5 TABLET in children have not been established yet. Consult your doctor before taking.
Inform your doctor if you are pregnant or breastfeeding before taking BENIDIP CH 4/12.5 TABLET. The most common side effects of taking BENIDIP CH 4/12.5 TABLET are glucose intolerance, sleepiness, ankle swelling, headache, and tiredness.
Uses Of BENIDIP CH 4/12.5 TABLET
- Used to manage high blood pressure
How BENIDIP CH 4/12.5 TABLET Works
BENIDIP CH 4/12.5 TABLET works by lowering the blood pressure. Benidipine relaxes blood vessels and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure.
How to use BENIDIP CH 4/12.5 TABLET
Take BENIDIP CH 4/12.5 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
Side Effects Of BENIDIP CH 4/12.5 TABLET
Common
- glucose intolerance
- sleepiness
- ankle swelling
- headache
- flushing (sense of warmth)
- tiredness
- palpitations
- nausea
- increased blood uric acid
- decreased potassium level in blood
- altered blood lipid level
Rare
Stop taking and contact your doctor immediately if you experience:
- excess thirst, tiredness, drowsiness, restlessness, muscle cramps, nausea, vomiting or increased heart rate
- light-headedness or dizziness
How To Manage Side Effects
Nausea:
Stick to simple meals, avoid oily or spicy food. Consult your doctor if the symptoms does not improve.
Headache:
Avoid bright lights, take enough rest, and drink lots of water. Consult your doctor if the symptoms does not improve.
Warning & Precautions
Pregnancy
Safety and effectiveness of BENIDIP CH 4/12.5 TABLET in pregnant women has not been established yet. Consult your doctor before taking it.
Breastfeeding
Safety and effectiveness of BENIDIP CH 4/12.5 TABLET in breastfeeding women has not been established yet. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or use machines while taking BENIDIP CH 4/12.5 TABLET as it can make you feel dizzy or weak.
Alcohol
Do not drink alcohol while taking BENIDIP CH 4/12.5 TABLET as it can make you drowsy.
Kidney
BENIDIP CH 4/12.5 TABLET should be used with caution in patients with kidney disease. Dose will be adjusted by your doctor. Consult your doctor before taking.
Liver
BENIDIP CH 4/12.5 TABLET should be used with caution in patients with liver disease. Dose will be adjusted by your doctor. Consult your doctor before taking.
Allergy
Do not take BENIDIP CH 4/12.5 TABLET if you are allergic to Benidipine or Chlorthalidone or any other ingredients of this medicine.
Others
BENIDIP CH 4/12.5 TABLET is not recommended for use if you have:
- low blood pressure
Use in pediatrics:
Safety and effectiveness of BENIDIP CH 4/12.5 TABLET is not established in children. Consult your doctor before taking.
Use in geriatrics:
BENIDIP CH 4/12.5 TABLET should be used with caution in elderly patients. Dose will be adjusted by your doctor. Consult your doctor before taking.
Interactions
A. Drug - Drug interactions:
Before taking BENIDIP CH 4/12.5 TABLET, inform your doctor if you are taking any of the following medicine:
- benazepril, metoprolol, ramipril, hydrochlorothiazide
- anti-TB (rifampin)
- itraconazole (used to manage fungal infection)
- cardiac glycoside (digoxin)
- H2 blockers (cimetidine)
Overdosage:
If you or anyone else accidentally take too much of BENIDIP CH 4/12.5 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, weakness, dizziness, and electrolyte imbalance.
Synopsis
| Drug | : | Benidipine , Chlorthalidone |
| Pharmacological Category | : | Calcium channel blocker, Thiazide diuretics |
| Therapeutic Indication | : | High blood pressure |
| Dosage Forms | : | Tablet |
More Information
- Keep BENIDIP CH 4/12.5 TABLET out of reach of children
- Store below 30°C
FAQs About BENIDIP CH 4/12.5 TABLET
Can BENIDIP CH 4/12.5 TABLET be used in pregnancy?
Safety and effectiveness of BENIDIP CH 4/12.5 TABLET in pregnant women has not been established yet. Effects on the pregnant women have not been observed but the newborn baby had certain effects of this medicine so consult your doctor before taking it.
How does BENIDIP CH 4/12.5 TABLET work?
BENIDIP CH 4/12.5 TABLET works by lowering the blood pressure. Benidipine relaxes blood vessels and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure.
What is BENIDIP CH 4/12.5 TABLET used for?
It is used in the management of hypertension. Hypertension (high blood pressure) is a common condition in which the long-term force of the blood against artery walls is high enough that it may eventually cause heart disease. Symptoms include headaches, shortness of breath or nosebleeds (if condition is severe).
Can I consume alcohol while taking BENIDIP CH 4/12.5 TABLET?
No, do not consume alcohol while taking BENIDIP CH 4/12.5 TABLET as it can make you feel excessively sleepy.
Is it safe to drive while taking BENIDIP CH 4/12.5 TABLET?
Do not drive or use machines while taking BENIDIP CH 4/12.5 TABLET as it can make you feel tired and dizzy.
References
1. KD Tripathi. Diuretics. Essentials of medical pharmacology. Eighth Edition. 2011. Page – 630-631.
2. S. Muneta, K. Kohara, K. Hiwada. Effects of Benidipine hydrochloride on 24-hour blood pressure and blood pressure response to mental stress in elderly patients with essential hypertension. [Accessed on 17th June 2022] https://pubmed.ncbi.nlm.nih.gov/10190762/
3. Benidipine. [Revised in July 2008] [Accessed on 17th June 2022] https://www.ohara-ch.co.jp/appendix/pdf/inc03/benidipineHydrochloride8T-SIE.pdf
4. Benidipine. drugbank. [Revised in May 2021] [Accessed on 17th June 2022] https://go.drugbank.com/drugs/DB09231
5. Chlorthalidone. Rxlist [Revised in February 2021] [Accessed on 17th June 2022] https://www.rxlist.com/thalitone-drug.htm#overdosage
6. Chlorthalidone. Mayoclinic. [Revised in February 2022] [Accessed on 17th June 2022] https://www.mayoclinic.org/drugs-supplements/chlorthalidone-oral-route/precautions/drg-20071817?p=1
7. Benidipine, Chlorthalidone. Mayoclinic. [Revised in July 2021] [Accessed on 17th June 2022] https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20373410
Useful Diagnostic Tests
- Blood test
- Liver function test
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