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Sanofi India Limited

Avil 25mg Tablet 15'S

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    Introduction About AVIL 25MG TABLET

    Avil 25mg Tablet is often considered by individuals seeking support during seasonal changes or when exposed to environmental elements like dust, pet dander, or pollen. Containing Pheniramine maleate, a first-generation antihistamine this medicine may help manage discomfort associated with histamine-related responses such as sneezing, watery eyes, skin irritation, or nasal congestion. Due to its sedating nature, some prefer using it during evening hours when drowsiness may be more manageable or even beneficial.

    Pheniramine works by blocking histamine receptors in the body, helping to reduce the intensity of allergic sensations. It may be suitable for adults and adolescents who experience recurrent mild allergic symptoms or skin-related sensitivity, especially when looking for short-term support. Those with infrequent exposure to allergens, or who need relief from temporary discomfort, might include Avil 25mg as part of their wellness care. However, it should be used under medical supervision for individuals with chronic conditions or multiple medications.  

    The recommended usage typically involves taking one tablet once or twice daily, depending on individual sensitivity and a healthcare provider’s advice. It can be taken with or without food, although taking it after meals may reduce the chances of mild digestive side effects. Avoid consuming alcohol or other sedatives during use, as this may intensify drowsiness. Patients with glaucoma, enlarged prostate, asthma or epilepsy should consult a healthcare provider before using this tablet.

    Caution is advised during pregnancy and breastfeeding, as Pheniramine may cross the placental barrier and be present in breast milk. A doctor should evaluate the risk-benefit balance before use. Common side effects can include drowsiness, dry mouth, dizziness, or light-headedness. If any unexpected or persistent effects occur prompt medical consultation is advised.

    Uses Of AVIL 25MG TABLET

    • Relief from seasonal sensitivity-related symptoms such as sneezing, nasal irritation, or runny nose
    • Management of skin-related allergic discomfort, including mild itching, redness, or rashes
    • Discomfort caused by environmental allergens like dust, pollen, pet dander, or pollution
    • Mild allergic responses resulting from insect bites or skin contact with irritants
    • Support in easing symptoms triggered by histamine activity affecting the skin or airways
    • Temporary relief from sensitivity or discomfort due to changes in surroundings or allergens
    • Assistance in calming mild swelling or localized irritation caused by allergy-related triggers

    Benefits of AVIL 25MG TABLET

    Avil tablet for allergy discomfort

    Avil Tablet is often considered by individuals experiencing discomfort related to environmental or seasonal exposure, such as pollen, dust, or animal dander. It contains Pheniramine maleate, an antihistamine that helps counter the effects of histamine — a chemical released by the body during allergic reactions. While it does not treat the condition itself, many find it helpful in managing the sensations commonly associated with allergic responses, such as runny nose, watery eyes, or sneezing. Its mild sedative effect may also be suitable for those seeking evening relief.

    Avil tablet for seasonal sensitivity

    Seasonal shifts often trigger sensitivities in individuals prone to changes in weather, flowering plants, or airborne particles. During such times, Avil Tablet is frequently included in wellness plans to help manage body responses to common irritants. The active ingredient, Pheniramine maleate, works by reducing the body's reaction to allergens, which may support relief from sensations like nasal congestion, mild rash, or eye irritation. It is typically recommended for short-term use and may be best taken in the evening due to its drowsiness-causing effect.

    Avil tablet for mild itching sensation

    People experiencing mild, non-specific skin itching—possibly due to insect exposure, dry weather, or fabric irritation—may consider Avil Tablet as part of their self-care routine. The antihistamine properties of Pheniramine may help ease skin discomfort caused by histamine release. However, it is important to avoid using the tablet without identifying the cause of the itching, especially if the sensation is persistent or severe. For optimal results and safety, it is advisable to follow dosage guidance and consult a healthcare provider if symptoms continue.

    How AVIL 25MG TABLET Works

    How Avil helps manage allergy symptoms

    Avil 25mg Tablet is commonly included in wellness routines of individuals experiencing discomfort linked to seasonal or environmental sensitivities. It contains Pheniramine maleate, an antihistamine that works by responding to histamine—a chemical that the body releases when exposed to allergens like dust, pollen, or pet dander. Histamine is responsible for symptoms such as sneezing, nasal irritation, watery eyes, or mild skin discomfort.

    By reducing the body's sensitivity to histamine, Avil may help make these experiences more manageable. Some individuals report feeling more at ease during allergy seasons or after contact with common indoor irritants. Its calming, mildly sedating effect can also make it a preferred choice during evening hours. However, the tablet should be used responsibly, especially when alertness is required during the day.

    Role of Avil in Blocking Histamine Activity

    The primary function of Avil lies in its ability to block histamine H1 receptors in the body. When an allergen triggers the immune system, histamine is released and binds to these receptors, resulting in common allergic sensations. Pheniramine maleate, the active compound in Avil, competes with histamine for these binding sites, effectively limiting histamine's impact.

    By doing so, Avil may help reduce the severity of bodily responses such as mild rashes, runny nose, nasal congestion, or general itching. Unlike second-generation antihistamines, Avil crosses the blood-brain barrier, which can cause drowsiness. This sedative quality is sometimes seen as beneficial by individuals using the tablet for night-time comfort, especially during periods of heightened sensitivity.

    How to use AVIL 25MG TABLET

    Best Time to Take Avil 25: Morning or Night?

    • Avil 25mg has a sedating effect, making it more suitable for night-time use.
    • Taking it in the evening may help avoid daytime drowsiness or reduced alertness.
    • Individuals who do not experience drowsiness may take it during the day if advised by a healthcare provider.
    • It’s best to take it at a consistent time each day, based on your personal response and professional guidance.

    Recommended Dosage and Frequency of Avil 25mg Tablet

    • Usual adult dose: One tablet once or twice daily, as per healthcare advice.
    • Dosage may vary depending on age, body weight, and health condition.
    • Not recommended to exceed the advised frequency or double the dose if one is missed.
    • Dose adjustments may be required for elderly individuals, or those with kidney/liver concerns.
    • Always follow medical supervision for personalized dosage instructions.

    Can Avil be taken on an empty stomach?

    • Yes, Avil 25mg can be taken with or without food.
    • Taking it after meals may help reduce the chance of mild stomach discomfort.
    • Ideal for individuals with sensitive digestion or a history of acidity or nausea.
    • Swallow the tablet with water and avoid lying down immediately after ingestion.

    Can Avil Be Taken Daily?   

    • Avil 25 may be used daily under medical supervision, especially for short-term or occasional support.
    • It is not generally intended for continuous long-term daily use.
    • Long-term use should be discussed with a doctor, especially if symptoms recur frequently.
    • Daily intake without evaluation may increase the risk of excessive drowsiness or interaction with other medicines.
    • Repeated use may suggest an underlying condition that should be properly assessed.

    What if I forgot to take AVIL 25MG TABLET

    If you happen to forget a dose of Avil 25mg Tablet, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, it is better to skip the missed one rather than taking two tablets close together. Doubling up on the dose may increase the risk of side effects such as drowsiness, dry mouth, or mild confusion. Consistency in taking the tablet helps maximize its benefits, so setting a daily reminder or alarm might be helpful if missed doses occur frequently. If you're unsure about how to adjust your schedule, it's advisable to consult a healthcare professional.

    Overdose

    Taking more than the recommended dose of Avil 25mg Tablet can lead to heightened side effects, including excessive drowsiness, dizziness, confusion, dry mouth, or blurred vision. In some cases, overuse may also cause restlessness or irritability, particularly in children. If an overdose is suspected, immediate medical attention should be sought. It is important not to attempt self-treatment or induce vomiting. Always store Avil tablets in a secure place, away from the reach of children, to prevent accidental ingestion.

    Side Effects Of AVIL 25MG TABLET

    Common side effect of Avil 25mg Tablet:

    • sedation (drowsiness)

    When to Seek Medical Attention?

    Stop taking AVIL 25MG TABLET and inform your doctor immediately if you experience any of the following side effects:

    • swelling of the face, lips, mouth or throat, which may cause difficulty in breathing or swallowing
    • hives
    • fainting, headache
    • yellowing of the skin and eyes (jaundice)
    • changes in your usual behaviour or mood
    • severe sedation, confusion or restlessness
    • waves of sudden severe stomach pain
    • hallucinations (seeing and hearing things that aren’t there), vision problems
    • irregular heartbeat
    • frequent infections such as fever, severe chills, sore throat or mouth ulcers

    Warning & Precautions

    Pregnancy

    Use with Caution

    AVIL 25MG TABLET should be used with caution in pregnant women only if clearly advised by the doctor. Consult your doctor before taking it.  

    Breastfeeding

    Use with Caution

    AVIL 25MG TABLET should be used with caution in breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking it.

    Driving and Using Machines

    Use with Caution

    Do not drive or use machines if you feel drowsy after taking AVIL 25MG TABLET.

    Alcohol

    Consult your doctor

    Avoid consumption of alcohol while taking AVIL 25MG TABLET as it may increase the adverse central nervous system effects of this medicine.     

    Liver

    Use with Caution

    AVIL 25MG TABLET should be used with caution in patients having severe hepatic disease and your doctor may adjust the dose in such patients. Consult your doctor before taking it.

    Allergy

    Contraindicated

    Do not take AVIL 25MG TABLET if you are allergic to Pheniramine or any other ingredients of this medicine.  

    Lungs

    Use with Caution

    AVIL 25MG TABLET should be used with caution in patients having lung diseases such as asthma, bronchitis. Consult your doctor before taking it.

    Heart Disease

    Use with Caution

    AVIL 25MG TABLET should be used with caution in patients having severe cardiovascular disease. Consult your doctor before taking it.  

    Use In Pediatrics

    Contraindicated

    AVIL 25MG TABLET is not recommended for use in children (below 5 years of age) and if your baby is new-born or born prematurely. Consult your child’s doctor for advice.

    Other Warnings for AVIL 25MG TABLET

    Before taking AVIL 25MG TABLET inform your doctor if you have:

    • narrow angle glaucoma (increased pressure within the eye)
    • enlarged prostate
    • any scheduled surgery
    • intolerant to certain sugars such as lactose

    Safety Advice

    Precautions to follow before taking Avil

    Before using Avil 25mg Tablet, it is important to share your complete medical history with a healthcare provider. Special caution is advised in individuals with existing medical conditions such as asthma, glaucoma, enlarged prostate, heart rhythm disorders, liver or kidney concerns. Since Avil may cause drowsiness, users should avoid tasks that require full alertness—like driving or operating heavy machinery—until they understand how their body responds to the medicine.

    If you are already taking medications that act on the nervous system, such as sleep aids, anti-anxiety drugs, antidepressants, or muscle relaxants, Avil may enhance their sedative effects. Avoid alcohol while using this medicine, as it can further increase sleepiness or reduce mental clarity. Always follow recommended dosage guidelines and avoid combining Avil with other products containing antihistamines to prevent accidental overuse.

    Is Avil 25 safe for long-term use?

    Avil 25mg Tablet is typically recommended for short-term or occasional use based on symptom frequency. Its active ingredient, Pheniramine Maleate, belongs to the first-generation class of antihistamines that may cause drowsiness and other anticholinergic effects when taken regularly or over a prolonged period. Long-term or frequent use may result in tolerance (reduced effectiveness), and in rare cases, it could contribute to cognitive slowing, dry mouth, constipation, or urinary retention.

    If symptoms persist or require frequent relief, it is advisable to consult a healthcare professional for a review of underlying causes and to explore alternative options. Regular assessment helps ensure safe use and prevents unnecessary side effects, especially in those with chronic conditions.

    Safety Advice for Elderly Users of Avil Tablet

    Older adults may be more sensitive to the side effects of Avil 25mg Tablet, particularly its sedative and anticholinergic properties. In this age group, the risk of drowsiness, confusion, dizziness, blurred vision, and difficulty in urination may be more pronounced. These effects can increase the risk of falls or impact independence in daily activities.

    For elderly individuals, the dosage should be carefully selected—often starting at the lower end of the recommended range. Monitoring for changes in alertness or balance is essential. If the person is already using other medications that affect the nervous system, added caution is necessary. Where possible, non-sedating alternatives may be preferred in long-term allergic discomfort management. Always consult a healthcare provider for age-appropriate recommendations

    Diet and Lifestyle Advice

    Maintaining the right lifestyle choices can enhance the effectiveness of Avil 25mg Tablet and minimize unwanted effects. As this medication may cause drowsiness and other anticholinergic effects, it's important to follow simple precautions in your daily routine:

    Dietary Tips

    • Avoid Alcohol: Alcohol can intensify the sedative effect of Avil, increasing the risk of drowsiness, dizziness, or slowed reaction times.
    • Stay Hydrated: Drink plenty of water throughout the day, as Avil may cause a dry mouth or mild dehydration.
    • Limit Caffeine Intake: While not directly harmful, caffeine can counteract Avil’s calming effect and may lead to restlessness in sensitive individuals.
    • Light, Balanced Meals: If you experience mild nausea or stomach discomfort, take Avil after a light meal. Avoid overly spicy or heavy meals that may irritate the digestive tract.
    • Avoid Grapefruit: Though not commonly reported, grapefruit may interfere with how certain medications are processed in the liver. It's best avoided when using multiple medications.

    Lifestyle Modifications

    • Rest After Dosing: Since Avil may cause sleepiness, schedule its use during periods of rest or nighttime hours, especially if using it occasionally.
    • Avoid Driving or Machinery: Refrain from activities requiring full alertness until you understand how Avil affects your coordination and focus.
    • Establish a Sleep Routine: If taking Avil at night, combine it with a consistent bedtime routine for better rest.
    • Caution with Screen Time: Reduce screen exposure close to bedtime if using Avil for nighttime allergies—it may interfere with natural sleep signals.
    • Monitor Activity Levels: If dizziness or balance issues occur, reduce physical exertion and engage in low-impact activities until symptoms subside.

    Difference between Avil 25mg and Avil 50mg

    Parameter

    Avil 25mg Tablet

    Avil 50mg Tablet

    Active Ingredient

    Pheniramine Maleate 25 mg

    Pheniramine Maleate 50 mg

    Strength

    Lower dose

    Higher dose

    Usage Context

    Mild to moderate allergy-related discomfort

    Moderate to severe allergic conditions

    Sedation Level

    Moderate drowsiness

    Higher chance of drowsiness

    Recommended For

    First-time users, elderly, lighter symptoms

    Individuals who need stronger symptom control

    Frequency

    As directed, usually once or twice a day

    Typically once a day under medical supervision

    Common Use Cases

    Sneezing, mild itching, dust/pollen sensitivity

    More intense itching, skin reactions, insect bites

    Caution Needed

    With sedatives or alcohol

    Stronger caution with driving, alcohol, and CNS depressants

    Doctor Consultation

    Recommended before long-term use

    Strongly advised for correct dosage & supervision

     

    Avil or cetirizine which is better

    Parameter

    Avil (Pheniramine Maleate)

    Cetirizine

    Class

    First-generation antihistamine

    Second-generation antihistamine

    Sedation Effect

    Higher; can cause drowsiness

    Minimal; usually non-drowsy

    Speed of Action

    Rapid onset

    Fast onset, slightly longer-lasting

    Duration of Action

    Shorter duration (requires more frequent dosing)

    Longer duration (once daily is often sufficient)

    Best Time to Take

    Night (due to drowsiness)

    Morning or night

    Common Use Cases

    Skin allergies, insect bites, hay fever symptoms

    Sneezing, runny nose, pollen allergies

    Suitable for Day Use?

    Not ideal due to drowsiness

    Generally safe for day use

    Doctor Preference

    In cases needing strong sedation or itching relief

    For regular daytime allergy management

    Availability

    OTC in most regions

    Widely available, often OTC

    Drug - Drug interaction

    Avil is widely used for managing allergic discomfort and mild skin irritations, it may interact with several medications. These interactions can increase the risk of drowsiness, delayed reflexes, or other unwanted effects. Understanding these combinations and how to manage them can help ensure safer use of Avil 25mg, especially if taken regularly or alongside other medicines.

    1.Sedatives, Sleeping Aids, or Anxiety Medications

    • Examples: Lorazepam, Diazepam, Alprazolam, Zolpidem
    • Interaction: May enhance drowsiness, mental clouding, or coordination issues.
    • Management: Avoid combining unless specifically advised. If combined, avoid driving or operating machinery.

    2. Opioid Analgesics

    • Examples: Codeine, Tramadol, Morphine
    • Interaction: Increased sedation and risk of slowed breathing.
    • Management: Use only under close supervision. Monitor for signs of excessive sleepiness or breathing difficulty.

    3. Other Antihistamines or Cold Medications

    • Examples: Cetirizine, Diphenhydramine, Chlorpheniramine (OTC cold and allergy products)
    • Interaction: Risk of duplication of side effects like dry mouth, blurred vision, or drowsiness.
    • Management: Read labels carefully to avoid duplicate antihistamines. Use one product at a time unless advised

    4. Antidepressants – Tricyclics and MAO Inhibitors

    • Examples: Amitriptyline, Imipramine, Phenelzine, Selegiline
    • Interaction: Enhanced anticholinergic effects (dry mouth, urinary retention, blurred vision).
    • Management: Avoid combining without healthcare advice. Allow a washout period of at least 14 days with MAO inhibitors.

    5. Muscle Relaxants

    • Examples: Cyclobenzaprine, Methocarbamol
    • Interaction: Can intensify sedative and coordination-impairing effects.
    • Management: Use with caution. Monitor for excessive drowsiness or dizziness, especially in elderly users.

    Drug - Food interaction

    Certain foods and beverages can influence how the body responds to Avil, particularly due to its sedative (sleep-inducing) properties. Being aware of food-related interactions can help you avoid side effects like increased drowsiness or digestive discomfort and improve the medicine's overall effectiveness.

    Alcohol

    • Interaction: Alcohol can significantly increase drowsiness and slow reflexes when combined with Avil.
    • Management: Avoid alcohol entirely while taking Avil. Combining the two may affect concentration, coordination, and increase the risk of accidents.

    Caffeine-Containing Foods or Beverages

    • Interaction: While caffeine doesn’t directly interact with Avil, it may counteract its sedative effects, reducing its calming benefit and leading to inconsistent responses.
    • Management: If you're taking Avil before sleep or during rest periods, limit caffeine intake from coffee, tea, energy drinks, or chocolate.

    Spicy or Acidic Foods

    • Interaction: Spicy or acidic foods may irritate the stomach lining and may worsen digestive discomfort if you are prone to nausea or acidity with medications.
    • Management: If you experience stomach upset, consider taking Avil after a light meal and avoid irritant foods temporarily.

    Synopsis

    Drug :  

    Pheniramine

    Pharmacological Category :  

    Antihistamine

    Therapeutic Indication :  

    Allergic conditions, Conditions of the respiratory tract Itching skin conditions, Motion sickness and symptoms of Meniere’s disease                                                           

    Dosage Forms :  

    Tablet, Injection

    More Information

    Storage

    • Keep Avil 25mg Tablet out of the sight and reach of children
    • Store Avil 25mg Tablet below 30°C

    FAQs About AVIL 25MG TABLET

    Q: What is Avil 25mg Tablet used for?

    A: Avil 25mg Tablet is used to help relieve symptoms associated with allergies such as sneezing, itching, nasal congestion, and mild skin irritation. It works by blocking the effects of histamine, a natural substance involved in allergic responses.

    Q: Can Avil be taken during pollen season?

    A: Yes, Avil 25mg is often taken during pollen season to manage allergy-related discomfort like sneezing or nasal congestion. It helps reduce the effects of environmental triggers by blocking histamine activity in the body.

    Q: Is it okay to take Avil 25mg for skin discomfort?

    A: Avil 25mg is commonly used to relieve mild skin-related allergy symptoms such as itching, redness, or irritation. It helps calm the body's response to allergens that affect the skin.

    Q: Is Avil 25mg useful for itching or rashes?

    A: Yes, Avil 25mg is frequently used for temporary relief from itching, rashes, or minor allergic skin reactions. Its antihistamine action reduces the body’s sensitivity to allergens.

    Q: Why do people take Avil at night?

    A: Avil may cause drowsiness due to its sedative effect, making it more suitable for nighttime use. Taking it at night may also help users sleep more comfortably when allergy symptoms are bothersome.

    Q: How long do side effects of Avil last?

    A: Common side effects like drowsiness or dry mouth usually subside within a few hours to a day. If any unusual or prolonged effects occur, consulting a healthcare provider is advisable.

    Q: Does Avil Cause Drowsiness or Sedation?

    A: Yes, Avil belongs to the first-generation antihistamines known for causing drowsiness or sedation. Users are generally advised to avoid driving or operating machinery after taking it.

    Q: How long does drowsiness from Avil last?

    A: Drowsiness from Avil may last for several hours, typically up to 6–8 hours depending on the individual’s sensitivity. Taking it in the evening can help minimize impact on daytime activities.

    Q: Is it safe to drive after taking Avil tablet?

    A: Driving or operating heavy machinery after taking Avil is not recommended, as the medicine can cause reduced alertness and slower reaction times due to its sedating effects.

    Q: Is Avil safe for elderly or diabetic patients?

    A: Elderly or diabetic individuals should consult a healthcare provider before using Avil, as they may be more sensitive to its side effects or potential interactions with other medications.

    Q: Is Avil 25 safe for long-term use?

    A: Long-term use of Avil should be guided by medical advice. While it is generally safe for short-term relief, regular or extended use should be monitored to avoid unwanted effects like tolerance or prolonged drowsiness.

    Q: Does Avil interact with any health conditions?

    A: Avil may interact with conditions like glaucoma, asthma, or enlarged prostate. Individuals with existing health issues should consult a healthcare provider before starting the medicine.

    Q: Can Avil cause dependency or habit-forming?

    A: Avil is not known to be habit-forming. However, reliance on it for sleep or regular relief without medical supervision may not be advisable in the long run.

    Q: Can I take Avil again if symptoms return quickly?

    A: Re-dosing may be appropriate in some cases, but timing and frequency should follow the instructions provided or a healthcare professional’s advice to avoid overuse or excess sedation.

    Q: Is Avil effective for skin allergies or insect bites?

    A: Yes, Avil 25mg is often used to ease discomfort from skin allergies and minor insect bites. It helps reduce itching, swelling, or irritation caused by allergic reactions.

    References

    1. K.D. Tripathi. Histamines and Antihistamines. Essentials of medical pharmacology. Seventh edition. 2013. Page – 164.

    2. C Collins-Williams. Antihistamines in Asthma. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1987 [Accessed on 31st May 2025]   

    3. Aastha Gupta, Pooja Arora, Purnima Malhotra, Kabir Sardana. Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 31st May 2025] 

    4. Pheniramine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 31st May 2025]   

    5. Sanofi India Limited. Avil. Pheniramine Maleate [Revised in February 2021]. [Accessed on 31st May 2025]   

    6. Sanofi-aventis Australia Pty ltd. Avil. Pheniramine Maleate [Revised in February 2020]. [Accessed on 31st May 2025]   

    Author Details

    Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)
    Reviewed For Accuracy By Dr. M N Himaja - MBBS
    Last updated on 02 Jun 2025 | 02:56 PM(IST)
    Lab updated