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Introduction About AUGMENTIN 1.2GM INJECTION
AUGMENTIN 1.2GM INJECTION is used in the management of various bacterial infections such as respiratory tract infections (pneumonia, acute exacerbation of chronic bronchitis), urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, and infections of genital organs in females.
AUGMENTIN 1.2GM INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine, and pelvic region. Along with management with this medicine, your doctor might order bacterial culture tests to enhance the outcomes of the management.
It contains a combination of medicines called Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It works by preventing the growth of the bacteria and thus clearing up the infection.
AUGMENTIN 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment who had a history of liver problems or jaundice after taking penicillin antibiotics. It should be used with caution in patients suffering from glandular fever (a viral infection causing sore throat, high fever, swelling of salivary glands, etc.), liver disease, kidney disease, who are not passing urine daily, convulsions (fits), or large intestine inflammation.
AUGMENTIN 1.2GM INJECTION is not recommended for use in pregnant women unless necessary. It should be used with caution in breastfeeding women, as it may pass through breast milk. AUGMENTIN 1.2GM INJECTION should be used with caution in children as it may require dose modification.
The most common side effects after receiving AUGMENTIN 1.2GM INJECTION are diarrhea, thrush (fungal infection), etc. Consult your doctor immediately if any of your symptoms get worse or persist.
Uses Of AUGMENTIN 1.2GM INJECTION
How AUGMENTIN 1.2GM INJECTION Works
AUGMENTIN 1.2GM INJECTION helps in managing bacterial infection, where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall), leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell, clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases and hence enhances the antibacterial activity of amoxicillin.
How to use AUGMENTIN 1.2GM INJECTION
- This medicine will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection.
- Your doctor will decide the exact dose and duration of management for you depending on your age, body weight, and disease condition.
Side Effects Of AUGMENTIN 1.2GM INJECTION
Common Side Effects of AUGMENTIN 1.2GM INJECTION:
- diarrhoea
- thrush (candida fungal infection)
Stop receiving AUGMENTIN 1.2GM INJECTION and consult your doctor immediately in case you experience:
- severe allergic reaction, which includes rashes, collapsing or fainting, swelling of the face and throat, which may cause difficulty breathing, fever, joint pain, swollen lymph nodes of the neck, armpits, and groin, and red or purple raised spots on skin due to inflammation of blood vessels
- watery diarrhea with blood or mucus, fever, and abdominal pain that occurs due to inflammation of the large intestine
Warning & Precautions
Pregnancy
Monitoring requiredAUGMENTIN 1.2GM INJECTION is not recommended for use in pregnant women unless necessary.
Breastfeeding
Use with CautionAUGMENTIN 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breast milk.
Driving and Using Machines
ContraindicatedDo not drive or operate machinery after receiving AUGMENTIN 1.2GM INJECTION.
Kidney
Consult your doctorAUGMENTIN 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients suffering from kidney problems.
Liver
Consult your doctorAUGMENTIN 1.2GM INJECTION is not recommended for use in patients who had a history of liver problems or jaundice after taking penicillin antibiotics. It should be used with caution in patients suffering from liver disease.
Allergy
ContraindicatedDo not receive AUGMENTIN 1.2GM INJECTION if you are allergic to amoxicillin, clavulanic acid, or any other ingredients in this medicine.
Use In Pediatrics
Use with CautionAUGMENTIN 1.2GM INJECTION should be used with caution in children as it may require dose modification.
Use In Geriatrics
Use with CautionAUGMENTIN 1.2GM INJECTION should be used with caution in the elderly.
Others
Before receiving AUGMENTIN 1.2GM INJECTION, inform your doctor if you have:
- glandular fever (viral infection causing sore throat, high fever, swelling of salivary glands, etc.)
- not been urinating regularly
- convulsions (fits)
- large intestine inflammation
- urine and blood tests
Interactions
A. Drug-Drug interactions:
Before receiving AUGMENTIN 1.2GM INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used to manage gout (Ex. allopurinol, probenecid)
- medicines used to manage blood clots (Ex. warfarin)
- methotrexate (used for the management of cancer, severe psoriasis)
- medicine used to manage organ transplant rejection (Ex. mycophenolate mofetil)
- medicines used for management of pregnancy (oral contraceptives)
Overdosage:
AUGMENTIN 1.2GM INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose of AUGMENTIN 1.2GM INJECTION are nausea, diarrhea, fits, and an upset stomach.
Synopsis
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Penicillins and Beta-Lactamase Inhibitors |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Drops, Injections |
FAQs About AUGMENTIN 1.2GM INJECTION
Q: What are the uses of AUGMENTIN 1.2GM INJECTION?
A: AUGMENTIN 1.2GM INJECTION is used in adults and children for the management of various bacterial infections such as respiratory tract infections, urinary tract infections, bone and joint infections, middle ear infections, tonsillitis, sinusitis, skin and soft tissue infections, intra-abdominal sepsis, dental infections, and infections of genital organs in females. It is also used as prophylaxis against various bacterial infections associated with major surgeries.
Q: What are the side effects of AUGMENTIN 1.2GM INJECTION?
A: The most common side effects after receiving AUGMENTIN 1.2GM INJECTION are vomiting, diarrhea, thrush (fungal infection), etc. Consult your doctor immediately in case any of the side effects worsen.
Q: How does AUGMENTIN 1.2GM INJECTION work?
A: AUGMENTIN 1.2GM INJECTION helps in managing bacterial infection, where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall), leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell, clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases, hence enhancing the antibacterial activity of amoxicillin.
Q: Is AUGMENTIN 1.2GM INJECTION safe for use in pregnant and breastfeeding women?
A: No, AUGMENTIN 1.2GM INJECTION is not recommended for use in pregnant women unless necessary, and AUGMENTIN 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breastmilk. Consult your doctor before receiving AUGMENTIN 1.2GM INJECTION.
Q: How AUGMENTIN 1.2GM INJECTION is given?
A: This medicine will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection. Your doctor will decide the exact dose and duration of management for you depending on your age, body weight, and disease condition.
Q: Who should avoid using AUGMENTIN 1.2GM INJECTION?
A: AUGMENTIN 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment, a history of liver problems or jaundice after taking penicillin antibiotics, or who are allergic to amoxicillin or clavulanic acid.
Q: What precautions must be taken while using AUGMENTIN 1.2GM INJECTION?
A: Before receiving AUGMENTIN 1.2GM INJECTION, inform your doctor if you have glandular fever, not been urinating regularly, convulsions (fits), large intestine inflammation, or suffering from kidney problems or liver disease.
Q: Is AUGMENTIN 1.2GM INJECTION safe for kids?
A: AUGMENTIN 1.2GM INJECTION should be used with caution in children as it may require dose modification.
Q: What should I do if I experience an allergic reaction after receiving AUGMENTIN 1.2GM INJECTION?
A: Signs of an allergic reaction include rash, swelling of the face, lips, or throat, difficulty breathing, and joint pain. If you experience any of these symptoms, stop receiving the injection and seek immediate medical help.
Q: Can I drive after receiving AUGMENTIN 1.2GM INJECTION?
A: It is advised not to drive or operate heavy machinery after receiving this injection, as it may cause dizziness or other side effects that impair your ability to perform such tasks.
Q: What happens if I miss a dose of AUGMENTIN 1.2GM INJECTION?
A: Since the injection is administered by a healthcare professional, it’s unlikely you will miss a dose. However, if you are receiving treatment on an outpatient basis and miss a scheduled appointment, contact your healthcare provider for guidance.
Q: What should I do if I accidentally receive an overdose of AUGMENTIN 1.2GM INJECTION?
A: Although this injection is administered by a healthcare professional, if an overdose occurs, symptoms such as nausea, diarrhea, or convulsions may appear. Contact your healthcare provider immediately for further management
References
1. KD Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page-723, 724.
2. Justin Evans, Maryam Hannoodee, and Micah Wittler. Amoxicillin Clavulanate. National Centre for Biotechnology. NLM. National Institute of Health. stat pearls. December 2021. [Accessed on 8th October 2024] click here
3. GlaxoSmithKline Trading Services Limited Human Products and Regulatory Authority (HPRA). [Revised in March 2019] [Accessed on 8th October 2024] click here
4. Antibiotice SA. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 8th October 2024] click here
5. Istituto Biochimico Italiano G. Lorenzini S.p.A. Human Products and Regulatory Authority (HPRA). [Revised in May 2023] [Accessed on 8th October 2024] click here
6. GlaxoSmithKline Pharmaceuticals Limited. Amoxicillin + Clavulanic acid. [Revised in July 2022] [Accessed on 8th October 2024] click here
7. Medreich Limited. Amoxicillin + Clavulanic acid. [Revised in June 2015] [Accessed on 8th October 2024] click here
8. Cipla Limited. Amoxicillin + Clavulanic acid. [Revised in September 2019] [Accessed on 8th October 2024] click here
9. Augpen Injection (Amoxicillin + Clavulanic acid). Zuventus Healthcare Limited. [Accessed on 8th October 2024] click here
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