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Introduction About ATAZOR R TABLET
ATAZOR R TABLET is a combination of Atazanavir and Ritonavir which belongs to the group of medicines called Anti-viral agents. It is used to manage HIV infection. HIV (human immunodeficiency virus) infection is a viral infection that damages our immune system and weakens our body’s ability to fight against various infections.
Before taking ATAZOR R TABLET inform your doctor if you have any liver problems, kidney problems or hepatitis B or C infection. You must also inform your doctor if you have diabetes, any muscle problems, blood-related or bleeding problems, weak immune system, obesity, erectile dysfunction or have recently taken any steroid medicines as a precaution.
Although ATAZOR R TABLET can manage HIV infection, it is important for you to follow certain measures to manage the spread of infections to the other people (such as avoid having unprotected sexual intercourse or sharing needles or personal items like toothbrush, razors etc with other people).
Inform your doctor before taking this medicine if you are pregnant or planning to become pregnant. ATAZOR R TABLET is not recommended for use in breastfeeding women.
The most common side effects of taking ATAZOR R TABLET are headache, dizziness, nausea, vomiting, stomach pain, diarrhea, stomach upset, loss of appetite, increased appetite, weight loss, tingling and numbness of body parts, fever, general sensation of being unwell, lack of sleep, muscle pains or cramps, joint pain and high blood sugar or cholesterol levels. Consult your doctor if any of these side effects trouble you.
Uses Of ATAZOR R TABLET
- Manage HIV infection
How ATAZOR R TABLET Works
ATAZOR R TABLET is an anti-viral medicine. It controls the multiplication of virus within the body, by blocking the actions of certain viral enzymes (HIV-protease) that is required for their growth and survival. As a result, it reduces the number of HIV cells present within the body and controls the infection.
How to use ATAZOR R TABLET
Take ATAZOR R TABLET with meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection. Do not stop taking ATAZOR R TABLET without consulting your doctor as it may reduce its effectiveness.
Side Effects Of ATAZOR R TABLET
Common
- headache, dizziness
- nausea, vomiting
- diarrhea, upper stomach pain, indigestion, wind
- loss of appetite or increased appetite
- weight loss or weight gain
- mouth ulcers
- flushing
- cough, throat pain, fever
- tingling or numbness of body parts
- weakness, tiredness
- bad taste or changes in taste
- joint pain, back pain, muscle pain
- skin rash, itching, redness, swelling
- lack of sleep, anxiety, confusion
- increase in blood cholesterol levels
- increased urination
- fits
- thirst (dehydration)
- abnormally heavy periods
- swelling of body parts
- fainting, high or low blood pressure
- blurred vision
- cold hands and feet
- acne
Uncommon
- diabetes
- sleepiness
- loss of memory
- shortness of breath
- hair loss
- protein loss in urine
- breast enlargement in men
Rare
- abnormal manner of walking
Stop taking ATAZOR R TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of kidney stones (bloody urine, pain at the sides of the abdomen, painful urination)
- gall stones causing pain in the right side of the stomach
- opportunistic infections or flaring up of old infections
- signs of auto-immune disorders (such as muscle weakness, rapid or irregular heartbeat, tremor, hyperactivity, general weakness)
- signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving)
- signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach)
- severe skin rashes with raised red spots on the skin with itching, blistering and peeling accompanied with fever
- inflammation of pancreas causing severe stomach pain, nausea and vomiting
- persistent diarrhea and vomiting
- abnormal heartbeat
- severe muscle weakness, tenderness and pain
How To Manage Side Effects
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Nausea and vomiting:
Take ATAZOR R TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Warning & Precautions
Pregnancy
ATAZOR R TABLET should be used with caution among pregnant women. Therefore, consult your doctor before taking it.
Breastfeeding
Breastfeeding should be discontinued in mothers infected with HIV infection. However, consult your doctor before taking ATAZOR R TABLET if you wish to breastfeed.
Driving and Using Machines
Do not drive or operate any machines if your ability is affected by ATAZOR R TABLET.
Alcohol
Avoid consumption of alcohol while taking ATAZOR R TABLET.
Kidney
ATAZOR R TABLET should be used with caution in patients with kidney problems (such as dialysis). Therefore, consult your doctor before taking it.
Liver
ATAZOR R TABLET is not recommended for use in patients with moderate to severe liver problems. It should be used with caution in patients with hepatitis B or C infection or gall stones. Therefore, consult your doctor before taking it.
Allergy
Do not take ATAZOR R TABLET if you are allergic to Atazanavir or to ritonavir.
Others
Before taking ATAZOR R TABLET inform your doctor if you:
- are overweight
- have a weak immune system
- take corticosteroids to heal any auto-immune conditions
- are an alcoholic
- have type A or B haemophilia (a bleeding disorder)
- have erectile dysfunction
- have diabetes
Use in Paediatrics:
ATAZOR R TABLET should be used with caution in children and in adolescents (aged between 6-18 years; minimum body weight 35 kg). Therefore, consult your doctor before taking it.
Use in Geriatrics:
ATAZOR R TABLET should be used with caution in elderly people. Therefore, consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking ATAZOR R TABLET inform your doctor if you are taking any of the following medicines such as:
- rifampicin, rifabutin (medicines used to manage tuberculosis)
- medicines used to manage allergic symptoms (such as astemizole or terfenadine)
- cisapride (a medicine used to manage heartburn)
- medicines used to manage psychiatric disorders (such as lurasidone, clozapine, quetiapine, pimozide, haloperidol, risperidone, thioridazine)
- medicines used to manage depression (such as lurasidone, amitriptyline, desipramine, fluoxetine, imipramine, nefazodone, nortriptyline, paroxetine, sertraline, trazodone)
- quinidine or bepridil (medicines used to correct heart rhythm)
- medicines used to manage migraine (such as ergotamine, dihydroergotamine)
- medicines used to stop excessive bleeding after childbirth (such as ergonovine, methylergonovine)
- alfuzosin (a medicine used to manage enlarged prostate)
- St. John’s wort (a herbal preparation used for depression)
- medicines used to reduce anxiety and to induce sleep (such as triazolam, midazolam)
- medicines used to control blood cholesterol levels (such as atorvastatin, pravastatin, fluvastatin, lomitapide, simvastatin and lovastatin)
- medicines used to manage hepatitis C infection (such as sofosbuvir/velpatasvir/voxilaprevir, grazoprevir-containing products, including elbasvir/grazoprevir fixed dose combination and glecaprevir/pibrentasvir)
- other medicines used for HIV infection (such as amprenavir, atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, saquinavir, tipranavir, didanosine, maraviroc, raltegravir, zidovudine)
- medicine used to manage erectile dysfunction (such as sildenafil, vardenafil or tadalafil)
- oral contraceptive (birth control pills) such as ethinylestradiol
- medicines used to reduce stomach acid production (such as pantoprazole, omeprazole, ranitidine, famotidine)
- medicines used to manage heart problems (such as amiodarone, diltiazem, systemic lidocaine, verapamil, disopyramide, mexiletine, amlodipine, diltiazem and nifedipine)
- medicines used to manage asthma (such as salmeterol, theophylline, fluticasone, budesonide)
- medicines used to suppress immune functions (such as cyclosporin, tacrolimus and sirolimus)
- medicines used to manage bacterial infection (such as fusidic acid, clarithromycin)
- medicines used to manage fungal infection (such as ketoconazole, itraconazole and voriconazole)
- medicines used to manage blood clots (such as apixaban, dabigatran, edoxaban, rivaroxaban and warfarin)
- medicines used to manage epilepsy (such as carbamazepine, phenytoin, phenobarbital, lamotrigine, divalproex)
- medicines used to manage cancer (such as abemaciclib; afatinib, apalutamide, ceritinib, encorafenib, dasatinib, ibrutinib, nilotinib, venetoclax, vincristine, vinblastine, irinotecan, neratinib)
- buprenorphine (a medicine used to manage opioid addiction and pain).
- ranolazine (a medicine used to manage chronic chest pain)
- medicines used for pain relief (such as pethidine, piroxicam, propoxyphene)
- colchicine (a medicine used to manage gout)
- corticosteroids (used for pain and inflammation) such as dexamethasone, fluticasone propionate, prednisolone, triamcinolone
- bosentan, riocioguat (medicines used for increased pressure in the lungs)
- amphetamine or amphetamine derivatives (CNS stimulants)
- medicines used to manage low blood platelet count (Ex. fostamatinib)
- atovaquone (a medicine used to manage a certain type of pneumonia and malaria)
- bupropion (a medicine used to stop smoking)
Overdosage:
If you or anyone else accidentally took more ATAZOR R TABLET, consult your doctor immediately. Symptoms of overdosage might include tingling or numbness of body parts.
Synopsis
| Drug | : | Atazanavir, Ritonavir |
| Pharmacological Category | : | Protease Inhibitors |
| Therapeutic Indication | : | HIV infection |
| Dosage Forms | : | Tablet, Kit |
More Information
- Keep ATAZOR R TABLET out of reach of children
- Store ATAZOR R TABLET at room temperature
FAQs About ATAZOR R TABLET
Q: What is ATAZOR R TABLET?
A: ATAZOR R TABLET is an antiviral medicine used to manage HIV infection. It acts by reducing the multiplication of viral cells within the body
Q: Is ATAZOR R TABLET safe?
A: ATAZOR R TABLET should be used only under medical supervision. It may cause few side effects like headache, dizziness, nausea, vomiting, stomach pain, diarrhea, stomach upset, loss of appetite, increased appetite, weight loss, tingling and numbness of body parts, fever, general sensation of being unwell, lack of sleep, muscle pains or cramps, joint pain and high blood sugar or cholesterol levels. Consult your doctor if any of these side effects trouble you.
Q: How does ATAZOR R TABLET work in our body?
A: ATAZOR R TABLET acts by blocking the actions of certain viral enzymes (HIV-protease transcriptase) that is required for the viral cell to grow and multiply. This reduces the multiplication of viral cells within the body.
Q: Can I stop taking ATAZOR R TABLET if I feel unwell?
A: No. Do not stop taking ATAZOR R TABLET without consulting your doctor. Take ATAZOR R TABLET regularly, because if you miss a dose of ATAZOR R TABLET or take it at irregular intervals, you may not achieve better results.
Q: What to do if I forget to take a dose of ATAZOR R TABLET?
A: If you miss a dose of ATAZOR R TABLET take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular time. Do not take a double dose of ATAZOR R TABLET to compensate the missed dose.
Q: Can ATAZOR R TABLET manage HIV completely?
A: No. ATAZOR R TABLET cannot not manage HIV infection completely. It can reduce only the number of viral cells present in the body and maintains them at a lower level.
Q: What are the precautions to be followed while taking ATAZOR R TABLET?
A: Before taking ATAZOR R TABLET inform your doctor if you have kidney or liver problems (such as hepatitis C or B infection), muscle problems, bleeding problems, erectile dysfunction, diabetes or have taken steroids recently. Regularly visit your doctor and take all the blood tests recommended for you. Consult your doctor before taking ATAZOR R TABLET if you are pregnant or breastfeeding. Take ATAZOR R TABLET regularly without fail. Inform your doctor immediately if you experience any signs of allergic reactions after taking ATAZOR R TABLET.
Q: Can ATAZOR R TABLET be used in children?
A: ATAZOR R TABLET should be used with caution in children and in adolescents (aged between 6-18 years; minimum body weight 35 kg). Therefore, consult your doctor before taking it.
Q: How to take ATAZOR R TABLET?
A: Take ATAZOR R TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ATAZOR R TABLET should be taken with meals. Continue to take ATAZOR R TABLET regularly as advised by your physician for maximum benefits.
References
1. K.D. Tripathi. Antiviral Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 810.
2. Chad J Achenbach, Kristin M Darin, Robert L Murphy and Christine Katlama. Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2011. [Accessed on 20th January 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127229/
3. Zentiva Pharma UK Limited. Atazanavir 150 mg hard capsules Atazanavir 200 mg hard capsules Atazanavir 300 mg hard capsules. Electronic Medicines Compendium (EMC) [Revised in December 2020] [Accessed on 20th January 2023]. https://www.medicines.org.uk/emc/files/pil.10704.pdf
4. AbbVie Deutschland GmbH & Co. KG. Norvir 100 mg film-coated tablets ritonavir. Electronic Medicines Compendium (EMC) [Revised in August 2022] [Accessed on 20th January 2023]. https://www.medicines.org.uk/emc/files/pil.510.pdf
5. Matrix Laboratories Limited. Atazanavir Sulfate and Ritonavir Tablets, 300 mg/100 mg. U.S. Food and Drug Administration. [Revised in November 2011]. [Accessed on 20th January 2023]. https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/022282PI.pdf
6. Central Drugs Standard Control Organization. Atazanavir 150mg + Ritonavir 50mg capsules. December 2006. Atazanavir + Ritonavir (300mg + 100mg) FC Tablets. November 2008. [Accessed on 20th January 2023]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Complete Blood Count
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