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Introduction About AROBIA PLUS SOFTGEL
AROBIA PLUS SOFTGEL is a combination of Calcitriol, Calcium carbonate, Docosahexaenoic acid (DHA), Eicosapentaenoic acid, Elemental boron, Folic acid, and Methylcobalamin which belongs to the group of medicines called Nutritional Supplements. It is used to manage joint inflammation, osteoporosis, different types of arthritis, osteopenia, etc.
Osteoporosis is a condition that causes thinning and weakening of bones because of excessive absorption of calcium from the bones. It is characterized by symptoms such as bleeding gums, weak grip strength, brittle fingernails, loss of height, frequent fractures, and neck and back pain.
Arthritis is a condition causing inflammation of one or more joints. It is characterized by symptoms such as swelling, pain, stiffness, and diminished motion in the involved joints. Osteopenia is the reduction in bone mineral density (BMD), resulting in bone weakening. It is characterized by symptoms such as back pain, loss of height, stooping in posture, and an increased frequency of bone fractures.
AROBIA PLUS SOFTGEL is not recommended for use if you are allergic to calcium, folic acid, calcitriol, or any other metabolite of vitamin D, such as alfacalcidol and cholecalciferol. It is also not recommended for use if you have kidney stones, high levels of calcium in your blood, metastatic calcification (extra deposits of calcium in your body), a deficiency of vitamin B12 (due to pernicious anaemia or a vegetarian diet), or are not well because of high levels of vitamin D in your body.
AROBIA PLUS SOFTGEL should be used with caution in patients with signs of impaired kidney function who have a high tendency to kidney stone (calculus) formation, other kidney problems, or non-alcoholic fatty liver. AROBIA PLUS SOFTGEL should be used with caution in pregnant and breastfeeding women. It should be used with caution in children (under 6 years of age) and elderly patients (aged 65 years or above).
The common side effects associated with the use of AROBIA PLUS SOFTGEL are constipation, indigestion, nausea, and vomiting. Contact your doctor or a nearby hospital if any of the conditions worsen.
Uses Of AROBIA PLUS SOFTGEL
- Manages osteoporosis and hypocalcaemia during pregnancy and lactation
How AROBIA PLUS SOFTGEL Works
AROBIA PLUS SOFTGEL helps in managing bone weakening, where Calcitriol plays a very important role in aiding the absorption of calcium by acting on certain gut cells to increase the production of calcium transport proteins, whereas calcium carbonate acts by directly increasing the calcium stores in the body.
B vitamins such as folic acid and methylcobalamin play a vital role in enhancing bone density, whereas docosahexaenoic acid and eicosapentaenoic acid lower bone breakdown, suppress inflammation, and enhance calcium absorption from the blood.
Elemental boron plays a vital role in enhancing bone strength by increasing the half-life of bone-depositing agents such as oestrogen and vitamin D in the blood. Boron also enhances wound healing, reduces inflammation, and lowers the count of free radicals at the site of inflammation.
How to use AROBIA PLUS SOFTGEL
Take AROBIA PLUS SOFTGEL as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of AROBIA PLUS SOFTGEL
Common
- constipation
- indigestion
- nausea
- vomiting
Uncommon
- signs of an increase in blood calcium levels such as loss of appetite, weight loss, nausea, vomiting, headache, sluggishness, drowsiness, weakness
- signs of an increase in, or alcohol. try to lose your weight in case you are overweight. try doing regular exercise. stay hydrated and avoid fasting
- urine calcium levels such as lower abdominal pain
Rare
- signs of allergic reactions such as itchy skin, skin rashes, and reddening of the skin
- signs of changes in kidney function such as nausea, vomiting, and abdominal pain
- signs of very high levels of blood calcium levels such as high fever, feeling thirsty, dehydration, passing more water than normal, wetting the bed, constipation, stomach pain, blockage of the bowel, an uneven heartbeat, infections in the bladder, stoppage of normal growth
- diarrhoea
- flatulence
- heartburn
Stop taking AROBIA PLUS SOFTGEL and contact your doctor if you experience any of the following side effects:
- signs of severe allergic reactions on the skin such as itchy skin, skin rashes, and reddening of the skin
- signs of allergic reactions (anaphylactic reactions) such as sudden noise in breathing, fluttering or tightness of the chest, collapse
- frequent urge to urinate
- headache
- loss of appetite
- nausea or vomiting
- unusual tiredness or weakness
How To Manage Side Effects
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Indigestion
Try to take AROBIA PLUS SOFTGEL with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
Use with CautionAROBIA PLUS SOFTGEL should be used with caution if you are pregnant, think you are pregnant or plan to get pregnant. Consult and inform your doctor before taking it.
Breastfeeding
Use with CautionAROBIA PLUS SOFTGEL should be used with caution in breastfeeding women as it passes through the milk. Consult your doctor before taking it.
Driving and Using Machines
SafeAROBIA PLUS SOFTGEL is not likely to affect your being able to drive or use any tools or machines.
Kidney
Consult your doctorAROBIA PLUS SOFTGEL is not recommended for use in patients with kidney stones. It should be used with caution in patients with signs of impaired kidney function, who have a high tendency to kidney stone (calculus) formation, or other kidney problems. Consult your doctor for advice before taking it.
Liver
Use with CautionAROBIA PLUS SOFTGEL should be used with caution in patients with non-alcoholic fatty liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedAROBIA PLUS SOFTGEL is not recommended for use if you are allergic to calcium, folic acid, calcitriol, another metabolite of vitamin D (alfacalcidol and cholecalciferol), or any of the other ingredients of this medicine. Consult your doctor before taking it.
Heart Disease
Use with CautionAROBIA PLUS SOFTGEL should be used with caution in patients with heart disorders. Consult your doctor before taking it.
Use In Pediatrics
Use with CautionAROBIA PLUS SOFTGEL should be used with caution in children (below 4 years). Consult your doctor before taking it.
Use In Geriatrics
Use with CautionAROBIA PLUS SOFTGEL should be used with caution in elderly patients (above 70 years). Consult your doctor before taking it.
Others
AROBIA PLUS SOFTGEL is not recommended for use if you:
- have high blood calcium levels
- have high levels of calcium in urine
- have metastatic calcification (extra deposits of calcium in your body)
- are not well because of high levels of vitamin D in your body
- have a deficiency of vitamin B12, possibly due to pernicious anaemia or a vegetarian diet
Before taking AROBIA PLUS SOFTGEL, inform your doctor if you:
- are undergoing therapy for a folate-dependent tumour
- have a family history of neural tube defects (NTDs)
- have diabetes
- are obese
Interactions
A. Drug-Drug Interactions:
Before taking AROBIA PLUS SOFTGEL, inform your doctor, if you are taking any of the following medicine:
- diuretics or water tablets (a medicine used to manage high blood pressure) ex. bendroflumethiazide, chlortalidone, indapamide
- cardiac glycosides (a medicine used to manage heart diseases) ex. digoxin or digitoxin
- medicine used to manage high levels of blood cholesterol such as ion-exchange resins ex. cholestyramine
- levothyroxine (hormonal preparation used to manage thyroid deficiency)
- medicines used to manage bacterial infections such as tetracycline antibiotics (ex. doxycycline), quinolone antibiotics (ex. ciprofloxacin, lomefloxacin, norfloxacin, sparfloxacin), others (ex. chloramphenicol, co-trimoxazole)
- bisphosphonate (a medicine used to manage or manage bone disorders) ex. risedronate
- supplements containing iron, zinc, or strontium ranelate preparations
- other vitamin d supplements
- medicines containing magnesium such as antacids (medicines used to manage indigestion) ex. magnesium hydroxide
- corticosteroids (medicines used to manage pain and inflammation) ex. hydrocortisone, prednisolone, dexamethasone
- phosphate (a medicine used to manage certain urinary tract infections)
- anti-epileptics (medicines used to manage epilepsy and fits) such as phenytoin, phenobarbital, primidone
- sulfasalazine (a medicine used to manage arthritis or inflammatory bowel disease, including ulcerative colitis or Crohn’s disease)
- methotrexate (a medicine used to manage severe active rheumatoid arthritis, severe psoriasis, and certain types of cancer)
B. Drug-Food Interactions:
Avoid eating food which is rich in vitamin D (dairy products like milk and cheese) or has added vitamin D while taking AROBIA PLUS SOFTGEL. Consult your doctor before taking it.
Overdosage:
If you or anyone else accidentally takes too much of AROBIA PLUS SOFTGEL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are excessive thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, tiredness, mental disturbances, bone pain, frequent urination, kidney problems, irregular heartbeat, loss of appetite, weight loss, feeling sick, being sick, constipation, headache, sluggishness, drowsiness, or weakness.
Synopsis
| Drug | : | Calcitriol, Calcium carbonate, Docosahexaenoic acid (DHA), Eicosapentaenoic acid, Elemental boron, Folic acid, and Methylcobalamin |
| Pharmacological Category | : | Nutritional supplements |
| Therapeutic Indication | : | Manage osteoporosis and hypocalcaemia during pregnancy and lactation |
| Dosage Forms | : | Capsule |
More Information
- Keep the medicine out of reach of children
- Store AROBIA PLUS SOFTGEL at room temperature
FAQs About AROBIA PLUS SOFTGEL
Q: What is AROBIA PLUS SOFTGEL used for?
A: AROBIA PLUS SOFTGEL is used to manage osteoporosis and hypocalcaemia during pregnancy and lactation that occur due to increased nutrition demand in such conditions. Consult your doctor before taking it.
Q: What happens if you take more AROBIA PLUS SOFTGEL than your required dose?
A: If you or anyone else accidentally takes too much AROBIA PLUS SOFTGEL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are excessive thirst, nausea, vomiting, constipation, abdominal pain, muscle weakness, tiredness, mental disturbances, bone pain, frequent urination, kidney problems, an irregular heartbeat, loss of appetite, weight loss, constipation, headache, sluggishness, drowsiness, or weakness.
Q: What side effects are seen with AROBIA PLUS SOFTGEL?
A: The common side effects associated with the use of AROBIA PLUS SOFTGEL are constipation, indigestion, nausea, and vomiting. Contact your doctor or a nearby hospital if any of the conditions worsen.
Q: Who should avoid taking AROBIA PLUS SOFTGEL?
A: AROBIA PLUS SOFTGEL is not recommended for use if you are allergic to calcium, folic acid, calcitriol, or any other metabolite of vitamin D, such as alfacalcidol and cholecalciferol. It is also not recommended for use if you have kidney stones, high levels of calcium in your blood, metastatic calcification (extra deposits of calcium in your body), a deficiency of vitamin B12 (due to pernicious anaemia or a vegetarian diet), or are not well because of high levels of vitamin D in your body.
Q: Is AROBIA PLUS SOFTGEL safe to use in children or elderly patients?
A: AROBIA PLUS SOFTGEL should be used with caution in children (aged below 4 years) and elderly patients (aged above 70 years). Consult your doctor before taking it.
Q: How does AROBIA PLUS SOFTGEL work?
A: AROBIA PLUS SOFTGEL helps in managing bone weakening, where Calcitriol plays a very important role in aiding the absorption of calcium by acting on certain gut cells to increase the production of calcium transport proteins, whereas calcium carbonate acts by directly increasing the calcium stores in the body.
B vitamins such as folic acid and methylcobalamin play a vital role in enhancing bone density, whereas docosahexaenoic acid and eicosapentaenoic acid lower bone breakdown, suppress inflammation, and enhance calcium absorption from the blood.
Elemental boron plays a vital role in enhancing bone strength by increasing the half-life of bone-depositing agents such as oestrogen and vitamin D in the blood. Boron also enhances wound healing, reduces inflammation, and lowers the count of free radicals at the site of inflammation.
Q: Is AROBIA PLUS SOFTGEL safe for use by pregnant and breastfeeding women?
A: AROBIA PLUS SOFTGEL should be used with caution if you are pregnant, think you are pregnant or plan to get pregnant. It should also be used with caution in breastfeeding women. Consult your doctor before taking it.
Q: Is AROBIA PLUS SOFTGEL safe to use in liver patients?
A: AROBIA PLUS SOFTGEL should be used with caution in patients with non-alcoholic fatty liver disease (abnormally increased lipid levels in liver tissues unrelated to alcoholism). Consult your doctor before taking it.
Q: Is AROBIA PLUS SOFTGEL safe to use in kidney patients?
A: AROBIA PLUS SOFTGEL is not recommended for use in patients with kidney stones. It should be used with caution in patients with signs of impaired kidney function who have a high tendency to kidney stone (calculus) formation or other kidney problems. Consult your doctor for advice before taking it.
Q: What if I forget to take my AROBIA PLUS SOFTGEL dose?
A: If you forgot to take your AROBIA PLUS SOFTGEL dose, take it as early as possible. Do not double up the dose to make up for the forgotten one. Consult your doctor before taking it.
References
1. KD Tripathi. Drugs Affecting Calcium Balance. Essentials of medical pharmacology. Seventh edition. 2013. Page 341.
2. Mitra Hariri, Sara Zohdi. Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Clinical Trials. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. January 2019. [Assessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360993/
3. Mark A. Plantz; Khaled Bittar. Dietary Calcium. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. May 2022. [Assessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK549792/
4. A A Leaf. Vitamins for babies and young children. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. February 2007. [Assessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083301/
5. Meghan Meehan, Sue Penckofer. The Role of Vitamin D in the Aging Adult. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2014. [Assessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399494/
6. Atnahs Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Assessed on 10th September 2022] https://www.medicines.org.uk/emc/files/pil.11802.pdf
7. Takeda AS. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Assessed on 10th September 2022] https://www.medicines.org.uk/emc/files/pil.12847.pdf
8. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in January 2019] [Assessed on 10th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/b7d79cb3-6f64-46bd-81da-574bfaa8cba0.pdf
9. Bionova. NEVICAL FORTE SOFTGEL. [Assessed on 10th September 2022] https://www.bionova.co.in/nevical-forte-softels.html
Useful Diagnostic Tests
- Blood tests
- Urine analysis
Author Details
