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Introduction About ARH L DRY SYRUP
ARH L DRY SYRUP is a combination of Artemether and Lumefantrine which belongs to the group of medicines called Anti-malarial agents. It is used to manage uncomplicated malarial infection caused by plasmodium falciparum (a type of malaria parasite) in infants and children.
Also, it manages malarial infections in areas where malarial parasites are resistant to other anti-malarial medicines. Malaria is a mosquito-borne infection caused by plasmodium parasites, typically transmitted through the bite of an infected Anopheles mosquito. It is characterized by symptoms such as chills, fever, headache, muscles pain and tiredness.
ARH L DRY SYRUP is not recommended for use in children with severe liver or kidney impairment, heart conditions such as arrhythmia, slow heartbeat or severe heart disease, severe type of malarial infection affecting the brain, lungs or kidney, low levels of electrolytes such as potassium or magnesium in blood.
Before administering ARH L DRY SYRUP to your child, inform child’s doctor if your child feels too sick to eat or drink, experiences worsening of the condition or has any allergies.
ARH L DRY SYRUP is recommended for use in infants and children. Your child’s doctor may adjust the dose based on child’s body weight.
The most common side effects of taking ARH L DRY SYRUP are headache, dizziness, stomach pain, nausea, vomiting and loss of appetite. Consult your child’s doctor if any of the side effects worsen.
Uses Of ARH L DRY SYRUP
- Manage uncomplicated malarial infection caused by plasmodium falciparum (a type of malaria parasite)
- Manage malarial infections in areas where malarial parasites are resistant to other anti-malarial medicines
How ARH L DRY SYRUP Works
ARH L DRY SYRUP effectively manages malarial infections, where artemether effectively kills the malarial parasites by binding to haem (part of molecules that contains iron which is toxic to malarial parasites) which is produced during the breakdown of haemoglobin. Lumefantrine works by binding to hemin where it manages the formation of a toxic malarial pigment called hemozoin, thereby it manages malarial infection. In addition to this artemether and lumefantrine blocks nucleic acid and protein synthesis in parasite that damages the parasitic cell membrane of plasmodium falciparum which leads to the death of parasite. Thus, it helps in managing the malarial infection.
How to use ARH L DRY SYRUP
Give ARH L DRY SYRUP to your child as advised by the physician. Add cooled drinking water after boiling to the powder and shake the bottle until all the powder is dissolved. Readjust the volume by adding water up to the mark. Shake well before use. Your child’s doctor will decide the correct dose and duration of ARH L DRY SYRUP for your child depending upon child’s age, body weight and disease condition.
Side Effects Of ARH L DRY SYRUP
Common
- palpitations
- headache, dizziness
- stomach pain
- nausea, vomiting
- loss of appetite
- joint or muscle pain
- fatigue, abnormal physical weakness
- sleep disorders
- loss of memory
- tingling or pricking sensation
- diarrhoea
- itching
- coughing
- electrocardiogram QT prolongation (irregular heart rhythm which is seen in the electrocardiogram)
- gait disturbances
- sleeplessness
Uncommon
- sleep disturbances
- drowsiness
- clonus (involuntary muscle movements)
- numbness
- ataxia (impaired balance)
- excessive sleepiness
Rare
- signs of allergic reactions such as (rashes, itching, trouble breathing or swallowing difficulties and dizziness)
Stop giving ARH L DRY SYRUP to your child and contact doctor immediately if your child experiences any of the following side effects:
- signs of severe allergic reactions (such as rashes or reddening of the face)
How To Manage Side Effects
Nausea and vomiting:
Follow simple meal plan for your child while administering ARH L DRY SYRUP. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.
Diarrhoea:
Advise your child to drink plenty of water and stay hydrated. Avoid giving your child a high-fat diet or spicy foods. Try to avoid giving any medicine on your own to your child to manage diarrhea. Consult child’s doctor if the symptom gets worse.
Stomach pain:
Advice your child to rest and relax. Tell your child to eat and drink slowly or try to have lesser and more frequent meals. Keep a heat pad on child’s stomach to relieve pain. Consult child’s doctor if the symptom gets worse.
Headache:
Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ARH L DRY SYRUP is not recommended for use in pregnant women as it is used only in children. Consult your doctor for advice.
Breastfeeding
ARH L DRY SYRUP is not recommended for use in breast-feeding women as it is used only in children. Consult your doctor for advice.
Driving and Using Machines
Do not let your child ride bicycles or drive other vehicles or operate any tools if your child experiences dizziness or fatigue after administration of ARH L DRY SYRUP.
Kidney
ARH L DRY SYRUP is not recommended for use in children with severe kidney impairment and severe type of malarial infection affecting the kidneys. Consult your child’s doctor for advice before administration of ARH L DRY SYRUP to your child.
Liver
ARH L DRY SYRUP is not recommended for use in children with severe liver impairment. Consult your child’s doctor for advice before administration of ARH L DRY SYRUP to your child.
Allergy
Talk to your child’s doctor if your child is allergic to Artemether, Lumefantrine or any other ingredients of this medicine.
Lungs
ARH L DRY SYRUP is not recommended for use in children with severe type of malarial infection affecting the lungs. Consult your child’s doctor for advice before administration of ARH L DRY SYRUP to your child.
Heart Disease
ARH L DRY SYRUP is not recommended for use in children with heart conditions such as arrhythmia, slow heartbeat, severe heart disease or abnormal electrical signal in the ECG (prolongation of the QT interval) and if anyone of the child’s family members (such as parents, grandparents, brothers and sisters) died suddenly due to a problem with heart rate or already had problems with heart rate at birth.
Others
ARH L DRY SYRUP is not recommended for use if your child:
- has low levels of electrolytes such as potassium or magnesium in blood
- has severe type of malarial infection that has affected the brain
- has severe water loss or problems with eating
Before giving ARH L DRY SYRUP to your child, inform your child’s doctor if your child:
- feels too sick to eat or drink
- condition gets worse
- has any allergies
Use in paediatrics:
ARH L DRY SYRUP is recommended for use in infants and children. Your child’s doctor may adjust the dose based on child’s body weight. Consult your child’s doctor for advice before administration of ARH L DRY SYRUP.
Use in geriatrics:
ARH L DRY SYRUP is not recommended for use in elderly patients as it is used only in children. Consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Before giving ARH L DRY SYRUP to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines:
- antimalarials (medicines used to manage malaria) Ex. mefloquine, halofantrine, quinine
- antiretroviral medicines (medicines used to manage HIV infection) Ex. ritonavir, atazanavir
- medicines used to manage arrhythmias Ex. flecainide and metoprolol)
- neuroleptics (medicines used to manage mental disorders) Ex. clozapine, chlorpromazine
- antidepressants (medicines used to manage depression) Ex. imipramine, amitriptyline, clomipramine)
- antibiotics (medicines used to manage bacterial infections) Ex. azithromycin, ciprofloxacin
- antifungals (medicines used to manage fungal infections) Ex. ketoconazole, itraconazole
- medicines used to manage allergic conditions Ex. terfenadine, astemizole
- cisapride (used to manage heart burn)
Overdosage:
If your child or anyone else accidentally takes too much of ARH L DRY SYRUP, consult your child’s doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Artemether, Lumefantrine |
| Pharmacological Category | : | Antimalarials |
| Therapeutic Indication | : | Manages acute uncomplicated malaria |
| Dosage Forms | : | Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry syrup |
More Information
- Keep ARH L DRY SYRUP out of reach of children
- Store at room temperature
FAQs About ARH L DRY SYRUP
What is ARH L DRY SYRUP used for?
ARH L DRY SYRUP is used in infants and children for the management of uncomplicated malaria (mosquito born disease with symptoms of fever with chills, tiredness, nausea, vomiting and stomach pain) caused by a parasite called plasmodium falciparum. Also, ARH L DRY SYRUP manages malarial infections in areas where malarial parasites are resistant to other anti-malarial medicines.
Can ARH L DRY SYRUP be used in children with kidney problems?
ARH L DRY SYRUP is not recommended for use in children with severe kidney impairment and severe type of malarial infection affecting the kidneys. Consult your child’s doctor for advice before administration of ARH L DRY SYRUP to your child.
What are the common side effects of ARH L DRY SYRUP?
The most common side effects of taking ARH L DRY SYRUP are headache, dizziness, stomach pain, nausea, vomiting, joint or muscle pain, diarrhea, cough, itching and loss of appetite. Consult your child’s doctor if any of the side effects worsen.
How to administer ARH L DRY SYRUP to my child?
Give ARH L DRY SYRUP to your child as advised by the physician. Add cooled drinking water after boiling to the powder and shake the bottle until all the powder is dissolved. Readjust the volume by adding water up to the mark. Shake well before use. Your child’s doctor will decide the correct dose and duration of ARH L DRY SYRUP for your child depending upon child’s age, body weight and disease condition.
Is ARH L DRY SYRUP safe to use in children with heart problems?
ARH L DRY SYRUP is not recommended for use in children with heart conditions such as arrhythmia, slow heartbeat, severe heart disease or abnormal electrical signal in the ECG (prolongation of the QT interval) and if anyone of the child’s family members (such as parents, grandparents, brothers and sisters) died suddenly due to a problem with heart rate or already had problems with heart rate at birth.
References
1. KD Tripathi. Anti-Malarial Drugs. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 889.
2. Derbie A, Mekonnen D, Adugna M, Yeshitela B, Woldeamanuel Y, Abebe T. Therapeutic Efficacy of Artemether-Lumefantrine (Coartem) for the Treatment of Uncomplicated Falciparum Malaria in Africa: A Systematic Review. NIH. National Library of Medicine, National center for biotechnology information. October 2020 [Accessed on 3rd November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599419/
3. Dafra Pharma. Randomised Efficacy Study of Two Artemether-Lumefantrine Oral Formulations for the Treatment of Uncomplicated P. Falciparum Malaria. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in January 2008] [Accessed 3rd November 2022] https://clinicaltrials.gov/ct2/show/NCT00529867
4. Asterisk Lifesciences Ltd (MFG). Gvither Plus 20/120 (Artemether and Lumefantrine Powder for Oral Suspension). [Accessed on 3rd November 2022] https://fdaghana.gov.gh/img/pils/Gvither%2020_120mg%20Powder%20for%20Oral%20Suspension%20(Artemether_Lumefantrine).pdf
5. Getz pharma ltd. Artheget (Artemether + Lumefantrine). [Accessed on 3rd November 2022] https://getzpharma.com/wp-content/uploads/2016/07/Artheget-Range-Leaflet-Pakistan.pdf
Useful Diagnostic Tests
- Complete blood count
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