APP UP Tablet 10'S
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Introduction About APP UP TABLET
APP UP TABLET contains cyproheptadine, which belongs to the group of medicines called Antihistamines. It is used in the management of allergic conditions such as seasonal and perineal rhinitis, hay fever, skin rashes, and allergic conjunctivitis.
Perennial rhinitis refers to specific allergens that cause an allergic reaction year-round, such as pet hair or dander, food allergies, or medicines. Whereas, seasonal allergies typically occur with weather changes or environmental changes such as pollen, insects, moisture, dryness, fungi, mold, etc.
APP UP TABLET is not recommended for debilitated patients above 65 years of age with renal, hepatic, or cardiac conditions. APP UP TABLET must be used in pregnant women only if recommended by your doctor. It is not recommended for use in breastfeeding mothers.
The medicine should be used with caution in adolescents and children (above 7 years of age) only. Consult your doctor before taking it. The most common side effects include dizziness, drowsiness, and high fever. Contact your doctor if any of the symptoms worsen.
Uses Of APP UP TABLET
Manages allergic conditions in children (above 7 years of age) and adults, such as:
- seasonal (occurring during a specific season) and perennial rhinitis (occurring year-round)
- vasomotor rhinitis (reoccurring inflammation of the mucous membrane in the nose)
- allergic conjunctivitis (eye inflammation caused by allergy)
- urticaria (hives) and angioedema (swelling beneath the skin)
- amelioration of allergic reactions to blood or plasma (allergic severe reactions after blood or plasma transfusions)
- cold urticaria (skin reaction to cold)
- dermatographia (a condition causing raised red lines after a scratch)
- It is also used as adjuvant therapy for serious allergic reactions
How APP UP TABLET Works
APP UP TABLET manages allergic reactions by binding with certain receptors and blocking them from binding with histamine in the body. Histamine is a mediator found in our body that is responsible for causing allergic symptoms (such as inflammation, itching and irritation etc.) as a response to allergic conditions. Thereby, providing us relief from the allergic condition.
How to use APP UP TABLET
Take APP UP TABLET as advised by your physician. It can be taken independent of meals. Swallow the medicine with a glass of water. Do not crush or chew APP UP TABLET. Your doctor will decide the correct dose, frequency and duration of the management for you depending upon your age, body weight, and disease condition.
Side Effects Of APP UP TABLET
Common
- dizziness, drowsiness
- confusion, agitation
- urinary retention
- tachycardia
- facial flushing
- hyperpyrexia (high temperature)
- dry mucous membrane
- dilated pupil
- constipation
- seizures
- athetosis (involuntary movement of limbs)
- hallucination, delirium
- weight gain
- loss of appetite
Rare
- hepatotoxicity
Stop taking APP UP TABLET and contact your doctor immediately if you experience any of the following side effects:
- central nervous system: disturbed coordination, restlessness, excitation, nervousness, tremor, irritability, insomnia, paraesthesia (tickling sensation), neuritis (inflammation of the nerve), euphoria (mood swings), hysteria (mental disorder), and faintness
- skin layer: rash and swelling, excessive sweating, a rash with a severe itch, photosensitivity
- special senses: acute labyrinthitis (inflammation of the inner ear), blurred vision, double vision, vertigo (spinning sensation), tinnitus (ringing in the ears)
- cardiovascular: hypotension, palpitation, tachycardia, extrasystoles (additional heartbeat), severe allergic shock
- hematologic: haemolytic anaemia, leukopenia (low white blood cells), agranulocytosis (high risk of infection), thrombocytopenia (low platelets in the blood)
- digestive system: cholestasis (type of liver disease), liver failure, hepatitis (inflammation of the liver), liver function abnormality, dryness of mouth, epigastric distress (pain on the upper stomach), anorexia (eating disorder), nausea, vomiting, diarrhoea, constipation, jaundice
- genitourinary: urinary frequency, difficult urination, menses
- respiratory: dryness of nose and throat, thickening of bronchial secretions, tightness of chest and wheezing
How To Manage Side Effects
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Constipation:
Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.
Warning & Precautions
Pregnancy
APP UP TABLET must be used in pregnant women only if recommended by your doctor. Consult your doctor before taking APP UP TABLET.
Breastfeeding
APP UP TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking APP UP TABLET.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy or feel that your mental alertness or motor coordination is affected after taking APP UP TABLET.
Alcohol
Avoid consumption of alcohol while taking APP UP TABLET because it causes an additive effect, making you feel dizzy or drowsy.
Kidney
APP UP TABLET should be taken with caution in patients with severe kidney disease. Consult your doctor before taking APP UP TABLET.
Liver
APP UP TABLET should be taken with caution in patients with severe liver disease. Consult your doctor before taking APP UP TABLET.
Allergy
Do not take APP UP TABLET if you are allergic to cyproheptadine.
Lungs
APP UP TABLET should be taken with caution in patients with a history of bronchial asthma. Consult your doctor before taking APP UP TABLET.
Heart Disease
APP UP TABLET should be taken with caution in patients with cardiovascular disease and hypertension. Consult your doctor before taking APP UP TABLET.
Others
APP UP TABLET is not recommended for use if you are suffering from:
- angle-closure glaucoma
- peptic ulcer
- prostatic hypertrophy or bladder neck obstruction (enlargement of the prostate gland)
- intestinal obstruction (pyloroduodenal)
Before taking APP UP TABLET, inform your doctor if you are suffering from:
- increased intraocular pressure (eye pressure)
- hyperthyroidism
Use in paediatrics:
APP UP TABLET should be used with caution in children above 7 years of age and adolescents (under 18 years of age). Consult your doctor before taking APP UP TABLET.
Use in geriatrics:
APP UP TABLET is not recommended in debilitated elderly patients aged over 60 years and above with decreased hepatic, renal or cardiac function. Consult your doctor before taking APP UP TABLET.
Interactions
A. Drug-Drug interactions:
Before taking APP UP TABLET, inform your doctor if you are taking any of the following medicine
- medicines used to manage depression such as MAO inhibitors (Mono Amine Oxidase inhibitors) (Ex. selegiline)
- other depressants such as CNS depressants (Ex. barbiturates)
- medicine used as sedatives (Ex. diazepam)
- medicines used as hypnotics (Ex. zopiclone)
- medicines used as tranquillizers to manage mental disturbances (Ex. alprazolam)
- anti-anxiety medicine used to manage anxiety (Ex. clonazepam)
Overdosage:
If you or anyone else have accidentally taken too much of APP UP TABLET, consult your doctor immediately or visit the nearby hospital. In children, it could cause diminishing mental alertness and sometimes cause excitation, whereas in adults, it could cause symptoms such as dry mouth, fixed dilated pupils, flushing and gastrointestinal symptoms such as diarrhoea, vomiting, etc.
Synopsis
| Drug | : |
Cyproheptadine |
| Pharmacological Category | : |
Antihistamines |
| Therapeutic Indication | : |
Manages symptoms associated with allergic conditions |
| Dosage Forms | : |
Tablets, capsules, syrup, drops |
More Information
- Keep out of reach from children
- Store at room temperature
FAQs About APP UP TABLET
Does APP UP TABLET make you gain weight?
Yes, though APP UP TABLET is an antihistamine, it is also used to stimulate the appetite and promote weight gain. On the contrary, it is a negative effect as it can cause obesity due to the rapid weight gain in the person after taking it. Consult your doctor before taking APP UP TABLET.
Can APP UP TABLET be used for insect bites?
Yes, APP UP TABLET can be used to manage allergic reactions caused by insect bites. Inflammation and irritation caused by the insect bite are restricted by APP UP TABLET causing relief from symptoms. Consult a doctor before taking it.
Can I take APP UP TABLET with anti-depressants?
No, APP UP TABLET is not recommended for use with an anti-depressant (Ex. Sertraline, citalopram), as co-administration of these two medicines may increase the risk of having an additive effect on the medicine and can cause unnecessary complications. Consult a doctor for advice before taking APP UP TABLET.
Does APP UP TABLET make you feel sleepy?
Yes, APP UP TABLET has a sedative property that may make you feel sleepy or drowsy. Avoid driving or using heavy machinery while taking APP UP TABLET.
How long should I take APP UP TABLET?
APP UP TABLET should be taken for as long as your doctor has prescribed it. However, consult your doctor immediately if you experience any of the side effects and they persist or worsen with rash, fever, or weight gain.
When should I avoid it before taking APP UP TABLET?
Avoid taking APP UP TABLET if you are suffering from bronchial asthma, glaucoma, enlarged prostate, urinary problems or stomach ulcers. Inform your doctor about your medical condition before starting APP UP TABLET therapy.
Does APP UP TABLET cause dry mouth?
Yes, APP UP TABLET can cause dry mouth. If you experience mouth dryness or feel excessively thirsty, increase your fluid intake, rinse your mouth with water frequently, and apply lip balm if you feel your lips are dry or chapped out.
References
1. K D Tripathi. Antiemetics. Essentials of Medical Pharmacology. 8th edition. Page - 174.
2. Bertrand, Valérie et al. Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. National Library of Medicine. (PMC). [Accessed on 18th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525494/
3. Najib, Khadijehsadat et al. Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial. National Library of Medicine. (PMC). [Accessed on 18th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442838/
4. Emcure Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Accessed on 18th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/087056s045lbl.pdf
5. Merck Sharp & Dohme. Ltd [Revised in October 2007] [Accessed on 18th June 2022] https://apps.medicines.org.au/files/mkpperia.pdf
6. Ronak Exim Private Limited. [Accessed on 18th June 2022] https://fdaghana.gov.gh/img/smpc/Happyrona%204mg%20Tablets%20(Cyproheptadine).pd
7. Marlex Pharmaceuticals Inc. [Revised in October 2021] [Accessed on 18th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c382a921-f801-4b63-885a-00e71d3c19c7
8. Ciplamed. [Revised in November 2013] [Accessed on 18th June 2022] https://www.ciplamed.com/content/ciplactin-tablets
9. Cadila Healthcare Ltd. Safety Data Sheet. [Accessed on 18th June 2022] https://imgcdn.mckesson.com/CumulusWeb/Click_and_learn/SDS_9ZYDUS_CYPROHEPTADINE_HCL_TAB_4MG_100_BT.pdf
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