New Revised MRP, 100% GST benefit passed APLEVANT 1.5mg Prefilled Pen 1's
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Introduction About APLEVANT 1.5MG PREFILLED PEN
APLEVANT 1.5MG PREFILLED PEN contains Dulaglutide which belongs to a group of medicines called Incretin mimetics. It is used to manage type II diabetes mellitus along with diet and exercise. Type 2 diabetes is a condition in which body does not make enough insulin, and the insulin that your body produces does not work as well as it should. When this happens, sugar (glucose) builds up in blood.
GLP-1 makes your pancreas to produce more insulin after you eat and helps in maintaining blood glucose levels in the normal range. It helps the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps in moving sugar from the blood into other body tissues where it is used for energy.
Always use this medicine as advised by your doctor. It is not recommended for the children and adolescents under 18 years of age. It is not recommended for use in patients with severe stomach or intestinal problems. Do not take APLEVANT 1.5MG PREFILLED PEN if you are pregnant or breast-feeding women or if you are trying to become pregnant. Consult your doctor for advice.
The most common side effects are nausea, diarrhoea, vomiting, decreased appetite and indigestion. Consult your doctor if any of the above side effects worsen or persists for a longer duration.
Uses Of APLEVANT 1.5MG PREFILLED PEN
- Used to manage type II diabetes mellitus along with diet and exercise
How APLEVANT 1.5MG PREFILLED PEN Works
APLEVANT 1.5MG PREFILLED PEN activates GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase in the pancreatic beta cells. GLP-1 makes your pancreas to produce more insulin after you eat and helps in maintaining blood glucose levels in the normal range. It helps the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps in moving sugar from the blood into other body tissues where it is used for energy.
How to use APLEVANT 1.5MG PREFILLED PEN
APLEVANT 1.5MG PREFILLED PEN will be given to you only by a doctor or a nurse into under the skin (subcutaneous injection) of your stomach area (abdomen) or upper leg (thigh).
Side Effects Of APLEVANT 1.5MG PREFILLED PEN
Common
- low blood sugar
- nausea and vomiting
- diarrhea
- abdominal (stomach) pain
- feeling less hungry (decreased appetite)
- indigestion
- constipation
- stomach bloating
Stop receiving APLEVANT 1.5MG PREFILLED PEN and contact your doctor immediately if you experience any of the following side effects:
- anaphylactic reactions, angioedema (symptoms are rashes, itching and rapid swelling of the tissues of the neck, face, mouth or throat, hives and difficulties breathing)
How To Manage Side Effects
Diarrhea
Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicines without consulting your doctor.
Headache
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Warning & Precautions
Pregnancy
Monitoring requiredAPLEVANT 1.5MG PREFILLED PEN is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
Breastfeeding
Monitoring requiredAPLEVANT 1.5MG PREFILLED PEN is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you have signs of low blood sugar (hypoglycaemia) while taking APLEVANT 1.5MG PREFILLED PEN.
Alcohol
ContraindicatedConsumption of alcohol is not recommended during management with this medicine.
Kidney
Use with CautionAPLEVANT 1.5MG PREFILLED PEN should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
Liver
Use with CautionAPLEVANT 1.5MG PREFILLED PEN should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Allergy
ContraindicatedDo not use APLEVANT 1.5MG PREFILLED PEN if you are allergic to Dulaglutide or any other ingredients of this medicine.
Others
APLEVANT 1.5MG PREFILLED PEN is not recommended for use if you:
- or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC)
- have severe stomach or intestinal problems
Interactions
Before taking APLEVANT 1.5MG PREFILLED PEN inform your doctor if you are taking prescription, non-prescription medicines or herbal supplements.
Synopsis
| Drug | : | Dulaglutide |
| Pharmacological Category | : | Glucagon-like Peptide-1 Agonists (GLP-1 Agonist) |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Injection, Prefilled syringe |
More Information
- Keep APLEVANT 1.5MG PREFILLED PEN out of reach of children
- Store APLEVANT 1.5MG PREFILLED PEN at temperature 2-8°C
FAQs About APLEVANT 1.5MG PREFILLED PEN
Q: Can APLEVANT 1.5MG PREFILLED PEN be used in pregnant women?
A: APLEVANT 1.5MG PREFILLED PEN is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
Q: How long can you stay on APLEVANT 1.5MG PREFILLED PEN?
A: APLEVANT 1.5MG PREFILLED PEN may take this medicine up to 5 weeks to start lowering your blood glucose levels but the maximum effect will not be seen for 3-6 months. Consult your doctor for advice.
Q: What is APLEVANT 1.5MG PREFILLED PEN made of?
A: APLEVANT 1.5MG PREFILLED PEN is novel glucagon-like peptide-1 agonist (GLP-1) and biologic drug consisting of the dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to human IgG4-Fc heavy chain by a small peptide linker.
Q: Can APLEVANT 1.5MG PREFILLED PEN be used to manage type 1 diabetes?
A: No APLEVANT 1.5MG PREFILLED PEN should not be used in patients with type 1 diabetes mellitus or for sdiabetic ketoacidosis.
Q: What should I avoid while using APLEVANT 1.5MG PREFILLED PEN?
A: Avoid fried or fatty foods and foods high in sugar while using this medicine to reduce the risk of nausea and vomiting. Eat slowly and eat smaller meals that are light and bland.
Q: What to monitor while using APLEVANT 1.5MG PREFILLED PEN?
A: Always monitor renal function in patients with renal impairment experiencing severe gastrointestinal reactions. Observe for signs and symptoms of pancreatitis. And also monitor for progression of diabetic retinopathy in patients with a history of diabetic retinopathy.
Q: Does APLEVANT 1.5MG PREFILLED PEN reduce liver fat?
A: This medicine significantly reduces LFC and improves GGT levels in participants with NAFLD. There were non-significant reductions in PFC, liver stiffness, serum AST and serum ALT.
Q: Is APLEVANT 1.5MG PREFILLED PEN short or long acting?
A: APLEVANT 1.5MG PREFILLED PEN is a long-acting agonist which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day.
Q: Does APLEVANT 1.5MG PREFILLED PEN cause hair loss?
A: No. It does not cause hair loss from using the medicine. Hair loss was not a side effect seen in studies of APLEVANT 1.5MG PREFILLED PEN.
Q: How quickly does APLEVANT 1.5MG PREFILLED PEN work?
A: APLEVANT 1.5MG PREFILLED PEN starts working shortly after you start using it. However, it may take several weeks to a month to see the full effects of this medicine.
References
1. Celeste B Burness, Lesley J Scott; Dulaglutide: A Review in Type 2 Diabetes; [Published on Dec 2015] [Accessed on 18th December 2023] https://pubmed.ncbi.nlm.nih.gov/26423061/
2. Eli Lilly and Company; Trulicity (dulaglutide) for the Treatment of Type 2 Diabetes [Published on 2014] [Accessed on 18th December 2023] https://www.clinicaltrialsarena.com/projects/trulicity-type-2-diabetes/
3. Eli Lilly and Company Indianapolis, IN 46285, USA; U.S. Food & Drug Administration; [Revised on Jan 2017] [Accessed on 18th December 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125469s007s008lbl.pdf
4. Eli Lilly Italia S.p.A.,Via Gramsci 731/733, 50019, Sesto Fiorentino, Firenze (FI), Italy; Electronic Medicines Compendium (EMC); [Revised on Oct 2019] [Accessed on 18th December 2023] https://www.medicines.org.uk/emc/files/pil.3634.pdf
Useful Diagnostic Tests
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Glucose-Fasting Urine
- Insulin-Fasting
- Insulin Postprandial (PP)
Author Details
