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Introduction About AMVIL TABLET
AMVIL TABLET contains Pheniramine which belongs to the group of medicines called Antihistamines. It is used in the management of allergic conditions (such as hay fever, angioneurotic oedema, drug rashes, serum sickness, allergic conjunctivitis, food allergy), conditions of the respiratory tract which involves increased secretions (vasomotor rhinitis, acute rhinitis).
It is also used to manage itching skin conditions (such as neurodermatitis, lichen planus, eczema, acute and chronic urticaria, pruritus in jaundice and diabetes, pruritis of the anus or genitals, radiation sickness). It is also used to manage motion sickness and nausea, vomiting and vertigo due to Meniere’s disease (diseases of the inner ear) and other disturbances.
AMVIL TABLET should be used with caution in patients having asthma, bronchitis, severe liver or heart diseases, narrow angle glaucoma (increased pressure within the eye), intolerant to certain sugars such as lactose or if you have any planned surgery to undergo.
AMVIL TABLET should be used with caution in pregnant and breast-feeding women only if clearly advised by the doctor. AMVIL TABLET should not be used in children (below 5 years of age) including new-borns and premature babies.
The most common side effect of taking AMVIL TABLET is sedation (sleepiness). Ask for your doctor’s advice if the symptom worsens or bothers you.
Uses Of AMVIL TABLET
Manage:
- allergic conditions (such as hay fever, angioneurotic oedema, drug rashes, serum sickness, allergic conjunctivitis, food allergy)
- conditions of the respiratory tract which involves increased secretions (vasomotor rhinitis, acute rhinitis)
- itching skin conditions (such as neurodermatitis, lichen planus, eczema, acute and chronic urticaria, pruritus in jaundice and diabetes, pruritis of the anus or genitals, radiation sickness)
- motion sickness, nausea, vomiting and vertigo due to Meniere’s disease (diseases of the inner ear) and other disturbances
How AMVIL TABLET Works
AMVIL TABLET acts on certain receptors called H1 receptors and inhibits the action of a chemical called histamine. This inhibition reduces itching, allergic reactions and reduces the dilation of the vessels leading to less redness and oedema (swelling).
How to use AMVIL TABLET
Take AMVIL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not take the medicine on empty stomach. Your doctor will decide the correct dose and duration of the medicine for you depending upon your age, body weight and disease condition.
Side Effects Of AMVIL TABLET
Common
- sedation (drowsiness)
Rare
Stop taking AMVIL TABLET and inform your doctor immediately if you experience any of the following side effects:
- swelling of the face, lips, mouth or throat, which may cause difficulty in breathing or swallowing
- hives
- fainting, headache
- yellowing of the skin and eyes (jaundice)
- changes in your usual behaviour or mood
- severe sedation, confusion or restlessness
- waves of sudden severe stomach pain
- hallucinations (seeing and hearing things that aren’t there), vision problems
- irregular heartbeat
- frequent infections such as fever, severe chills, sore throat or mouth ulcers
How To Manage Side Effects
Drowsiness:
Try maintaining consistent sleep schedule. Move slowly and carefully to manage the risk of falling down, also avoid doing activities which requires mental concentration until you fell normal. Consult your doctor for advice if the symptom gets worse.
Warning & Precautions
Pregnancy
AMVIL TABLET should be used with caution in pregnant women only if clearly advised by the doctor. Consult your doctor before taking it.
Breastfeeding
AMVIL TABLET should be used with caution in breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or use machines if you feel drowsy after taking AMVIL TABLET.
Alcohol
Avoid consumption of alcohol while taking AMVIL TABLET as it may increase the adverse central nervous system effects of this medicine.
Liver
AMVIL TABLET should be used with caution in patients having severe hepatic disease and your doctor may adjust the dose in such patients. Consult your doctor before taking it.
Allergy
Do not take AMVIL TABLET if you are allergic to Pheniramine or any other ingredients of this medicine.
Lungs
AMVIL TABLET should be used with caution in patients having lung diseases such as asthma, bronchitis. Consult your doctor before taking it.
Heart Disease
AMVIL TABLET should be used with caution in patients having severe cardiovascular disease. Consult your doctor before taking it.
Others
Before taking AMVIL TABLET inform your doctor if you have:
- narrow angle glaucoma (increased pressure within the eye)
- enlarged prostate
- any scheduled surgery
- intolerant to certain sugars such as lactose
Use in paediatrics:
AMVIL TABLET is not recommended for use in children (below 5 years of age) and if your baby is new-born or born prematurely. Consult your child’s doctor for advice.
Interactions
A. Drug–Drug Interactions:
Before taking AMVIL TABLET inform your doctor if you are taking any of the following medicines:
- monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, phenelzine (used to manage depression)
- zolpidem, triazolam, alprazolam, diazepam (used to manage sleep disturbances and anxiety)
- atropine (used to manage low heart rate and reduce bronchial secretions)
- other anticholinergic drugs (used to manage nausea and vomiting due to motion sickness (Ex. scopolamine) and parkinson’s disease (Ex. benztropine))
Overdosage:
If you or anyone else accidentally takes too much of AMVIL TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of AMVIL TABLET are agitation and convulsions especially in children and hallucinations, restlessness, disorientation in adults.
Synopsis
| Drug | : |
Pheniramine |
| Pharmacological Category | : |
Antihistamine |
| Therapeutic Indication | : |
Allergic conditions, Conditions of the respiratory tract Itching skin conditions, Motion sickness and symptoms of Meniere’s disease |
| Dosage Forms | : |
Tablet, Injection |
More Information
- Keep AMVIL TABLET out of reach of children
- Store AMVIL TABLET at room temperature
FAQs About AMVIL TABLET
Can AMVIL TABLET impair my ability to drive?
The most common side effect of AMVIL TABLET is sedation (drowsiness), which means it can make you sleepy. Do not drive or use machines if you feel drowsy after taking AMVIL TABLET. You can continue with the activities once you feel normal again.
Is AMVIL TABLET safe for use in asthmatic patients?
AMVIL TABLET should be used with caution in patients having lung diseases such as asthma. Since AMVIL TABLET is an antihistamine which means it dry up the secretions in the upper and lower respiratory tract which may cause difficulty in breathing. Consult with your doctor for advice before taking AMVIL TABLET.
Can AMVIL TABLET be used in children?
AMVIL TABLET is not recommended for use in children (below 5 years of age) and if your baby is new-born or born prematurely. Consult your child’s doctor for advice to select a suitable alternative for your child to manage the specific condition.
Can AMVIL TABLET be used in pregnant women?
AMVIL TABLET should be used with caution in pregnant women only if clearly advised by the doctor. Consult your doctor before taking AMVIL TABLET if you are pregnant or planning to get pregnant.
Is AMVIL TABLET safe to use in patients with liver disease?
AMVIL TABLET should be used with caution in patients having severe hepatic disease and your doctor may adjust the dose in such patients. Your doctor may monitor your liver function test during management with this medicine to manage the risk of any unusual effects. Consult your doctor for advice before taking AMVIL TABLET.
References
1. K.D. Tripathi. Histamines and Antihistamines. Essentials of medical pharmacology. Seventh edition. 2013. Page – 164.
2. C Collins-Williams. Antihistamines in Asthma. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1987 [Accessed on 6th July 2022] https://pubmed.ncbi.nlm.nih.gov/3333250/
3. Aastha Gupta, Pooja Arora, Purnima Malhotra, Kabir Sardana. Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 6th July 2022] https://pubmed.ncbi.nlm.nih.gov/30142724/
4. Pheniramine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Pheniramine
5. Sanofi India Limited. Avil. Pheniramine Maleate [Revised in February 2021]. [Accessed on 6th July 2022] https://www.sanofi.in/dam/jcr:a419c36b-e92e-4a38-8b6f-9aefe636b9e7/Avil%20-%20PI%2025072019.pdf
6. Sanofi-aventis Australia Pty ltd. Avil. Pheniramine Maleate [Revised in February 2020]. [Accessed on 6th July 2022] https://media.healthdirect.org.au/medicines/GuildLink_Information/191053/CMI/swcavilt10220.pdf
Useful Diagnostic Tests
- Chest X-ray
- Complete blood count
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