New Revised MRP, 100% GST benefit passed Amlovas CH 5/6.25mg Tablet 10'S
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Introduction About AMLOVAS CH 5/6.25MG TABLET
AMLOVAS CH 5/6.25MG TABLET is a combination of Amlodipine and Chlorthalidone which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) and certain type of angina (chest pain) known as Prinzmetal or variant angina.
It can also be used to manage heart failure and diabetes insipidus (a condition in which an individual produces large amounts of dilute urine and is constantly thirsty) and can reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases.
Take this medicine preferably in the mornings with food. While taking AMLOVAS CH 5/6.25MG TABLET, do not drink alcohol/grapefruit juice or go for a low-salt diet, as they may make further reduce your blood pressure. Consult your doctor for the best diet that can suit your health condition.
Before taking AMLOVAS CH 5/6.25MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, high blood cholesterol levels, dehydration or very low blood sodium, potassium or magnesium levels as a precaution.
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in patients with other severe heart problems such as narrowing of heart valves or cardiogenic shock. It is also not suitable for use in patients with severe hypotension (low blood pressure).
Do not take AMLOVAS CH 5/6.25MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding without consulting your doctor.
The most common side effects of taking AMLOVAS CH 5/6.25MG TABLET are headache, dizziness, sleepiness, tiredness, racing heartbeat, indigestion, constipation, muscle cramps, low blood potassium or sodium levels, impotence in men and low sex drive. Contact your doctor if any of these side effects trouble you.
Uses Of AMLOVAS CH 5/6.25MG TABLET
It is used to manage:
- Hypertension (high blood pressure)
- Heart failure
- Angina (Prinzmetal angina)
- Diabetes insipidus (a condition causing excessive urination and thirst)
- Edema (fluid retention)
How AMLOVAS CH 5/6.25MG TABLET Works
AMLOVAS CH 5/6.25MG TABLET contains two medicines namely amlodipine and chlorthalidone. Amlodipine is a vasodilator. It relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows blood to flow more smoothly across the blood vessels.
Chlorthalidone is a diuretic (water pill). It removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine. This action reduces fluid retention (edema) from the body. Collectively, these actions improve blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.
How to use AMLOVAS CH 5/6.25MG TABLET
Always take AMLOVAS CH 5/6.25MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. AMLOVAS CH 5/6.25MG TABLET is preferably taken during the mornings with food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking AMLOVAS CH 5/6.25MG TABLET without consulting your doctor.
Side Effects Of AMLOVAS CH 5/6.25MG TABLET
Common
- headache, dizziness, sleepiness
- palpitations (fast heartbeat)
- flushing (redness and warmth of the skin)
- stomach pain, nausea, diarrhea, constipation, indigestion
- changes in bowel habit
- tiredness, weakness
- visual disturbances, double vision
- muscle pains
- low blood potassium levels causing muscle weakness, twitching or abnormal heartbeat
- high blood uric acid levels
- increased blood cholesterol levels
- low blood sodium levels (causing tiredness, confusion, muscle twitching, fits or fainting)
- low blood magnesium levels
- high blood sugar levels (causing tiredness, weakness or excessive thirst)
- skin rash
- low blood pressure which may make you feel dizzy while standing up
- impotence in men
Uncommon
- anxiety, depression
- insomnia (sleeplessness)
- changes in taste
- tingling sensation in limbs, loss of pain sensation
- ringing in the ears
- low blood pressure
- increased sweating
- increased urination at night
- inability to obtain an erection, enlargement of the breasts in men
- joint pain, back pain
- weight gain or decrease in weight
- gout
Rare
- confusion
- high blood calcium levels (causing agitation, eye pain or inflammation, stomach pain)
- sugar in urine
- skin sensitivity
- fast or slow heartbeat
- pins and needles
- kidney problems
Stop taking AMLOVAS CH 5/6.25MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
How To Manage Side Effects
Nausea and vomiting:
Take AMLOVAS CH 5/6.25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, consult your doctor before taking it.
Breastfeeding
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk and harm the nursing infant. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking AMLOVAS CH 5/6.25MG TABLET.
Alcohol
Avoid consumption of alcohol while taking AMLOVAS CH 5/6.25MG TABLET as it might make you feel dizzier and drowsier.
Kidney
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver diseases. Therefore, consult your doctor before taking it.
Allergy
Do not take AMLOVAS CH 5/6.25MG TABLET if you are allergic to Amlodipine or Chlorthalidone.
Heart Disease
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of recent heart attack or heart failure. Therefore, consult your doctor before taking it.
Others
AMLOVAS CH 5/6.25MG TABLET is not recommended for use if you:
- have abnormally very low blood pressure
- are not passing urine at all
- have low blood potassium levels (hypokalemia)
- have low blood sodium levels (signs include tiredness, confusion, muscle twitching, fits or lack of consciousness)
- high blood calcium levels
- have gout
- have Addison’s disease (a problem in adrenal gland)
Before taking AMLOVAS CH 5/6.25MG TABLET, inform your doctor if you have:
- severe uncontrollable increase in blood pressure (hypertensive crisis)
- are on a low-salt diet
- have diabetes
- have high blood cholesterol levels
- are undergoing any surgery (including dental surgery)
Use in Pediatrics:
AMLOVAS CH 5/6.25MG TABLET is not recommended for use in children aged below 6 years. It should be used in children and adolescents (aged between 6-17 years) only if prescribed by the physician. Therefore, consult your doctor for advice before administration.
Use in Geriatrics:
AMLOVAS CH 5/6.25MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor for advice before taking it.
Interactions
A. Drug - Drug interactions:
Before taking AMLOVAS CH 5/6.25MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to reduce elevated blood pressure and other heart problems (Ex. atenolol, propranolol, enalapril, lisinopril, amlodipine, nifedipine, diltiazem, verapamil, methyldopa, guanethidine)
- ketoconazole, itraconazole (used to manage fungal infections)
- ritonavir, indinavir, nelfinavir (used in management of HIV infections)
- rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
- dantrolene (a medicine used to manage muscle spasms)
- medicines used to control elevated cholesterol levels (Ex. simvastatin, cholestyramine)
- medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
- St. John’s wort (an herbal medicine used to manage depression)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
- corticotropin (a medicine used to correct hormone problems)
- medicines used for cancer (Ex. temsirolimus, cyclophosphamide, methotrexate)
- medicines used to manage asthma (such as salbutamol, formoterol)
- amphotericin B (a medicine used to manage fungal infections)
- carbenoxolone (a medicine used to manage mouth ulcers)
- anticholinergics (used to manage stomach muscle spasms) such as atropine, hyoscine
- lithium (a medicine used to manage various mental health problems)
- digoxin (a medicine used to manage irregular heartbeat)
- allopurinol (a medicine used to manage gout)
- amantadine (a medicine used for parkinsonism or viral infections)
- non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
- calcium and vitamin D supplements
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking AMLOVAS CH 5/6.25MG TABLET, as it could further decrease your blood pressure.
Overdosage:
If you or anyone else accidentally took more AMLOVAS CH 5/6.25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.
Synopsis
| Drug | : | Amlodipine, Chlorthalidone |
| Pharmacological Category | : | Calcium-channel blockers, Thiazide Diuretics |
| Therapeutic Indication | : | Hypertension, Angina, Heart failure, Edema, Diabetes insipidus |
| Dosage Forms | : | Tablet |
More Information
- Keep AMLOVAS CH 5/6.25MG TABLET out of the sight and reach of children
- Store AMLOVAS CH 5/6.25MG TABLET at room temperature
FAQs About AMLOVAS CH 5/6.25MG TABLET
Q: What are the uses of AMLOVAS CH 5/6.25MG TABLET?
A: AMLOVAS CH 5/6.25MG TABLET is used to manage hypertension (high blood pressure) and certain type of angina (chest pain) known as Prinzmetal or variant angina. It can also be used to manage heart failure and diabetes insipidus and can reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases.
Q: What type of a medicine is AMLOVAS CH 5/6.25MG TABLET?
A: AMLOVAS CH 5/6.25MG TABLET relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows blood to flow more smoothly across the blood vessels. It also removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine. Collectively, these actions decrease fluid retention, improves blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.
Q: What happens when I stop taking AMLOVAS CH 5/6.25MG TABLET?
A: Do not stop taking AMLOVAS CH 5/6.25MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take AMLOVAS CH 5/6.25MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
Q: What is the best time to take AMLOVAS CH 5/6.25MG TABLET?
A: Take this medicine preferably in the mornings with food. However, consult your doctor for advice.
Q: What to do if I forgot to take a dose of AMLOVAS CH 5/6.25MG TABLET?
A: If you have missed a dose of AMLOVAS CH 5/6.25MG TABLET, take it as soon as you remember. However, if it is time for the next dose of AMLOVAS CH 5/6.25MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of AMLOVAS CH 5/6.25MG TABLET to compensate the missed ones.
Q: What precautions should be followed while taking AMLOVAS CH 5/6.25MG TABLET?
A: Before taking AMLOVAS CH 5/6.25MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe high or low blood pressure or other heart problems (such as narrowing of the arteries, cardiogenic shock or a recent heart attack). Do not take AMLOVAS CH 5/6.25MG TABLET if you are pregnant and breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking AMLOVAS CH 5/6.25MG TABLET?
A: Avoid consumption of alcohol while taking AMLOVAS CH 5/6.25MG TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more AMLOVAS CH 5/6.25MG TABLET?
A: If you or anyone else accidentally took more AMLOVAS CH 5/6.25MG TABLET, consult your doctor immediately. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.
Q: Can I take AMLOVAS CH 5/6.25MG TABLET daily?
A: Take AMLOVAS CH 5/6.25MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take AMLOVAS CH 5/6.25MG TABLET every day or not.
Q: What are the side effects of AMLOVAS CH 5/6.25MG TABLET?
A: The most common side effects of taking AMLOVAS CH 5/6.25MG TABLET are headache, dizziness, sleepiness, tiredness, racing heartbeat, indigestion, constipation, muscle cramps, low blood potassium or sodium levels, impotence in men and low sex drive. Contact your doctor if any of these side effects trouble you.
Q: Can I stop taking AMLOVAS CH 5/6.25MG TABLET once my symptoms subside?
A: No. Do not stop taking AMLOVAS CH 5/6.25MG TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take AMLOVAS CH 5/6.25MG TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can AMLOVAS CH 5/6.25MG TABLET causes electrolyte imbalance?
A: Yes. AMLOVAS CH 5/6.25MG TABLET may alter the levels of certain electrolytes (sodium or potassium) in the body. To avoid this, your doctor will closely monitor the electrolytes levels in the blood periodically. However, if you experience any unusual symptoms such as chest pain, muscle weakness, irregular heartbeat, confusion, drowsiness, nausea or vomiting, consult your doctor for advice.
Q: Can the use of AMLOVAS CH 5/6.25MG TABLET affect my sexual life?
A: Yes. AMLOVAS CH 5/6.25MG TABLET may cause impotence in men and low sex drive in both men and women. Consult your doctor if they trouble you.
Q: Can AMLOVAS CH 5/6.25MG TABLET be taken during pregnancy?
A: AMLOVAS CH 5/6.25MG TABLET is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before taking it.
Q: Is AMLOVAS CH 5/6.25MG TABLET safe to use in kidney disease?
A: AMLOVAS CH 5/6.25MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Q: Can the use of AMLOVAS CH 5/6.25MG TABLET affect the liver?
A: Yes. AMLOVAS CH 5/6.25MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Does AMLOVAS CH 5/6.25MG TABLET cause frequent urination?
A: Yes. AMLOVAS CH 5/6.25MG TABLET may cause frequent urination. It is because AMLOVAS CH 5/6.25MG TABLET contains a medicine called chlorthalidone which is a diuretic (water pill). It excretes the excess water from the body in the form of urine. Therefore, it is advised to take AMLOVAS CH 5/6.25MG TABLET at least 5 hours before bedtime to avoid the urge at night to urinate.
References
1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Diuretics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 549, 562, 559 & 583.
2. Paul Muntner, PhD, Emily B. Levitan, PhD, Amy I. Lynch, PhD, Lara M. Simpson, PhD, Jeffrey Whittle, MD, Barry R. Davis, MD, PhD, John B. Kostis, MD, Paul K. Whelton, MD and Suzanne Oparil, MD. Effect of Chlorthalidone, Amlodipine and Lisinopril on Visit-to-Visit Variability of Blood Pressure: Results From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. . National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. April 2014. [Accessed on 2nd January 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141643/
3. Kishen G. Bulsara; Manouchkathe Cassagnol. Amlodipine. StatPearls. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. January 2022. [Accessed on 1st October 2022]. https://www.ncbi.nlm.nih.gov/books/NBK519508/
4. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 2nd January 2023]. https://www.medicines.org.uk/emc/files/pil.3478.pdf
5. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 2nd January 2023]. https://www.medicines.org.uk/emc/files/pil.13960.pdf
6. Atlantic Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 2nd January 2023]. https://www.medicines.org.uk/emc/files/pil.11982.pdf
Useful Diagnostic Tests
- Kidney Function Test
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