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Alkem Laboratories Ltd

ALSITA M 100 FORTE Tablet 10's

Diabetes
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    Introduction About ALSITA M 100 FORTE TABLET

    ALSITA M 100 FORTE TABLET is used to control blood sugar levels in patients with type II diabetes mellitus, along with proper diet and exercise. It is a combination of Metformin and Sitagliptin, which belongs to the group of medicines called Antidiabetic agents.

    Before taking ALSITA M 100 FORTE TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. During therapy with ALSITA M 100 FORTE TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. You may asked to make certain lifestyle changes, such as following a healthy diet, regular physical exercise, and quitting alcohol consumption, to achieve better results.

    ALSITA M 100 FORTE TABLET is not recommended for use in patients with severe, uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock, or problems with breathing or blood circulation. Consult your doctor before taking ALSITA M 100 FORTE TABLET if you are pregnant or breastfeeding. The most common side effects of taking ALSITA M 100 FORTE TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain. Consult your doctor if they bother you.

    Uses Of ALSITA M 100 FORTE TABLET

    How ALSITA M 100 FORTE TABLET Works

    ALSITA M 100 FORTE TABLET is an antidiabetic medicine. It contains two medicines, namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body. Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon, and a stronger insulin response to glucose.

    How to use ALSITA M 100 FORTE TABLET

    • Take ALSITA M 100 FORTE TABLET, preferably after meals or as advised by your physician
    • Swallow the medicine with a glass of water. Do not crush or chew the medicine
    • Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition
    • Do not stop taking unless your doctor advises you to stop

    Side Effects Of ALSITA M 100 FORTE TABLET

    Common side effects of ALSITA M 100 FORTE TABLET:

    • hypoglycemia (low blood sugar)
    • flatulence, diarrhea, constipation, stomach pain, and loss of appetite
    • swelling of the hands and legs (edema)
    • metallic taste
    • drowsiness, dizziness
    • dry mouth

    Stop taking and consult your doctor immediately if you experience any of the following side effects:

    • serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
    • severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
    • signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
    • signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

    Warning & Precautions

    Pregnancy

    Contraindicated

    ALSITA M 100 FORTE TABLET is not recommended for use by pregnant women. Therefore, inform your doctor before taking this medicine if you are pregnant, think you may be pregnant, or are planning to have a baby.

    Breastfeeding

    Contraindicated

    ALSITA M 100 FORTE TABLET is not recommended for use by breastfeeding women.  

    Driving and Using Machines

    Use with Caution

    Do not drive or operate any machines if you feel dizzy after taking ALSITA M 100 FORTE TABLET.

    Alcohol

    Consult your doctor

    Avoid consumption of alcohol while taking ALSITA M 100 FORTE TABLET, as it may increase the risk of unwanted side effects.

    Kidney

    Contraindicated

    ALSITA M 100 FORTE TABLET is not recommended for use in patients with severely reduced kidney functions.

    Liver

    Consult your doctor

    ALSITA M 100 FORTE TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gallstones.

    Allergy

    Contraindicated

    Do not take ALSITA M 100 FORTE TABLET if you are allergic to metformin or sitagliptin or any other ingredients of this medicine.

    Heart Disease

    Contraindicated

    ALSITA M 100 FORTE TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack).  

    Use In Pediatrics

    Contraindicated

    ALSITA M 100 FORTE TABLET is not recommended for use in children and adolescents (aged below 18 years).  

    Use In Geriatrics

    Use with Caution

    ALSITA M 100 FORTE TABLET should be used with caution in elderly patients (aged above 65 years).

    Others

    It is not recommended for use if you:

    • have severe, uncontrollable diabetes
    • have nausea, vomiting, diarrhea, or rapid weight loss
    • have lactic acidosis or ketoacidosis (a buildup of lactic acid or ketones in the body)
    • are dehydrated
    • have any severe systemic infection
    • have shock or problems in blood circulation
    • have problems in breathing
    • are an alcoholic
    • are scheduled for any X-rays in the upcoming days

    Before taking the medicine, inform your doctor if you:

    • have or ever had pancreatitis (inflammation of the pancreas)
    • have alcohol dependence
    • have high blood lipid levels
    • have type I diabetes mellitus (insulin-dependent diabetes)
    • are about to have a major surgery
    • are fasting
    • are malnourished, starved, on an irregular diet, or feeling weak
    • perform extreme muscle exercises
    • have a vitamin B12 deficiency

    Interactions

    A. Drug-Drug interactions:

    Before taking ALSITA M 100 FORTE TABLET, inform your doctor if you are taking any of the following medicines, such as:

    • Anti-diabetics (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
    • iodine contrast medium
    • Bronchodilators (Ex. salbutamol or terbutaline)
    • corticosteroids Ex. hydrocortisone, prednisolone)
    • diuretics (Ex. furosemide, hydrochlorothiazide)
    • NSAID’s (Ex. ibuprofen and celecoxib)
    • Antihypertensives (Ex. atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, and telmisartan)
    • alcohol-containing medicines (such as cough syrups)
    • H2 blockers (Ex. cimetidine)
    • Anti-viral agents (Ex. dolutegravir)
    • Anti-Anginal agents (Ex. ranolazine)
    • Antibiotics (Ex. trimethoprim)
    • Cardiac glycosides (Ex. digoxin)

    Overdosage:

    If you or anyone else accidentally took more ALSITA M 100 FORTE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, and fast breathing.

    Synopsis

    Drug :   Metformin, Sitagliptin
    Pharmacological Category :   Biguanides, DPP-4 Inhibitors
    Therapeutic Indication :   Type II diabetes mellitus          
    Dosage Forms :   Tablet, Capsule, Combi pack

    More Information

     

     

    FAQs About ALSITA M 100 FORTE TABLET

    Q: What is ALSITA M 100 FORTE TABLET used for?

    A: It is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.

    Q: How and when to take ALSITA M 100 FORTE TABLET?

    A: Take ALSITA M 100 FORTE TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

    Q: How long should I take ALSITA M 100 FORTE TABLET?

    A: You need to take as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

    Q: What is the best time to take ALSITA M 100 FORTE TABLET?

    A: It must be taken with meals to avoid gastrointestinal side effects.

    Q: What should I do if I forget to take a dose of ALSITA M 100 FORTE TABLET?

    A: If you forgot to take a dose of ALSITA M 100 FORTE TABLET, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and take the next one regularly.

    Q: What are the most common side effects of taking ALSITA M 100 FORTE TABLET?

    A: The most common side effects are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain.

    Q: Can I stop taking ALSITA M 100 FORTE TABLET without consulting your doctor?

    A: No. You should not stop taking ALSITA M 100 FORTE TABLET without consulting your doctor because it may lead to a reversal of symptoms.

    Q: Will taking a higher dose of ALSITA M 100 FORTE TABLET be more effective?

    A: No, taking a higher dose will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

    Q: What precautions do I need to follow while taking ALSITA M 100 FORTE TABLET?

    A: Before taking ALSITA M 100 FORTE TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results.

    Q: Can I take medication for high blood pressure along with ALSITA M 100 FORTE TABLET?

    A: It is not advisable to take medicines to control blood pressure while taking ALSITA M 100 FORTE TABLET without consulting your doctor.

    Q: What should I do if I experience low blood sugar after taking ALSITA M 100 FORTE TABLET?

    A: Low blood sugar is a common side effect. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat), consume a sugary snack or sugar drink immediately.

    Q: Can ALSITA M 100 FORTE TABLET be taken with insulin?

    A: Co-administration of ALSITA M 100 FORTE TABLET with insulin is considered risky as it increases the chance of hypoglycemia (decreased blood sugar levels.

    Q: Can ALSITA M 100 FORTE TABLET be used in pregnant women?

    A: No. it is not recommended for use by pregnant women.

    Q: How much ALSITA M 100 FORTE TABLET should I take?

    A: It should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body condition, and severity of the disease.

    Q: Can ALSITA M 100 FORTE TABLET cause constipation?

    A: Yes. Constipation is a common side effect. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly when taking this medicine.

    References

    1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-274 & 275.

    2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 19th January 2024] click here

    3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 19th January 2024]  click here

    4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 19th January 2024] click here

    5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 19th January 2024] click here

    6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 19th January 2024] click here

    7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 19th January 2024] click here

    8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 19th January 2024] click here

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    Author Details

    Written By Srilekha. R - B.Pharm
    Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)
    Last updated on 18 Nov 2024 | 12:26 PM(IST)
    Lab updated