ALSITA GM 2 FORTE Tablet 10's

Introduction About ALSITA GM 2 FORTE TABLET

ALSITA GM 2 FORTE TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride,  Metformin and Sitagliptin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin.

Before taking ALSITA GM 2 FORTE TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding before taking the medicine. ALSITA GM 2 FORTE TABLET is not suitable for use by children and adolescents under 18 years of age.

Avoid consumption of alcohol during management with ALSITA GM 2 FORTE TABLET as it may increase or decrease the blood sugar lowering action of ALSITA GM 2 FORTE TABLET and increases the risk of lactic acidosis. The most common side effects of taking ALSITA GM 2 FORTE TABLET are taste disturbance, nausea, diarrhea, stomachache, and vomiting. Contact your doctor if any of the above symptoms worsen.

Uses Of ALSITA GM 2 FORTE TABLET

• It is used to manage type 2 diabetes mellitus

How ALSITA GM 2 FORTE TABLET Works

ALSITA GM 2 FORTE TABLET is a combination of Glimepiride, Metformin, and Sitagliptin. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing the intestinal absorption of glucose, and in muscles by increasing insulin sensitivity and improving peripheral glucose uptake and utilization. Glimepiride blocks the ATP-sensitive potassium channel by binding non-specifically to the B sites of both sulfonylurea receptor-1 (SUR1) and sulfonylurea receptor-2A (SUR2A) subunits as well as the A site of SUR1 subunit of the channel to promote insulin secretion from the beta cell. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar when there is too much sugar in the blood.

How to use ALSITA GM 2 FORTE TABLET

Take ALSITA GM 2 FORTE TABLET as advised by your physician. Swallow ALSITA GM 2 FORTE TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking ALSITA GM 2 FORTE TABLET without informing your doctor.

Overdose

If you or anyone else take too much of ALSITA GM 2 FORTE TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ALSITA GM 2 FORTE TABLET includes risk of low blood sugar levels, and it may cause lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.

Side Effects Of ALSITA GM 2 FORTE TABLET

Common side effects of ALSITA GM 2 FORTE TABLET:

• nausea
• diarrhea
• abdominal pain
• hypoglycaemia
• taste change
• flatulence
• stomach pain
• headache
• skin rash
• upper respiratory tract infection

Stop taking ALSITA GM 2 FORTE TABLET and consult your doctor immediately if you experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels including loss of consciousness, seizures

How To Manage Side Effects

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.

Nausea And Vomiting

Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.

Stomach Pain

Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own; consult your doctor if the symptom does not improve on its own.

Warning & Precautions

Pregnancy

Contraindicated

ALSITA GM 2 FORTE TABLET may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Consult your doctor for advice.

Breastfeeding

Contraindicated

ALSITA GM 2 FORTE TABLET is not recommended for breast-feeding women as it may pass through the breast milk, since there are no limited studies available. A decision on whether to continue should be made, considering the benefit and the potential risk of adverse effects on the child. Consult your doctor before taking the medicine.

Driving and Using Machines

Use with Caution

ALSITA GM 2 FORTE TABLET have no or negligible influence on the ability to drive and use machines. However, when driving or using machines, it should be taken into account that dizziness and somnolence have been reported with sitagliptin. In addition, patients should be alerted to the risk of hypoglycaemia.

Alcohol

Contraindicated

Avoid consumption of alcohol during management with ALSITA GM 2 FORTE TABLET as it may increase or decrease the blood sugar lowering action of ALSITA GM 2 FORTE TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking ALSITA GM 2 FORTE TABLET

Kidney

Consult your doctor

ALSITA GM 2 FORTE TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking ALSITA GM 2 FORTE TABLET.

Liver

Consult your doctor

ALSITA GM 2 FORTE TABLET is not recommended if you have severe liver disease, and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function. Consult your doctor before taking ALSITA GM 2 FORTE TABLET.

Allergy

Contraindicated

Do not take ALSITA GM 2 FORTE TABLET if you are allergic (hypersensitive) to Glimepiride, Metformin or Sitagliptin or other sulfonylureas (such as glipizide, glibenclamide) or sulphonamides (such as sulfamethoxazole).

Use In Pediatrics

Contraindicated

ALSITA GM 2 FORTE TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult the child’s doctor for advice.

Use In Geriatrics

Monitoring required

A lower dose is required, and close monitoring of glycaemic levels and onset of gastrointestinal symptoms is necessary for elderly patients. Consult your doctor before taking ALSITA GM 2 FORTE TABLET.

Other Warnings for ALSITA GM 2 FORTE TABLET

Before taking ALSITA GM 2 FORTE TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take ALSITA GM 2 FORTE TABLET

ALSITA GM 2 FORTE TABLET is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes with nausea, vomiting, rapid weight loss, diarrhea, lactic acidosis (lactic acid build up in the bloodstream) or ketoacidosis (ketone bodies accumulate in the blood)
• dehydration
• severe infection (such as infection affecting lungs or kidneys)

Drug - Drug interaction

• Imidazoles (Ex. Miconazole, Fluconazole)
• Antibiotics (Ex. Rifampin, vancomycin)
• Diuretics (Ex. Furosemide)
• Calcium-channel blockers (Ex. Nifedipine)
• Potassium-sparing diuretic (Ex. Amiloride, triamterene)
• Cardiac glycosides (Ex. digoxin, morphine, procainamide, quinidine, quinine)
• H2 blockers (Ex. Ranitidine)
• Antibacterial drugs (Ex. Trimethoprim)
• Corticosteroids
• Anti-psychotics (Ex. Phenothiazine)
• Anti-Thyroid agents
• Estrogens, Oral contraceptives
• Anti-convulsants (Ex. Phenytoin)
• Pyridinecarboxylic acids (Ex. Nicotinic acid

Synopsis

More Information

FAQs About ALSITA GM 2 FORTE TABLET

References

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eight edition. 2019. Page-299.

2. Kesavadev J, Pillai PBS, Shankar A, Krishnan G, Jothydev S. Sitagliptin 100 mg vs glimepiride 1-3 mg as an add-on to insulin and metformin in type 2 diabetes (SWIM). Endocr Connect. 2017. [Accessed on 15th July 2026]

3. Merck Sharp & Dohme B.V. Electronic Medicines Compendium (EMC). [Revised in June 2023] [Accessed on 15th July 2026

4. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC) [Revised in December 2020] [Accessed on 15th July 2026]

5. Elara Pharma services Limited. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 15th July 2026]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, also known as Glycated Haemoglobin, Glycosylated Haemoglobin

Author Details

Written By Dr. Shruthi M R - BDS

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 16 Jul 2026 | 12:25 PM(IST)