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Glaxosmithkline Pharmaceuticals Ltd

Alpha D3 0.25Mcg Capsule 10'S

Osteoporosis
MRP ₹82.35 (Inclusive of all taxes)
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    Introduction About ALPHA D3 0.25MCG CAPSULE

    ALPHA D3 0.25MCG CAPSULE contains Alfacalcidol, which belongs to the group of medicines called Vitamin D analogues. It is used to manage osteodystrophy (changes in bone caused by kidney failure) and changes in parathyroid glands (responsible for producing parathyroid hormone, which controls the amount of calcium in the body).

    ALPHA D3 0.25MCG CAPSULE is also used to manage hypocalcaemia (decreased calcium levels) in newborn babies and osteomalacia or rickets (softening and deformity of the bones due to a lack of calcium).

    During the management with ALPHA D3 0.25MCG CAPSULE, your doctor may conduct blood tests to determine the amount of calcium and phosphorus in the blood, an enzyme called alkaline phosphatase, or the parathyroid hormone. You may also have other tests, such as X-rays, to determine the dose that fits you.

    ALPHA D3 0.25MCG CAPSULE is not recommended for use in patients with hypercalcaemia (high levels of calcium in the blood) or calcification (high levels of calcium in your body tissues). Contact your doctor before taking.

    ALPHA D3 0.25MCG CAPSULE should be used with caution in patients with kidney disease, kidney stones, granulomas, or sarcoidosis (collection of inflammatory cells). Contact your doctor before taking.

    ALPHA D3 0.25MCG CAPSULE should be used with caution by pregnant and breastfeeding women. Consult with your doctor before taking. ALPHA D3 0.25MCG CAPSULE can be used in children and elderly patients. Your doctor will decide the correct dose and duration depending on your age, body weight, and disease condition. Consult with your doctor before taking.

    The most common side effects of taking ALPHA D3 0.25MCG CAPSULE are abdominal pain, rash, and itching. Contact your physician if the symptoms worsen or don’t improve.

    Uses Of ALPHA D3 0.25MCG CAPSULE

    To manage:

    • Osteodystrophy
    • Hyperparathyroidism & hypoparathyroidism
    • hypocalcaemia (decreased calcium levels) in newborn babies
    • osteomalacia or rickets

    How ALPHA D3 0.25MCG CAPSULE Works

    ALPHA D3 0.25MCG CAPSULE works by increasing the amount of vitamin D (controls the levels of calcium and phosphorus required for healthy bones and teeth) in the body. ALPHA D3 0.25MCG CAPSULE stimulates calcium absorption in the intestines, increases urinary calcium excretion and serum calcium levels, and suppresses parathyroid hormone (PTH) secretion. Thus, increasing the levels of calcium and phosphate in the body and restoring the essential functions and activities of vitamin D.

    How to use ALPHA D3 0.25MCG CAPSULE

    Take ALPHA D3 0.25MCG CAPSULE as advised by your physician. Swallow the medicine with water, and do not crush or chew the medicine. Dose and duration will be decided by your physician depending upon your age, body weight, and disease condition.

    Side Effects Of ALPHA D3 0.25MCG CAPSULE

    Common

    • abdominal pain
    • rash, itching

    Uncommon

    • headache
    • nausea, vomiting, diarrhea, constipation
    • muscle pain
    • fatigue
    • calcinosis (deposition of calcium in the body)
    • feeling weak or unwell

    Stop taking ALPHA D3 0.25MCG CAPSULE and contact your physician immediately if you experience any of the following side effects:

    • signs of an allergic reaction such as severe rashes, swelling of the face or throat, and difficulty breathing
    • signs of too much calcium or phosphate in your body, such as muscle pain or bone pain and weakness, the need to pass urine more often, feeling thirsty, fatigue, nausea, vomiting, constipation, loss of appetite, sweating a lot, headache, confusion, and drowsiness
    • signs of kidney problems such as decreased frequency of urination, swelling of feet or ankles, fever, and pain in one side (kidney stones) 

    How To Manage Side Effects

    Constipation

    Eat fiber-rich foods such as fresh fruits, vegetables, and cereals. Drink more water and exercise regularly. Contact your doctor if constipation does not improve.

    Diarrhea

    Drink lots of fluids, such as water or fruit juices, to keep you hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if diarrhea worsens.

    Dizziness Or Drowsiness

    Try to rest and relax. Get enough sleep. Do not drive or operate any machinery if you feel dizzy. Avoid alcohol consumption, as it aggravates dizziness. Contact your doctor if the dizziness worsens.

    Nausea And Vomiting

    Take ALPHA D3 0.25MCG CAPSULE, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if nausea and vomiting worsen.

    Skin rash Or Itching

    Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if the itching worsens.

    Stomach Pain

    Try to rest and relax. Eat small and frequent meals. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.

    Warning & Precautions

    Pregnancy

    Use with Caution

    ALPHA D3 0.25MCG CAPSULE should be used with caution in pregnant women. Therefore, consult your doctor before taking it.

    Breastfeeding

    Use with Caution

    ALPHA D3 0.25MCG CAPSULE should be used with caution in breastfeeding women. Therefore, consult your doctor before taking it.

    Driving and Using Machines

    Use with Caution

    Do not drive or operate machines if you feel dizzy after taking ALPHA D3 0.25MCG CAPSULE.

    Kidney

    Use with Caution

    ALPHA D3 0.25MCG CAPSULE should be used with caution in patients with kidney disease or kidney stones. Therefore, consult your doctor before taking it.

    Allergy

    Contraindicated

    Do not take ALPHA D3 0.25MCG CAPSULE if you are allergic to Alfacalcidol, sesame oil, or other ingredients of this medicine.

    Use In Pediatrics

    Monitoring required

    ALPHA D3 0.25MCG CAPSULE can be used in children and adolescents (aged below 18 years) if prescribed by the physician.

    Use In Geriatrics

    Consult your doctor

    ALPHA D3 0.25MCG CAPSULE can be used for elderly patients. Your doctor will decide the correct dose and duration depending on your age, body weight, and disease condition. Consult with your doctor before taking.

    Others

    ALPHA D3 0.25MCG CAPSULE is not recommended for use if you have:

    • hypercalcaemia (high levels of calcium in the blood)
    • calcification (elevated calcium levels in body tissues).

    Before taking ALPHA D3 0.25MCG CAPSULE, inform your doctor if you have:

    • granulomas or sarcoidosis

    Interactions

    A. Drug-Drug interactions:

    Before taking ALPHA D3 0.25MCG CAPSULE, inform your doctor if you are taking any of the following medicines:

    • barbiturates, phenytoin, carbamazepine, or primidone (medicines used to manage fits)
    • digoxin (medicine used for heart failure)
    • thiazide diuretics such as chlorothiazide (medicines used for high blood pressure)
    • other medicines that contain vitamin D or calcium (Ex. calcipotriol, doxercalciferol, and calcitriol)
    • antacids containing magnesium or aluminium (medicines used for heartburn or indigestion)
    • bile acid sequestrants such as cholestyramine (medicines used for lowering cholesterol levels)

    Overdosage:

    If you or anyone else accidentally takes too much of ALPHA D3 0.25MCG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include too much calcium or phosphate in your blood, causing weakness or pain in muscles or bones, the need to pass urine more often, feeling thirsty, fatigue, nausea, vomiting, constipation, loss of appetite, sweating a lot, headache, confusion, and drowsiness.

    Synopsis

    Drug :   Alfacalcidol
    Pharmacological Category :   Vitamin D analogues
    Therapeutic Indication :   Osteodystrophy, hyperparathyroidism, hypoparathyroidism, hypocalcaemia in newborn babies, osteomalacia, or rickets          
    Dosage Forms :   Tablet, Capsule, Soft gel capsule

    More Information

    Storage

    • Keep ALPHA D3 0.25MCG CAPSULE out of the sight and reach of children
    • Store ALPHA D3 0.25MCG CAPSULE below 30°C

    FAQs About ALPHA D3 0.25MCG CAPSULE

    Q: What is ALPHA D3 0.25MCG CAPSULE used for?

    A: ALPHA D3 0.25MCG CAPSULE is used to manage osteodystrophy (changes in bone caused by kidney failure), changes in parathyroid glands (responsible for producing parathyroid hormone, which controls the amount of calcium in the body) include hyperparathyroidism (glands may make the amount of calcium in your blood too high) and hypoparathyroidism (glands may make the amount of calcium in your blood too low), low levels of calcium in the blood of newborn babies (hypocalcaemia), and osteomalacia or rickets (softening and deformity of the bones due to a lack of calcium). Contact your doctor before taking ALPHA D3 0.25MCG CAPSULE.

    Q: What are the side effects of ALPHA D3 0.25MCG CAPSULE?

    A: The most common side effects of taking ALPHA D3 0.25MCG CAPSULE are abdominal pain, rash, and itching. Contact your physician if the symptoms worsen.

    Q: Is it safe to take ALPHA D3 0.25MCG CAPSULE?

    A: Yes. ALPHA D3 0.25MCG CAPSULE is safe when it is taken at the dose prescribed by your physician, and it is not recommended for use in patients with an allergic history to alfacalcidol, hypercalcaemia (high levels of calcium in the blood), or calcification (high levels of calcium in your body tissues). Contact your doctor before taking.

    Q: Do I need to undergo any tests while being managed with ALPHA D3 0.25MCG CAPSULE?

    A: During the management with ALPHA D3 0.25MCG CAPSULE, your doctor may conduct blood tests to determine the amount of calcium and phosphorus in the blood, an enzyme called alkaline phosphatase, or the parathyroid hormone. You may also have other tests, such as X-rays, to determine the dose that fits you.

    Q: Do I need to take any other medicines along with ALPHA D3 0.25MCG CAPSULE to maintain calcium and phosphate levels?

    A: Your doctor may prescribe another medicine called a phosphate-binding agent or a calcium supplement to take as well as ALPHA D3 0.25MCG CAPSULE. This will help to keep the right amount of calcium and phosphate in your blood. Consult with your doctor.

    References

    1. K.D. Tripathi. Hormones and drugs affecting calcium balance. Essentials of medical pharmacology. Eighth edition. 2019. Page-368.

    2. Mahidol University. A Randomised Trial Comparing Pulse Calcitriol and Alfacalcidol for the Treatment of Secondary Hyperparathyroidism in Haemodialysis Patients. NIH U.S. National Library of Medicine. ClinicalTrials.gov. May 2010. [Accessed on 16th September 2024] https://clinicaltrials.gov/ct2/show/NCT01115543

    3. A Shiraishi, S Higashi, H Ohkawa, N Kubodera, T Hirasawa, I Ezawa, K Ikeda, E Ogata. The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. October 1999. [Accessed on 16th September 2024] https://pubmed.ncbi.nlm.nih.gov/10485984/

    4. LEO Pharma A/S. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 16th September 2024] https://www.medicines.org.uk/emc/files/pil.5516.pdf

    Useful Diagnostic Tests

    • Calcium
    • Vitamin D 1,25 Dihydroxy
    • Thyroid Profile-Total (T3,T4&Tsh)
    • Thyroid Profile-Free (Ft3, Ft4 & Tsh)
    • Extended Arthritis Care
    • Comprehensive Arthritis Care
    • Basic Bone Care
    • Advance Bone Care
    • Comprehensive Bone Care
    • Phosphorus-Inorganic, Serum
    • Basic Arthritis Care Plan
    • Bone Strength Package
    • Arthritis Profile-Basic
    • Arthritis Profile-Advanced

    Author Details

    Written By Srilekha. R - B.Pharm
    Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)
    Last updated on 20 Sep 2024 | 04:44 PM(IST)
    Lab updated