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Introduction About AHABIR 250MG TABLET
AHABIR 250MG TABLET contains Abiraterone, which belongs to a group of medicines called Androgen biosynthesis inhibitors. AHABIR 250MG TABLET is used with prednisone or prednisolone in adult men to manage prostate cancer that has spread to other parts of the body.
AHABIR 250MG TABLET is also used to manage early stages of prostate cancer when used with androgen deprivation therapy (management that lowers testosterone hormone) and prednisone/prednisolone (medication) in affected individuals. AHABIR 250MG TABLET is not recommended for use in patients allergic to abiraterone. It is also not recommended for use in patients suffering from severe liver disease.
Before taking AHABIR 250MG TABLET, inform your doctor if you have high blood pressure, any other blood vessel problems (such as blood pressure, stroke), swelling in the feet, ankles, or legs, diabetes, lung problems (such as shortness of breath), heart problems (such as heart failure, irregular or rapid heart rate), kidney, and/or liver problems.
AHABIR 250MG TABLET is not recommended for use in pregnant and breastfeeding women since it is intended to be used only in male patients.While taking AHABIR 250MG TABLET, male patients must use a suitable contraceptive method to avoid exposure of this medicine to their female partners.
AHABIR 250MG TABLET is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years or older) after consulting the doctor.
The most common side effects of taking AHABIR 250MG TABLET are swelling in the legs or feet, high blood pressure, urinary tract infection, diarrhea, indigestion, chest pain, an irregular heartbeat, and/or a rash. Contact your doctor if any of the symptoms worsen.
Uses Of AHABIR 250MG TABLET
AHABIR 250MG TABLET is used with prednisone/prednisolone:
- To manage prostate cancer that has spread to other parts of the body
- To manage early stages of prostate cancer when used with androgen deprivation therapy (management that lowers testosterone hormone) in affected individuals
How AHABIR 250MG TABLET Works
AHABIR 250MG TABLET is an androgen biosynthesis inhibitor that works by inhibiting the production of the 17α-hydroxylase (CYP17) enzyme needed to produce testosterone (male sex hormone), which enables the growth of cancer cells in the prostate gland. Since AHABIR 250MG TABLET suppresses the production of testosterone, the cancer cells in the prostate gland won't be able to grow, thus managing its effects on the gland in affected individuals.
How to use AHABIR 250MG TABLET
Take AHABIR 250MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Avoid taking medicine with food. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of AHABIR 250MG TABLET
Common
- swelling in the legs or feet
- signs of hypokalemia (low potassium level in the blood) such as muscle twitches, muscle cramps, and faintness
- high blood pressure
- urinary tract infection
- diarrhea, indigestion
- chest pain, irregular heartbeat, rapid heart rate
- severe infections such as sepsis (a life-threatening complication of an infection)
- bone fractures
- blood in urine
Uncommon
- adrenal insufficiency (a disorder in which the adrenal glands won't be able to produce enough hormones)
- abnormal heart rhythm
- muscle weakness/pain
Rare
- lung irritation (allergic alveolitis)
- signs of acute liver failure such as stomach pain, nausea, vomiting, and yellowing of the skin or white of the eyes
Stop taking AHABIR 250MG TABLET and contact your doctor if you experience any of the following side effects:
- signs of low potassium levels in the blood, such as muscle weakness, muscle twitches, and/or a pounding heartbeat
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the symptom gets worse.
Indigestion
Try to reduce your consumption of tea, coffee, cola, or alcohol and lose weight if you are obese. Avoid smoking, and do not eat for three to four hours before going to bed. Consult your doctor if the symptoms get worse.
Skin rash Or Itching
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
ContraindicatedAHABIR 250MG TABLET is not intended for use in women.
Breastfeeding
ContraindicatedAHABIR 250MG TABLET is not recommended for use in breastfeeding women since it is intended to be used only in male patients.
Driving and Using Machines
Use with CautionAHABIR 250MG TABLET is unlikely to affect your ability to drive or operate machines. Consult your doctor before taking AHABIR 250MG TABLET.
Kidney
Use with CautionAHABIR 250MG TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking AHABIR 250MG TABLET.
Liver
Use with CautionAHABIR 250MG TABLET is not recommended for use in patients with severe liver damage. It should be used with caution in patients with other liver diseases. Consult your doctor before taking AHABIR 250MG TABLET.
Allergy
ContraindicatedDo not take AHABIR 250MG TABLET if you are allergic to abiraterone and/or any other ingredients in this medicine.
Lungs
Use with CautionAHABIR 250MG TABLET should be used with caution in patients with lung problems such as shortness of breath. Consult your doctor before taking AHABIR 250MG TABLET.
Heart Disease
Use with CautionAHABIR 250MG TABLET should be used with caution in patients with heart problems such as heart failure, irregular or rapid heart rate, and/or heart rhythm problems. Consult your doctor before taking AHABIR 250MG TABLET.
Use In Pediatrics
ContraindicatedAHABIR 250MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking AHABIR 250MG TABLET.
Use In Geriatrics
Use with CautionAHABIR 250MG TABLET should be used with caution in elderly patients (aged 75 years or older). Consult your doctor before taking AHABIR 250MG TABLET.
Others
Before taking AHABIR 250MG TABLET, inform your doctor if you:
- have high blood pressure
- have signs of a low potassium level in the blood, such as constipation, muscle damage, fatigue, and/or numbness
- have any other blood vessel problems, such as blood pressure or stroke
- have gained weight rapidly
- have swelling in the feet, ankles, and/or legs
- have possible side effects on your bones
- have diabetes
- are intolerant to certain sugars, such as lactose
Interactions
A. Drug-Drug Interactions:
Before taking AHABIR 250MG TABLET, inform your doctor if you are taking any of the following medicines:
- tranquilizers (medicines used to manage fear, agitation, anxiety, tension, and related states of mental disturbance) Ex. diazepam, lorazepam, and chlordiazepoxide
- medicines used to manage diabetes (Ex. metformin, insulin, and pramlintide)
- St. John’s wort (an herbal medicine used to manage depression)
- ketoconazole (medicine used to manage skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff)
- RA-223 (a radioactive drug used to manage prostate cancer)
- quinidine, procainamide, amiodarone, and sotalol (medicines used to manage an irregular heartbeat)
- medicines used in androgen deprivation management to manage prostate cancer (Ex. leuprolide, goserelin, triptorelin, and histrelin)
- methadone (medicine used for pain relief and part of drug addiction therapy)
- moxifloxacin (an antibiotic used to manage bacterial infections)
- antipsychotics (used for serious mental illnesses) Ex. aripiprazole, asenapine, and cariprazine
B. Drug-Food Interactions:
AHABIR 250MG TABLET should not be taken with grapefruit juice since it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally takes too much of AHABIR 250MG TABLET, contact your doctor immediately or go to a hospital right away.
Synopsis
| Drug | : | Abiraterone |
| Pharmacological Category | : | Androgen biosynthesis inhibitors |
| Therapeutic Indication | : | Prostate cancer |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep AHABIR 250MG TABLET out of reach of children
- Store AHABIR 250MG TABLET at room temperature
FAQs About AHABIR 250MG TABLET
Q: What is AHABIR 250MG TABLET used for?
A: AHABIR 250MG TABLET is used with prednisone or prednisolone in adult men to manage prostate cancer that has spread to other parts of the body. It is also used to manage early stages of prostate cancer when used with androgen deprivation therapy (a management that lowers testosterone hormone) and prednisone/prednisolone (a medication) in affected individuals.
Q: Can AHABIR 250MG TABLET be taken along with food?
A: No. AHABIR 250MG TABLET should not be taken along with food since it may increase the absorption of this medicine and can increase the risk of side effects. Take this medicine one hour before or after two hours of eating the food. Consult your doctor before taking the medicine.
Q: What are the side effects of AHABIR 250MG TABLET?
A: The most common side effects of taking AHABIR 250MG TABLET are swelling in the legs or feet, high blood pressure, urinary tract infection, diarrhea, indigestion, chest pain, an irregular heartbeat, and/or a rash. Contact your doctor if any of the symptoms worsen.
Q: Is AHABIR 250MG TABLET safe to use with children?
A: No, AHABIR 250MG TABLET is not recommended for use in children and adolescents (aged below 18 years). If AHABIR 250MG TABLET is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.
Q: Can AHABIR 250MG TABLET be taken by a diabetic patient?
A: AHABIR 250MG TABLET should be used with caution in patients with high blood sugar. Consult your doctor before taking AHABIR 250MG TABLET, who may advise you to check your blood sugar level before AHABIR 250MG TABLET is advised to be taken.
References
1. Beverly Moy, Richard J. Lee and Mathew Smith. Natural products in cancer chemotherapy: Hormones and related drugs. Goodman & Gilman’s: The pharmacological basics of therapeutics. 12th Edition. New York MC Graw Hill Medical 2011. Page – 1767.
2. Yasser Rehman, Jonathan E Rosenberg. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2012. [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/22291466/
3. Matthew R Smith, Dana E Rathkopf, Peter F A Mulders, Joan Carles, Hendrik Van Poppel, Jinhui Li, Thian Kheoh, Thomas W Griffin, Arturo Molina, Charles J Ryan. Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2015. [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/26151676/
4. Merckle GmbH. Health Products Regulatory Authority (HPRA). [Revised in May 2022] [Accessed on 26th April 2022] http://www.hpra.ie/img/uploaded/swedocuments/80fd6aa1-a8b2-4f60-92bf-ac7a2e96c6a4.pdf
5. Biocon Biologics India Limited. ABSTET. [Revised in July 2019] [Accessed on 26th April 2022] https://www.biocon.com/docs/domestic-market-pi/onco/ABSTET%20PI.pdf
6. Azista Industries Private Limited. Abiraterone acetate 250mg tablets. [Accessed on 26th April 2022] https://www.azistaindustries.com/abiraterone-acetate-tablets-exporters/
Useful Diagnostic Tests
- Prostate Specific Antigen (Free) PSA
- Prostate Specific Antigen (Total) PSA
- Healthians Prostate Cancer Package
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