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Afdura Tablet 10'S - Bladder And Prostate Disorders-Dru

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Introduction About AFDURA TABLET

AFDURA TABLET is a combination of Alfuzosin and Dutasteride which belongs to the group of medicines called Alpha-1 adrenergic blockers and 5-Alpha reductase inhibitors respectively. AFDURA TABLET is indicated for the management of signs and symptoms of benign prostatic hyperplasia (BPH) in adult men with an enlarged prostate.

Benign Prostatic Hyperplasia (also known as enlarged prostate) is a non-cancerous growth of prostate gland, which is predominantly caused by excessive production of a stress hormone called dihydrotestosterone (DHT) in men. Symptoms of BPH includes urinary problems such as difficulty in passing urine, urinary incontinence (unintentional passing of urine), frequent urination at night and sexual dysfunction or painful ejaculation.

Before taking AFDURA TABLET inform your doctor if you have low blood pressure, liver, kidney or heart disease as a precaution. During management with AFDURA TABLET, your doctor will regularly monitor your serum prostate-specific antigen (PSA) levels to rule out risk of prostate cancer.

Women who are pregnant or think they may be pregnant should not handle the leaked medicine or be exposed to the semen of men taking AFDURA TABLET, as it could cause serious abnormalities in the growing fetus. Usage of condom during sexual intercourse is recommended among fertile men to avoid conception.

Men being managed with AFDURA TABLET should not donate blood for at least 6 months after their last dose, in order to manage the exposure of the medicine to pregnant women via blood transfusion. AFDURA TABLET should be used with caution in elderly patients (aged 65 years or above).

The most common side effects of taking AFDURA TABLET are dizziness, fainting, weakness and decreased sex drive or breast enlargement in men. Contact your doctor if any of the side effects worsen.

Uses Of AFDURA TABLET

Manage signs and symptoms of benign prostatic hyperplasia (BPH) in adult men

How AFDURA TABLET Works

AFDURA TABLET effectively reduces the symptoms of BPH, where dutasteride acts by inhibiting the activity of an enzyme called 5-alpha reductase, which is responsible for the conversion of testosterone into dihydrotestosterone (a stress hormone that causes BPH) and alfuzosin acts by relaxing the muscles surrounding the bladder and prostate by inhibiting the alpha-1 adrenergic receptors of the lower urinary tract. As a result, AFDURA TABLET helps in shrinkage of an enlarged prostate, making it easier for the urine to pass through and provide relief from symptomatic BPH.

How to use AFDURA TABLET

Take AFDURA TABLET as advised by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Try to take AFDURA TABLET at the same time each day immediately after meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.

Overdose

If you or anyone else accidentally take too much of AFDURA TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage include severe hypotension (decrease in blood pressure causing severe dizziness and fainting).

Side Effects Of AFDURA TABLET

Common

Common side effects of AFDURA TABLET:

dizziness or fainting
headache, nausea, stomach pain
general weakness or tiredness
sexual impotence (unable to achieve or maintain an erection), decreased sex drive and difficulty with ejaculation
gynecomastia (breast enlargement or tenderness in men)

Stop taking AFDURA TABLET and contact your doctor immediately if you experience any of the following side effects:

priapism (persistent painful penile erection unrelated to sexual activity)
chest pain
severe allergic reactions (such as skin rash with redness and lumps, swelling of face, eyelids, lips, mouth and tongue causing difficulty in breathing or swallowing)

How To Manage Side Effects

Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Headache

Rest and relax. Drink lot of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Nausea And Vomiting

AFDURA TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking AFDURA TABLET.

Other Warnings for AFDURA TABLET

Before taking AFDURA TABLET, inform your physician if you:

have orthostatic hypotension (feeling dizzy or faint while standing up)
have an upcoming cataract surgery
are going to have blood test for PSA (Prostate Specific Antigen)

Who should not take AFDURA TABLET

AFDURA TABLET is not recommended for use if you:

have prostate cancer

Drug - Drug interaction

Before taking AFDURA TABLET inform to your doctor, if you are taking any of these medicines:

medicines used to manage fungal infections (Ex. ketoconazole or itraconazole)
medicines used to manage high blood pressure and other heart problems (such as nitroglycerin, verapamil, atenolol or diltiazem)
antibiotics (used to manage bacterial infections) such as troleandomycin and ciprofloxacin
other alpha blockers (used to manage enlarged prostate or high blood pressure) such as prazosin, doxazosin, terazosin
medicines used to manage erectile dysfunction (Ex vardenafil, sildenafil and tadalafil)
warfarin (used to manage formation of blood clots in the body)
ritonavir (used to manage HIV infection)
cimetidine (used to manage stomach ulcers)

Synopsis

Drug	:	Alfuzosin, Dutasteride
Pharmacological Category	:	Alpha-1 adrenergic blockers, 5-Alpha reductase inhibitors
Therapeutic Indication	:	Benign Prostatic Hyperplasia
Dosage Forms	:	Tablet, Capsule

More Information

Keep AFDURA TABLET out of reach of children
Store at room temperature

FAQs About AFDURA TABLET

Q: Can the use of AFDURA TABLET cause long-lasting painful penile erection?

A: Yes, AFDURA TABLET can rarely cause a serious condition called priapism (persistent painful penile erection unrelated to sexual activity). Stop taking AFDURA TABLET and contact your doctor immediately if you experience persistent painful erections of the penis that is unrelated to sexual activity, because this condition can lead to permanent erectile dysfunction if not managed properly.

Q: Can the use of AFDURA TABLET cause prostate cancer?

A: Yes, AFDURA TABLET can increase the risk of high-grade prostate cancer in men and so your doctor would regularly monitor your serum prostate specific antigen (PSA) levels. Current clinical findings show that men taking dutasteride develops a serious form of prostate cancer more often than men who are not relied on dutasteride therapy. However, the mechanism behind the incidence of prostate cancer is not clear.

Q: Use of AFDURA TABLET by male individuals affects pregnancy?

A: Before taking AFDURA TABLET, inform your doctor if you are planning to have a baby, because this medicine can be found in the semen of men taking it. Both pregnant women and women of child-bearing potential must not be exposed to AFDURA TABLET either through direct handling or through semen, because it could cause serious abnormalities to the growing fetus. Usage of condom during sexual intercourse is recommended among fertile men to avoid conception.

Q: Can AFDURA TABLET cause infertility?

A: Yes, AFDURA TABLET can cause sexual impotence, decreased sex drive or difficulty in ejaculation in men because it reduces the sperm count, semen volume and sperm movement. Consult your doctor if this bothers you.

Q: Can the use of AFDURA TABLET make me feel dizzy?

A: Yes, AFDURA TABLET can cause dizziness in some people. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. However, if you experience severe persistent dizziness and fainting while standing up, please consult your doctor.

Q: What to do If I forget to take AFDURA TABLET?

A: You should take AFDURA TABLET immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.

Q: Is AFDURA TABLET safe to use in children?

A: AFDURA TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking AFDURA TABLET. If your child experiences any symptoms of difficulty in urination consult child’s doctor immediately.

References

1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma and Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 142-144 & 303.

2. B Ventimiglia, S Consoli, M Serrao, A Tsirgiotis. Efficacy of dutasteride, alfuzosin or both on Quality of Life in patients with prostatic hyperplasia and BOO.A two-year spontaneous, observational, self-controlled study. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April-June 2008. [Accessed on 15th May 2026]

3. Mostafa Elhilali, Mark Emberton, Haim Matzkin, R Jeroen A van Moorselaar, Rudolf Hartung, Niels Harving, Antonio Alcaraz, Guy Vallancien, ALF-ONE Study Group. Long-term efficacy and safety of alfuzosin 10 mg once daily: a 2-year experience in 'real-life' practice. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2006. [Accessed on 15th May 2026]

4. Zhongbao Zhou, Shiqiang Song, Zhenli Gao, Jitao Wu, Jiajia Ma and Yuanshan Cui. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. NCBI; PMC US National Library of Medicine, National Institute of Health. February 2019. [Accessed on 15th May 2026]

5. R Jeroen A van Moorselaar, Rudolf Hartung, Mark Emberton, Niels Harving, Haim Matzkin, Mostafa Elhilali, Antonio Alcaraz, Guy Vallancien, ALF-ONE Study Group. Alfuzosin 10 mg once daily improves sexual function in men with lower urinary tract symptoms and concomitant sexual dysfunction. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2005. [Accessed on 15th May 2026]

6. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 15th May 2026]

7. APL Swift Services (Malta) Limited or Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in August 2019] [Accessed on 15th May 2026]

8. Cipla Ltd. Alfusin D Tablets (Alfuzosin hydrochloride + Dutasteride). Ciplamed.com. [Revised in December 2013] [Accessed on 15th May 2026]

Useful Diagnostic Tests

Prostate Specific Antigen (PSA)

Lab updated