ACEPARON 325mg Tablet 10's (N)

INTRODUCTION ABOUT ACEPARON 325MG TABLET

ACEPARON 325MG TABLET is a combination of Aceclofenac and Paracetamol, which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs. It is used in the management of acute painful inflammatory conditions (such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis) which can be associated with/without fever in affected individuals.

ACEPARON 325MG TABLET is not recommended for use in patients allergic (hypersensitive) to aceclofenac and paracetamol. It is also not recommended for use in patients with lung problems (such as asthma or bronchospasm), kidney problems (such as severely impaired renal organ function), liver problems (such as a severely impaired hepatic function) and/or heart problems (such as severe heart failure).

Before taking ACEPARON 325MG TABLET, inform your doctor if you have a history of gastrointestinal ulceration (stomach ulcer) with ulcerative colitis /Crohn’s disease (chronic inflammatory bowel disease), bleeding diathesis (increased susceptibility of bleeding/bruising) and/or haematological abnormalities.

ACEPARON 325MG TABLET is generally not recommended for use in pregnant women unless it is clearly considered necessary. It is also not recommended for use in breast feeding women. Consult your doctor before taking this medicine.

ACEPARON 325MG TABLET is not recommended for use in children (aged below 6 years) which should be used with caution in elderly patients (aged 65 years and above).

The most common side effects of taking ACEPARON 325MG TABLET are gastrointestinal disorders (such as indigestion, abdominal pain, nausea), rash, red itchy welts, bedwetting, headache, dizziness and/or drowsiness. Consult your doctor if any of these symptoms worsen.

USES OF ACEPARON 325MG TABLET

• Manage acute painful inflammatory conditions (such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis) which can be associated with/without fever in affected individuals

HOW ACEPARON 325MG TABLET WORKS

ACEPARON 325MG TABLET provides relief from pain and reduces fever where aceclofenac and paracetamol works by blocking the action of prostaglandin (chemical messengers responsible for pain, fever and inflammation) thus reducing fever and providing relief from fever in affected individuals.

DIRECTIONS FOR USE

Take ACEPARON 325MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ACEPARON 325MG TABLET

HOW TO MANAGE SIDE EFFECTS

Indigestion:

Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea or alcohol and lose weight if you are obese. Try to avoid smoking and don’t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.

Nausea:

Try to take ACEPARON 325MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.

Headache:

If ACEPARON 325MG TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking ACEPARON 325MG TABLET. If it lasts more than a week or severe, inform your doctor.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals, fresh fruit and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.

WARNING & PRECAUTIONS

PREGNANCY

ACEPARON 325MG TABLET is generally not recommended for use in pregnant women unless it is clearly considered necessary. Consult your doctor before taking this medicine.

BREASTFEEDING

ACEPARON 325MG TABLET is not recommended for breast feeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not take ACEPARON 325MG TABLET while driving or operating machines since it may cause blurred vision, dizziness and/or drowsiness.

KIDNEY

ACEPARON 325MG TABLET is not recommended for use in patients with kidney problems such as severely impaired renal organ function. It should be used with caution in patients with kidney problems such as mild hepatic impairment. Consult your doctor before taking this medicine.

LIVER

ACEPARON 325MG TABLET is not recommended for use in patients with liver problems such as severely impaired hepatic function. Consult your doctor before taking this medicine.

ALLERGY

Do not take ACEPARON 325MG TABLET if you are allergic (hypersensitive) to aceclofenac, paracetamol and/or other ingredients of this medicine.

LUNGS

ACEPARON 325MG TABLET is not recommended for use in patients with lung problems such as asthma, bronchospasm. Consult your doctor before taking this medicine.

HEART DISEASE

ACEPARON 325MG TABLET is not recommended for use in patients with heart problems such as severe heart failure. Consult your doctor before taking this medicine.

INTERACTIONS

A. Drug - Drug interactions:

Before taking ACEPARON 325MG TABLET, inform your doctor if you are taking any of the following medicine:

• other analgesics such as aspirin, cyclooxygenase-2 selective inhibitors (Ex. celecoxib, valdecoxib)
• anti-hypertensives (medicines used to reduce hypertension) Ex. atenolol, proponolol
• diuretics (used to reduce hypertension) Ex. hydrochlorothiazide, furosemide
• cardiac glycosides (to manage heart failure) Ex. digoxin, digitoxin
• lithium (medicine used to manage depression)
• methotrexate (medicine used to manage cancer)
• mifepristone (used for abortion)
• corticosteroids (used to manage inflammation and allergy) Ex. prednisone, dexamethasone
• anti-coagulants (medicine used to manage blood clots) Ex. warfarin
• quinolone antibiotics (used to manage bacterial infections) Ex. ciprofloxacin, levofloxacin
• antiplatelets (medicine used to manage blood clotting) Ex.warfarin
• selective serotonin reuptake inhibitors (medicines used to depression) Ex. citalopram, dapoxetine, escitalopram, fluoxetine
• cyclosporin (used to manage organ rejection after transplantation)
• tacrolimus (used to manage moderate to severe atopic dermatitis)
• zidovudine (used to manage HIV)
• anti-diabetic agents (medicines used to manage high blood sugar) Ex. glipizide, glyburide
• cholestyramine (used to manage high cholesterol level)
• metoclopramide, domperidone (used to manage nausea and vomiting)
• chloramphenicol (used to manage serious bacterial infections)

Overdosage:

If you or anyone else accidentally takes too much of ACEPARON 325MG TABLET, consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep ACEPARON 325MG TABLET out of reach of children
• Store ACEPARON 325MG TABLET at room temperature

FAQs ABOUT ACEPARON 325MG TABLET

Q: What is ACEPARON 325MG TABLET used for?

A: ACEPARON 325MG TABLET is used to manage acute painful inflammatory conditions (such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis) which can be associated with/without fever in affected individuals.

Q: How ACEPARON 325MG TABLET works?

A: ACEPARON 325MG TABLET is a combination of Aceclofenac and Paracetamol as active ingredients. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs). It works by inhibiting the production of certain chemicals in the body, specifically prostaglandins. Prostaglandins are substances that contribute to inflammation, pain, and fever. By reducing the production of prostaglandins, Aceclofenac helps alleviate inflammation and pain associated with conditions such as arthritis, ankylosing spondylitis, and other inflammatory disorders. Paracetamol is an analgesic and antipyretic. It works by inhibiting the production of prostaglandins in the brain. While the exact mechanism is not fully understood, it is believed that paracetamol acts centrally (in the brain) to reduce pain and fever. Unlike NSAIDs, paracetamol has little to no anti-inflammatory effect.

Q: What are the most common side effects of taking ACEPARON 325MG TABLET?

A: The most common side effects of taking ACEPARON 325MG TABLET are gastrointestinal disorders (such as indigestion, abdominal pain, nausea), rash, red itchy welts, bedwetting, headache, dizziness and/or drowsiness. Consult your doctor if any of these symptoms worsen.

Q: Does ACEPARON 325MG TABLET cause nausea?

A: Yes, ACEPARON 325MG TABLET causes nausea as it is the commonest side effect to occur after taking the medicine. If such side effect experienced, then try to take ACEPARON 325MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.

Q: Can ACEPARON 325MG TABLET be used in pregnant and breast-feeding women?

A: No, ACEPARON 325MG TABLET is not recommended for use during pregnancy and in breast feeding since it may affect the foetus and nursing child. Therefore, consult your doctor before taking it.

Q: Can I drink alcohol while taking ACEPARON 325MG TABLET?

A: It's generally advisable to avoid alcohol while taking ACEPARON 325MG TABLET, as it may increase the risk of certain side effects such as liver damage or gastrointestinal bleeding. Consult your healthcare provider for personalized advice.

Q: How often can I take ACEPARON 325MG TABLET?

A: ACEPARON 325MG TABLET is typically taken 1-2 times a day, or as directed by your healthcare provider. Do not exceed the recommended dosage or frequency of administration unless advised by a healthcare professional.

Q: Is ACEPARON 325MG TABLET habit-forming?

A:ACEPARON 325MG TABLET is not known to be habit-forming when used as prescribed. However, it's important to follow the recommended dosage and duration of management to minimize the risk of dependence or misuse.

Q: Can ACEPARON 325MG TABLET be taken with food?

A: Yes, ACEPARON 325MG TABLET can be taken with food or after meals to reduce the risk of stomach irritation. However, if you experience any stomach upset despite taking it with food, consult your healthcare provider.

Q: Can ACEPARON 325MG TABLET be taken for a toothache?

A: ACEPARON 325MG TABLET can be used for dental pain, including toothaches, as it contains Aceclofenac and Paracetamol, which provide pain relief. However, it's important to consult a dentist to determine the underlying cause of the toothache and appropriate management.

REFERENCES

1. KD Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 204, 206.

2. Anil Pareek, Nitin Chandurkar, V D Sharma, Mohan Desai, Seema Kini, Girish Bartakke. A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. April 2009. [Accessed on 26th March 2022] https://pubmed.ncbi.nlm.nih.gov/19351223/

3. Antoni Sicras-Mainar , Salomé de Cambra-Florensa, Ruth Navarro-Artieda. Consumption of oral analgesics and dosage forms in elderly patients: population-based study. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov.  May 2009. [Accessed on 26th March 2022] https://pubmed.ncbi.nlm.nih.gov/19712600/

4. Vibcare Pharma Pvt. Ltd. ACRIMOL. [Accessed on 26th March 2022] https://vibcare.co.in/aceclofenac-paracetamol/

5. Bliss Gvs Pharma Limited. Food and Drugs Authority- Ghana. [Revised in June 2016] [Accessed on 26th March 2022] https://fdaghana.gov.gh/img/pils/Alfenac-P%20Tablet%20(Aceclofenac%20and%20Paracetamol).pdf

USEFUL DIAGNOSTIC TESTS

• Erythrocyte sedimentation rate (ESR)
• C-reactive protein (CRP)

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop - Pharm.D

Last updated on 03 Jul 2024 | 03:10 PM(IST)