ACEGABA NT 100 Tablet 15's

Introduction About ACEGABA NT 100 TABLET

ACEGABA NT 100 TABLET is a combination of Gabapentin and Nortriptyline. It belongs to the group of medicines called anticonvulsants and antidepressants respectively. It is commonly used to manage nerve pain (neuropathic pain) caused by nerve damage or nerve dysfunction.

Gabapentin works by calming overactive nerve cells and reducing the pain signals sent to the brain. Nortriptyline helps balance certain natural chemical messengers in the brain, supporting the body’s ability to control nerve-related pain.

This medicine should be used with caution in people with kidney, heart, or liver problems, those with a history of mood disorders, and in adults aged 65 years and above. Inform your doctor before taking this medicine.

ACEGABA NT 100 TABLET is not recommended for use in pregnant or breastfeeding women unless advised by a doctor. It is also not recommended for use in children below 6 years of age.

The most common side effects include. Consult your doctor if any of these side effects persist or worsen. sleepiness, dizziness, dry mouth, blurred vision, and constipation

Uses Of ACEGABA NT 100 TABLET

• Used to manage neuropathic pain  

Benefits of ACEGABA NT 100 TABLET

1) Relief from Neuropathic (Nerve) Pain

ACEGABA NT 100 TABLET helps reduce pain caused by nerve damage. It works by relaxing overactive nerves and easing uncomfortable sensations.

2) Diabetic Nerve Pain (Diabetic Peripheral Neuropathy)

If you have diabetes and experience burning, tingling, or numbness in your hands or feet, this medicine can help reduce those symptoms and improve daily comfort.

3) Post-Herpetic Neuralgia (Pain After Shingles)

After shingles, some people continue to have long-lasting nerve pain. ACEGABA NT 100 TABLET helps control this persistent pain and provides relief.

4) Sciatica Pain

Sciatica causes pain that travels from the lower back down to the legs. ACEGABA NT 100 TABLET can help reduce this nerve pain and improve movement. It may be used along with physiotherapy if your doctor advises.

5) Chronic Nerve Damage Pain

This medicine is also helpful for long-term nerve pain caused by spinal cord injury or other nerve-related conditions.

How ACEGABA NT 100 TABLET Works

Dual Mechanism of Gabapentin and Nortriptyline
Gabapentin and Nortriptyline work through two different but complementary pathways to help manage neuropathic pain. Gabapentin stabilizes abnormal electrical activity in nerves, while Nortriptyline enhances natural pain-modulating neurotransmitters in the brain. This combined approach supports more comprehensive nerve pain management under medical supervision.

Role of Gabapentin in Reducing Nerve Hypersensitivity
By limiting excessive neurotransmitter release, Gabapentin helps decrease heightened nerve responsiveness often seen in neuropathic conditions, supporting improved symptom control.

Nortriptyline’s Role in Central Pain Modulation
By strengthening the brain’s natural pain-suppressing systems, Nortriptyline may help reduce the intensity and persistence of chronic nerve pain signals.

Impact on Brain–Spinal Cord Communication
The combination supports balanced signaling between peripheral nerves, the spinal cord, and higher brain centers. This may help reduce exaggerated pain responses associated with nerve injury or dysfunction.

How to use ACEGABA NT 100 TABLET

Recommended Dosage as Directed by a Healthcare Professional

• ACEGABA NT 100 TABLET should be taken strictly as prescribed by your doctor.
• The dosage depends on your medical condition, severity of symptoms, response to treatment, and overall health profile. Do not adjust the dose without consulting your healthcare provider.
• Take the tablet exactly as instructed on your prescription label. Follow the recommended frequency and duration to ensure consistent therapeutic benefit and to reduce the risk of side effects.

When to Take ACEGABA NT 100 TABLET

• Your doctor may advise taking ACEGABA NT 100 TABLET once daily, often in the evening, as it may cause drowsiness in some individuals. Always follow your physician’s timing recommendation based on your condition and tolerance.
• Taking ACEGABA NT 100 TABLET at the same time each day helps maintain steady medicine levels in the body. Consistency improves effectiveness and reduces the likelihood of missed doses.

How to take

• Swallow the tablet whole with a glass of water. Do not crush, chew, or break it unless specifically advised by your doctor, as altering the tablet may affect how the medicine is absorbed.
• ACEGABA NT 100 TABLET may generally be taken with or without food. However, taking it with food may help reduce mild stomach discomfort in sensitive individuals. Follow your doctor’s specific guidance.

Duration of Therapy as Advised by Your Doctor

• The duration of treatment varies depending on the underlying condition and response to therapy.
• Do not stop taking ACEGABA NT 100 TABLET abruptly without medical advice, as sudden discontinuation may lead to withdrawal symptoms or worsening discomfort.

What if I forgot to take ACEGABA NT 100 TABLET

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for the missed one.

Side Effects Of ACEGABA NT 100 TABLET

Common

• Sleepiness
• Dizziness
• Tiredness
• Unsteady
• Blurred vision
• Shaking
• Dry mouth
• Constipation

When to consult your doctor?

• Sudden mood changes, suicidal thoughts, or self-harm behavior
• Severe dizziness, sleepiness, or loss of coordination
• Allergic reactions (rash, swelling, difficulty breathing)
• Heart problems like palpitations or irregular heartbeat
• Severe nausea, vomiting, or urinary problems
• Worsening nerve pain or unusual neurological symptoms

How To Manage Side Effects

Constipation

• Stay Hydrated: Drink plenty of water to help soften stools and support regular bowel movements.
• Eat a High-Fiber Diet: Include fruits, vegetables, whole grains, and legumes to improve bowel function.
• Exercise Regularly: Gentle physical activity like walking can help stimulate digestion.
• Avoid Holding Stool: Go to the bathroom when you feel the urge to prevent constipation from worsening.
• Seek Medical Advice: Contact your doctor if constipation persists, is severe, or is accompanied by abdominal pain or blood in stools.

Dizziness Or Drowsiness

• Get Up Slowly: Move gradually from sitting or lying positions to avoid sudden lightheadedness.
• Hold onto Something Stable: Sit or hold onto a support if you feel lightheaded.
• Avoid Risky Activities: Do not drive, operate machinery, or climb heights until you feel steady.
• Seek Medical Advice: Inform your doctor if dizziness is severe, persistent, or affects daily activities.

Warning & Precautions

Pregnancy

Contraindicated

ACEGABA NT 100 TABLET taken during pregnancy may increase the risk of birth defects in the baby. Therefore, this medicine is not recommended during pregnancy. Always consult your doctor before taking this medicine.

Breastfeeding

Contraindicated

ACEGABA NT 100 TABLET passes into breast milk, and its effects on the baby are not known.  Therefore, ACEGABA NT 100 TABLET is not recommended while breastfeeding. Always consult your doctor before taking this medicine.

Driving and Using Machines

Use with Caution

ACEGABA NT 100 TABLET may cause drowsiness, dizziness, or reduced alertness. Do not drive or operate machinery if you feel unwell after taking this medicine. Always consult your doctor if you experience such symptoms.

Kidney

Use with Caution

ACEGABA NT 100 TABLET is mainly removed by the kidneys, so side effects may be higher in patients with kidney problems. Use with caution in kidney-impaired patients and adjust the dose as advised by your doctor. Always consult your doctor before use.

Liver

Contraindicated

ACEGABA NT 100 TABLET is not recommended for patients with severe liver disease. You should consult your doctor before taking this medicine.

Allergy

Contraindicated

Do not take ACEGABA NT 100 TABLET if you are allergic to gabapentin, nortriptyline, or any other ingredient in the medicine.
Seek immediate medical attention if you notice signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing.

Heart Disease

Contraindicated

ACEGABA NT 100 TABLET is not recommended for patients who have had a recent heart attack, any heart block, or irregular heart rhythms (arrhythmias). Always consult your doctor before taking this medicine if you have any heart problems..

Use In Pediatrics

Contraindicated

ACEGABA NT 100 TABLET is not recommended for children and adolescents (under 18 years of age). Always consult your pediatrician before using this medicine.

Use In Geriatrics

Use with Caution

ACEGABA NT 100 TABLET should be used with caution in elderly patients. Consult your doctor before using this medicine.

Other Warnings for ACEGABA NT 100 TABLET

Before taking this medicine inform to your doctor if you have

• mood or mental health changes, such as confusion, anxiety, restlessness, sleep problems, or unusual behaviour.
• nervous system problems, such as numbness, tingling, unsteadiness, tremors, or ringing in the ears.
• Unexplained weight changes 

Who should not take ACEGABA NT 100 TABLET

ACEGABA NT 100 TABLET is not recommended if you:

• Suffer from mania (abnormally raised mood)

Drug - Drug interaction

1)Painkillers (e.g., naproxen, hydrocodone, morphine)

• Interaction: May increase gabapentin levels in the blood.
• Effects: Could increase dizziness, drowsiness, or other side effects.
• Management: Inform your doctor if side effects occur. Dose adjustment may be needed.

2)Cimetidine or Probenecid

• Interaction: May affect how gabapentin and nortriptyline are removed from the body.
• Effects: Could increase medicine levels, causing more side effects.
• Management: Doctor may monitor you and adjust the dose.

3)Antacids containing aluminium or magnesium

• Interaction: May reduce gabapentin absorption.
• Effects: May make the medicine less effective.
• Management: Take gabapentin at least 2 hours after antacids.

4)Norethindrone (oral contraceptive)

• Interaction: Gabapentin may increase norethindrone levels.
• Effects: Could affect hormone levels.
• Management: Consult your doctor for monitoring.

5)Other anticholinergic or sympathomimetic drugs (e.g., atropine, ephedrine)

• Interaction: Requires careful monitoring.
• Effects: May increase risk of side effects like dizziness or rapid heartbeat.
• Management: Dose adjustments may be needed.

6)Reserpine

• Interaction: May cause unusual stimulating effects in some patients.
• Effects: Could cause restlessness or changes in mood.
• Management: Inform your doctor if symptoms occur.

7)Diabetes medicines

• Interaction: Gabapentin or nortriptyline may affect blood sugar.
• Effects: Could cause low or high blood sugar.
• Management: Monitor blood sugar closely; adjust medications as advised.

8)SSRIs (e.g., fluoxetine, sertraline, paroxetine)

• Interaction: May require lower doses of nortriptyline.
• Effects: Could increase side effects like dizziness, drowsiness, or nausea.
• Management: Doctor may adjust the dose.

9)Other antiepileptic drugs (e.g., phenytoin, carbamazepine, valproic acid, phenobarbitone)

• Interaction: Gabapentin does not significantly affect their metabolism.
• Effects: Usually no major interaction.
• Management: Monitor as advised by your doctor.

Synopsis

More Information

Why Are Nerve-Related Symptoms Different from Other Types of Pain, and How Can ACEGABA NT 100 TABLET Help?

Not all pain feels the same. Nerve-related pain, also called neuropathic pain, is different from regular muscle or joint pain. It may present as:

• Burning or tingling sensations
• Numbness
• Electric shock-like pain
• Stabbing or shooting pain

This type of pain occurs due to damage or dysfunction of nerves, which can happen in conditions such as diabetes, infections, injuries, or chronic nerve disorders.

Many people may mistake nerve pain for general body pain, which can delay proper diagnosis and treatment. Early identification of nerve-related symptoms helps in better symptom management and improves quality of life.

How ACEGABA NT 100 TABLET Helps

• ACEGABA NT 100 TABLET is commonly prescribed to manage neuropathic pain.
• It works by calming overactive nerves and reducing abnormal nerve signals that cause tingling, burning, or shooting pain.
• By targeting the source of nerve pain, it helps improve comfort and daily functioning.

Important Safety Information

• Take this medicine only as prescribed by your doctor.
• Do not stop it suddenly without medical guidance, as this may worsen symptoms.
• If your symptoms persist or worsen, consult your healthcare provider promptly.

FAQs About ACEGABA NT 100 TABLET

Q: What is ACEGABA NT 100 TABLET used for?

A: ACEGABA NT 100 TABLET is used to manage neuropathic pain, which may occur due to nerve damage from disease, injury, or infection. Always consult your doctor before taking it.

Q: Can ACEGABA NT 100 TABLET be used during pregnancy?

A: It is generally not recommended for use in pregnant women unless clearly necessary. Consult your doctor before use.

Q: Can ACEGABA NT 100 TABLET be used while breastfeeding?

A: ACEGABA NT 100 TABLET may pass into breast milk. Nursing mothers should avoid this medicine or consult their doctor for advice.

Q: Can ACEGABA NT 100 TABLET be used in children?

A: This medicine is not recommended for children or adolescents under 18 years. Consult your doctor before use.

Q: Is it safe to take ACEGABA NT 100 TABLET if I have heart problems?

A: Patients with heart conditions such as heart attack, arrhythmias, or coronary artery disease should avoid this medicine unless advised by a doctor.

Q: Can I drink alcohol while taking ACEGABA NT 100 TABLET?

A: Avoid alcohol, as it may increase dizziness, drowsiness, and impair coordination.

Q: Does ACEGABA NT 100 TABLET cause drowsiness or dizziness?

A: Yes, it may cause dizziness or sleepiness. Do not drive or operate machinery until you know how it affects you.

Q: Are there any common side effects of ACEGABA NT 100 TABLET?

A: Common side effects may include numbness, tingling, unsteadiness, mood changes, or weight changes. Consult your doctor if symptoms persist.

Q: Can ACEGABA NT 100 TABLET interact with other medicines?

A: Yes, it may interact with painkillers, antacids, heart medicines, diabetes medicines, SSRIs, or other prescribed drugs. Inform your doctor about all medications before use.

Q: How should I stop taking ACEGABA NT 100 TABLET?

A: Do not stop suddenly after long-term use, as it may cause nausea, headache, or general discomfort. Follow your doctor’s instructions for tapering the dose.

References

1. Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 303-326.

2. James M. O’Donnell, Robert R. Bies, and Richard C. Shelton. Drug Therapy of Depression and Anxiety Disorders. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 267-277.

3. KD. Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 411- 424.

4. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drug. Essentials of medical pharmacology. Seventh edition. 2013. Page – 454- 468.

5. Ian Gilron 1, Joan M Bailey, Dongsheng Tu, Ronald R Holden, Alan C Jackson, Robyn L Houlden. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. The Lancets. September 2009 [Accessed on 28th March 2026]

6. Gabapentin and Nortriptyline. Leleon [Accessed on 28th March 2026]

7.  Taj Pharma India Ltd. Gabapentin and Nortriptyline Tablets 100mg+10mg, [Accessed on 28th March 2026] 

8. Alkem Laboratories Limited,Pentanerv-NT 100, [Accessed on 28th March 2026] 

9. INTAS PHARMACEUTICALS LTD. GABAPIN NT, [Accessed on 28th March 2026] 

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 28 Mar 2026 | 12:51 PM(IST)