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Introduction About ACE PROXYVON CR TABLET
ACE PROXYVON CR TABLET is a combination of Aceclofenac and Rabeprazole which belongs to the group of medicines called Analgesics and Proton pump inhibitors respectively. It is used to manage inflammation and relive pain in conditions like rheumatoid arthritis (autoimmune disease that causes inflammation in the joints), osteoarthritis (loss of the cartilage and bone tissue causing joint pain), back pain or postsurgical pain.
Do not use ACE PROXYVON CR TABLET if you are allergic to other NSAIDs like ibuprofen or aspirin. Before taking ACE PROXYVON CR TABLET, inform your doctor if you have a history of stomach ulcer or tumour, have vomited blood, passed blood in faeces, have any kidney, heart, liver, bowel or blood clotting problems, porphyria, diabetes, chicken pox or if you have undergone any bypass surgery.
Avoid smoking while taking ACE PROXYVON CR TABLET. ACE PROXYVON CR TABLET is not recommended for use in pregnant women, breast-feeding women, children and adolescents (under 18 years of age) so, consult your doctor for advice.
The most common side effects of taking ACE PROXYVON CR TABLET are headache, nausea, vomiting, pain or discomfort right below your ribs, gastrointestinal irritation or bleeding, diarrhoea, constipation and stomach pain. Consult your doctor if any of the symptoms worsen over time.
Uses Of ACE PROXYVON CR TABLET
Relieves pain and inflammation in conditions like:
- rheumatoid arthritis
- osteoarthritis
- back pain
- postsurgical pain
How ACE PROXYVON CR TABLET Works
ACE PROXYVON CR TABLET relieves pain and inflammation where Aceclofenac blocks the release of prostaglandins (certain chemicals) responsible for causing pain and inflammation and Rabeprazole relieves acidity caused by aceclofenac by specific inhibition of an enzyme system at the secretory surface of stomach cells, that results in blockage of the final step of acid production.
How to use ACE PROXYVON CR TABLET
Always take ACE PROXYVON CR TABLET as directed by your physician. Swallow it with a glass of water and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ACE PROXYVON CR TABLET management depending upon your age, body weight and disease condition.
Side Effects Of ACE PROXYVON CR TABLET
Common
- headache
- nausea, vomiting, pain or discomfort right below your ribs
- gastrointestinal irritation or bleeding
- diarrhoea, constipation, stomach pain
Uncommon
- mouth ulcers
- inflammation or irritation of stomach lining, gas
- itching, rash, hives, skin inflammation or redness
- high blood urea and creatinine levels
- nervousness, drowsiness, sleepiness
- chest infection, painful and blocked sinuses
- indigestion, dry mouth, belching
- muscle, leg or joint pain
- bladder infection
- chest pain, chills, fever
- fracture of the hip, wrist or back
Rare
- problems with eyesight
- heart failure, high blood pressure, breathlessness
- stomach or bowel bleeding or ulceration
- allergic reactions (facial swelling, low blood pressure, breathing difficulties)
- loss of appetite
- depression
- upset stomach, sore mouth, taste disturbance
- liver inflammation, jaundice (yellowing of the skin or eyes)
- itchy rash, sweating, skin blisters
- kidney inflammation
- increased weight
Stop taking ACE PROXYVON CR TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction like anaphylactic shock (fever, difficulty breathing, wheezing, abdominal pain, vomiting, swollen face and throat)
- frequent infections, such as a sore throat, fever or mouth ulcers
- bruising or bleeding
- severe skin rashes such as Stevens-Johnson Syndrome and toxic epidermal necrolysis (large blisters and the skin peeling away, rash appearing in the mouth, throat or eyes, fever, headache and joint pain)
- meningitis (high fever, headache, vomiting, red rashes, neck stiffness, sensitivity to light)
- blood in faeces or black tarry stools, vomit with blood or dark particles
- kidney failure
- indigestion, heartburn, stomach pain
- blood disorders (extreme tiredness, breathlessness, aching of the joints and becoming prone to repeated infections and bruising)
How To Manage Side Effects
Nausea or vomiting:
Take ACE PROXYVON CR TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Constipation:
Drink five litres of water a day. Avoid drinking caffeine and alcohol as they cause dehydration. Take a balanced diet with fruits, vegetables and fibre rich foods. Eat fewer high-fat foods, like meat, eggs and cheese. Exercise more regularly. If symptom persists, contact your doctor.
Diarrhoea:
Drinking plenty of water and other electrolyte balanced fluids (like diluted fruit juices, broths, sports drinks and caffeine-free sodas) will keep you hydrated throughout the day. Try to eat less high-fat foods, like meat, eggs and cheese. Exercise more regularly. If symptom persists, contact your doctor.
Headache:
Take some rest, in a quiet place and avoid using mobile phones and other electronic devices for a while. Drink water as inadequate hydration may worsen your headache. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
ACE PROXYVON CR TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ACE PROXYVON CR TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you experience sleepiness, dizziness, spinning sensation, drowsiness, tiredness or any difficulty with your eyesight after taking ACE PROXYVON CR TABLET.
Kidney
ACE PROXYVON CR TABLET is not recommended for use in patients with severe kidney disease.
ACE PROXYVON CR TABLET should be used with caution in patients having other kidney diseases. Consult your doctor before taking it.
Liver
ACE PROXYVON CR TABLET is not recommended for use in patients who have or suspect they have severe liver failure.
ACE PROXYVON CR TABLET should be used with caution in patients with other liver diseases. Consult your doctor before taking it.
Allergy
Do not take ACE PROXYVON CR TABLET if you are allergic to Aceclofenac, Rabeprazole, aspirin, any other NSAIDs (Ex. ibuprofen, naproxen or diclofenac) or any of the other ingredients of this medicine.
Lungs
ACE PROXYVON CR TABLET should be used with caution in patients having asthma or any other breathing problems. Consult your doctor before taking it.
Heart Disease
ACE PROXYVON CR TABLET is not recommended for use in patients having heart diseases like heart attack and cerebrovascular diseases like stroke or mini stroke or those who have undergone a surgery to clear or bypass blockages.
ACE PROXYVON CR TABLET should be used with caution in patients with angina, blood clots, high blood pressure, cholesterol or other body fats such as triglycerides. Consult your doctor before taking it.
Others
ACE PROXYVON CR TABLET is not recommended for use if you:
- had, have or suspect that you have a stomach ulcer
- have vomited blood or passed bloody stools
- have blood circulation problems
- have bleeding or blood clotting disorders
- glaucoma (increased eye pressure)
Before taking ACE PROXYVON CR TABLET inform your doctor if you:
- have stomach or bowel disorders (Ex. ulcerative colitis, Crohn’s disease, ulceration, bleeding or holes in the stomach or bowel) or stomach tumour
- have or had blood circulation problems to your brain
- have porphyria (rare genetic disorder)
- smoke
- have diabetes
- have systemic lupus erythematosus (an autoimmune condition)
- have connective tissue disorders
- have chicken pox
- are recovering from any major surgery
- have reduced levels or risk factors for reduced vitamin B12
- are about to have a specific blood test (Chromogranin A)
- ever had a skin reaction after management with a medicine that reduces stomach acid
Use in paediatrics:
ACE PROXYVON CR TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
ACE PROXYVON CR TABLET should be used with caution in elderly people. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking ACE PROXYVON CR TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used for mental health problems (Ex. fluoxetine, fluvoxamine, citalopram, escitalopram, paroxetine, sertraline, lithium)
- medicines used to manage heart failure, irregular heartbeats, high blood pressure and other heart problems (Ex. digoxin, enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, moxonidine, propranolol, quinidine, procainamide)
- medicines used to manage bacterial infection (ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin)
- medicines used to manage fungal infection (Ex. ketoconazole, itraconazole)
- medicines used to manage fluid retention (Ex. hydrochlorothiazide, furosemide, amiloride)
- medicines that stop blood clotting (Ex. warfarin, heparin)
- methotrexate (used to manage cancer and autoimmune disorders like arthritis and skin conditions)
- mifepristone (used to terminate pregnancy)
- medicines used to manage swelling and inflammation (Ex. hydrocortisone, prednisolone)
- medicines used to suppress the immune system after transplant (Ex. ciclosporin, tacrolimus)
- zidovudine (used to manage HIV)
- medicines used to reduce blood sugar levels in diabetes (Ex. glibenclamide, gliclazide, tolbutamide)
- other medicines used to reduce pain (Ex. aspirin, ibuprofen, naproxen, celecoxib, etoricoxib)
- clopidogrel (used to dissolve blood clots)
Overdosage:
If you or anyone else accidentally take too much of ACE PROXYVON CR TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Aceclofenac, Rabeprazole |
| Pharmacological Category | : | NSAIDs, Proton pump inhibitors |
| Therapeutic Indication | : | Pain and inflammation |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep ACE PROXYVON CR TABLET out of reach of children
- Store ACE PROXYVON CR TABLET at room temperature
FAQs About ACE PROXYVON CR TABLET
Can I take paracetamol along with ACE PROXYVON CR TABLET?
No, if you take paracetamol along with ACE PROXYVON CR TABLET, it will result in overdosing of NSAIDs, affecting the liver. Avoid taking any other painkillers along with ACE PROXYVON CR TABLET without your doctor’s advice.
Is ACE PROXYVON CR TABLET recommended for patients with heart diseases?
ACE PROXYVON CR TABLET is not recommended for use in patients with heart diseases like heart attack and cerebrovascular diseases like stroke or mini stroke and should be used with caution in patients with angina and high blood pressure. Consult your doctor for advice. The doctor will determine a proper dose or select a suitable alternative management for you.
Can ACE PROXYVON CR TABLET cause headache?
Yes, headache is a common side effect caused by ACE PROXYVON CR TABLET. Take some rest, in a quiet place and avoid using mobile phones and other electronic devices for a while. Drink water as inadequate hydration may worsen your headache. If symptom persists, contact your doctor.
Can I take additional doses of ACE PROXYVON CR TABLET if my pain does not reduce?
No, you are not advised to take additional doses of ACE PROXYVON CR TABLET without doctor’s advice as it may cause seriously harmful effects. If you or anyone else accidentally took too much of ACE PROXYVON CR TABLET, consult your doctor immediately.
What if I miss a dose of ACE PROXYVON CR TABLET?
If you miss a dose of ACE PROXYVON CR TABLET, take it as soon as you remember. However, skip that dose if it's almost time to take the next dose. Do not take ACE PROXYVON CR TABLET two times to make up for the missed dose.
Can I stop taking ACE PROXYVON CR TABLET if I feel better?
Keep taking ACE PROXYVON CR TABLET until your doctor tells you to stop, unless you experience any unusual effects, worsening of your condition or any new symptoms. Contact your doctor in such situation.
References
1. KD. Tripathi. NSAIDs and Antipyretic-Analgesics. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Eighth edition. 2019. Page- 129, 701.
2. Gwee, K. A., Goh, V., Lima, G., & Setia, S Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: risks versus benefits. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. February 2018. [Accessed on 24th November 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817415/
3. Iolascon G, Giménez S, Mogyorósi D. A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. November 2021. [Accessed on 24th November 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643213/
4. Accord Healthcare Limited Electronic Medicines Compendium (EMC) [Revised in January 2021] [Accessed on 24th November 2022]. https://www.medicines.org.uk/emc/files/pil.4240.pdf
5. Balkanpharma Dupnitsa AD. Electronic Medicines Compendium (EMC) [Revised in September 2021] [Accessed on 24th November 2022]. https://www.medicines.org.uk/emc/files/pil.2843.pdf
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