ACCECLOMAXX MR Tablet 10's

Introduction About ACCECLOMAX MR TABLET

ACCECLOMAX MR TABLET is used to manage muscular pains and spasms. It can also be used to provide relief from joint pain (Ex. osteoarthritis and rheumatoid arthritis) and back pain (Ex. ankylosing spondylitis). It is a combination of Aceclofenac, Chlorzoxazone, and Paracetamol, which belong to the group of medicines called Analgesics and Muscle relaxants, respectively. 

Chlorzoxazone acts by increasing the effects of certain chemical messengers (such as GABA) in the brain and spinal cord that induce muscle relaxation. As a result, it manages muscle twitching, relieves pain caused by muscle spasms, and improves muscle movement. Aceclofenac and paracetamol work by blocking the release of certain chemicals (such as prostaglandins) in the body that cause pain, inflammation, and swelling. Collectively, these actions help reduce muscle spasms, joint pain, and inflammation.

Take ACCECLOMAX MR TABLET, preferably with meals, to avoid gut irritation. Avoid consuming alcohol, as it could aggravate the risk of stomach problems. Do not take ACCECLOMAX MR TABLET if you have any ulcers, bleeding, or perforations in the gut.

Before taking ACCECLOMAX MR TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have diabetes, hypertension, high blood cholesterol, any inflammation in the bowel or intestines, blood clots, bleeding problems, or a previous history of stomach ulcers.

ACCECLOMAX MR TABLET is not recommended for use in patients with liver failure or stroke. It is also not suitable for use by pregnant or breastfeeding women. The most common side effects of taking ACCECLOMAX MR TABLET are nausea, vomiting, indigestion, heartburn, and stomach pain. Consult your doctor if any of these side effects worsen.

Uses Of ACCECLOMAX MR TABLET

It is used to manage:

• Muscle pain and spasms
• Joint pain and back pain

How ACCECLOMAX MR TABLET Works

ACCECLOMAX MR TABLET contains three medicines, namely Chlorzoxazone, Aceclofenac, and paracetamol. Chlorzoxazone is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the brain and spinal cord that induce muscle relaxation. As a result, it manages muscle twitching, relieves pain caused by muscle spasms, and improves muscle movement.

Aceclofenac and paracetamol are analgesic agents. They provide pain relief by blocking the release of certain chemicals (such as prostaglandins) in the body that cause pain, inflammation, and swelling. Collectively, these actions help reduce muscle spasms, joint pain, and inflammation.

How to use ACCECLOMAX MR TABLET

Take ACCECLOMAX MR TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken with meals to avoid gastric irritation.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Side Effects Of ACCECLOMAX MR TABLET

How To Manage Side Effects

Constipation

Increase fiber intake through fruits, vegetables, and whole grains. Stay hydrated by drinking plenty of water. Maintain regular meal times and avoid skipping meals. Exercise regularly to promote bowel movements. Establish a bathroom routine and avoid ignoring the urge to go. Avoid processed foods and prioritize probiotic-rich foods for gut health. Consult your doctor if constipation persists.

Diarrhea

Drink plenty of clear fluids, like water, diluted fruit juices, or oral rehydration solutions, to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.

Dizziness Or Drowsiness

Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.

Mouth Ulcers

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel to the affected areas of the mouth if required. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.

Skin rash Or Itching

Keep the affected area clean and dry and avoid scratching to prevent further irritation or infection. Apply calamine lotion to help reduce itching and inflammation. Applying cool compresses and wearing loose, breathable clothing can also provide relief. If the rash persists, consult your doctor.

Warning & Precautions

Pregnancy

Contraindicated

ACCECLOMAX MR TABLET is not recommended for use by pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

ACCECLOMAX MR TABLET is not recommended for use by breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, or vision problems after taking ACCECLOMAX MR TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking ACCECLOMAX MR TABLET, as it may make you feel dizzier or drowsier.

Kidney

Consult your doctor

ACCECLOMAX MR TABLET is not recommended for use in patients with moderate-to-severe kidney diseases. It should be used with caution in patients with mild kidney problems. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

ACCECLOMAX MR TABLET is not recommended in patients with severe liver problems (such as liver failure). It should be used with caution in patients with mild liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take ACCECLOMAX MR TABLET if you are allergic to Aceclofenac, Chlorzoxazone, or Paracetamol.

Lungs

Contraindicated

ACCECLOMAX MR TABLET is not recommended for use in patients who have previously experienced asthma attacks or breathing difficulties after taking any pain-relieving medicine.

Heart Disease

Consult your doctor

ACCECLOMAX MR TABLET is not recommended for use in patients with severe heart problems (such as a heart attack). It should be used with caution in patients with other heart problems (such as angina). Therefore, consult your doctor before taking it.

Use In Pediatrics

Monitoring required

ACCECLOMAX MR TABLET is not recommended for use in children and adolescents (aged below 18 years) unless considered necessary by the physician. Therefore, consult your doctor for advice before taking it.

Use In Geriatrics

Use with Caution

ACCECLOMAX MR TABLET should be used with caution with elderly patients. Therefore, consult your doctor for advice before taking it.

Interactions

A. Drug-Drug Interactions:

• Other analgesics (Ex. aspirin, ibuprofen, naproxen, celecoxib, and etoricoxib)
• Cardiovascular agents (Ex. enalapril, lisinopril, losartan, candesartan, methyldopa, clonidine, propranolol, and digoxin)
• Diuretics (Ex. furosemide, hydrochlorothiazide)
• Immunosuppressants (Ex. ciclosporin or tacrolimus)
• Anticoagulants (Ex. warfarin, heparin, and clopidogrel)
• Anti-hyperlipidaemic (Ex. cholestyramine)
• Corticosteroids (Ex. hydrocortisone, prednisolone)
• Anti-emetics (Ex. domperidone, metoclopramide)
• Antibacterials (Ex. chloramphenicol, ciprofloxacin, ofloxacin, levofloxacin, and moxifloxacin)
• Anti-depressants (Ex. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline)
• Antineoplastic (Ex. methotrexate)
• Anti-retroviral (Ex. zidovudine)
• Antidiabetics (Ex. glibenclamide, gliclazide, and tolbutamide)

Overdosage:

If you or anyone else accidentally took more ACCECLOMAX MR TABLET, visit the nearby hospital or consult your doctor immediately.

Synopsis

More Information

FAQs About ACCECLOMAX MR TABLET

Q: What is the use of ACCECLOMAX MR TABLET?

A: ACCECLOMAX MR TABLET is used to manage muscular pains and spasms. It can also be used to provide relief from joint pain (Ex. osteoarthritis and rheumatoid arthritis) and back pain (Ex. ankylosing spondylitis).

Q: How does ACCECLOMAX MR TABLET work?

A: ACCECLOMAX MR TABLET works by reducing pain and inflammation in the muscles and bones. It increases the effects of certain chemical messengers (such as GABA) in the brain and spinal cord that induce muscle relaxation and blocks the release of certain chemicals (such as prostaglandins) in the body that cause pain, inflammation, and swelling. Collectively, these actions help reduce muscle spasms, joint pain, and inflammation.

Q: How do I take ACCECLOMAX MR TABLET?

A: Take ACCECLOMAX MR TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not chew or crush the medicine. It is preferably taken with meals to avoid gastric irritation.

Q: What is the best time to take ACCECLOMAX MR TABLET?

A: ACCECLOMAX MR TABLET can be taken at any time of the day. However, your doctor will decide the best time to take ACCECLOMAX MR TABLET.

Q: Can I stop taking ACCECLOMAX MR TABLET once I start feeling better?

A: No. Do not stop taking ACCECLOMAX MR TABLET without consulting your doctor, as it may make your symptoms reappear once again. If you feel better during the midway point of therapy, consult your doctor for advice.

Q: Can I take ACCECLOMAX MR TABLET daily?

A: Take ACCECLOMAX MR TABLET as advised by your physician. Your doctor will evaluate your health condition and suggest whether you can take ACCECLOMAX MR TABLET every day or not.

Q: Will taking a higher dose of ACCECLOMAX MR TABLET be more effective?

A: No. Taking a higher dose of ACCECLOMAX MR TABLET will not be effective; rather, it will make you drowsier. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What should I do if I forget to take a dose of ACCECLOMAX MR TABLET?

A: If you forgot to take a dose of ACCECLOMAX MR TABLET, take it as soon as you remember. However, if it is time for the next dose of ACCECLOMAX MR TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ACCECLOMAX MR TABLET to compensate for the missed ones. Consult your doctor for advice.

Q: What are the side effects of ACCECLOMAX MR TABLET?

A: The most common side effects of taking ACCECLOMAX MR TABLET are nausea, vomiting, indigestion, heartburn, and stomach pain. Consult your doctor if any of these side effects worsen.

Q: Does ACCECLOMAX MR TABLET make me feel sleepy?

A: ACCECLOMAX MR TABLET may cause sleepiness in some individuals. Therefore, restrict yourself from engaging in hazardous activities that require complete alertness. Do not drive or handle any heavy tools or machines. Also, avoid consuming alcohol, as it may make you feel more drowsy. Consult your doctor if your sleepiness worsens.

Q: Can I consume alcohol while taking ACCECLOMAX MR TABLET?

A: Avoid consumption of alcohol while taking ACCECLOMAX MR TABLET, as it might make you feel dizzier and drowsier.

Q: Is ACCECLOMAX MR TABLET safe to use in diabetic patients?

A: ACCECLOMAX MR TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking ACCECLOMAX MR TABLET as a precaution. Your doctor will closely monitor your blood sugar levels to avoid the risk of side effects.

Q: Can ACCECLOMAX MR TABLET be taken during pregnancy?

A: ACCECLOMAX MR TABLET is not recommended for use by pregnant women. Therefore, consult your doctor before taking it.

Q: Can the use of ACCECLOMAX MR TABLET affect the liver?

A: Yes. ACCECLOMAX MR TABLET may affect the way your liver works. It can elevate the levels of certain liver enzymes in your body. Therefore, it is not recommended for use in patients with liver failure. It should be used with caution in patients with other mild liver problems. Consult your doctor before taking it.

References

1. KD. Tripathi. Nonsteroidal Anti-Inflammatory Drugs and Antipyretic-Analgesics. Skeletal Muscle Relaxants. Essentials of Medical Pharmacology. Seventh Edition. Page – 204, 206 & 357.

2. Sanjeev Kumar, Seema Rani, Ramchander Siwach, and Prem Verma. To compare the efficacy and safety of a fixed-dose combination of thiocolchicoside and aceclofenac versus chlorzoxazone, aceclofenac, and paracetamol in patients with acute lower backache associated with muscle spasm. NIH, National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July-December 2014. [Accessed on 5th June 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137632/

3. Innova Captab Ltd. National Agency for Food and Drug Administration. [Accessed on 5th June 2024] https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/Jan2_2022/Aceclofenac-Paracetamol-Chlorzoxazone-Tablets.pdf

4. Rivopharm UK Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2023] [Accessed on 5th June 2024] https://www.medicines.org.uk/emc/files/pil.2389.pdf

5. STAT Rx USA LLC. Chlorzoxazone Tablet. Dailymed.com. [Revised in September 2011]. [Accessed on 5th June 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ddd41f29-8c98-4fae-94e3-104a8e9365fc

6. GlaxoSmithKline. PARACETAMOL/CHLORZOXAZONE. [Accessed on 5th June 2024] https://gskpro.com/content/dam/global/hcpportal/en_TZ/PI/MYOLGIN-NCDS-v-03.pdf

7. Solubiomix, LLC. Chlorzoxazone 250 mg. Dailymed.com. [Revised in October 2022]. [Accessed on 5th June 2024] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=c3d40a90-6df8-4b44-bc61-d7655c52bacb&type=pdf

8. Reliable 1 Laboratories LLC. Acetaminophen 325mg – Acetaminophen tablet. Dailymed.com. [Revised in October 2021]. [Accessed on 5th June 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=25626b46-78f8-7226-e054-00144ff8d46c

9. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in July 2023] [Accessed on 5th June 2024] https://www.medicines.org.uk/emc/files/pil.5164.pdf

10. Central Drugs Standard Control Organization. FDC division. Annexure A. Aceclofenac, chlorzoxazone, and paracetamol. December 2018. [Accessed on 5th June 2024] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadPublic_NoticesFiles/fdc294saka.pdf

11. Leeford Healthcare Pvt. Ltd. Acimol MR. [Accessed on 5th June 2024] https://www.leeford.in/product/533/acimol-mr

12. Hetero Healthcare Ltd., Vetory MX Tablet. [Accessed on 5th June 2024] https://www.heterohealthcare.com/vetory-mx-tablet

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Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 06 Jun 2024 | 06:00 PM(IST)