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INTRODUCTION
ZYLORIC 100MG contain Allopurinol which belongs to a group of medicine called enzyme inhibitors. It helps in reducing the level of uric acid in the body. This medicine reduces or prevent the formation of uric acid deposition in conditions such as gout or some types of kidney stones or kidney problems or when you are having treatment for cancer or some other conditions.
Increased uric acid production leads to deposition of sodium urate microcrystals at the joints and kidney. ZYLORIC 100MG lowers the level of uric acid in the blood and urine by slowing down the speed of certain chemical reactions in your body. This medicine is rarely recommended for use in children and adolescents, except in malignant condition (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome. The common side effects are skin rash, increased level of thyroid stimulating hormone in the blood. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF ZYLORIC 100MG
- Helps in reducing the level of uric acid in the body in conditions such as gout or some types of kidney stones or kidney problems or during treatment of cancer
HOW ZYLORIC 100MG WORKS
ZYLORIC 100MG lowers the level of uric acid in the blood and urine by slowing down the speed of certain chemical reactions in your body.
DIRECTIONS FOR USE
Always take ZYLORIC 100MG exactly as your doctor has told you. It must be taken after food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF ZYLORIC 100MG
SERIOUS
- fever and chills, headache, aching muscle (flu-like symptom) and generally feeling unwell
- serious hypersensitivity reactions involving skin rash, joint pain and abnormalities in blood and liver function tests (these may be signs of a multi-organ sensitivity disorder)
- bleeding in the lip, eye, mouth, nose, or genital
- ulcer of the mouth, throat, nose, genital areas
- conjunctivitis
- widespread blister or peeling of the skin
- vomiting blood (haematemesis)
- liver problems such as liver inflammation
- serious allergic reaction which causes swelling of the face, lips, tongue or throat, or difficulty breathing or swallowing, severe boils
- change in the amount of blood cell causing increased bruising, nosebleeds, sore throat, or infection
- swollen lymph glands, joint pain, swollen blood vessels, yellowing of the skin or eyes
- kidney damage
- potentially life-threatening skin rashes (such as Stevens-Johnson syndrome, toxic epidermal necrolysis)
COMMON
- skin rash
- increased level of thyroid stimulating hormone in the blood
HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If does not get better, speak to a doctor.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Fever:
Drink plenty of fluids and water. Avoid taking cold bath or showers.
WARNING & PRECAUTIONS
PREGNANCY
ZYLORIC 100MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
ZYLORIC 100MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause drowsiness, giddy or coordination problems.
ALCOHOL
Consumption of alcohol is not recommended during treatment with ZYLORIC 100MG.
KIDNEY
ZYLORIC 100MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
ZYLORIC 100MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take ZYLORIC 100MG if you are allergic (hypersensitive) to Allopurinol or any other ingredients in this medicine.
HEART DISEASE
ZYLORIC 100MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- high blood pressure
- currently having an attack of gout
- thyroid problems
- an intolerance to some sugars
- cancer or Lesch-Nyhan syndrome
INTERACTIONS
Talk to your doctor if you are taking,
- aspirin
- ACE inhibitor such as captopril (used to treat high blood pressure)
- antibiotics such as ampicillin and amoxicillin (used to treat bacterial infections)
- anticoagulants such as dicoumarol, phenprocoumon, warfarin (used to thin the blood)
- chlorpropamide and tolbutamide (used to treat diabetes)
- phenytoin, carbamazepine (used to treat epilepsy)
- azathioprine, mercaptopurine, cyclophosphamide (used for chemotherapy)
- ciclosporin (used to suppress the immune system following organ transplant and in immune related disorders)
- theophylline (used to treat asthma and breathing disorders)
- thiazide diuretics
- medicines used to reduce uric acid levels (e.g. probenecid, salicylate)
- anti-viral drug such as vidarabine
- other medicine (used to treat gout)
- didanosine (used to treat HIV infection)
- aluminium hydroxide
- cytostatics such as doxorubicin, bleomycin, procarbazine, alkyl halogenides
SYNOPSIS
| Drug | : | Allopurinol |
| Pharmacological Category | : | Antigout Agent |
| Therapeutic Indication | : | Gout, kidney stones or kidney diseases, during cancer treatment |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
REFERENCES
1. KD Tripathi. Antirheumatoid and Antigout Drugs. Essentials of Medical Pharmacology. Seventh Edition,2013. Page - 216-217.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 141-145.
3. J. T. Scott, A. P. Hall, and R. Grahame. Allopurinol in treatment of gout. US National Library of Medicines, National Institutes of Health. 6 Aug 1966. [Accessed 07 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1943105/
4. Accord Healthcare Limited; Electronic Medicines Compendium (EMC); [Revised on Dec 2018] [Accessed 07 Dec 2020] https://www.medicines.org.uk/emc/files/pil.6006.pdf
5. Accord; Electronic Medicines Compendium (EMC); [Revised on Jan 2020] [Accessed 07 Dec 2020] https://www.medicines.org.uk/emc/files/pil.5693.pdf
6. Accord Healthcare Limited; Electronic Medicines Compendium (EMC); [Revised on Apr 2019] [Accessed 07 Dec 2020] https://www.hpra.ie/img/uploaded/swedocuments/72ad026a-cf77-4a4a-b929-1c98eeaf813c.pdf
USEFUL DIAGNOSTIC TESTS
- Creatinine
- Creatinine - Spot
- Uric Acid
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