ZYLORIC 100mg Tablet 10's


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ALLOPURINOL 100MG
By GLAXOSMITHKLINE PHARMACEUTICALS LTD
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Rs.19.26
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Drug Information

What is Allopurinol used for?

Allopurinol is used to treat the following conditions:

  • Excess uric acid formation;
  • Gout (Pain and inflammation occur when uric acid crystallises and deposits in the joints);
  • Certain types of kidney stones;
  • Excess of uric acid for cancer patient receiving chemotherapy;
  • Certain skin diseases due to increased uric acid level in blood;
  • Metabolic disorders.

Allopurinol is used in combination with other antibiotics.

Allopurinol may also be prescribed for other conditions as determined by your doctor.

How does Allopurinol work?

Allopurinol is a xanthine oxidase inhibitor. It inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. Purine is a colourless crystalline compound with basic properties, forming uric acid on oxidation.

Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation.

How to take Allopurinol?

  • The dosage of oral tablet of Allopurinol depends on the age, weight and medical condition of an individual. Take Allopurinol as prescribed by your doctor.
  • Allopurinol is taken once daily.
  • Allopurinol should be taken after food to avoid stomach upset.
  • Drink full glass of water with this medicine. It is better to take at least 8 to 10 glasses of fluid a day when under this medication.
  • Do not take large or small amounts or for long duration than recommended. 
  • If you miss a dose of Allopurinol, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What should you do when you have taken an overdose of Allopurinol?

If you have taken an overdose of Allopurinol, please contact your doctor immediately.

Symptoms of overdose may include the following:

  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Skin rash

What are the drugs that interact with Allopurinol?

Drugs that interact with Allopurinol:

  • Acetaminophen
  • Amlodipine
  • Ascorbic acid
  • Aspirin
  • Atorvastatin
  • Ciclosporin
  • Chlorpropamide
  • Cholecalciferol
  • Clopidogrel
  • Colchicine
  • Cyanocobalamin
  • Cyclophosphamide
  • Didanosine
  • Duloxetine
  • Esomeprazole
  • Furosemide
  • Insulin glargine
  • Levothyroxine
  • Metoprolol Succinate
  • Metoprolol Tartrate
  • Omega-3 polyunsaturated fatty acids
  • Phenytoin
  • Pregabalin
  • Rosuvastatin
  • Theophylline
  • Warfarin

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Allopurinol?

Most common side effects of Allopurinol are: 

  • Diarrhoea
  • Nausea
  • Vomiting, abdominal pain
  • Headache
  • Drowsiness
  • Skin rash

Please stop your tablets and contact your physician immediately if you have

  • swelling of the tongue or throat, face, lips or difficulty breathing or swallowing;
  • life-threatening skin rashes (Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported;
  • increased bruising, nosebleeds, sore throats or infections;
  • swollen lymph glands, joint pain, swollen blood vessels;
  • yellowing of the skin or eyes and inflammation of the liver;
  • blood in the urine or fits;
  • delayed multi-organ hypersensitivity syndrome (DRESS) which includes fever, rash and blood abnormalities;
  • fever and chills, headache, aching muscles (flu-like symptoms) and generally feeling unwell;
  • ulcers of the mouth, throat, nose, genitals and conjunctivitis (red and swollen eyes).

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Allopurinol?

Seek doctor’s advice before taking any other drug or herbal products while on Allopurinol.

You are advised not to take Allopurinol if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Allopurinol?

Tell your doctor if

  • you are allergic to Allopurinol or other antibiotics from the same class.
  • you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • you have liver disease.
  • you have kidney related problems.
  • you have diabetes.
  • you have high blood pressure.
  • you are on unusual diet or fasting.
  • you have heart problems and you take diuretics and / or a medicine called ACE-inhibitors.
  • you are planning a surgery or any procedure.
  • you are pregnant or trying to conceive or are breastfeeding.

Frequently asked questions about Allopurinol

  • How should Allopurinol be stored?
    • Allopurinol tablets must be stored in a cool temperature below 30°C in a dry place.
    • The tablets must not be exposed to light and moisture as it becomes less active. Allopurinol must be kept out of children’s reach.
  • Should I follow any special dietary instructions while taking Allopurinol?
  • No, you can have your normal diet unless advised by your doctor. Drink at least 8 to 10 glasses of fluid while on this medication.

  • Can I drive while taking Allopurinol?
  • Allopurinol does not affect the driving ability. However, if you are feeling dizzy, it is better to avoid driving.

  • Can I drink alcohol with Allopurinol?
  • It is better to avoid alcohol while taking Allopurinol as the medicine potentiates the effect of alcohol.

    Disclaimer:

    The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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