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INTRODUCTION
ZINCODERM G CREAM is a combination of Clobetasol propionate, Gentamicin and Zinc sulphate which belongs to a group of medicines called Topical Corticosteroids, Aminoglycoside antibiotics and Astringents respectively. ZINCODERM G CREAM is used to treat bacterial skin infections, which include eczema, psoriasis and contact dermatitis. It is also used to treat skin swelling, irritation and redness.
Eczema is an inflammatory skin condition generally characterised by symptoms such as dry skin, red rashes and itchy, bumpy skin. Psoriasis is a skin disease that causes a rash with itchy, scaly patches that most commonly occur on the knees, elbows, trunk and scalp. Contact dermatitis is a skin condition that occurs due to direct contact with a substance or an allergic reaction to it and is generally characterised by symptoms such as bumps, blisters, dry skin and an itchy rash.
ZINCODERM G CREAM is not recommended for use in patients allergic to clobetasol propionate, gentamicin or zinc sulfate. It is also not recommended for use in patients with skin problems such as acne, rosacea (severe flushing of the skin on and around your nose), perioral dermatitis (a spotty red rash around your mouth), itching around the anus and genitals, infected or itchy skin and widespread plaque psoriasis.
Before applying ZINCODERM G CREAM, inform your doctor if you have had previous bone symptoms (such as bone pain), a previous allergic reaction with another steroid, broken or damaged skin, a chronic leg ulcer and/or psoriasis. ZINCODERM G CREAM should be used with caution during pregnancy and in women who are breastfeeding.ZINCODERM G CREAM is not recommended for use in children under the age of one year.
The most common side effects of using ZINCODERM G CREAM are burning, pain, irritation and/or itching at the application site. Consult your doctor if any of these symptoms get worse.
USES OF ZINCODERM G CREAM
- Treats bacterial skin infections which include eczema, psoriasis and contact dermatitis
- Reduces swelling, irritation and redness of the skin due to certain skin problems
HOW ZINCODERM G CREAM WORKS
ZINCODERM G CREAM helps to treat bacterial skin infections and reduce swelling, irritation & redness of the skin, where clobetasol propionate prevents inflammation by blocking the production of certain chemical messengers (prostaglandins) that make the skin red, swollen & itchy, gentamicin causes bacterial cell destruction by inhibiting bacterial protein synthesis and zinc sulphate helps shielding the skin from bacterial invasion and locking in hydration and moisture by forming a barrier on the applied skin site.
DIRECTIONS FOR USE
Always apply ZINCODERM G CREAM, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Treated areas on the face need not be covered with a plaster or bandage. Do not apply ZINCODERM G CREAM on your face beyond 5 days. Avoid applying ZINCODERM G CREAM around your eyes, including eyelids.
SIDE EFFECTS OF ZINCODERM G CREAM
COMMON
- burning, pain, irritation or itching sensation at the site of application
UNCOMMON
- signs of stretch marks such as skin thinning
- noticeable blood vessels under the surface of the skin
RARE
Stop applying ZINCODERM G CREAM and contact your doctor if you experience any of the following side effects:
- signs of allergic reaction and infection such as generalized rash, swollen skin,
- psoriasis (itchy skin) with raised bumps filled with pus under the skin
- irritation
- sensitization/superinfection
HOW TO MANAGE SIDE EFFECTS
Itchy Skin:
Avoid scratching your skin. Cool your skin by holding onto a damp towel. Try to have cool or warm baths. Wear loose clothing and do not wear tight clothes. Try to avoid applying perfumed soaps, deodorants or moisturizers and always use unperfumed moisturizers.
WARNING & PRECAUTIONS
PREGNANCY
ZINCODERM G CREAM should be used with caution during pregnancy and in women planning to become pregnant. Consult your doctor before applying for the medicine.
BREASTFEEDING
ZINCODERM G CREAM should be used with caution in breastfeeding women. It is advised not to be applied on the breast area while feeding the baby. Consult your doctor before applying the medicine.
ALLERGY
ZINCODERM G CREAM is not recommended for use if you are allergic to clobetasol propionate, gentamicin, zinc sulphate or any other ingredients of this medicine.
OTHERS
ZINCODERM G CREAM is not recommended for use if you:
- have skin problems such as acne (pimples), rosacea (severe flushing of skin on and around your nose), perioral dermatitis (spotty red rash around your mouth), itching around your anus or genitals, infected skin (unless the infection is being treated with an anti-infective medicine at the same time), itchy skin (which is not inflamed), widespread plaque psoriasis (except single lesions)
Before applying ZINCODERM G CREAM, inform your doctor if you:
- had previous bone symptoms such as bone pain, swelling and tenderness near the affected area, weakened bone
- had previously had an allergic reaction to another steroid
- are planning to apply the cream under an airtight dressing including a child’s nappy
- have broken/damaged skin or within skin folds
- have a large surface area to apply the medicine
- have psoriasis (itchy skin)
- have a chronic leg ulcer
- site of the application is facing
Use in Pediatrics:
ZINCODERM G CREAM is not recommended for use in children (below 1 year). It should be used with caution in children (above 1 year) and adolescents (below 18 years). Consult your doctor before applying ZINCODERM G CREAM.
Use in Geriatrics:
ZINCODERM G CREAM should be applied with caution in elderly patients (aged 65 years or above). Consult your doctor before applying ZINCODERM G CREAM.
INTERACTIONS
A. Drug-Drug Interactions:
Before applying ZINCODERM G CREAM, inform your doctor if you are applying any of the following medicine:
- ritonavir (a medicine used to treat HIV infection)
- itraconazole (a medicine used to treat fungal infections)
Overdosage:
If you or anyone else applies too much of ZINCODERM G CREAM or accidentally swallows it, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Clobetasol propionate, Gentamicin, Zinc sulphate |
| Pharmacological Category | : | Topical Corticosteriods, Aminoglycoside antibiotics and Astringents |
| Therapeutic Indication | : | Bacterial skin infections which include eczema, psoriasis and contact dermatitis, To reduce swelling, irritation and redness of the skin due to skin infections |
| Dosage Forms | : | Cream |
MORE INFORMATION
- Keep ZINCODERM G CREAM out of reach from children
- Store ZINCODERM G CREAM at room temperature
FAQs ABOUT ZINCODERM G CREAM
Q: What ZINCODERM G CREAM is used for?
A: ZINCODERM G CREAM is used to treat bacterial skin infections, which include eczema, psoriasis and contact dermatitis. It is also used to reduce swelling, irritation and redness of the skin due to certain skin problems.
Q: Is ZINCODERM G CREAM safe to be used by children?
A: ZINCODERM G CREAM is not recommended for use in children under the age of one year. It should be used with caution in children (above 1 year) and adolescents (below 18 years). Consult your doctor before applying ZINCODERM G CREAM.
Q: Who should avoid applying ZINCODERM G CREAM?
A: ZINCODERM G CREAM is not recommended for use in patients allergic to clobetasol propionate, gentamicin or zinc sulfate. It is also not recommended for people who have acne, rosacea (severe flushing of the skin on and around the nose), perioral dermatitis (spotty red rash around your mouth), itching around your anus or genitals, infected and itchy skin or widespread plaque psoriasis.
Q: Is ZINCODERM G CREAM safe to be used by pregnant and breastfeeding women?
A: ZINCODERM G CREAM should be avoided during pregnancy and in women who are planning to become pregnant. It should be used with caution in breastfeeding women and it is advised not to be applied on the breast area while feeding the baby. Consult your doctor before applying the medicine.
Q: How does ZINCODERM G CREAM work?
A: ZINCODERM G CREAM helps to treat bacterial skin infections and reduce swelling, irritation and redness of the skin. Clobetasol propionate prevents inflammation by blocking the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy.
REFERENCES
1. KD Tripathi. Aminoglycoside Antibiotics, Drugs Acting on Skin & Mucous Membranes and Antiseptics, Disinfectants & Ectoparasiticides. Essentials of medical pharmacology. Seventh edition. 2013. Page – 747, 895, 892.
2. Clobetasol propionate. NIH National Library of Medicine. National Center for Biotechnology Information. PubChem [Revised in July 2022] [Accessed on 21st July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasol-propionate#section=Biological-Half-Life
3. Zinc Sulfate. NIH National Library of Medicine. National Center for Biotechnology Information. PubChem. [Revised in July 2022] [Accessed on 21st July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Zinc-sulfate
4. Glaxo Operations UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 21st July 2022] https://www.medicines.org.uk/emc/files/pil.939.pdf
5. GENTAMICIN SULFATE cream. DailyMed. NIH.National Library of Medicine. [Revised in June 2022] [Accessed on 21st July 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9e550dc9-509e-da05-8a97-ecbd0f5dd633
6. CLOBETASOL PROPIONATE- clobetasol propionate cream. DailyMed. NIH.U.S. National Library of Medicine. [Revised in November 2021] [Accessed on 21st July 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=550d6cbd-88d0-c82b-f7c9-927064f2ba36
7. Apex Labs. Zincoderm - G Cream. [Accessed on 21st July 2022] https://www.apexlab.com/p-topical-corticosteroid-antibacterial.php
USEFUL DIAGNOSTIC TESTS
- Patch test
PRODUCT DETAILS
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