INTRODUCTION
ZACLO G CREAM is a combination of Clobetasol and Gentamicin which belongs to the group of medicines called Corticosteroids and Antibiotics respectively. It is used to treat bacterial infections and inflammations of the skin.
During the treatment your doctor might regularly examine your skin to avoid any untoward side effects.
Avoid smoking while using ZACLO G CREAM. Consult your doctor before using this medicine.
ZACLO G CREAM is not recommended for use in children (ages less than 1 year). Before using ZACLO G CREAM, inform your doctor if you have skin conditions like fungal infections, severe flushing on and around your nose, spotty red rash around your mouth, infected or itchy skin around the genitals.
ZACLO G CREAM should be used with caution in pregnant women. ZACLO G CREAM is not recommended for use in breastfeeding women.
The most common side effects of using ZACLO G CREAM are burning, pain, irritation or itching where the medicine is applied. Contact your doctor if any of the side effects worsen.
USES OF ZACLO G CREAM
- Used to treat bacterial skin infections
HOW ZACLO G CREAM WORKS
ZACLO G CREAM treats affected skin where Clobetasol induces certain proteins (lipocortins), that control the production of inflammatory mediators like prostaglandins and leukotrienes, thus reducing inflammation, and Gentamicin binds to 30s ribosomal subunit, disrupting mRNA translation, resulting in the formation of shortened or non-functional proteins.
DIRECTIONS FOR USE
Apply ZACLO G CREAM as directed by your physician. It is for external use only. Apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes. Your doctor will decide the right dose depends on your age, body weight and severity of infection.
SIDE EFFECTS OF ZACLO G CREAM
COMMON
- burning, pain, irritation or itching (application site reactions)
UNCOMMON
- skin thinning that may cause stretch marks
- blood vessels under the skin surface may become more visible
RARE
Stop using ZACLO G CREAM and consult your doctor immediately if you experience any of the following side effects:
- rounding of the face
- increased risk of infection
- dryness of skin
- easy damage or wrinkling of the skin
- worsening of skin problems (generalized rash or swelling)
- raised bumps with pus under the skin
- blurred vision or other visual disturbances
- new bone pain or worsening of previous bone symptoms
- overgrowth of non-susceptible organisms like fungi, irritation, sensitization, or superinfection
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionZACLO G CREAM should be used with caution in pregnant women. Consult your doctor before using the medicine.
BREASTFEEDING
ContraindicatedZACLO G CREAM is not recommended for use in breastfeeding women. Consult your doctor before using the medicine.
ALLERGY
ContraindicatedDo not use ZACLO G CREAM if you are allergic to Clobetasol, Gentamicin, or any other ingredients of this medicine.
OTHERS
ZACLO G CREAM is not recommended for use if you:
- have acne
- have rosacea (sudden reddening of skin on and around your nose)
- have perioral dermatitis (red spotty rash around your mouth)
- have itching around genital parts
- have any infection
- have itchy skin without inflammation
- have widespread plaque psoriasis
Before using ZACLO G CREAM inform your doctor if you:
- have psoriasis
Use in Pediatrics:
ZACLO G CREAM is not recommended for use in children (less than 1 year of age). Consult your doctor before using the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before using ZACLO G CREAM, inform your doctor if you are taking any of the following medicine:
- other medicines used to treat inflammation (Ex. prednisolone, hydrocortisone)
- medicines used to control your immune system (Ex. ciclosporin, tacrolimus)
Overdosage:
If you or anyone else accidentally applies too much of ZACLO G CREAM, contact your doctor immediately or visit nearby hospital.
SYNOPSIS
| Drug | : | Clobetasol, Gentamicin |
| Pharmacological Category | : | Corticosteroid, Antibiotics |
| Therapeutic Indication | : | Bacterial skin infections |
| Dosage Forms | : | Cream |
MORE INFORMATION
- Keep ZACLO G CREAM out of reach of children
- Do not store above 30°C
FAQs ABOUT ZACLO G CREAM
Q: For how long can I use ZACLO G CREAM?
A: Use ZACLO G CREAM for as long as your doctor advises you to. If you use it over a long time or in large amounts it may increase your chances of getting side effects, and your skin may get more sensitive to the medicine.
Q: What special precautions should I take while using ZACLO G CREAM?
A: Take special care if you are going to use ZACLO G CREAM near your eyes. Do not smoke or go near flames as it may cause severe burns. Consult your doctor in case of any concerns.
Q: What if I accidently get ZACLO G CREAM in my eye?
A: If you accidentally get ZACLO G CREAM in your eye, immediately wash it out with plenty of water. If you begin to have any problems with your sight or your eye is hurting, contact your doctor immediately.
Q: Can I stop using ZACLO G CREAM?
A: Do not stop using ZACLO G CREAM without asking your doctor as abrupt discontinuation might worsen your condition. If you have any more doubts regarding the use of this medicine, ask your doctor.
Q: What if I forget to apply a dose of ZACLO G CREAM?
A: If you forget to apply a dose of ZACLO G CREAM, do it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not apply extra medicine to make up for a forgotten dose.
Q: Can ZACLO G CREAM be used on infants?
A: No. ZACLO G CREAM is not recommended for children (below 1 year of age). Your doctor will decide the correct dose or select a suitable alternative therapy for your child.
Q: Can ZACLO G CREAM be used in breastfeeding?
A: ZACLO G CREAM is not recommended for use during breast feeding. Do not apply it on your breast area so that the baby does not accidentally ingest the medicine.
REFERENCES
1. KD. Tripathi. Aminoglycosides Antibiotics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 747.
2. PubChem Compound Summary for CID 5311051, Clobetasol. National Center for Biotechnology Information. June 2022. [Accessed on 27th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasol#section=Mechanism-of-Action
3. Bruno J. Chaves; Prasanna Tadi. Gentamicin. StatPearls [Internet]. StatPearls Publishing. May 2022. [Accessed on 27th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK557550/#article-22211.s3
4. Glaxo Operations UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 27th June 2022] https://www.medicines.org.uk/emc/files/pil.939.pdf
5. Padagis Israel Pharmaceuticals Ltd. Gentamicin. [Revised in September 2021] [Accessed on 27th June 2022] file:///C:/Users/NMSLAP468/Downloads/20210925_4cfbe37e-11d6-46fc-b287-0561387b17b7.pdf
6. Wellona Pharma. Clobetasol propionate + Gentamicin. [Accessed on 27th June 2022] https://wellonapharma.com/product/finished/clobetasol-propionate-and-gentamicin-cream
USEFUL DIAGNOSTIC TESTS
- Patch testing
PRODUCT DETAILS
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