INTRODUCTION

XYLOCAINE 2% contains Lignocaine (Lidocaine) which belongs to a group of medicines called local anaesthetics produces a temporary loss of feeling or numbness of the skin. It is used before certain types of examinations and helps to relieve the pain from inflammation of the urinary bladder and the urethra.

Lignocaine (Lidocaine) is a potent local anaesthetic of the amide type. Like other local anaesthetics, it prevents both the generation and conduction of nerve impulses by slowing depolarisation. This results from blocking of the large transient increase in permeability of the cell membrane to sodium ions that follows initial depolarisation of the membrane. It acts reversible blockade of impulse propagation by prevention of sodium flux. As a local anesthetic, lidocaine blocks initiation and conduction of nerve impulses by decreasing the permeability of the nerve cell membrane to sodium ions.

Before using XYLOCAINE 2% tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. It is not recommended for children below 2 years of age. The common side effects are dizziness, irritation, redness at the application site.  Avoid contact with the eyes because numbness in the eyes may prevent you from noticing if you get something in eye.

USES OF XYLOCAINE 2%

Used,

• to relieve the pain from inflammation of the urinary bladder and the urethra
• in before certain types of examinations by doctor

HOW XYLOCAINE 2% WORKS

XYLOCAINE 2% blocks nerve transmission, when applied to a limited area of the body, which they bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization.

DIRECTIONS FOR USE

Always use XYLOCAINE 2% according to the dose and frequency as advised by your doctor.  

• Clean the affected area well, before each application
• Tear off the paper cover
• Screw plunger rod clockwise into grey rubber until rubber rotates
• Twist the protective tab and then, without bending, pull slightly to break the seal
• Extrude a small amount of Jelly and inspect the syringe to ensure that there is no plastic fragment present in the Jelly
• The syringe must not be used and must be discarded if there is any broken plastic fragment
• If the protective tab is intact and no plastic fragment is found in the Jelly, the syringe is ready for use

SIDE EFFECTS OF XYLOCAINE 2%

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• mexiletine, propranolol (treats uneven heart beats)
• prilocaine or bupivacaine (other local anaesthetics)
• cimetidine (treats gastrointestinal problems)
• fluvoxamine (treats depression)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT XYLOCAINE 2%

How long does it take XYLOCAINE 2% to work?

It usually starts to work within 5 to 15 minutes after you apply it. The effect usually lasts 20 to 30 minutes.

Does XYLOCAINE 2% suitable for children?

Consult your doctor for advice before using this medicine for children below 2 years of age.

Any caution for XYLOCAINE 2%?

Avoid contact with the eyes because numbness in the eyes may prevent you from noticing if you get something in your eye.

REFERENCES

1. KD Tripathi MD. Drugs acting on peripheral (somatic) nervous system. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 366.

2. Catterall WA, Mackie K. Local Anesthetics. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 572-573.

3. Hume JR, Grant AO. Agents Used in Cardiac Arrhythmias. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 238-239.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 798-799.

5. Dörte Wolf and Joachim Otto. Efficacy and Safety of a Lidocaine Gel in Patients from 6 Months up to 8 Years with Acute Painful Sites in the Oral Cavity: A Randomized, Placebo-Controlled, Double-Blind, Comparative Study. Nov 29, 2015; [Accessed Feb 1, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677000/

6. AstraZeneca Canada Inc. [Revised on April 2, 2008] [Accessed Feb 1, 2021] https://pdf.hres.ca/dpd_pm/00005549.PDF