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Uphold Tablet 4'S
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INTRODUCTION
UPHOLD TABLET is a combination of Dapoxetine and Tadalafil, which belong to the group of medicines called Selective serotonin reuptake inhibitors and Phosphodiesterase type 5 (PDE5) inhibitors, respectively. It is used to manage premature ejaculation and erectile dysfunction in adult men.
Premature ejaculation is a common sexual dysfunction that occurs when a man ejaculates sperm very early with less sexual stimulation or before he wants to. Erectile dysfunction (also known as impotence) is a sexual condition where a man cannot sustain a hard-erected penis, which is required for normal sexual activity.
Dapoxetine is a selective serotonin reuptake inhibitor. It delays ejaculation (the release of semen) by increasing the activity of a particular chemical called serotonin in the brain. This promotes control over ejaculation and helps your body hold sperm for a longer period. Tadalafil is a PDE5 inhibitor. It improves penile function by relaxing the blood vessels supplying the penis. Collectively, they delay sperm release and improve control over ejaculation and penile erections.
UPHOLD TABLET is also not suitable for use by healthy men who do not have any sexual problems. Take UPHOLD TABLET at least one hour before planning to have sex. Avoid taking UPHOLD TABLET with grapefruit juice.
Before taking UPHOLD TABLET, inform your doctor if you have any previous history of fainting or dizziness due to low blood pressure. You must also inform your doctor if you have epilepsy, lung problems, mental health problems, or bleeding disorders before taking UPHOLD TABLET as a precaution. UPHOLD TABLET is not recommended for use in patients with liver or heart problems. It is also not suitable for use with children under the age of 18.
The most common side effects of taking UPHOLD TABLET are flushing, headache, dizziness, blurred vision, muscle pain, nausea, tiredness, increased sweating, restlessness, and a decrease in sex drive. Consult your doctor if any of these side effects trouble you.
Also, inform your doctor immediately if you experience any prolonged painful penile erections without sexual stimulation (priapism), experience dizziness upon standing up suddenly, or if you have sudden mood changes or suicidal thoughts after taking UPHOLD TABLET.
USES OF UPHOLD TABLET
It is used by adult men to manage:
- Premature ejaculation
- Erectile dysfunction
HOW UPHOLD TABLET WORKS
UPHOLD TABLET effectively improves penile functions and delays sperm release in patients with sexual problems. It contains two medicines called dapoxetine and tadalafil. Dapoxetine delays ejaculation by blocking the reuptake of a chemical messenger called serotonin between the nerve cells. This increases the activity of serotonin within the brain, which therefore increases the time taken to release the semen (ejaculate) during sexual intercourse.
Tadalafil improves penile erections by improving the blood supply to the penis. It works by blocking the effects of certain enzymes (PDE5) in the body that limit blood flow to the penis. As a result, it relaxes the blood vessels supplying the penis, improves penile function, and makes it stay erected throughout the process of sexual intercourse.
DIRECTIONS FOR USE
Take UPHOLD TABLET as advised by your physician. Swallow UPHOLD TABLET with a glass of water. Do not chew or crush the medicine. UPHOLD TABLET can be taken with or without meals. Take UPHOLD TABLET at least 30 minutes to 1 hour before planning to have sexual intercourse. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and health condition.
SIDE EFFECTS OF UPHOLD TABLET
COMMON
- dizziness, headache
- back pain, muscle pain, pain in arms and legs
- nausea, vomiting
- feeling irritable, anxious, agitated, or restless
- sensation of numbness, tingling or prickling
- increased sweating
- hot flushes
- diarrhea, constipation, wind, stomach pain, indigestion
- problems in sleeping or strange dreams, difficulty in concentration
- tiredness or sleepiness
- blocked nose
- a rise in blood pressure
- decrease in sex drive
- ringing in the ears
- blurred vision, color tinge to vision, visual disturbance
- dry mouth
UNCOMMON
- fainting
- change in mood, feeling overly excited or feelings of paranoia (feeling threatened)
- feeling confused, disoriented, or unable to think clearly
- abnormal heartbeat (slow or fast heart rate)
- feeling depressed or nervous
- feeling hot, jittery, abnormal, or drunk
- eye problems (eye irritation, pain or redenss, watery eyes, double vision, abnormal sensation in the eye, seeing light flashes)
- low blood pressure
- feeling itchy or cold sweats
- spinning sensation
- abnormal taste
- skin rash
- reduced sense of touch
- signs of inflammation of the lining of the nose such as runny nose, sneezing
- upper abdominal pain
- signs of gastro-esophageal reflux disease such as heartburn
- presence of blood in urine or semen
- pain in the arms or legs
- nosebleed
RARE
- penile bleeding
- dry nose
- throat tightness, numbness of mouth
- temporary decrease in blood flow to brain
- sudden decrease or loss of hearing
- sudden onset of sleep (Ex. narcolepsy)
- urge to empty bowel
- memory loss
Stop taking UPHOLD TABLET and contact your doctor if you experience any of the following side effects:
- severe allergic reaction (such as wheeziness, difficulty in breathing or dizziness, swelling of the face, lips, eyelids, or throat)
- prolonged or painful erection (priapism)
- chest pain especially during or after sexual intercourse
- severe skin reactions (blistering of skin around the mouth, genitals or eyes, severe peeling and swelling of skin along with fever)
- sudden decline or loss of vision
- fits or seizures
- fainting or light headedness while standing
- mood changes, suicidal thoughts, or a tendency for self-harming
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens or if you feel dizzy upon standing up suddenly.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take UPHOLD TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your vomiting worsens.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedUPHOLD TABLET is not intended for use in women.
BREASTFEEDING
ContraindicatedUPHOLD TABLET is not intended for use in women.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you experience dizziness or blurred vision after taking UPHOLD TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking UPHOLD TABLET as it may cause dizziness, or sleepiness.
KIDNEY
Use with CautionUPHOLD TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
LIVER
ContraindicatedUPHOLD TABLET is not recommended for use in patients with moderate or severe liver diseases. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take UPHOLD TABLET if you are allergic to Dapoxetine or Tadalafil.
LUNGS
Use with CautionUPHOLD TABLET should be used with caution in patients with pulmonary arterial hypertension. Therefore, consult your doctor before taking it.
HEART DISEASE
ContraindicatedUPHOLD TABLET is not recommended for use in patients with heart problems (such as heart failure, low blood pressure, problems with the heart rhythm). Therefore, consult your doctor before taking it.
USE IN PEDIATRICS
ContraindicatedUPHOLD TABLET is not recommended for use in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.
USE IN GERIATRICS
ContraindicatedUPHOLD TABLET is not recommended for use in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
OTHERS
UPHOLD TABLET is not recommended for use if you:
- have a history of fainting
- have or ever had signs of mania such as feeling overexcited, irritable, or not being able to think clearly
- have severe depression
- have recently had a stroke
- have low blood pressure
- have signs of retinitis pigmentosa (a rare inherited eye disease) such as decreased vision at night or in low light and loss of side vision
Before taking UPHOLD TABLET, inform your doctor if you:
- have a history of feeling dizzy due to low blood pressure
- have schizophrenia (a psychiatric disease)
- have epilepsy
- have a history of bleeding or blood clotting problems
- have or at risk of developing glaucoma
- have sickle cell anemia (an abnormality of red blood cells)
- have leukemia (cancer of blood cells)
- have multiple myeloma (cancer of bone marrow)
- have a deformity of your penis
- have Peyronie’s disease (development of fibrous scar tissue in the penis that causes painful erection)
- currently have a stomach ulcer
- have bleeding problems such as hemophilia
- are alcoholic
- had any pelvic surgery or surgery in your prostate gland
INTERACTIONS
A. Drug-Drug Interactions:
Before taking UPHOLD TABLET, inform your doctor, if you are taking any of the following medicines such as:
- nitrates or amyl nitrites (used for reliving chest pain) Ex. nitroglycerin, isosorbide dinitrite
- other medicines used to manage prostate problems or blood pressure such as alpha blockers (Ex. silodosin, doxazosin)
- riociguat (a medicine used to manage increased pressure in the lungs)
- medicines used to manage depression (Ex. fluoxetine, sertraline, citalopram, escitalopram, amitriptyline, isocarboxazid, selegiline, nefazodone and St. john’s wort)
- thioridazine (a medicine used to manage a mental disorder called schizophrenia)
- lithium (a medicine used to manage bipolar disorder)
- tryptophan (a medicine used to induce sleep)
- medicines used to manage migraines (Ex. almotriptan, sumatriptan)
- non-steroidal anti-inflammatory drugs (used to manage pain and inflammation) Ex. ibuprofen and aspirin
- tramadol (a medicine used to relieve pain)
- antibiotics (used to manage bacterial infections) Ex. telithromycin, linezolid, erythromycin, and clarithromycin
- medicines used to manage HIV infection (Ex. ritonavir, saquinavir, nelfinavir, atazanavir amprenavir and fosamprenavir)
- medicines used to manage fungal infections (such as ketoconazole, itraconazole and fluconazole)
- warfarin (a medicine used to manage blood clotting)
- other medicines used to manage erectile dysfunction (such as sildenafil or vardenafil)
- medicines used to manage high blood pressure or chest pain (such as verapamil and diltiazem)
- aprepitant (a medicine which is used to manage nausea)
- medicines used to reduce anxiety and alter mental stability (Ex. morphine, pethidine, alprazolam, midazolam, clonazepam, MDMA (ecstasy) or lysergic acid diethylamide)
B. Drug-Food Interactions:
Avoid drinking grapefruit juice within 24 hours prior to taking UPHOLD TABLET as it may increase the level of UPHOLD TABLET in the body.
Overdosage:
If you or anyone else accidentally took more UPHOLD TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea and vomiting.
SYNOPSIS
| Drug | : | Dapoxetine, Tadalafil |
| Pharmacological Category | : | Selective serotonin reuptake inhibitors (SSRI) Phosphodiesterase type 5 inhibitors |
| Therapeutic Indication | : | Premature Ejaculation, Erectile Dysfunction |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep UPHOLD TABLET out of reach of children
- Store UPHOLD TABLET at room temperature
FAQs ABOUT UPHOLD TABLET
Q: What UPHOLD TABLET is used for?
A: UPHOLD TABLET is used to manage premature ejaculation and erectile dysfunction in adult men.
Q: How to take UPHOLD TABLET?
A: Take UPHOLD TABLET at least 30 minutes to 1 hour before having sexual intercourse. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: Can I take UPHOLD TABLET daily?
A: UPHOLD TABLET is generally prescribed as one dose per day. However, your doctor will decide whether you can take this medicine daily or not, depending upon your health condition. Do not take UPHOLD TABLET more than once a day without consulting your doctor.
Q: How long does it take for UPHOLD TABLET to start working?
A: It may take around 30 minutes to 1 hour for UPHOLD TABLET to start working, therefore take this medicine at least one hour before planning to have sex. This time may vary from person to person depending upon their health condition.
Q: Who can take UPHOLD TABLET?
A: UPHOLD TABLET can be used in adult men with sexual problems. It is not suitable for use in healthy men who does not have any sexual problems or in men who are not sexually stimulated. It is also not advisable for use in children or adolescents (aged below 18 years).
Q: Is UPHOLD TABLET effective?
A: Yes. UPHOLD TABLET effectively improves penile erection (make penis firm) and delays sperm release during sexual intercourse in patients with sexual problems.
Q: Can healthy men consume UPHOLD TABLET to improve sexual performance?
A: UPHOLD TABLET is not an aphrodisiac (sex-stimulating agent). It does not induce sexual thoughts or can improve sexual performance/pleasure in healthy men. It would help you to get an erection only if you are sexually stimulated.
Q: What happens if I consume a high dose of UPHOLD TABLET than prescribed by my doctor?
A: Do not consume a higher dose of UPHOLD TABLET than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose does not help you, contact your doctor.
Q: Can men taking UPHOLD TABLET father a child?
A: There is no confirmed proof that UPHOLD TABLET could affect fertility in men. However, it is better to consult your doctor before taking UPHOLD TABLET if you are planning to father a child.
Q: Is UPHOLD TABLET safe?
A: Yes. UPHOLD TABLET is safe to use. But inform your doctor immediately if you experience painful prolonged erection or chest pain after taking UPHOLD TABLET. It can also cause headache dizziness, flushing or muscle pain in some individuals. Contact your doctor if they bother you.
Q: Can I consume alcohol while taking UPHOLD TABLET?
A: Avoid consumption of alcohol while taking UPHOLD TABLET as it could reduce the effectiveness of UPHOLD TABLET.
Q: How long does the effects of UPHOLD TABLET would last long?
A: The effects of UPHOLD TABLET would normally last long for 4 hours. However, this time may vary from person to person depending upon their age and health condition. Consult your doctor if the effects of UPHOLD TABLET does not last long until sexual intercourse.
Q: Can UPHOLD TABLET make you last longer?
A: Yes. UPHOLD TABLET delays the release of sperms (ejaculation) in patients suffering from premature ejaculation.
Q: Will taking UPHOLD TABLET affect my sexual life?
A: Long term use of UPHOLD TABLET may negatively impact your sex life. It may cause sexual problems such as decrease in sex drive. Talk to your doctor if you are facing any sexual problems while taking UPHOLD TABLET.
Q: How UPHOLD TABLET works?
A: UPHOLD TABLET delays the ejaculation (release of semen) by increasing the activity of a particular chemical called serotonin in the brain. This promotes the control over ejaculation and helps your body to hold sperms for a longer period. It also improves penile functions by improving blood supply to the penis.
Q: Can I stop taking UPHOLD TABLET by my own without consulting doctor?
A: Do not stop taking UPHOLD TABLET without consulting your physician, as sudden discontinuation of UPHOLD TABLET may cause withdrawal symptoms like sleeping problems or dizziness.
Q: Can UPHOLD TABLET cause bipolar disorder?
A: UPHOLD TABLET may cause mood changes in some individuals. Inform your doctor immediately if you experience any sudden changes in mood. Also, it is important to inform you doctor if you already have bipolar disorder as a precaution before starting treatment with UPHOLD TABLET.
REFERENCES
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction & Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 304 & 464.
2. Aykut Bugra Sentürk, Ali Haydar Yilmaz, Basri Çakiroglu, Muhammet Yaytokgil, Cemil Aydin, Musa Ekici, Serdar Aykan, Mustafa Sungur. Combination or alone? Which one is the Best in Premature Ejaculation Treatment? HAYDARPASA NUMUNE MEDICAL JOURNAL. October 2018. [Accessed on 7th July 2022] https://jag.journalagent.com/hnhjournal/pdfs/HNHJ-87699-RESEARCH_ARTICLE-SENTURK.pdf
3. Hamed Mohseni Rad, Telma Zahirian Moghadam, Ali Hosseinkhani and Nima Nima Soluki. Comparison of Dapoxetine /Tadalafil and Paroxetine/Tadalafil Combination Therapies for the Treatment of the Premature Ejaculation: A Randomized Clinical Trial. ScienceDirect. November 2021. [Accessed on 7th July 2022] https://www.researchgate.net/publication/360618767_Comparison_of_Dapoxetine_Tadalafil_and_ParoxetineTadalafil_Combination_Therapies_for_the_Treatment_of_the_Premature_Ejaculation_A_Randomized_Clinical_Trial
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed 7th July 2022] https://www.medicines.org.uk/emc/files/pil.8636.pdf
5. Menarini - Von Heyden GmbH. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed 7th July 2022] https://www.medicines.org.uk/emc/files/pil.1269.pdf
AUTHOR DETAILS
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 31 Oct 2023 | 06:03 PM(IST)
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