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TOPXIME 1500mg Injection 1's
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INTRODUCTION
TOPXIME 1500MG INJECTION contains Cefuroxime which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as lower respiratory tract infections, meningitis, septicemia, abdominal infections, urinary tract infections, skin and soft tissue infections, ear, nose and throat infections, obstetric and gynecological infections, bone, joint infections and gonorrhea. TOPXIME 1500MG INJECTION is also used to prevent infections, before and after surgery.
Tell your doctor before receiving TOPXIME 1500MG INJECTION if you have or had a history of kidney or liver diseases, fungal diseases or diarrhoea. If you are pregnant or breastfeeding, inform your doctor before receiving TOPXIME 1500MG INJECTION. Inform your doctor if you are allergic (hypersensitive) to cephalosporins, penicillin or any antibiotics before receiving the medicine.
Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. TOPXIME 1500MG INJECTION should be used with caution in elderly patients, consult your doctor before receiving the medicine. The most common side effect of receiving this medicine is pain at the injection site, swelling and redness. Consult your doctor immediately if any of the above symptoms worsen.
USES OF TOPXIME 1500MG INJECTION
It is used to treat:
- respiratory tract infections
- urinary tract infections
- ear, nose, throat infections
- soft tissue infections
HOW TOPXIME 1500MG INJECTION WORKS
TOPXIME 1500MG INJECTION contains Cefuroxime which is a second-generation cephalosporin that interferes with the synthesis of the bacterial cell wall by binding to specific binding proteins located inside the bacterial cell wall. This leads to breaking down the cell wall of the bacteria and reducing its stability, thus causing cell damage, and eventually causing bacterial elimination.
DIRECTIONS FOR USE
TOPXIME 1500MG INJECTION will be given to you only by a doctor or nurse by intramuscularly (into a muscle) or intravenously (into the vein). Your doctor will administer the correct dose for you depending upon your age, body weight and severity of infection.
SIDE EFFECTS OF TOPXIME 1500MG INJECTION
COMMON
- pain (injection site), swelling and redness along a vein
- increase in liver enzyme
- changes in white blood cells (neutropenia or eosinophilia)
- low levels of red blood cells (anemia)
- high temperature
- sore throat
UNCOMMON
- skin rashes, urticaria (itchy red wheals), pruritus (bumpy rash)
- gastrointestinal disturbances
- diarrhoea
- nausea
- increase in bilirubin (a substance produced by the liver)
- positive coomb’s test
RARE
Stop receiving TOPXIME 1500MG INJECTION and consult your doctor immediately if you experience any of the following side effects
- severe allergic reaction (raised and itchy rash, swelling on face, mouth causing difficulty to breath)
- skin rash with blisters and peeling of skin (signs of Steven-Johnson’s syndrome/ toxic epidermal necrolysis)
- skin rash with blisters looking like a small dark spot surrounded by a paler area, with a dark ring around the edge
- fungal infections
- severe diarrhoea (Pseudomembranous colitis), causing severe diarrhoea, usually with blood and mucus, stomach pain, and fever
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorThe safety of TOPXIME 1500MG INJECTION during pregnancy has not been clearly established. The use of this medicine in pregnant women requires that the potential benefit from the drug be weighed against the possible risk to the mother and fetus. Consult your doctor before receiving the medicine.
BREASTFEEDING
Use with CautionTOPXIME 1500MG INJECTION should be used with caution during breastfeeding as it may pass into the breast milk. Consult your doctor before receiving the medicine.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate heavy machines if you feel dizziness after receiving TOPXIME 1500MG INJECTION.
KIDNEY
Use with CautionTOPXIME 1500MG INJECTION should be used with caution in patients with a history of kidney problems. Consult your doctor before receiving the medicine.
LIVER
Use with CautionTOPXIME 1500MG INJECTION should be used with caution in patients with a history of liver problems. Consult your doctor before receiving TOPXIME 1500MG INJECTION.
ALLERGY
ContraindicatedDo not receive TOPXIME 1500MG INJECTION if you are allergic (hypersensitive) to Cefuroxime, cephalosporin, penicillin, monobactams, carbapenems or to any other ingredients of this medicine.
USE IN PEDIATRICS
Consult your doctorYour doctor will administer the right dose depends on your child’s age, body weight and severity of the infection. Consult your doctor before receiving TOPXIME 1500MG INJECTION.
USE IN GERIATRICS
Use with CautionTOPXIME 1500MG INJECTION should be used with caution in elderly patients suffering kidney problems. Consult your doctor before receiving.
OTHERS
TOPXIME 1500MG INJECTION is not recommended if you have:
- severe persistent diarrhoea along with sickness
Before receiving TOPXIME 1500MG INJECTION inform your doctor if you:
- have gastrointestinal disorder (diarrhoea)
- have fungal infection
INTERACTIONS
A. Drug-Drug interactions:
Before receiving TOPXIME 1500MG INJECTION, inform your doctor if you are receiving any of the following medicine:
- medicine to treat bacterial infections such as aminoglycoside-type antibiotics (Ex. gentamycin)
- medicine used to treat increase high blood pressure (Ex. furosemide)
- medicine used to treat gout (Ex. probenecid)
- medicine used to treat blood clots such as oral anticoagulants (Ex. warfarin)
- medicines used for contraception (Ex. ethinyl estradiol)
Overdosage:
It is unlikely to receive overdose since it will be administered by the doctor or nurse. If you experience any unusual side effects, consult your doctor immediately.
SYNOPSIS
| Drug | : | Cefuroxime |
| Pharmacological Category | : | Cephalosporin Antibiotics |
| Therapeutic Indication | : | Treats Bacterial infections |
| Dosage Forms | : | Tablet, Injection, Capsule, Syrup, Dry Suspension, Drops, Dispersible tablet |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT TOPXIME 1500MG INJECTION
Q: What is TOPXIME 1500MG INJECTION used for?
A: It is used to treat bacterial infections such as lower respiratory tract infections, meningitis, septicemia, abdominal infections, urinary tract infections, skin and soft tissue infections, ear, nose and throat infections, obstetric and gynecological infections, bone, joint infections and gonorrhea. TOPXIME 1500MG INJECTION is also used to prevent infections, before and after surgery.
Q: Can I take oral contraceptive pills while receiving TOPXIME 1500MG INJECTION?
A: No, TOPXIME 1500MG INJECTION may interact with birth control pills and lowers its efficiency. So, you should tell your doctor if you are using any birth control pills.
Q: Can TOPXIME 1500MG INJECTION be given to breastfeeding mothers?
A: TOPXIME 1500MG INJECTION should be used with caution as it may pass into the breast milk. Consult your doctor before receiving. It should only be given if the expected benefits outweigh any potential risk to the baby.
Q: Can TOPXIME 1500MG INJECTION cause diarrhoea?
A: Yes, TOPXIME 1500MG INJECTION may cause serious diarrhea during or after use. Usually, discontinuation of medicine can subside diarrhea. However, if diarrhea persists or if there is blood in the stool then immediately consult your doctor.
Q: In what condition TOPXIME 1500MG INJECTION should be avoided?
A: Before receiving TOPXIME 1500MG INJECTION tell your doctor if you have a history of serious anaphylactic reaction to cefuroxime or any other cephalosporin antibiotics.
REFERENCES
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology. Seventh Edition,2013. Page - 727.
2. Gold B, Rodriguez WJ. Cefuroxime: mechanisms of action, antimicrobial activity, pharmacokinetics, clinical applications, adverse reactions and therapeutic indications. National Library of Medicine. PubMed Central (PMC). [Accessed on 7th September 2022] https://pubmed.ncbi.nlm.nih.gov/6344037/
3. GlaxoSmithKline Manufacturing S.P.A. [Revised in July 2014] [Accessed on 7th September 2022] https://gskpro.com/content/dam/global/hcpportal/en_GE/PI/Zinacev-PIL-GDSv31-2016-02-05.pdf
4. Hawke’s Bay Hospital Pharmacy. [Revised in August 2008] [Accessed on 7th September 2022] https://gskpro.com/content/dam/global/hcpportal/en_GE/PI/Zinacev-PIL-GDSv31-2016-02-05.pdf
5. Acs Dobfar S.P.A. The Electronic Medicines Compendium (Emc). [Revised in May 2022] [Accessed on 7th September 2022] https://www.medicines.org.uk/emc/files/pil.149.pdf
6. Hikma Pharmaceuticals USA Inc. [Revised in April 2020] [Accessed on 7th September 2022] https://hawkesbay.health.nz/assets/Patient-Medication-Information/Cefuroxime-PIL.pdf
7. Villerton Invest SA. The Electronic Medicines Compendium (emc). [Revised in May 2021] [Accessed on 7th September 2022] https://www.medicines.org.uk/emc/files/pil.8747.pdf
8. Hikma Pharmaceuticals USA Inc. [Revised in May 2021] [Accessed on 7th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=703cc338-c0b6-4a02-b8db-c27aeff181df
9. Fresenius Kabi Canada Ltd. [Revised in April 2020] [Accessed on 7th September 2022] https://www.fresenius-kabi.com/fr-ca/documents/Cefuroxime-PM-ENG-v6.0-052820.pdf
10. GlaxoSmithKline South Africa (Pty) Ltd. [Revised in September 2000] [Accessed on 7th September 2022] https://www.fresenius-kabi.com/fr-ca/documents/Cefuroxime-PM-ENG-v6.0-052820.pdf
11. Facta Farmaceutici S.P.A. [Revised in September 2018] [Accessed on 7th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/2204203.PA1226_009_002.af47d81e-3068-479b-9c91-8a209488572d.000001Cefuroxime%20PIL.180710.pdf
12. Acs Dobfar Spa. [Revised in May 2021] [Accessed on 7th September 2022] https://www.medicines.org.uk/emc/files/pil.8747.pdf
13. Biopharma S.R.L. [Revised in August 2019] [Accessed on 7th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/16a140d0-b6c7-4bce-94ec-01f2c5a8858c.pdf
14. Ciplamed. [Revised in July 2016] [Accessed on 7th September 2022] https://www.ciplamed.com/content/novacef-injection
15. GlaxoSmithKline Pvt. Ltd. [Revised in August 2001] [Accessed on 7th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50643s11lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
PRODUCT DETAILS
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