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INTRODUCTION
TENVIR AF 25MG contains tenofovir alafenamide which is an antiviral medicine. It is used to treat chronic (long-term) hepatitis B in adults and adolescents 12 years of age and older, who weigh at least 35 kg. Hepatitis B is an infection affecting the liver, caused by the hepatitis B virus. This medicine stops the virus from multiplying and thus controls the infection. It works by interfering with the normal working of enzymes (in HIV reverse transcriptase; in hepatitis B DNA polymerase) that are essential for the viruses to reproduce themselves.
It is not recommended for pregnant or breastfeeding. Before taking, tell your doctor if you have liver, kidney or heart problems. Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy. The common side effects are diarrhea, vomiting, nausea, dizziness, rash, feeling weak.
USES OF TENVIR AF 25MG
- Treat chronic hepatitis B virus infection [HBV] in adults with compensated liver disease
HOW TENVIR AF 25MG WORKS
TENVIR AF 25MG stops the virus from multiplying and thus controls the infection. It works by interfering with the normal working of enzymes (in HIV reverse transcriptase; in hepatitis B DNA polymerase) that are essential for the viruses to reproduce themselves.
DIRECTIONS FOR USE
Always take TENVIR AF 25MG exactly as prescribed by your doctor. Swallow the medicine whole with plenty of water.
SIDE EFFECTS OF TENVIR AF 25MG
COMMON
- headache
- diarrhea
- vomiting and nausea
- dizziness
- stomach pain
- joint pain (arthralgia)
- rash, itchiness
- feeling bloated
- wind (flatulence)
- feeling tired
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Headache:
Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.
Rash:
Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.
Diarrhea:
Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.
WARNING & PRECAUTIONS
PREGNANCY
TENVIR AF 25MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
TENVIR AF 25MG should be used with caution for breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy.
ALCOHOL
Avoid consumption of alcohol while taking this medicine.
KIDNEY
TENVIR AF 25MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
TENVIR AF 25MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic to the medicine.
OTHERS
If you are not sure whether you have HIV, your doctor should offer you HIV testing before you start taking TENVIR AF 25MG for hepatitis B.
INTERACTIONS
Talk to your doctor if you are taking:
- medicines used to treat bacterial infections including tuberculosis, containing rifabutin, rifampicin or rifapentine
- medicines used to treat the HIV, such as ritonavir or cobicistat boosted darunavir, lopinavir or atazanavir
- anticonvulsants used to treat epilepsy, such as carbamazepine, oxcarbazepine, phenobarbital or phenytoin
- herbal remedies used to treat the depression and anxiety, containing St. John’s wort (Hypericum perforatum)
- medicines used to treat fungal infections
SYNOPSIS
| Drug | : | Tenofovir |
| Pharmacological Category | : | Antihepadnaviral, Reverse Transcriptase Inhibitor, Nucleotide (Anti-HBV) |
| Therapeutic Indication | : | Treat chronic hepatitis B virus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT TENVIR AF 25MG
Can TENVIR AF 25MG be used in pregnant women?
No. It is not recommended for use in the pregnant women. Consult your doctor before taking.
Does TENVIR AF 25MG cure hepatitis B?
It can treat hepatitis B very effectively in some people. In some situation, it is more effective than adefovir and lamivudine.
REFERENCES
1. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. Chapter – 58; Antiviral agents; 12th ed. New York, New York: McGraw-Hill Medical, 2011. Page – 1618, 1619.
2. Syed Abdul Basit, Altaf Dawood, John Ryan & Robert Gish; Tenofovir alafenamide for the treatment of chronic hepatitis B virus infection; [Published on 2017] https://www.tandfonline.com/doi/full/10.1080/17512433.2017.1323633
3. Gilead Sciences Ireland UC; Electronic Medicines Compendium (EMC); [Revised on Aug 2020] [Accessed 13 Oct 2020] https://www.medicines.org.uk/emc/files/pil.2314.pdf
4. Accord Healthcare Limited; Electronic Medicines Compendium (EMC); [Revised on Aug 2020] [Accessed 13 Oct 2020] https://www.medicines.org.uk/emc/files/pil.771.pdf
5. Accord Healthcare Limited; National institute for health science; [Revised on Aug 2015] [Accessed 13 Oct 2020] http://www.io.nihr.ac.uk/wp-content/uploads/migrated/Tenofovir-alafenamide-May-2015.pdf
6. Gilead Sciences, Inc; U.S. Food and Drug Administration; [Revised on Aug 2020] [Accessed 13 Oct 2020] https://www.gilead.com/~/media/files/pdfs/medicines/liver-disease/vemlidy/vemlidy_pi.pdf?la=e
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