INTRODUCTION

RYBELSUS 7MG TABLET contains Semaglutide which belongs to the group of medicines called Antidiabetics. It is used to treat adults (aged 18 years and older) with type 2 diabetes when diet and exercise is not enough to control blood sugar levels.

Type 2 diabetes is a condition in which your body fails to make enough insulin and the insulin that your body produces does not work as well as it is expected to. Symptoms include increased thirst, urination and hunger, fatigue, blurry vision, numbness in hands.

RYBELSUS 7MG TABLET is not recommended for use if you have type 1 diabetes, diabetic ketoacidosis, medullary thyroid carcinoma and Multiple Endocrine Neoplasia syndrome type 2. Consult your doctor before taking it.

RYBELSUS 7MG TABLET should be used with caution in patients with fast heart rate, kidney disease, acute pancreatitis. Consult your doctor before taking it.

RYBELSUS 7MG TABLET is not recommended for use in pregnant and breastfeeding women, in children and adolescents below 18 years of age. It should be used with caution in elderly patients. Contact your doctor before taking it.

The most common side effects of taking RYBELSUS 7MG TABLET are nausea, diarrhea and low blood sugar (cold sweat, cool pale skin, headache, fast heartbeat, nausea or very hungry, changes in vision). Contact your doctor if any of the symptoms worsen.

USES OF RYBELSUS 7MG TABLET

• Treats type 2 diabetes

HOW RYBELSUS 7MG TABLET WORKS

RYBELSUS 7MG TABLET belongs to a class of medicines called GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists) which helps the body to make more insulin when your blood sugar is high.

DIRECTIONS FOR USE

Take RYBELSUS 7MG TABLET as advised by your physician. It should be taken on an empty stomach. Swallow the medicines with a glass of water. Do not crush or chew the medicine.

After taking RYBELSUS 7MG TABLET wait at least 30 minutes before having your first meal or drink of the day or taking other oral medicines. Your physician will fix the correct dose and frequency for you based upon your age, body weight and disease condition. Do not stop using this medicine without telling your doctor. Otherwise, your blood sugar levels may raise.

SIDE EFFECTS OF RYBELSUS 7MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take RYBELSUS 7MG TABLET, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if your constipation persist.

Stomach pain:

Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the stomach pain did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the flatulence does not improve, contact your doctor.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Contact your doctor if your diarrhoea did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking RYBELSUS 7MG TABLET, inform your doctor if you are taking any of the following medicine:

• levothyroxine (used for thyroid disease)
• oral anticoagulants Ex. warfarin (used to treat blood clot)
• insulin, glimepiride (medicines used to treat diabetes)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are nausea.

SYNOPSIS

MORE INFORMATION

• Keep RYBELSUS 7MG TABLET out of the sight and reach of children
• Store RYBELSUS 7MG TABLET below 25°C

FAQs ABOUT RYBELSUS 7MG TABLET

Q: Can I stop taking RYBELSUS 7MG TABLET when my symptoms are relieved?

A: Do not stop taking the medicine abruptly as stopping the medicine may increase the blood sugar levels. Complete the full course of treatment even if you feel better. 

Q: When is the best time to take RYBELSUS 7MG TABLET?

A: Take this medicine at least 30 minutes before the first food, drink or other oral medicines of the day with a glass of water. After taking RYBELSUS 7MG TABLET wait at least 30 minutes before having your first meal or drink of the day or taking other oral medicines.

Q: What If I forget to take RYBELSUS 7MG TABLET?

A: If you forget to take a dose of RYBELSUS 7MG TABLET, skip the missed dose and just take your normal dose the next day. Do not take a double dose to make up for a missed dose.

Q: Can RYBELSUS 7MG TABLET be taken with food?

A: Take RYBELSUS 7MG TABLET as advised by your physician. It should be taken on an empty stomach. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will fix the correct dose and frequency for you based upon your age, body weight and disease condition.

Q: What to eat when taking RYBELSUS 7MG TABLET?

A: Eat slowly and eat smaller meals. Eat foods that are light and bland. Drink clear or ice-cold drinks (like water or unsweetened tea). Avoid fried, greasy or sweet foods. It is important that you continue with your diet and exercise plan as told by your doctor.

Q: Does RYBELSUS 7MG TABLET cause diarrhea?

A: Yes. RYBELSUS 7MG TABLET may cause nausea, vomiting and diarrhoea during treatment. These side effects can cause dehydration (loss of fluids). Drink lots of fluids, such as water or fruit juices to prevent dehydration. This is especially important if you have kidney problems. Contact your doctor if any of the symptoms worsen.

REFERENCES

1. Barbara G. Wells, Joseph T. Dipiro, Terry L. Schwinghammer, Cecily V. Dipiro. Diabetes mellitus. Pharmacotherapy Handbook. 9th edition. 2015. Page- 161.

2. Mahapatra MK, Karuppasamy M, Sahoo BM. Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. January 2022. [Accessed on 27th January 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331/

3. Roder ME. Clinical potential of treatment with semaglutide in type 2 diabetes patients. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. December 2019. [Accessed on 27th January 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905643/

4. Novo Nordisk A/S. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 27th January 2022] https://www.medicines.org.uk/emc/files/pil.11507.pdf

5. Novo Nordisk Canada Inc. Semaglutide. [Revised in April 2020] [Accessed on 27th January 2022] https://www.novonordisk.ca/content/dam/nncorp/ca/en/products/Rybelsus-PM-EN-monograph.pdf

6. Novo Nordisk A/S. 2017. U.S. Food & Drug Administration. [Revised in September 2019] [Accessed on 27th December 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/213051s000lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin