INTRODUCTION

REXIDIN M FORTE GEL is a combination of Chlorhexidine, Metronidazole and Lignocaine which belong to the groups of medicines called Antiseptic Antibacterial agents, Nitroimidazoles and Local Anesthetics, respectively. REXIDIN M FORTE GEL is used to treat halitosis, gingivitis, oral stomatitis, pain due to mouth ulcers and food burns. It is also used to prevent plaque growth on the teeth.

Halitosis is a condition that occurs due to trapped bacteria on the uneven microscopic surface of the tongue that produces odours, contributing to bad breath in an individual. Gingivitis is a form of gum disease that occurs due to poor hygiene and is generally characterised by symptoms such as swollen and receding gums.

Oral stomatitis is a condition characterised by painful swelling and sores inside the mouth that occur due to an infection, an allergic reaction or irritating foods. Mouth ulcers are small lesions that develop in your mouth or at the base of your gums, which make eating and drinking uncomfortable.

REXIDIN M FORTE GEL is not recommended for use in patients who are allergic to chlorhexidine or metronidazole. lignocaine, methyl hydroxybenzoate, propyl hydroxybenzoate or para-aminobenzoic acid. Before applying REXIDIN M FORTE GEL, inform your doctor if you have traumatised (injured) mucosa, sepsis (a life-threatening infection) in the application site, poor general health, severe liver disease and renal dysfunction and/or a partial or complete heart block.

REXIDIN M FORTE GEL should be used with caution during pregnancy and only if necessary, in breastfeeding women. REXIDIN M FORTE GEL is not recommended for use by children (below 12 years of age). The most common symptoms of applying REXIDIN M FORTE GEL are dry mouth, altered taste sensations (such as metallic taste), discoloured or coated tongue, nausea, vomiting and abdominal discomfort. Consult your doctor if any of these symptoms get worse.

USES OF REXIDIN M FORTE GEL

• Treats halitosis, gingivitis, oral stomatitis, pain due to mouth ulcers and food burns
• Prevents plaque growth on the teeth

HOW REXIDIN M FORTE GEL WORKS

REXIDIN M FORTE GEL helps to treat mouth ulcers, halitosis, gingivitis and oral stomatitis and prevents plaque growth. Chlorhexidine heals ulcers by decreasing the number of bacteria in the mouth, leading to decreased swelling and redness of the gums, Metronidazole kills bacteria or other microorganisms by damaging their DNA and Lignocaine provides relief from painful mouth sores by forming a protective coating over the mouth sores and blocking their pain signals.

DIRECTIONS FOR USE

Always apply REXIDIN M FORTE GEL, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Treated areas on the face need not be covered with a plaster or bandage. Do not apply REXIDIN M FORTE GEL to your face beyond 5 days. Avoid applying REXIDIN M FORTE GEL around your eyes, including your eyelids.

SIDE EFFECTS OF REXIDIN M FORTE GEL

HOW TO MANAGE SIDE EFFECTS

Dry mouth:

Try to drink plenty of cold water and sip on cold, unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Consult and inform your doctor if the symptom gets worse.

Nausea and vomiting:

Try to take REXIDIN M FORTE GEL with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhoea. Consult your doctor and inform them if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

REXIDIN M FORTE GEL should be used with caution during pregnancy only if it is necessary. Consult your doctor before applying the medicine.

BREASTFEEDING

REXIDIN M FORTE GEL should be used with caution in breastfeeding women only if it is necessary. Consult your doctor before applying for the medicine.

DRIVING AND USING MACHINES

Do not drive or operate machines while applying REXIDIN M FORTE GEL since it may temporarily affect your ability to drive or operate machines.

KIDNEY

REXIDIN M FORTE GEL should be used with caution in patients with severe renal dysfunction. Consult your doctor before applying for the medicine.

LIVER

REXIDIN M FORTE GEL should be used with caution in patients with advanced liver disease. Consult your doctor before applying for the medicine.

ALLERGY

REXIDIN M FORTE GEL is not recommended for use if you are allergic to chlorhexidine or metronidazole. lignocaine, methyl hydroxybenzoate, propyl hydroxybenzoate, para amino benzoic acid or any other ingredients of this medicine.

HEART DISEASE

REXIDIN M FORTE GEL should be used with caution in patients with heart diseases such as partial or complete heart block. Consult your doctor before applying for the medicine.

INTERACTIONS

A. Drug-Drug Interactions:

Before applying  REXIDIN M FORTE GEL, inform your doctor, if you are applying  any of the following medicine:

• anticoagulants (used to prevent blood clots) such as coumarin derivatives (Ex. warfarin)
• anti-arrhythmic drugs (used to prevent and treat a heart rhythm that's too fast or irregular) Ex. amiodarone
• cimetidine (used to treat stomach ulcers)
• beta-blockers (used to treat high blood pressure)
• general anesthesia (used to induce unconsciousness during surgery) Ex. propofol, ketamine
• benzodiazepine, barbiturate (used to treat anxiety and insomnia)

Overdosage:

If you or anyone else applies too much of REXIDIN M FORTE GEL or accidentally swallows it, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are circumoral paraesthesia (burning, prickling or itching sensation), numbness of the tongue, light-headedness, hyperacusis (unusual tolerance to ordinary environmental sounds), ringing in the ears, visual disturbance, muscular tremors, generalized & grand mal convulsions (seizures), unconsciousness, hypoxia (low oxygen level), hypercarbia (increased carbon-di-oxide in the blood), apnoea (serious sleep disorder), severe low blood pressure, slow heart rate, irregular heartbeat, arrhythmia and cardiovascular collapse.

SYNOPSIS

MORE INFORMATION

• Keep REXIDIN M FORTE GEL out of reach from children
• Store REXIDIN M FORTE GEL at room temperature

FAQs ABOUT REXIDIN M FORTE GEL

Q: What is the function of REXIDIN M FORTE GEL?

A: REXIDIN M FORTE GEL is used to treat halitosis, gingivitis, oral stomatitis, pain due to mouth ulcers and food burns. It is also used to prevent plaque growth on the teeth.

Q: Is REXIDIN M FORTE GEL safe to be used by children?

A: REXIDIN M FORTE GEL is generally not recommended for use in children (those under the age of 12) unless necessary. It should be used with caution in children and adolescents (from 12 to 18 years of age). Consult your doctor before applying REXIDIN M FORTE GEL.

Q: Who should avoid applying REXIDIN M FORTE GEL?

A: REXIDIN M FORTE GEL is not recommended for use in patients who are allergic to chlorhexidine or metronidazole or lignocaine, methyl hydroxybenzoate, propyl hydroxybenzoate or para-aminobenzoic acid. It is also not recommended for use in children under the age of 12 unless necessary. Consult your doctor before applying for the medicine.

Q: Is REXIDIN M FORTE GEL safe to be used by pregnant and breastfeeding women?

A: REXIDIN M FORTE GEL should only be used in pregnant or breastfeeding women if necessary. Consult and inform your doctor before applying for the medicine.

Q: How does REXIDIN M FORTE GEL work?

A: REXIDIN M FORTE GEL helps to treat mouth ulcers, halitosis, gingivitis and oral stomatitis and prevents plaque growth. Chlorhexidine heals ulcers by decreasing the number of bacteria in the mouth, leading to decreased swelling and redness of the gums. Metronidazole kills bacteria or other microorganisms by damaging their DNA.

REFERENCES

1. KD Tripathi. Local Anaesthetics, Antiamoebic & Other Antiprotozoal Drugs, and Antiseptics, Disinfectants & Ectoparasiticides. Essentials of medical pharmacology. Seventh edition. 2013. Page – 366, 837, 900.

2. Arthiie Thangavelu, Sahaya Stelin Kaspar, Ramesh Periannan Kathirvelu, Bhuvaneshwari Srinivasan, Soundarya Srinivasan, and Rajasekar Sundram. Chlorhexidine: An Elixir for Periodontics. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in August 2020] [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595540/

3. Connor B. Weir; Jacqueline K. Le. Metronidazole. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in April 2022] [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK539728/

4. Gabriel B. Beecham, Trevor A. Nessel, Amandeep Goyal. Lidocaine. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in December 2021] [Accessed on 19th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK539881/

5. Purna Pharmaceuticals NV. Electronic Medicines Compendium (EMC). [Revised in May 2020] [Accessed on 19th July 2022] https://www.medicines.org.uk/emc/files/pil.21.pdf

6. Galderma Production Canada, Inc. Food & Drug Administration (FDA). [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021789lbl.pdf

7. Pharmacy Retailing (NZ) Limited. MEDSAFE - New Zealand Medicines and Medical Devices Safety Authority. [Revised in January 2018] [Accessed on 19th July 2022] https://www.medsafe.govt.nz/profs/Datasheet/x/Xylocainejelly.pdf

8. Agrawal Drugs Pvt. Limited. Notty Gel. [Accessed on 19th July 2022] https://www.adplindia.in/product/notty-gel/

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 29 Dec 2022 | 03:20 PM(IST)