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INTRODUCTION
REMO TABLET contains Remogliflozin which belongs to the group of medicines called Anti-diabetic agents. REMO TABLET is used to treat type 2 diabetes when diet and exercise alone are insufficient to provide adequate glycaemic control in adult patients.
REMO TABLET is also used as a combination therapy with metformin, when both metformin therapy and diet & exercise are inadequate provide glycaemic control in affected individuals.
REMO TABLET is not recommended for use in patients allergic to Remogliflozin. It is also not recommended for use in patients with liver problems (such as moderate to severe liver impairment), and/or kidney problems (such as moderate to severe renal impairment).
Before taking [GBKEYWORD], inform your doctor if you have type 1 diabetes, dehydration (associated with symptoms such as nausea, vomiting, and/or loss of excessive fluid from the body), and/or low blood pressure.
REMO TABLET is not recommended for use during pregnancy and in women planning for pregnancy. It is also not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breast milk.
REMO TABLET is not recommended for use in children and adolescents (aged below 18 years). It is also not recommended for use in elderly patients (aged 75 years/above). Consult your doctor before taking the medicine.
The most common side effects of taking REMO TABLET are constipation, diarrhoea, weakness, fever, chills, urinary tract infection, and/or headache. Consult your doctor if any of these symptoms worsens.
USES OF REMO TABLET
- Treats type 2 diabetes mellitus when diet and exercise alone are inadequate to provide glycaemic control in adults
HOW REMO TABLET WORKS
REMO TABLET helps in reducing blood glucose by increasing the excretion of glucose via urine. It does so by acting on certain proteins in the body which are responsible for the reabsorption of glucose from the kidney. REMO TABLET inhibits the action of these proteins hence, stopping the reabsorption of glucose and increasing urinary glucose excretion thus treating type 2 diabetes in affected individuals.
DIRECTIONS FOR USE
Take REMO TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, health condition, and body weight.
SIDE EFFECTS OF REMO TABLET
COMMON
- constipation
- diarrhoea
- weakness
- fever and chills
- urinary tract infection
- viral upper respiratory tract infection
- passing little or no urine
- signs of low blood sugar levels such as sweating, feeling tired, dizziness, and/or feeling shaky
- headache
- cough
- signs of orthostatic hypotension such as low blood pressure, light-headedness/ dizziness upon standing
UNCOMMON
- anaemia
- vertigo (spinning sensation)
- eye pain, increased flow of tears
- stomach pain, stomach discomfort, inflammation of the lining of the stomach, higher levels of gastric acid (heartburn)
- gastroesophageal reflux (stomach contents move backwards towards the mouth)
- inflammation of the mouth
- increases in creatinine (changes in frequency of urination, itching, swelling, fatigue)
- irregular heartbeats
- decreased appetite
- decreased weight
- build-up of lactate in the body (muscle ache, burning sensation, rapid breathing)
- excessive fluid consumption as a result of thirst
- inflammation or pain of joint, back pain, inflammation and swelling of the cartilage of the chest wall, musculoskeletal pain
- dizziness
- reduced sense of touch
- anxiety
- lack of sleep
- painful or difficult urination, frequent daytime urination, production of abnormally large volumes of urine
- inflammation of the glans (rounded head of the penis), posthitis (inflammation of the foreskin)
- oropharyngeal pain (persistent mouth pain), seasonal allergies
- rash, skin lesion, red itchy welts
- high blood pressure
RARE
Stop taking REMO TABLET and inform your doctor immediately if you experience any of the following side effects:
- signs of diabetic ketoacidosis such as nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, fruity smelling breath, a sweet or metallic taste in mouth, a different odour in urine or sweat, rapid weight loss
- signs of severe urinary tract infections such as fever, chills, burning sensation when passing urine, pain in back or sides, and/or blood in urine
- signs of Fournier’s Gangrene such as fever, pain and swelling in the genitals or anal area, unpleasant odour coming from the affected skin tissue, crackling sound when touching the affected area, and/or dehydration
- signs of dehydration such as very dry, sticky mouth, feeling very thirsty, passing little or no urine, feeling very sleepy or tired, and/or fast heartbeat
HOW TO MANAGE SIDE EFFECTS
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation does not improve.
Diarrhea:
Drink a lot of fluids, such as water, fruit juice, or squash to keep yourself hydrated. Do not consume any medicine by yourself without consulting your doctor. Ask for your doctor’s advice if diarrhea does not improve.
Headache:
If REMO TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking REMO TABLET. If it lasts more than a week or severe, inform your doctor.
WARNING & PRECAUTIONS
PREGNANCY
REMO TABLET is not recommended for use during pregnancy and in women planning for pregnancy. Women of childbearing potential should use effective contraceptive measures while in treatment with REMO TABLET. Consult your doctor before taking the medicine.
BREASTFEEDING
REMO TABLET is not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breast milk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
Do not drive or operate machines if you experience shaking, sweating, change in vision and/or feel dizzy after taking REMO TABLET.
ALCOHOL
Avoid consumption of alcohol while taking REMO TABLET since it may increase risk of diabetic ketoacidosis.
KIDNEY
REMO TABLET is not recommended for use in patients suffering from kidney problems such as moderate to severe renal impairment. Consult your doctor before taking the medicine.
LIVER
REMO TABLET is not recommended for use in patients with liver problems such as moderate to severe liver impairment. Consult your doctor before taking the medicines.
ALLERGY
Do not take REMO TABLET if you are allergic to Remogliflozin, and/or any other ingredients of this medicine.
OTHERS
Before taking REMO TABLET inform your doctor if you:
- have type 1 diabetes
- signs of dehydration such as nausea, vomiting, fever, loss of excessive fluid from the body
- have tendency of urinary tract infections
- have low blood pressure.
Use in Paediatrics:
REMO TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
REMO TABLET is not recommended for use in elderly patients (aged 75 years/above). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug - Drug Interactions:
Before taking REMO TABLET, inform your doctor, if you are taking any of the following medicine:
- ketoconazole (used to treat fungal infections)
- oral contraceptives (used to prevent pregnancy) Ex. estradiol, norethindrone
- medicines used to treat high blood pressure (Ex. ramipril, rosuvastatin, verapamil)
- other blood glucose lowering drugs (Ex. sulphonylureas, metformin, insulin)
- bupropion (used to treat depression)
- medicines used to remove water from body (diuretics) Ex. spironolactone, furosemide.
Overdosage:
If you or anyone else accidentally take too much of REMO TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea, vomiting, abdominal pain, diarrhoea, and/or flatulence.
SYNOPSIS
| Drug | : | Remogliflozin |
| Pharmacological Category | : | Sodium Glucose Co-Transporter-2 (SGLT2) Inhibitors |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep REMO TABLET out of reach of children
- Store REMO TABLET at a temperature between 15°C - 30°C
FAQs ABOUT REMO TABLET
What is REMO TABLET and why is it prescribed?
REMO TABLET contains Remogliflozin which belongs to the group of medicines called Anti-diabetic agents. It is used to treat type 2 diabetes mellitus when diet and exercise are unable to control the blood sugar levels. REMO TABLET can also be used with other drugs like metformin, together with diet and exercise.
What if I forget to take a dose of REMO TABLET?
If you forgot to take a dose of REMO TABLET then do not take the missed dose between meals. Wait until your next scheduled dose and meal and continue taking your medicine as per normal. Do not take a double dose of REMO TABLET to make up for a forgotten dose. Consult your doctor.
Can REMO TABLET be used in children and adolescents?
No. REMO TABLET is not recommended to use in children and adolescents (below 18 years of age). Consult your doctor before administering the medicine to the child.
What other things I need to take care of while taking REMO TABLET?
Since REMO TABLET works by acting on kidneys and excreting out excess blood sugar via urine, your urine test may test positive for presence of sugars in it. Also, your doctor may ask you for a regular kidney check-up while taking REMO TABLET. For all diabetic patients it is very important to take care of your feet regularly and strictly follow the advice regarding foot care given by your doctor in order to avoid gangrene. Consult with your doctor if you experience any unusual side effects.
Does REMO TABLET affects my ability to drive?
REMO TABLET may cause hypoglycaemia (low levels of blood sugar). Do not drive or use machines if you experience symptoms of hypoglycaemia such as shaking, sweating, change in vision and feel dizzy after taking REMO TABLET.
Can REMO TABLET be taken by elder patients?
REMO TABLET is not recommended for use in elderly patients above 75 years and should be used with caution in patients above the age of 65 years taking care of their kidney function. Consult your doctor before taking.
What is the best time to take REMO TABLET?
Take REMO TABLET as directed by your doctor. It can be taken with or without meals. Try to take REMO TABLET at the same time everyday which will make you remember to take it. Keep following the diet and exercises your doctor has advised you to.
Is REMO TABLET safe for pregnant and breast-feeding women?
REMO TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking it.
REFERENCES
1. Wiley. Remogliflozin. Metabolic Syndrome: Underlying Mechanisms and Drug Therapies. 2011. Page – 371.
2. Nasser Mikhail. Remogliflozin etabonate: a novel SGLT2 inhibitor for treatment of diabetes mellitus. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2015. [Accessed on 27th July 2022] https://pubmed.ncbi.nlm.nih.gov/26288025/
3. Torrent Pharmaceuticals Ltd. Zucator 100. [Revised in July 2020]. [Accessed on 27th July 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2859.pd
USEFUL DIAGNOSTIC TESTS
- Fasting blood sugar
- Postprandial glucose test
- Glycosylated haemoglobin
- Kidney Function Test
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