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INTRODUCTION
REGLAN contains Metoclopramide which belongs to a group of medicines called anti-emetics. It is used to prevent delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy) and also treats nausea and vomiting which occurs with a migraine. This medicine works on a part of your brain that prevents you from nausea and vomiting.
Metoclopramide acts by opposing the effect of dopamine in the central nervous system and other organ systems. This action helps to reduce feelings of sickness (nausea) and helps to stop vomiting.
REGLAN will be administered by your doctor or nurse. Before receiving this medicine, tell your doctor if you have or had any kidney, liver or heart impairment, epilepsy or bleeding disorders. Pregnant and breastfeeding mothers consult your doctor before using the medicine. It is not advisable for use in children below 1 year of age because it may increase the uncontrollable movements. The common side effects are drowsiness, uncontrollable movements, restlessness and weakness. Do not drive or handle any machines that require mental attention.
USES OF REGLAN
- Prevents delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy)
- Treats nausea and vomiting which occurs with a migraine
HOW REGLAN WORKS
REGLAN works by blocking a natural substance (dopamine) in the brain that controls vomiting and helps to speed the movement of food through the stomach and intestines, by stimulating the muscles of the gastrointestinal tract.
DIRECTIONS FOR USE
REGLAN will be administered as a slow injection into a vein (over at least 3 minutes) or by injection into a muscle by your doctor or nurse.
SIDE EFFECTS OF REGLAN
SERIOUS
- uncontrollable movements (involves head or neck)
- high fever, increase in blood pressure, convulsions, sweating, production of saliva
- itching, skin rashes, swelling of the face, lips or throat, breathing difficulty
COMMON
- drowsiness
- depression
- rigidity, tremors
- uncontrollable movements
- restlessness
- diarrhoea
- weakness
RARE
- confusional state
- convulsion (especially in patients with epilepsy)
HOW TO MANAGE SIDE EFFECTS
Drowsiness:
Get up and move around to feel awake, take naps and give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Diarrhoea:
Drink plenty of fluids to avoid dehydration. ORS also can be used to prevent dehydration.
WARNING & PRECAUTIONS
PREGNANCY
If necessary, REGLAN will be given during pregnancy. Your doctor will weigh the benefits and any potential risks before giving it to you. Consult your doctor for advice.
BREASTFEEDING
REGLAN is not recommended if you are breast-feeding because it may pass into breast milk and affect your baby. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or handle any machines if you experience drowsiness, dizziness or having uncontrollable twitching, jerking or writhing movements and unusual muscle tone causing distortion of the body or vision problems.
ALCOHOL
Alcohol should not be consumed during treatment with REGLAN because it may increase the sedative effects.
KIDNEY
REGLAN should be used with caution in patients suffering from kidney diseases, if needed dose will be adjusted accordingly. Consult your doctor for advice.
LIVER
REGLAN should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Metoclopramide.
HEART DISEASE
REGLAN should be used with caution in patients with abnormal heart beats. Consult your doctor for advice.
OTHERS
Tell your physician before taking this medicine, if you have or had,
- bleeding, obstruction, tear in your stomach
- tumour of the adrenal gland
- involuntary muscle spasms
- epilepsy
- parkinson’s disease
- abnormal blood pigment levels or NADH cytochrome-b5 deficiency
- increase in salt level in blood
- neurological problems
- porphyria (inherited blood disease)
INTERACTIONS
Tell your doctor if you are taking,
- levodopa (treats Parkinson’s disease)
- anticholinergics (relieves stomach cramps and spasms)
- morphine derivatives (treats severe pain)
- sedative medicines
- medicines used for mental health problems
- digoxin (treats heart failure)
- cyclosporine (treats problems with the immune system)
- mivacurium, suxamethonium (used to relax muscles)
- fluoxetine and paroxetine (treats depression)
- atovaquone (treats pneumonia)
- neuroleptic medicines (used for mental illness, nausea and vomiting)
- aspirin, paracetamol or opioids (treats pain)
SYNOPSIS
| Drug | : | Metoclopramide |
| Pharmacological Category | : | Anti-emetics |
| Therapeutic Indication | : | Treats nausea and vomiting |
| Dosage Forms | : | Tablet, Capsule, Injection, Syrup |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT REGLAN
What is REGLAN used for?
It is used to prevent delayed nausea and vomiting (occur after surgery, chemotherapy and radiotherapy) and also treats nausea and vomiting which occurs with a migraine.
How long does REGLAN last?
The onset of pharmacological action of this medicine is 1 to 3 minutes following an intravenous dose, 10 to 15 minutes following intramuscular administration.
Can REGLAN cause sleepiness?
It may cause drowsiness in some individuals, consult your doctor for advice.
REFERENCES
1. KD Tripathi MD. 5-HT, its antagonists and drug therapy of migraine. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013.Page –177.
2. Sasank Isola, Azhar Hussain, Anterpreet Dua, Karampal Singh and Ninos Adams. Metoclopramide. April 19, 2021. [Accessed on Sep 21, 2021] https://www.ncbi.nlm.nih.gov/books/NBK519517/
3. Ismet Parlak, Bulent Erdur, Mine Parlak, Ahmet Ergin, Ibrahim Turkcuer, Onder Tomruk, Cuneyt Ayrik, and Nesrin Ergin. Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects? [Published on Oct, 2007] [Accessed on Sep 21, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600133/
4. Hameln pharma Ltd. Siegfried Hameln GmbH. Electronic Medicines Compendium (EMC); [Revised on July, 2020] [Accessed on Sep 21, 2021] https://www.medicines.org.uk/emc/files/pil.6283.pdf
5. Sandoz Canada Inc. [Revised on Nov 18, 2014] [Accessed on Sep 21, 2021] https://www.sandoz.ca/sites/www.sandoz.ca/files/Metoclopramide%20HCl%20PMe%2020141118.pdf
6. Drugs.com. Metoclopramide. [Accessed on Sep 21, 2021] https://www.drugs.com/ppa/metoclopramide.html
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