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Introduction About REGESTRONE TABLET
REGESTRONE TABLET contains Norethisterone, which belongs to a group of medicines called Progestogens. It is used to manage heavy menstrual bleeding or abnormal uterine bleeding (that occurs due to hormonal imbalance), painful periods, irregular periods or periods that are more frequent than normal (polymenorrhoea), premenstrual tension, endometriosis (abnormal growth of endometrial tissue of the uterus that causes pain and menstrual irregularities), metriopatheias haemorrhagia (intermenstrual bleeding) and breast cancer. It is also used to delay the menstrual cycle.
REGESTRONE TABLET is not recommended for use in patients with pulmonary embolism (blood clots in the lung), liver disease, heart attack (myocardial infarction) or angina and deep vein thrombosis. REGESTRONE TABLET should be used with caution in patients with asthma, kidney disease, fits, and migraine headaches.
REGESTRONE TABLET is not recommended for use during pregnancy as it may affect the developing baby. Inform your doctor if you have had repeated miscarriages. REGESTRONE TABLET should be used with caution in breastfeeding women as it may pass through the breast milk. If you experience mood changes and depressive symptoms, contact your doctor as soon as possible.
The most common side effects of taking REGESTRONE TABLET are irregular bleeding, heavy menstruation, spotting between menstrual cycles, delayed or not having a menstrual cycle, stomach discomfort, nausea, vomiting, breast tenderness, headache, and dizziness. Contact your physician if the symptoms worsen
Uses Of REGESTRONE TABLET
REGESTRONE TABLET manages:
- heavy periods
- painful periods
- irregular periods
- increased frequency of periods
- premenstrual tension
- endometriosis (a disease where the tissue lining the uterus, grows outside the uterus)
- breast cancer
- metropathia
- haemorrhagia (intermenstrual bleeding)
- abnormal uterine bleeding
- to delay the next periods
How REGESTRONE TABLET Works
REGESTRONE TABLET inhibits the release of pituitary hormones that are responsible for the release of female hormones (such as oestrogen and progesterone) and thereby suppressing ovulation. This action modifies the lining of the endometrium and thus ceases bleeding in menstrual abnormalities in cancer REGESTRONE TABLET may act by pituitary inhibition or by direct action on tumour deposits.
How to use REGESTRONE TABLET
Follow the instructions given by your doctor. Take REGESTRONE TABLET as advised according to your symptoms and disease severity. Swallow the whole tablet with a glass of water.
Side Effects Of REGESTRONE TABLET
Common
- irregular bleeding, heavy menstruation
- spotting between menstrual cycles
- delayed or not having a menstrual cycle
- stomach discomfort, nausea, vomiting
- breast tenderness
- headache and dizziness
Rare
Stop taking REGESTRONE TABLET and contact your doctor immediately if you experience any of the following side effects:
- yellowing of the skin or white area of the eyes (jaundice)
- migraine headache for the very first time (a headache that usually restricts itself to one side of your head)
- high blood pressure
- symptoms of severe allergic reaction such as itchy skin rash, swelling of the face or tongue, hands or feet causing wheezing, difficulty breathing or feeling faint
- symptoms of a blood clot in the lungs include a sudden, severe, sharp pain in the chest, coughing up blood, shortness of breath, rapid heartbeats
- symptoms of a blood clot in the brain (stroke) include unusually severe or long headache, change in sight, difficulty speaking, collapsing, or fainting, and weakness or paralysis of any part of your body
- symptoms of a deep-vein thrombosis such as severe pain, tenderness or swelling in your calf, ankle or foot, purplish discolouration of the skin of the leg and red or warmth skin
How To Manage Side Effects
Nausea, vomiting:
Take the medicine with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea and vomiting get worse.
Headache:
Rest and relax. Apply a pain-relieving balm to your forehead if needed. Do not consume alcohol. Contact your doctor if your headache does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if you feel dizzy. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if the dizziness worsens.
Stomach pain:
Try to rest and relax. Eat small meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if the stomach pain does not improve.
Warning & Precautions
Pregnancy
REGESTRONE TABLET is not recommended for use during pregnancy and if you have a history of Idiopathic jaundice during pregnancy or an itchy rash or blisters on the abdomen known as pemphigoid gestationis (rare autoimmune skin disorder in pregnancy) and REGESTRONE TABLET should be used with caution in patients with a history of repeated miscarriages. Contact your doctor before taking REGESTRONE TABLET.
Breastfeeding
REGESTRONE TABLET should be used with caution in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking REGESTRONE TABLET.
Driving and Using Machines
REGESTRONE TABLET does not affect the ability to drive or operate machinery.
Kidney
REGESTRONE TABLET should be used with caution in patients with kidney disease. Contact your doctor before taking REGESTRONE TABLET.
Liver
REGESTRONE TABLET should be used with caution in patients with liver disease. Contact your doctor before taking REGESTRONE TABLET.
Allergy
Do not use REGESTRONE TABLET if you are allergic to norethisterone, similar other hormone medicines, or any other ingredients in the medicine.
Lungs
REGESTRONE TABLET is not recommended for use in patients who have or had a pulmonary embolism (blood clots in the lung) and should be used with caution in patients with asthma. Contact your doctor before taking REGESTRONE TABLET.
Heart Disease
REGESTRONE TABLET is not recommended for use in patients with active or recent angina (chest pain) or heart attack. Contact your doctor before taking REGESTRONE TABLET.
Others
REGESTRONE TABLET is not recommended for use if you have:
- blood disorders like porphyria
- clotting disorders like deep vein thrombosis or a family history of the same
- pruritis (a condition with severe generalised itching of the body)
- undiagnosed vaginal bleeding (not a period)
Before taking REGESTRONE TABLET tell your doctor if you have:
- epilepsy
- migraine headache
- are very overweight
- systemic lupus erythematosus.
- a blood clot in the veins
- are unable to move for long periods (Ex. after an operation)
- serious injury
- have major surgery or are going to have an operation (particularly abdominal or orthopaedic surgery to the lower limbs)
- blood tests (for liver function, thyroid function, and coagulation).
- vision impairment, bulging eyes, double vision
- depression
Interactions
A. Drug-Drug Interactions:
- antiepileptic medicines (used to manage fits) (phenytoin, carbamazepine, phenobarbitone)
- antibiotics ex. tetracyclines, co-trimoxazole, ampicillin, oxacillin (medicines used for bacterial infections)
- medicines used for tuberculosis (rifampicin, rifabutin)
- antiviral medicines for management of HIV (ritonavir, nelfinavir, efavirenz)
- anticancer medicines
- aminoglutethimide (used in Cushing’s syndrome)
- ciclosporin (immunosuppressants or medicines used to manage rejection of a transplanted organ)
- nonsteroidal anti-inflammatory drugs NSAID’s (medicines used for pain)
- medicines for managing high blood pressure (amlodipine, captopril, atenolol, telmisartan)
- st. john’s wort (medicines used to manage depression)
Overdosage:
If you or anyone else accidentally took more of REGESTRONE TABLET, contact your doctor immediately or visit a nearby hospital immediately if the symptoms worsen. The symptoms may include nausea, vomiting, breast enlargement and vaginal bleeding.
Synopsis
| Drug | : | Norethisterone |
| Pharmacological Category | : | Progestogens |
| Therapeutic Indication | : | Menstrual disorders and breast cancer |
| Dosage Forms | : | Tablet |
More Information
- Keep REGESTRONE TABLET below 25°C
- Keep REGESTRONE TABLET out of sight and reach from children
FAQs About REGESTRONE TABLET
Q: What is Regestrone used for?
A: Regestrone is utilized to manage irregular menstrual cycles, helps in regulating periods, heavy menstrual bleeding, reduces excessive blood loss during menstruation. Endometriosis, alleviates pain and inhibits the growth of endometrial tissue outside the uterus. Premenstrual syndrome (PMS) which eases symptoms like mood swings, bloating, and breast tenderness and Postponement of menstruation: delays periods for personal or medical reasons.
Q: How should I take Regestrone?
A: The dosage and duration depend on the specific condition being managed. For menstrual irregularities: Typically, one tablet daily for 10 days, starting 16 to 21 days after the last menstrual period. To postpone periods: One tablet two to three times daily, beginning three days before the expected period date. Always follow your doctor's prescription and guidance.
Q: Can I use Regestrone to postpone my periods?
A: Yes, Regestrone can be used to delay menstruation. It's generally taken one tablet two to three times daily, starting three days before the anticipated period date. Consult your healthcare provider for personalized advice.
Q: What are the possible side effects of Regestrone?
A: Common side effects include nausea and vomiting, headache, breast tenderness, mood changes, weight gain and vaginal spotting. If you experience severe or persistent side effects, contact your doctor.
Q: Who should not take Regestrone?
A: Regestrone is contraindicated in individuals with known hypersensitivity to norethisterone or any component of the tablet, liver dysfunction, undiagnosed vaginal bleeding, history of thromboembolic disorders and pregnancy. Consult your healthcare provider before starting Regestrone.
Q: Can Regestrone affect fertility?
A: Regestrone is primarily used to regulate menstrual cycles and does not have a long-term impact on fertility. However, it may delay ovulation during use, which can temporarily affect fertility.
Q: Can I take Regestrone during pregnancy or breastfeeding?
A: Regestrone is contraindicated during pregnancy due to potential risks to the fetus. Its use during breastfeeding is not recommended as it may pass into breast milk and affect the infant. Consult your doctor for alternative options.
Q: Will my period be heavier or lighter after stopping Regestrone?
A: After discontinuing Regestrone, menstrual flow may vary. Some women experience lighter periods, while others may notice a return to their normal flow. Individual responses differ.
Q: Can Regestrone cause weight gain?
A: Yes, weight gain is a possible side effect of Regestrone, often due to fluid retention. Maintaining a balanced diet and regular exercise can help manage this effect.
Q: Can Regestrone be taken with other medications?
A: Regestrone may interact with certain medications such as Anticoagulants, Anticonvulsants and Some antibiotics. Inform your doctor about all medications and supplements you're taking to avoid potential interactions.
References
1. K D Tripathi. Hormones and Related Drugs. Essentials of Medical Pharmacology. 7th Edition. Page 309-310.
2. Wockhardt UK Ltd. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 19th July 2022] https://www.medicines.org.uk/emc/product/1494/pil
3. Norethisterone. Torrent Pharmaceuticals Ltd. [Revised in May 2020] [Accessed on 19th Jul 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2955.pdf
4. Norethisterone. Torrent Pharmaceuticals Ltd. [Revised in July 2020] [Accessed on 19th Jul 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2950.pdf
5. Norethisterone. Leeford Health Care Ltd. Accessed on 19th Jul 2022] https://www.leeford.in/product/1516/rethrowel-10-cr
Useful Diagnostic Tests
- Complete blood count
- Thyroid functions
- HCG
- Pap smear
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