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INTRODUCTION
RCINEX 450 CAPSULE is a combination of Isoniazid and Rifampicin which belongs to the group of medicines called Antitubercular agents. It is used to treat tuberculosis and bacterial infection of membranes covering the brain, and spinal cord. It is also used to treat contagious disease of skin, nerves, mucous membrane, and other conditions in affected individuals.
RCINEX 450 CAPSULE is not recommended for use in patients allergic to Isoniazid, and/or Rifampicin. Before taking RCINEX 450 CAPSULE, inform your doctor if you are scheduled for any upcoming surgery, and/or suffering from pre-existing diseases, liver problems (such as cirrhosis of liver)/kidney problems (such as renal insufficiency).
RCINEX 450 CAPSULE should be used with caution during pregnancy and in women planning for pregnancy. It is also advised to be used with caution in breastfeeding women as it may pass through breast milk.
RCINEX 450 CAPSULE should be used with caution in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65years and above) after consulting the doctor.
The most common side effects of taking RCINEX 450 CAPSULE are hypersensitivity reaction (associated with signs such as skin rash, red itchy welt, and/or shortness of breath), loss of vision/hearing, flu-like syndrome, and/or arthralgia (joint stiffness). Consult your doctor if any of these symptoms worsens.
USES OF RCINEX 450 CAPSULE
- Treats tuberculosis and bacterial infection of membranes covering the brain, and spinal cord
- Treats contagious disease of skin, nerves, mucous membrane, and other conditions in affected individuals
HOW RCINEX 450 CAPSULE WORKS
RCINEX 450 CAPSULE treats tuberculosis infection, where Rifampicin works by inactivating bacterial enzyme (RNA-polymerase) resulting in its destruction and Isoniazid works by preventing the bacteria to form its own protective covering leading to its death thus treating tuberculosis in affected individuals.
DIRECTIONS FOR USE
Tablet, Capsule:
Take RCINEX 450 CAPSULE as advised by your physician. Swallow RCINEX 450 CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of the medicine depending upon your age, body weight and disease condition.
SIDE EFFECTS OF RCINEX 450 CAPSULE
COMMON
- signs of hypersensitivity (immune & inflammatory response) reactions such as skin rash, red itchy welt, shortness of breath, and/or wheezing
- loss of vision/hearing
- flu-like syndrome
- haemolytic anaemia (blood disorder)
- arthralgia (joint stiffness)
RARE
Stop taking RCINEX 450 CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- signs of severe thrombocytopenia (low platelet count) such as excessive bruising, prolonged bleeding (from cuts), bleeding from gums, and/or blood in urine/stools
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionRCINEX 450 CAPSULE is advised to be used with caution during pregnancy and in women planning for pregnancy. Consult your doctor before taking the medicine.
BREASTFEEDING
Use with CautionRCINEX 450 CAPSULE should be used with caution in breastfeeding women since the medicine may pass through breast milk. Consult your doctor before taking the medicine.
KIDNEY
Use with CautionRCINEX 450 CAPSULE should be used with caution in patients with kidney problems such as renal insufficiency. Consult your doctor before taking the medicine.
LIVER
Use with CautionRCINEX 450 CAPSULE should be used with caution in patients with liver problems such as cirrhosis of liver. Consult your doctor before taking the medicine.
ALLERGY
ContraindicatedDo not take RCINEX 450 CAPSULE if you are allergic to Isoniazid, Rifampicin, and/or any other ingredients of this medicine.
OTHERS
Before taking RCINEX 450 CAPSULE, inform your doctor if you:
- are suffering from pre-existing diseases
- are scheduled for upcoming surgery
Use in Paediatrics:
RCINEX 450 CAPSULE should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
RCINEX 450 CAPSULE should be used with caution in elderly patients (aged 65years and above). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
- oral contraceptive medicines (used to prevent pregnancy) Ex. desogestrel, ethinyl estradiol
Overdosage:
If you or anyone else accidentally takes too much of RCINEX 450 CAPSULE, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
SYNOPSIS
| Drug | : | Isoniazid, Rifampicin |
| Pharmacological Category | : | Anti-tubercular agents |
| Therapeutic Indication | : | Tuberculosis, Bacterial infection of membranes (covering the brain, and spinal cord), Contagious disease of skin, nerves, mucous membrane, and other conditions |
| Dosage Forms | : | Tablet, Dispersible tablet, Capsule, Powder, Pouch, Suspension |
MORE INFORMATION
- Keep RCINEX 450 CAPSULE out of reach of children
- Store RCINEX 450 CAPSULE at room temperature
FAQs ABOUT RCINEX 450 CAPSULE
Q. What is RCINEX 450 CAPSULE used for?
A. RCINEX 450 CAPSULE is used to treat tuberculosis and bacterial infection of membranes covering brain, and spinal cord which is also used to treat contagious disease of skin, nerves, and mucous membrane in affected individuals.
Q. How RCINEX 450 CAPSULE works?
A. RCINEX 450 CAPSULE treats tuberculosis infection, where Rifampicin works by inactivating bacterial enzyme (RNA-polymerase) resulting in its destruction and Isoniazid works by preventing the bacteria to form its own protective covering leading to its death thus treating tuberculosis in affected individuals.
Q. What are the common side effects of taking RCINEX 450 CAPSULE?
A. The most common side effects of taking RCINEX 450 CAPSULE are hypersensitivity reaction (associated with signs such as skin rash, red itchy welt, and/or shortness of breath), loss of vision/hearing, flu-like syndrome, and/or arthralgia (joint stiffness). Consult your doctor if any of these symptoms worsens.
Q. How RCINEX 450 CAPSULE should be taken?
A. Take RCINEX 450 CAPSULE as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q. Can RCINEX 450 CAPSULE be used in pregnant and breastfeeding women?
Yes, RCINEX 450 CAPSULE can be used but with caution in pregnant and breastfeeding women. Consult your doctor before taking the medicine.
REFERENCES
1. K.D. Tripathi. Antitubercular Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 767, 766.
2. Fatih Yakar, Namsan Yildiz, Aysun Yakar, Zeki Kiliçaslan. Isoniazid- and rifampicin-induced thrombocytopenia. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. February 2013. [Accessed on 14th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660205/
3. Wellona Pharma. Riwell-IS. [Accessed on 14th January 2023] https://wellonapharma.com/product/finished/rifampicin-and-isoniazid-tablets
USEFUL DIAGNOSTIC TESTS
- Mantoux test
AUTHOR DETAILS
Written By Dr. K .AZEEM HUSSAIN, B.D.S
Last updated on 30 Jan 2023 | 04:57 PM(IST)