INTRODUCTION

PYROLATE INJECTION contains Glycopyrrolate which belongs to the group of medicines called Anticholinergics. It is used before or during an operation to reduce saliva and other secretions and to reduce or prevent the slowness of the heartbeat during surgery.

PYROLATE INJECTION is also used to protect from the unwanted effects of certain drugs used to reverse the effects of muscle relaxing drugs such as neostigmine or pyridostigmine.

PYROLATE INJECTION is not recommended for use in patients having heart diseases, glaucoma (increased pressure in the eye), myasthenia gravis, enlarged prostate, stomach or bowel problems (pyloric stenosis or paralytic ileus) or if you are taking a specific medicine called neostigmine.

PYROLATE INJECTION should be used with caution in patients who have kidney diseases, down’s syndrome, gastric reflux, diarrhea, ulcerative colitis, overactive thyroid gland, or high temperature. PYROLATE INJECTION should be used with caution among pregnant and breastfeeding women. Caution must be exercised while using PYROLATE INJECTION in children and elderly patients above 60 years of age.

The most common side effects of receiving PYROLATE INJECTION are dry mouth, drowsiness, visual disturbances, fast irregular heartbeats, and an urge to pass urine but the inability to do so. Contact your physician for advice if any of the symptoms worsen.

USES OF PYROLATE INJECTION

• it is used before an operation to decrease the saliva and other secretions and to reduce acidity in the stomach contents
• it is used before or during an operation, to decrease or prevent slowness of the heartbeat during surgery
• it is used to protect from the unwanted effects of certain drugs used to reverse the effects of muscle relaxing drugs such as neostigmine or pyridostigmine

HOW PYROLATE INJECTION WORKS

PYROLATE INJECTION helps in decreasing the secretions of the body by blocking the activity of acetylcholine (a chemical messenger in the body responsible for acid and saliva production). Thus, decreasing the production of saliva and stomach acid.

DIRECTIONS FOR USE

PYROLATE INJECTION will be given to you only by a physician or a nurse into a vein as an intravenous infusion or into a muscle (intramuscular). The correct dose and duration will be decided by your physician for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF PYROLATE INJECTION

HOW TO MANAGE SIDE EFFECTS

Dizziness Or Drowsiness

Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the drowsiness doesn’t improve.

Dry Mouth

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.

WARNING & PRECAUTIONS

PREGNANCY

Use with Caution

PYROLATE INJECTION should be used with caution in pregnant women or are planning to have a baby. Consult with your doctor for advice.

BREASTFEEDING

Use with Caution

PYROLATE INJECTION should be used with caution in breast feeding women. Consult with your doctor for advice.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or use machines if you feel there is blurring of vision after receiving PYROLATE INJECTION.

KIDNEY

Consult your doctor

PYROLATE INJECTION should be used with caution in patients having kidney diseases. Your doctor may adjust your dose depending on your health condition. Consult with your doctor before receiving PYROLATE INJECTION.

ALLERGY

Contraindicated

Do not receive PYROLATE INJECTION if you are allergic to Glycopyrrolate or to any of the other ingredients of this medicine.

HEART DISEASE

Use with Caution

PYROLATE INJECTION is not recommended for use in patients having heart diseases such as QT prolongation (seen on ECG) characterized by irregular heartbeats. PYROLATE INJECTION should be used with caution in patients having history of heart diseases, heart attack, coronary heart disease, and rapid heartbeat. Consult with your doctor before receiving PYROLATE INJECTION.

USE IN PEDIATRICS

Consult your doctor

PYROLATE INJECTION should be used with caution in children. Your doctor will decide the correct dose and duration of PYROLATE INJECTION for your child depending on your child’s age, weight and health condition. Consult with your child’s doctor.

USE IN GERIATRICS

Consult your doctor

PYROLATE INJECTION should be used with caution in elderly patients above the age of 60 years. Your doctor will decide the correct dose and duration of PYROLATE INJECTION for you depending on your child’s age, weight and health condition. Consult with your doctor before receiving PYROLATE INJECTION.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving PYROLATE INJECTION, inform your physician if you are taking any of the following medicine:

• medicine used to treat depression (tricyclic antidepressants or monoamine oxidase inhibitor (MAOIs) antidepressants (Ex. amitriptyline, imipramine, phenelzine, or tranylcypromine)
• medicine used to treat severe mental disorders (Ex. clozapine)
• medicine used to treat severe pain (Ex. nefopam)
• medicine used to treat Parkinson’s disease or viral infection (Ex. amantadine, levodopa)
• medicine used to treat severe mental problems or nausea, vomiting, or vertigo (Ex. phenothiazines like chlorpromazine, fluphenazine, prochlorperazine, trifluoperazine)
• medicine used to treat allergies (antihistamines) (Ex. promethazine)
• medicine used to treat moderate to severe pain (Ex. pethidine)
• medicine used to treat nausea and vomiting (Ex. domperidone or metoclopramide)
• medicine used to treat fungal infections (Ex. ketoconazole)
• medicine used to treat Alzheimer’s disease (Ex. memantine)
• medicines that affect chemicals in the body which are involved in the transmission of nerve impulses to a muscle (parasympathomimetic) (Ex. carbachol, neostigmine, physostigmine)
• medicine used to prevent uncomplicated premature labor (Ex. ritodrine)
• medicine used to treat various conditions including asthma and inflammatory disease (corticosteroids) (Ex. prednisolone)
• medicine used to treat heart problems (Ex. slow-dissolving digoxin tablets, and disopyramide)
• medicine used to treat angina (Ex. Glyceryl trinitrate tablets)

Overdosage:

PYROLATE INJECTION will be administered to you only by a physician or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your physician or nurse if you experience any unusual symptoms. The symptoms of overdosage are hypotension, respiratory failure, a curare-like action (neuromuscular blockade leading to muscular weakness), and possibly paralysis.

SYNOPSIS

MORE INFORMATION

• Keep PYROLATE INJECTION out of reach of children
• Store PYROLATE INJECTION at a temperature, not more than 25°C

FAQs ABOUT PYROLATE INJECTION

Q: What is PYROLATE INJECTION and why is it given?

A: PYROLATE INJECTION contains Glycopyrrolate which belongs to the group of medicines called Anticholinergics. It is used before or during an operation to reduce saliva and other secretions and to reduce or prevent the slowness of the heartbeat during surgery. PYROLATE INJECTION is also used to protect from the unwanted effects of certain drugs used to reverse the effects of muscle relaxing drugs such as neostigmine or pyridostigmine.

Q: Does PYROLATE INJECTION affects my ability to drive?

A: PYROLATE INJECTION may cause your eyesight to become blurred which could interfere with your ability to drive or operate machinery safely. You should not drive or use machines after being given PYROLATE INJECTION until the doctor advises you that you are safe to do so.

Q: How is PYROLATE INJECTION given?

A: PYROLATE INJECTION will be given to you only by a physician or a nurse into a vein as an intravenous infusion or into a muscle (intramuscular). The correct dose and duration will be decided by your physician for you depending on your age, body weight, and disease condition.

Q: Can PYROLATE INJECTION cause dry mouth?

A: Yes. PYROLATE INJECTION may cause dry mouth. Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your physician for advice.

Q: Is it safe to use PYROLATE INJECTION in patients with heart problems?

A: PYROLATE INJECTION is not recommended for use in patients having heart diseases such as QT prolongation (seen on ECG) characterized by irregular heartbeats. PYROLATE INJECTION should be used with caution in patients having history of heart diseases, heart attack, coronary heart disease, and rapid heartbeat. Consult with your doctor before receiving PYROLATE INJECTION.

REFERENCES

1. Holly E. Gurgle and Donald K. Blumenthal. Drug Therapy for Dyslipidemias. Goodman & Gilman’s The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 605-618.

2. Science Direct. Glycopyrronium Bromide. [Accessed on 6th July 2022] https://www.sciencedirect.com/topics/medicine-and-dentistry/glycopyrronium-bromide

3. Hwang, J., Min, S., Kim, C. et al. Prophylactic glycopyrrolate reduces hypotensive responses in elderly patients during spinal anesthesia: a randomized controlled trial. Springer Link. December 2013. [Accessed on 6th July 2022] https://link.springer.com/article/10.1007/s12630-013-0064-y#citeas

4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2019] [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.3523.pdf

5. Pharmacy Retailing (NZ) Limited. Medsafe. [Revised in February 2019] [Accessed on 6th July 2022] https://www.medsafe.govt.nz/Profs/Datasheet/r/Robinulinj.pdf

6. B. Braun Melsungen AG. Electronic Medicines Compendium (EMC). [Revised in April 2022]. [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.2786.pdf

AUTHOR DETAILS

Written By Dr. Priyanka Goel, BDS
Last updated on 21 Mar 2023 | 05:34 PM(IST)