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(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Msn Laboratories Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

PULMONEXT KIT TABLET is a combination of Ambrisentan and Tadalafil which belongs to the group of medicines called Antihypertensives and Phosphodiesterase type 5 inhibitors respectively. It is used in the treatment of pulmonary arterial hypertension (PAH) to reduce the risks of disease progression and hospitalization of worsening pulmonary arterial hypertension (PAH). It is also used to improve exercising ability in affected individuals.

Pulmonary arterial hypertension is a condition in which blood pressure rises inside the blood vessels (the pulmonary arteries) that carry blood from the heart to the lungs. In this disease, arteries become narrower and it gets hard for heart to pump blood through them which is characterized by symptoms such as tiredness, dizziness and shortness of breath.

Your doctor might advise you to have regular blood tests to check whether you have anaemia and liver function test to assess your liver function.

Do not take grapefruit juice while having PULMONEXT KIT TABLET. It is not recommended for use in patients with lung problems such as idiopathic pulmonary fibrosis, moderate to severe liver impairment, serious heart diseases, history of heart attack within the last 90 days or stroke within the last 6 months, blood pressure problems and history of vision loss due to non-arteritic anterior ischemic optic neuropathy (loss of blood supply to nerve connecting eye to brain).

PULMONEXT KIT TABLET should be used with caution in patients with pulmonary veno-occlusive disease (disease causing blockage in the veins of lungs), mild to moderate hepatic cirrhosis (chronic liver damage) or mild to moderate kidney impairment.

PULMONEXT KIT TABLET is not recommended for use in pregnant women, women of childbearing potential who are not using reliable contraception, breastfeeding mothers and children or adolescents (aged below 18 years).

The common side effects associated with the use of PULMONEXT KIT TABLET are headache, dizziness, tiredness, nausea and diarrhea. Consult your doctor if any of the side effect worsens.

USES OF PULMONEXT KIT TABLET

  • Treats pulmonary arterial hypertension (PAH)

HOW PULMONEXT KIT TABLET WORKS

PULMONEXT KIT TABLET helps in treating pulmonary arterial hypertension (PAH) where ambrisentan widens the blood vessels returning blood to the lungs by blocking the action of certain chemical messengers that induce constriction and cell proliferation in the vessels and  tadalafil relaxes the muscles of blood vessels around the lungs, thereby improving the blood flow to the lungs and the ability to do physical activity.

DIRECTIONS FOR USE

Take PULMONEXT KIT TABLET as advised by your physician. Swallow PULMONEXT KIT TABLET with a glass of water. Do not crush or chew the medicine. Take PULMONEXT KIT TABLET after breakfast or after the first daily meal. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PULMONEXT KIT TABLET

COMMON

  • fast or irregular heartbeats
  • headache or migraine
  • runny or blocked nose, sinusitis (sinus infection), common cold
  • upper respiratory congestion in the sinuses
  • abdomen pain, constipation, diarrhoea
  • flushing
  • chest pain/discomfort
  • increased or abnormal uterine bleeding
  • indigestion, acid reflux, cough
  • ringing in the ears
  • dizziness
  • worsening of shortness of breath
  • nausea, vomiting
  • tiredness, weakness
  • disturbed or blurry vision
  • fainting
  • nose bleeding
  • rashes
  • back pain, muscle aches
  • pain in the legs and arms

UNCOMMON

  • seizures, memory loss
  • red, itchy skin
  • excessive sweating
  • bleeding in penis
  • blood in semen and/or urine
  • high blood pressure
  • eye pain
  • prolonged erection
  • pounding heart sensation

RARE

  • sudden vision loss
  • swelling of the eyelids
  • red eyes

Stop taking PULMONEXT KIT TABLET and contact your doctor immediately if you experience any of the following side effects:   

  • swelling (oedema) particularly in ankles or/and feet
  • heart failure (condition in which heart is not pumping out enough blood) causing shortness of breath, extreme tiredness and swelling in the ankles and legs
  • anaemia (reduced number of red blood cells) causing tiredness, weakness, shortness of breath, and feeling of being unwell
  • low blood pressure
  • signs of allergic reactions such as rash, itching or swelling (particularly on face, lips, tongue or throat resulting difficulty in breathing or swallowing)
  • sudden vision loss in one or both eyes
  • priapism (prolonged and painful penile erection)
  • sudden decrease or loss of hearing
  • signs of liver dysfunction such as loss of appetite, nausea, vomiting, fever, pain in your stomach, yellowing of your skin or the whites of your eyes (jaundice), dark-coloured urine, itchy skin
  • develop signs of pulmonary veno-occlusive disease (condition that occurs due to blockade of blood vessels to heart) such as shortness of breath, dry cough, weakness on exertion

HOW TO MANAGE SIDE EFFECTS

Headache:

Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the symptom persists for long or gets worsened.

Dizziness:

Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol or smoking. Consult your doctor if the symptom persists for long or gets worsened.

Diarrhoea:

Drink lot of fluids such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

Nausea and vomiting:

Try to take PULMONEXT KIT TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

PULMONEXT KIT TABLET is not recommended for use during pregnancy and in women with childbearing potential who are not using reliable contraception. Consult your doctor before taking PULMONEXT KIT TABLET.

BREASTFEEDING

PULMONEXT KIT TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking PULMONEXT KIT TABLET.

DRIVING AND USING MACHINES

Do not drive or operate any machines while taking PULMONEXT KIT TABLET since it may cause low blood pressure, dizziness, tiredness and weakness.  

ALCOHOL

Avoid consumption of alcohol while taking PULMONEXT KIT TABLET since it may enhance the blood pressure lowering effects and affect your ability to get an erection.

KIDNEY

PULMONEXT KIT TABLET is not recommended for use in patients with severe kidney impairment.  It should be used with caution in patients with mild to moderate kidney impairment. Consult your doctor for advice before taking PULMONEXT KIT TABLET.

LIVER

PULMONEXT KIT TABLET is not recommended for use in patients with moderate to severe liver impairment. It should be used with caution in patients with mild to moderate hepatic cirrhosis (chronic liver damage). Consult your doctor before taking PULMONEXT KIT TABLET.

ALLERGY

PULMONEXT KIT TABLET is not recommended for use if you are allergic to ambrisentan, tadalafil, soya or any other ingredients of this medicine.

LUNGS

PULMONEXT KIT TABLET is not recommended for use in patients with lung problems such as idiopathic pulmonary fibrosis (scarring of lung tissue). It should be used with caution in patients having pulmonary veno-occlusive disease (disease causing blockage in the veins of lungs). Consult your doctor before taking PULMONEXT KIT TABLET.

HEART DISEASE

PULMONEXT KIT TABLET is not recommended for use in patients with serious heart diseases or had a heart attack within the last 90 days. It should be used with caution in patients having other heart problems. Consult your doctor for advice before taking PULMONEXT KIT TABLET.

OTHERS

PULMONEXT KIT TABLET is not recommended for use if you:

  • had a stroke within the last 6 months
  • have low or uncontrolled high blood pressure
  • ever had loss of vision in one eye due to non-arteritic anterior ischemic optic neuropathy (loss of blood supply to nerve connecting eye to brain)
  • have anaemia

Before taking PULMONEXT KIT TABLET, inform your doctor if you:           

  • have any hereditary eye disease
  • have multiple myeloma (cancer of the bone marrow tissue)
  • have leukaemia (cancer of the blood-forming tissues)
  • have any penis deformation or unwanted or persistent erections lasting more than 4 hours
  • have peripheral oedema (swelling due to fluid retention in the hands, ankles or feet)
  • cannot tolerate to certain sugars such as lactose

Use in Paediatrics:

PULMONEXT KIT TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.

Use in Geriatrics:

PULMONEXT KIT TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking PULMONEXT KIT TABLET.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking PULMONEXT KIT TABLET, inform your doctor, if you are taking any of the following medicines:

  • other medicines used in the treatment of pulmonary arterial hypertension Ex. bosentan, riociguat, iloprost, epoprostenol
  • medicines used to treat angina pectoris (chest pain due to underlying heart disease) such as nitrates Ex. nitro-glycerine
  • medicines used to treat high blood pressure or urinary symptoms associated with benign prostatic hyperplasia such as alpha blocker (Ex. tamsulosin, terazosin, doxazosin, finasteride and alfuzosin)
  • medicines to treat high blood pressure Ex. enalapril
  • medicines used to treat fungal infections Ex. ketoconazole, itraconazole
  • medicines used to treat AIDS or HIV infection such as protease inhibitors Ex. ritonavir
  • medicines used to treat convulsions Ex. phenobarbital, phenytoin and carbamazepine
  • medicines used to treat tuberculosis Ex. rifampicin
  • medicines used to treat bacterial infection Ex. erythromycin, clarithromycin
  • medicine used after organ transplant or psoriasis Ex. cyclosporin A
  • medicines used to treat erectile dysfunction such as PDE5 inhibitors (Ex. sildenafil, vardenafil)
  • aspirin (used to reduce fever and relieve mild to moderate pain)
  • digoxin (used to treat irregular heartbeat)
  • theophylline (used to treat asthma)
  • warfarin (used to prevent or treat blood clots)
  • midazolam (used to relieve anxiety)
  • lovastatin (used to lower cholesterol and triglyceride (fat) levels)

B. Drug-Food Interactions:

Avoid drinking grapefruit juice while taking PULMONEXT KIT TABLET as it may lower the effect of the medicine.

Overdosage:

If you or anyone else accidentally takes too much of PULMONEXT KIT TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptom of PULMONEXT KIT TABLET includes headache, flushing, dizziness, nausea, nasal congestion or low blood pressure.

SYNOPSIS

Drug :   Ambrisentan, Tadalafil
Pharmacological Category :   Antihypertensives, Phosphodiesterase type 5 inhibitors
Therapeutic Indication :   Pulmonary arterial hypertension (PAH)        
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep PULMONEXT KIT TABLET out of reach of children
  • Store PULMONEXT KIT TABLET at room temperature

FAQs ABOUT PULMONEXT KIT TABLET

What is PULMONEXT KIT TABLET used for?

PULMONEXT KIT TABLET is used in the treatment of pulmonary arterial hypertension (PAH) to reduce the risks of disease progression and hospitalization of worsening pulmonary arterial hypertension (PAH). It is also used to improve exercising ability in affected individuals.

What happens if you take more PULMONEXT KIT TABLET than your required dose?

If you or anyone else accidentally takes too much of PULMONEXT KIT TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are headache, flushing, dizziness, nausea, nasal congestion or low blood pressure.

Is PULMONEXT KIT TABLET safe to use in patients with kidney problems?

PULMONEXT KIT TABLET is not recommended for use in patients with severe kidney impairment.  It should be used with caution in patients with mild to moderate kidney impairment. Consult your doctor for advice before taking PULMONEXT KIT TABLET.

Is PULMONEXT KIT TABLET safe to use in children?

PULMONEXT KIT TABLET is not recommended for use in children and adolescents (aged below 18 years) as its efficacy and effectiveness has not been fully established in this age group. Consult your child’s doctor for advice.

Can PULMONEXT KIT TABLET be used during pregnancy?

PULMONEXT KIT TABLET is not recommended for use during pregnancy and in women with childbearing potential who are not using reliable contraception. Consult your doctor before taking PULMONEXT KIT TABLET.

How does PULMONEXT KIT TABLET work?

PULMONEXT KIT TABLET helps in treating pulmonary arterial hypertension (PAH) where ambrisentan widens the blood vessels returning blood to the lungs by blocking the action of certain chemical messengers that induce constriction and cell proliferation in the vessels and tadalafil relaxes the muscles of blood vessels around the lungs, thereby improving the blood flow to the lungs and the ability to do physical activity.

Does PULMONEXT KIT TABLET lowers the blood pressure?

PULMONEXT KIT TABLET can cause low blood pressure characterized by light-headedness which is the common side effect of this medicine. Consult your doctor straight away if you get this symptom or if this happens suddenly after taking PULMONEXT KIT TABLET.

REFERENCES

1. European Society of Cardiology. Pulmonary Arterial Hypertension (Group 1). The ESC Textbook of Cardiovascular Medicine. Second edition. 2009. Page – 909.

2. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 304.

3. Paul M. Hassoun, Roham T. Zamanian, Rachel Damico, Noah Lechtzin, Rubina Khair, Todd M. Kolb, Ryan J. Tedford, Olivia L. Hulme, Traci Housten, Chiara Pisanello, Takahiro Sato, Erica H. Pullins, Celia P. Corona-Villalobos, Stefan L. Zimmerman, Mohamed A. Gashouta, Omar A. Minai, Fernando Torres, Reda E. Girgis, Kelly Chin, and Stephen C. Mathai. Ambrisentan and Tadalafil Up-front Combination Therapy in Scleroderma-associated Pulmonary Arterial Hypertension. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. November 2015. [Accessed on 2nd July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642204/

4. GlaxoSmithKline Trading Services Limited. Electronic Medicine Compendium (EMC). [Revised in March 2021] [Accessed on 2nd July 2022] https://www.medicines.org.uk/emc/files/pil.6258.pdf

5. Accord Healthcare Limited. Electronic Medicine Compendium (EMC). [Revised in October 2021] [Accessed on 2nd July 2022] https://www.medicines.org.uk/emc/files/pil.8637.pdf

6. Cipla Ltd. Endobloc T Kit (Ambrisentan + Tadalafil). [Revised in September 2019] [Accessed on 2nd July 2022] https://ciplamed.com/content/endobloc-t-kit

USEFUL DIAGNOSTIC TESTS

  • Complete blood count
  • Liver function test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    AMBRISENTAN 5 mg+TADALAFIL 20 mg
    Hsn Code
    30049099
ALTERNATE BRANDS
PULMONEXT KIT Tablet 10's
Prescription Pulmonary Arterial Hypertension (Pah) Rx required
Rs.1,592.10
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

PULMONEXT KIT Tablet 10's

PULMONEXT KIT Tablet 10's Mkt: Msn Laboratories Pvt Ltd

₹ 1,305.52 MRP ₹ 1,592.10