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Drug Information

What is Hydroxyprogesterone used for?

Hydroxyprogesterone is used for the treatment of uterine bleeding, hormonal imbalance and recurrent miscarriage.

Hydroxyprogesterone may also be prescribed for other conditions as determined by the doctor.

How does Hydroxyprogesterone work?

Hydroxyprogesterone is a hormone, which acts by releasing progesterone hormone in the body. This drug prevents uterine bleeding, delays menopause, and promotes growth and development of the foetus.

How to use Hydroxyprogesterone?

The dosage and the drug form depend on the age, weight and medical condition of an individual.

Hydroxyprogesterone injection should be administered by the healthcare provider.

If you miss a dose of Hydroxyprogesterone, consult your doctor immediately.

What are the drugs that interact with Hydroxyprogesterone?

Drugs that interact with Hydroxyprogesterone include the following:

  • Carbamazepine
  • Edoxaban
  • Phenytoin
  • Venetoclax

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Hydroxyprogesterone?

The following are the most common side effects of Hydroxyprogesterone:

  • Cough
  • Difficulty in urination
  • Fever
  • Flu-like symptoms

The following are the severe side effects, and you may require immediate medical attention:

  • Lumps in the breast
  • Redness or inflammation of the breast

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while receiving Hydroxyprogesterone?

  • Avoid the drug if you are allergic to Hydroxyprogesterone or related drugs.
  • Avoid Hydroxyprogesterone during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not exceed the dose more than what is prescribed.
  • Keep the medication out of reach of children.

What should you tell your doctor before receiving Hydroxyprogesterone?

  • Tell your doctor if you have any history of unexplained vaginal bleeding, cysts, lumps or fibroids in the breast or the uterus.
  • Inform your doctor if you have to undergo any surgery while on Hydroxyprogesterone medication.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.

Frequently Asked Questions about Hydroxyprogesterone

  1. How should Hydroxyprogesterone be stored?
  2. Hydroxyprogesterone injection should be stored at room temperature (15 - 30°C). Store the drug away from direct sunlight.

  3. What are the other formulations of Hydroxyprogesterone available?
  4. Apart from injection dosage form, Hydroxyprogesterone medicine is also available in tablet and syrup dosage forms.

  5. Is it safe to alter the dose of Hydroxyprogesterone?
  6. Avoid changing the dose of the drug without consulting the doctor as it may increase the risk of side effects.

  7. Do I need to be monitored for any laboratory parameters while receiving Hydroxyprogesterone?
  8. Yes, you must monitor your progesterone and oestrogen levels while receiving Hydroxyprogesterone medicine.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the opinion of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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