PRO 5 500mg Tablet 10'S

Cancer/Oncology Rx required
OUT OF STOCK

Best Price* ₹ 1,055.70 MRP ₹ 1,173.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Mylan Pharmaceuticals Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

PRO 5 500MG TABLET contains Capecitabine which belongs to the group of medicines called Anti-cancer medicines. It is used in the treatment of colon, rectal gastric and breast cancer.

PRO 5 500MG TABLET is also used to prevent new occurrence of colon cancer after complete removal of the tumor by surgery.  It may be used either alone or in combination with other medicines.

PRO 5 500MG TABLET is not recommended for use if you have severe liver, kidney disease or had severe reactions to fluoropyrimidine therapy (a group of anticancer medicines such as fluorouracil).

PRO 5 500MG TABLET should be used with caution in patients with liver, kidney disease, heart problems, brain disease or nerve damage, diabetes, history of eye problems. Consult your doctor before taking this medicine.

PRO 5 500MG TABLET is not recommended for use in pregnant and breastfeeding women, in children and adolescents. Consult your doctor before taking this medicine.

The most common side-effects of taking PRO 5 500MG TABLET are abdominal pain, rash, dry or itchy skin, tiredness, loss of appetite. Consult your doctor if any of these symptoms worsen.

USES OF PRO 5 500MG TABLET

  • To treat rectal, colon, gastric and breast cancer
  • To prevent new occurrence of colon cancer after the complete removal of the tumor by surgery

HOW PRO 5 500MG TABLET WORKS

PRO 5 500MG TABLET helps in the treatment of cancer by stopping the abnormal growth of cells. Thus, helps to treat cancer effectively.

DIRECTIONS FOR USE

Take PRO 5 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Take the medicine within 30 minutes after the end of a meal.

Your doctor will decide the correct dose and duration of PRO 5 500MG TABLET for you depending upon your age, body surface area and disease condition. Do not stop taking PRO 5 500MG TABLET unless your doctor has told you to.

SIDE EFFECTS OF PRO 5 500MG TABLET

COMMON

  • abdominal pain
  • rash, dry or itchy skin
  • tiredness
  • loss of appetite
  • dehydration and weight loss
  • sleeplessness (insomnia), depression
  • headache, sleepiness, dizziness
  • tingling sensations or numbness in the skin
  • changes in taste
  • increased tears, irritation in the eye, redness of eyes (conjunctivitis)
  • inflammation of the veins (thrombophlebitis)
  • shortness of breath, bleeding from nose, cough or runny nose
  • cold sores or other herpes infections
  • infections of the lungs or respiratory system (pneumonia or bronchitis)
  • bleeding from the gut, constipation, pain in upper abdomen, indigestion, excess wind
  • dry mouth
  • skin problems (rash, reddening, dry skin, itching, skin discoloration, skin loss
  • inflammation, nail disorder, hair loss (alopecia)
  • painful joints or limbs (hands and legs), chest or back
  • fever, swelling in the limbs, feeling ill
  • nerve pain
  • ringing or buzzing in the ears (tinnitus), loss of hearing
  • hiccups, change in voice
  • pain or altered/abnormal sensation in the mouth, pain in the jaw sweating, night sweats
  • muscle spasm
  • difficulty in urination, blood or protein in the urine
  • bruising or reaction at the injection site

UNCOMMON

  • blood infection, urinary tract infection, infection of the skin, infections in the nose and throat, fungal infections (including those of the mouth), influenza, gastroenteritis, tooth abscess
  • lumps under the skin (lipoma)
  • allergy
  • malnutrition
  • confusional state, panic attacks, depressed mood
  • decreased libido
  • difficulty speaking
  • impaired memory
  • loss of movement coordination, balance problems
  • fainting
  • nerve damage and altered sensation
  • blurred or double vision
  • vertigo, pain in ear
  • irregular and fast heartbeat (arrhythmias), chest pain and heart attack
  • blood clots in the deep veins
  • high or low blood pressure
  • hot flushes
  • cold limbs (hands or feet)
  • purple spots on the skin
  • respiratory problems such as blood clots in the veins in the lung (pulmonary embolism), collapsed lung, coughing up blood, asthma, shortness of breath on exertion
  • gastrointestinal problems (bowel obstruction, collection of fluid in the abdomen, inflammation of the small or large intestine, the stomach or the oesophagus, pain in the lower abdomen, abdominal discomfort, heartburn, blood in the stool
  • jaundice (yellowing of skin and eyes)
  • ulcer and blister on skin, skin reaction with sunlight, reddening of palms, swelling or pain of the face
  • joint swelling or stiffness of joints, bone pain, weakness or stiffness of muscles
  • fluid collection in the kidneys, increase in the frequency of urination during the night, incontinence (loss of bladder control)
  • unusual bleeding from the vagina
  • swelling (oedema)
  • chills and rigors

RARE

  • narrowing or blockage of tear duct (lacrimal duct stenosis)
  • liver failure, inflammation leading to dysfunction or obstruction in bile secretion (cholestatic hepatitis)
  • certain types of arrhythmias (including ventricular fibrillation, torsade de pointes and bradycardia)
  • eye inflammation causing eye pain and possibly eyesight problems
  • inflammation of the skin causing red scaly patches due to an immune system illness

Stop taking PRO 5 500MG TABLET and contact your doctor immediately if you experience any of the following side effects:

  • diarrhoea
  • nausea and vomiting
  • stomatitis (redness, pain, swelling or sores in mouth or throat)
  • hand-and-foot skin-reaction (pain, swelling, redness or tingling of hands and/or feet)
  • fever
  • infection
  • chest pain
  • steven johnson syndrome (painful red or purplish rash that spreads and blisters or other lesions begin to appear in mouth and lips), especially if you had before light sensitivity, infections of the respiratory system (Ex. bronchitis) and/or fever
  • angioedema (swelling of lips, face, throat or tongue causing difficulty to swallow or breathe, itchiness and rashes)

HOW TO MANAGE SIDE EFFECTS

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the flatulence does not improve, contact your doctor.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Contact your doctor if constipation persist.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the stomach pain does not improve, contact your doctor.

Headache:

Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if the headache did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Contact your doctor if the dizziness did not improve.

WARNING & PRECAUTIONS

PREGNANCY

PRO 5 500MG TABLET is not recommended for use in pregnant women. Woman of childbearing potential should use effective contraception during treatment with PRO 5 500MG TABLET and for 6 months after the last dose.

If you are a male patient and your female partner could become pregnant, you should use effective contraception during treatment with PRO 5 500MG TABLET and for 3 months after the last dose. Consult your doctor before taking PRO 5 500MG TABLET.

BREASTFEEDING

PRO 5 500MG TABLET is not recommended for use in breastfeeding women and do not breastfeed for 2 weeks after the last dose of PRO 5 500MG TABLET. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy, nauseous or tired after taking PRO 5 500MG TABLET.

KIDNEY

PRO 5 500MG TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking it.

PRO 5 500MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking PRO 5 500MG TABLET.

LIVER

PRO 5 500MG TABLET is not recommended for use in patients with severe liver disease. Consult your doctor before taking it.

PRO 5 500MG TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.

ALLERGY

Do not take PRO 5 500MG TABLET if you are allergic to Capecitabine or any of the other ingredients of this medicine.

HEART DISEASE

PRO 5 500MG TABLET should be used with caution in patients with heart problems (Ex. an irregular heartbeat or chest pain radiating to the jaw and back brought on by physical effort and due to problems with the blood flow to the heart). Consult your doctor before taking PRO 5 500MG TABLET.

OTHERS

PRO 5 500MG TABLET is not recommended for use if you:

  • previously have had severe reactions to fluoropyrimidine therapy (a group of anticancer medicines such as fluorouracil)
  • have severely low levels of white cells or platelets in the blood (leukopenia, neutropenia or thrombocytopenia)
  • have complete DPD deficiency (do not have any activity of the enzyme dihydropyrimidine dehydrogenase (DPD)
  • are being treated now or have been treated in the last 4 weeks for herpes zoster (chickenpox or shingles) with brivudine

Before taking PRO 5 500MG TABLET, inform your doctor if you:

  • have a partial deficiency in the activity of the enzyme dihydropyrimidine dehydrogenase (DPD)
  • have a family member who has partial or complete deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD)
  • have brain disease (Ex. cancer that has spread to the brain or nerve damage (neuropathy)
  • have calcium imbalance or other electrolyte imbalances
  • have diabetes
  • cannot keep food or water in your body because of severe nausea and vomiting
  • have history of eye problems
  • have diarrhea
  • are dehydrated
  • have a severe skin reaction
  • have intolerance to lactose or other sugars

Use in pediatrics:

PRO 5 500MG TABLET is not recommended for use in children and adolescents. Consult your doctor before taking PRO 5 500MG TABLET.

INTERACTIONS

A. Drug – Drug Interactions:

  • medicined used in the treatment of shingles and chickenpox (Ex. brivudine)
  • medicines used in the treatment of gout (Ex. allopurinol)
  • blood-thinning medicines Ex. coumarin, warfarin (medicines used to treat or prevent blood clots)
  • medicines used the treatment of seizures or tremors (Ex. phenytoin)
  • interferon alpha (used in the treatment of hepatitis B, C, lymphoma and other cancers)
  • radiotherapy and certain medicines used to treat cancer (Ex. folinic acid, oxaliplatin, bevacizumab, cisplatin, irinotecan, fluorouracil)
  • medicines used to treat folic acid deficiency (Ex. levomefolic acid)

Overdosage:

If you or anyone else accidentally take too much of PRO 5 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are nausea, vomiting, diarrhea, inflammation or ulceration of the gut or mouth, pain or bleeding from the intestine or stomach or bone marrow depression (reduction in certain kinds of blood cells).

SYNOPSIS

Drug :   Capecitabine
Pharmacological Category :   Nucleoside metabolic inhibitor
Therapeutic Indication :   Colon, gastric, rectal and breast cancer
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep PRO 5 500MG TABLET out of reach of children
  • Store below 30°C

FAQs ABOUT PRO 5 500MG TABLET

What should I inform my doctor before starting with PRO 5 500MG TABLET?

Before starting the treatment with PRO 5 500MG TABLET you should inform your doctor if you have kidney, liver or heart disease, diarrhea, dehydration, nausea and vomiting, brain disease (Ex. cancer that has spread to the brain or nerve damage (neuropathy), diabetes, history of eye problems or severe skin reactions.

What if I forget to take a dose of PRO 5 500MG TABLET?

If you have missed a dose, take it as soon as you remember it.  Do not take double dose to compensate for the missed dose of PRO 5 500MG TABLET. Continue taking the medicine as per your schedule. Talk to your doctor.

Is PRO 5 500MG TABLET a form of chemotherapy?

Yes. PRO 5 500MG TABLET is an oral chemotherapy medicine which is used in the treatment of cancers like rectal, colon, gastric or breast cancer. Your doctor will decide the correct treatment plan for you.

How long do I have to take PRO 5 500MG TABLET?

Your doctor will decide the correct dose of PRO 5 500MG TABLET and number of cycles for you depending upon your body weight, age and disease condition. PRO 5 500MG TABLET are usually taken for 14 days followed by a 7-day rest period. This 21-day period is one treatment cycle. In some cases, you will advise to take PRO 5 500MG TABLET every day while used in combination with other medicines.

Can I stop taking PRO 5 500MG TABLET if I feel better?

No. You should not stop taking PRO 5 500MG TABLET or change the dose until and unless your doctor asks you to. You will at a high risk of getting back the symptoms and dangerous tumor growth. Talk to your doctor.

Can PRO 5 500MG TABLET cause eye problems?

Prior to starting the treatment with PRO 5 500MG TABLET, you should inform your doctor if you have a history of eye problems. While your treatment with PRO 5 500MG TABLET you may need monitoring of your eyes. Talk to your doctor before taking PRO 5 500MG TABLET.

Does PRO 5 500MG TABLET shrink tumours?

No, PRO 5 500MG TABLET does not shrink tumours. PRO 5 500MG TABLET contains capecitabine, which works by stopping or reducing the abnormal growth of cells which is called a cytostatic activity. Only after being absorbed by the body, it is changed into an active anti-cancer medicine (more in tumor tissue than in normal tissue).  Therefore, it stops tumor growth and spreading without causing them to shrink.

Do PRO 5 500MG TABLET cause hair loss?

Yes, the most common side effect of PRO 5 500MG TABLET is hair loss. Before your cancer treatment, prepare in advance for changes in your hair. Talk to your doctor about what to expect. Use head coverings such as wig, scarf. Try to add iron and protein rich foods like green leafy vegetables and beans into snacks and meals.

Can I take double doses together to cure cancer soon?

No, do not take more PRO 5 500MG TABLET than the normal recommended dose as it may cause overdosage of PRO 5 500MG TABLET leading to harmful side effects such as diarrhea, inflammation of gut or mouth, pain or bleeding in stomach or bone marrow depression (reduction in blood cells), nausea and vomiting.

REFERENCES

1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of medical pharmacology. Seventh edition. 2013. Page – 864.

2. Sedat Tatar, Can E. Yalçin, Billur Sezgin, Ayse Y. Tas, Orkun Müftüoglu, Selahattin Özmen. Capecitabine-Induced Bilateral Ectropion: A Rare Ocular Manifestation Requiring Surgical Intervention. National Institute of Health NLM, National Centre for Biotechnology Information. PubMed Central. 2018 Oct-Dec. [Accessed on 18th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371725/

3. Walko CM, Lindley C. Capecitabine: a review. National Institute of Health NLM, National Centre for Biotechnology Information. PubMed.gov. January 2005. [Accessed on 18th June 2022] https://pubmed.ncbi.nlm.nih.gov/15763604/

4. Glenmark Pharmaceuticals s.r.o. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 18th June 2022] https://www.medicines.org.uk/emc/files/pil.9938.pdf

5. Hawke’s Bay District Health Board. Capecitabine. March 2018. [Accessed on 18th June 2022] https://hawkesbay.health.nz/assets/Patient-Medication-Information/Capecitabine-PIL-Booklet.pdf

6. Drug bank. Capecitabine. [Accessed on 18th June 2022] https://go.drugbank.com/drugs/DB01101

USEFUL DIAGNOSTIC TESTS

  • Complete blood count
  • Circulating tumor test (CTC)
  • Tumor Markers
  • Liver function test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    CAPECITABINE 500MG
    Hsn Code
    30049099
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