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INTRODUCTION
PRIMIWAL S 25MG contains Sildenafil which belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. It is used to treat adult men with erectile dysfunction, also known as impotence. It happens when a man cannot get, or keep a hard, erect penis suitable for sexual activity. Erectile dysfunction (ED) is inability of men to attain and maintain an erect penis with sufficient rigidity to allow sexual intercourse. This medicine works by helping to relax the blood vessels in penis, allowing blood to flow into penis when you get sexually excited.
Sildenafil acts by inhibiting PDE-5 and enhancing NO action in the penis. The mechanism of erection of the penis involves release of nitric oxide (NO) during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), resulting in smooth muscle relaxation and inflow of blood to the penis.
Always take this PRIMIWAL S 25MG exactly as directed by your doctor. It is not suitable for women or children and adolescents under 18 years of age. Before taking this medicine tell your doctor if you have severe heart or liver problems, if you have recently had a stroke or heart attack or if you have low blood pressure. Tell your doctor know if you suffer from these or any other health problems before taking it.
USES OF PRIMIWAL S 25MG
- Treats erectile dysfunction (ED)
HOW PRIMIWAL S 25MG WORKS
Sildenafil works by helping to relax the blood vessels which allows increased blood flow into the penis when you get sexually excited.
DIRECTIONS FOR USE
Always take this medicine exactly as your doctor has directed you. Swallow medicine whole with a glass of water. Do not take more than once a day.
SIDE EFFECTS OF PRIMIWAL S 25MG
SERIOUS
- erection (priapism)
- sudden vision loss (one or both eyes)
- sudden hearing decrease or hearing loss
COMMON
- headache
- flushing
- upset stomach
- abnormal vision andblurred vision
- stuffy or runny nose
- back pain
- muscle pain
- nausea
- dizziness
- rash
RARE
- fainting or irregular heartbeat
- decreased blood flow to parts of the brain, feeling of tightening of the throat, numb
- eye problems
- seeing halos around lights
- penile bleeding, presence of blood in semen
- dry and swelling of the inside of the nose
HOW TO MANAGE SIDE EFFECTS
Feeling sick (nausea) or indigestion:
Stick to simple meals and do not eat rich or spicy foods.
Headache:
Rest and drink plenty of fluids.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
WARNING & PRECAUTIONS
DRIVING AND USING MACHINES
PRIMIWAL S 25MG may cause dizziness or affect your vision. Do not drive or handle any machines while taking this medicine.
ALCOHOL
Drinking alcohol can impair your ability to get an erection. Do not drink excessive amounts of alcohol while taking this medicine.
KIDNEY
PRIMIWAL S 25MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
PRIMIWAL S 25MG is not recommended in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Sildenafil or any other ingredients in this medicine.
HEART DISEASE
PRIMIWAL S 25MG is not recommended in patients with severe heart disease. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- low blood pressure
- sickle cell anaemia, leukaemia, multiple myeloma (cancer of bone marrow)
- inherited eye diseases (retinitis pigmentosa)
- loss of vision
- deformity of your penis or Peyronie’s disease
- stomach ulcer or bleeding problem (haemophilia)
INTERACTIONS
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:
- nitroglycerin
- amyl nitrite
- riociguat (used to treat pulmonary arterial hypertension)
- protease inhibitors (used to treat HIV)
- alpha-blockers (terazosin hydrochloride)
- other medicines for erectile dysfunction
SYNOPSIS
| Drug | : | Sildenafil |
| Pharmacological Category | : | Phosphodiesterase-5 Enzyme Inhibitor |
| Therapeutic Indication | : | Erectile dysfunction |
| Dosage Forms | : | Tablet, Capsule, Oral solution, Injection, Jelly, Spray |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT PRIMIWAL S 25MG
Can I take PRIMIWAL S 25MG for premature ejaculation?
No, it is not known to have any beneficial effects in treating premature ejaculation. It is used for treatingerectile dysfunction.
Does PRIMIWAL S 25MGaffect fertility?
No, it does not affect fertility, neither negatively nor positively.
Is PRIMIWAL S 25MG safe to use in patients with diabetes?
Yes, if prescribed by your doctor then this medicine is safe to use in patients with diabetes.
REFERENCES
1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 304.
2. Michel T, Hoffman BB. Treatment of Myocardial Ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 752-53.
3. Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 197.
4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 1261-62.
5. James G McMurray, Robert A Feldman, Stephen M Auerbach, Herb DeRiesthal, Neal Wilson. Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction: Therapeutics and clinical risk management. Dec 2007. [Accessed Oct 3, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387281/
6. Upjohn UK Limited,Fareva Amboise, Zone Industrielle. Electronic Medicines Compendium (EMC); [Revised June 2020] [Accessed Dec 31,2020] https://www.medicines.org.uk/emc/files/pil.3172.pdf
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