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Introduction About PREXARON
PREXARON contains Citicoline which belongs to a group of medicines called Psychostimulants. PREXARON is used in adults to manage disturbances of consciousness that occurs due to head injuries, brain operation and acute cerebral infraction.
PREXARON is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. It is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) which is also used to manage Parkinson’s disease (age related degenerative brain condition).
PREXARON is not recommended for use in patients allergic to Citicoline. It is also not recommended for use in patients suffering from hypertonia (muscle overactivity).
Before taking PREXARON, inform your doctor if you are scheduled for any surgery and/or have kidney problems (such as renal insufficiency)/liver problems (such as hepatic insufficiency).
PREXARON should be used with caution in pregnant and breastfeeding women only if necessary. It is not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of taking PREXARON are nausea, vomiting, constipation, headache, low blood pressure and/or agitation. Consult your doctor if any of these symptoms worsens.
Uses Of PREXARON
- Manage disturbances of consciousness that occurs due to head injuries, brain operation and acute cerebral infraction
- Manage cognitive dysfunction that occurs due to Alzheimer’s disease and other cerebrovascular disease
- Manage Parkinson’s disease
- Helps in the acute and recovery phase of cerebral infarction/ischemic stroke in affected individuals
How PREXARON Works
PREXARON works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.
How to use PREXARON
Oral Drops:
Take PREXARON as advised by your physician. Shake well before use. Measure it with a dropper and take it as directed. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Syrup & Solution:
Take PREXARON as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of PREXARON
Common
- nausea, vomiting, constipation
- headache
- agitation
- low blood pressure
How To Manage Side Effects
Nausea and vomiting:
Take PREXARON with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.
Headache:
If PREXARON causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking PREXARON. If it lasts more than a week or severe, inform your doctor.
Warning & Precautions
Pregnancy
PREXARON should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking PREXARON.
Breastfeeding
PREXARON should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before taking PREXARON.
Kidney
PREXARON should be used with caution in patients with kidney problems such as kidney insufficiency. Consult your doctor before taking PREXARON.
Liver
PREXARON should be used with caution in patients with liver problems such as liver insufficiency. Consult your doctor before taking PREXARON.
Allergy
Do not take PREXARON if you are allergic to Citicoline or any of the other ingredients of this medicine.
Others
PREXARON is not recommended for use if you have:
- are hypertonic (muscle overactivity)
Use in Paediatrics:
PREXARON is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
PREXARON should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
Interactions
A.Drug - Drug interactions:
Before taking PREXARON, inform your doctor if you are taking any of the following medicine:
- levodopa (medicine used to manage Parkinson’s disease)
- meclofenoxate (used as a dietary supplement to manage dementia)
Overdosage:
If you or anyone else accidentally take too much of PREXARON, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Synopsis
| Drug | : | Citicoline |
| Pharmacological Category | : | Pyrimidine ribonucleoside diphosphates |
| Therapeutic Indication | : | Disturbance in consciousness (due to head injuries, brain operation, acute cerebral infraction), Cognitive dysfunction (due to Alzheimer’s disease), Parkinson’s disease |
| Dosage Forms | : | Tablet, Injection, Syrup, Solution, Oral drops |
More Information
- Keep PREXARON out of reach of children
- Do not store PREXARON above 30°C
FAQs About PREXARON
What is PREXARON is used for?
PREXARON is used in adults to manage disturbances of consciousness that occurs due to head injuries, brain operation and acute cerebral infraction. It is also used to manage cognitive dysfunction that occurs due to Alzheimer’s disease (brain disease that affects memory and thinking skills) and other cerebrovascular disease. The medicine is also indicated for use in acute and recovery phase of cerebral infarction (condition that occurs due to poor blood supply to the brain) which is also used to manage Parkinson’s disease (age related degenerative brain condition) in affected individuals.
What are the side effects of PREXARON?
The most common side effects of taking PREXARON are nausea, vomiting, constipation, headache, low blood pressure and/or agitation. Consult your doctor if any of these symptoms worsens.
How PREXARON works?
PREXARON works by increasing the synthesis of phosphatidylcholine (chemical that produces acetylcholine, responsible for memory and other bodily functions) which leads to improved cerebral function and cognitive function in Alzheimer’s disease and Parkinson’s disease. It also works by repairing neuronal membranes and damaged cholinergic neurons via potentiation of acetylcholine production and reduction of free fatty acid accumulation at stroke-induced nerve damage site which results in the management neuronal cell death thus helping in the recovery phase of cerebral infarction in affected individuals.
What happens if more than required dosage of PREXARON is taken?
If you or anyone else accidentally take too much of PREXARON, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Can PREXARON be used in pregnant and breastfeeding women?
Yes, PREXARON can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before taking PREXARON.
References
1. KD. Tripathi. CNS Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page - 491.
2. Cochrane Stroke Group, Arturo J Martí-Carvajal, Claudia Valli, Cristina Elena Martí-Amarista, Ivan Solà, Joan Martí-Fàbregas, Xavier Bonfill Cosp. Citicoline for treating people with acute ischemic stroke. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in August 2020] [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406786/
3. Pawel Grieb. Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2014] [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933742/
4. Antonino Maria Cotroneo, Alberto Castagna, Salvatore Putignano, Roberto Lacava, Fausto Fantò, Francesco Monteleone,5 Filomena Rocca, Alba Malara, Pietro Gareri. Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2013] [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569046/
5. UniLab, Inc. Citicoline. [Revised in June 2015] [Accessed on 7th May 2022] https://www.unilab.com.ph/products/cholinerv
6. Alkem Laboratories Limited. Ceham. [Accessed on 7th May 2022] https://www.alkemlabs.com/pdf/adverse/Ceham.pdf
Useful Diagnostic Tests
- Magnetic resonance imaging (MRI)
- Dopamine transporter (DAT) scan
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